Ileal sodium/bile acid cotransporter

An ileal sodium/bile acid cotransporter that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12908]

Synonyms

Apical sodium-dependent bile acid transporter;
ASBT;
Ileal Na(+)/bile acid cotransporter;
Ileal sodium-dependent bile acid transporter;
IBAT;
ISBT;
Na(+)-dependent ileal bile acid transporter;
Sodium/taurocholate cotransportin

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (33.33)	18.2507
2000's	2 (66.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (14)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sulfobromophthalein sodium	Homo sapiens (human)	Ki	144.0000	1	1
taurocholic acid	Homo sapiens (human)	Ki	41.5000	1	1
chenodeoxycholic acid	Homo sapiens (human)	Ki	3.3000	1	1
ursodeoxycholic acid	Homo sapiens (human)	Ki	75.0000	1	1
s 8921	Homo sapiens (human)	IC50	2.5500	1	1
deoxycholic acid	Homo sapiens (human)	Ki	6.3000	1	2
taurochenodeoxycholic acid	Homo sapiens (human)	Ki	6.1000	1	1
sodium taurodeoxycholate	Homo sapiens (human)	Ki	17.2000	1	1
cyclosporine	Homo sapiens (human)	Ki	24.0000	1	1
2164u90	Homo sapiens (human)	Ki	10.0000	1	1
ursodoxicoltaurine	Homo sapiens (human)	Ki	28.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
taurocholic acid	Homo sapiens (human)	Km	18.6667	2	3
glycochenodeoxycholic acid	Homo sapiens (human)	Km	5.7000	1	1
glycodeoxycholic acid	Homo sapiens (human)	Km	2.0000	1	1
glycoursodeoxycholic acid	Homo sapiens (human)	Km	4.1000	1	1

Enables

This protein enables 2 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
bile acid:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). [TC:2.A.28.-.-]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
microvillus	cellular component	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. [ISBN:0815316194]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Involved In

This protein is involved in 4 target(s):

Target	Category	Definition
sodium ion transport	biological process	The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
response to bacterium	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb]
bile acid and bile salt transport	biological process	The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]
transmembrane transport	biological process	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]

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