Proteins > Ubiquitin-like modifier-activating enzyme ATG7
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Ubiquitin-like modifier-activating enzyme ATG7

A ubiquitin-like modifier-activating enzyme ATG7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95352]

Synonyms

ATG12-activating enzyme E1 ATG7;
Autophagy-related protein 7;
APG7-like;
hAGP7;
Ubiquitin-activating enzyme E1-like protein

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pevonedistatHomo sapiens (human)IC505.500022

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
Atg12 activating enzyme activitymolecular functionCatalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]
Atg8 activating enzyme activitymolecular functionCatalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
axonemecellular componentThe bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. [GOC:bf, GOC:cilia, ISBN:0198547684]
secretory granule lumencellular componentThe volume enclosed by the membrane of a secretory granule. [GOC:rph]
ficolin-1-rich granule lumencellular componentAny membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
phagophore assembly sitecellular componentPunctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 17 target(s):

TargetCategoryDefinition
autophagosome assemblybiological processThe formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. [GOC:autophagy, PMID:9412464]
mitophagybiological processThe selective autophagy process in which a mitochondrion is degraded by macroautophagy. [PMID:15798367]
autophagybiological processThe cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation. [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]
cellular response to starvationbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. [GOC:jl]
protein transportbiological processThe directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
macroautophagybiological processThe autophagic process that proceeds via the formation of an autophagosome. [PMID:24366339]
regulation of circadian rhythmbiological processAny process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb]
positive regulation of apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of protein catabolic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators]
rhythmic processbiological processAny process pertinent to the generation and maintenance of rhythms in the physiology of an organism. [GOC:jid]
defense response to virusbiological processReactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]
cellular response to hyperoxiabiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. [GOC:mah]
autophagy of mitochondrionbiological processThe autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]
cellular response to nitrogen starvationbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. [GOC:jl]
piecemeal microautophagy of the nucleusbiological processDegradation of a cell nucleus by microautophagy. [GOC:autophagy, GOC:jp, PMID:18701704]
C-terminal protein lipidationbiological processThe covalent attachment of a lipid group to the carboxy-terminus of a protein. [GOC:jl]
protein modification by small protein conjugationbiological processA protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. [GOC:mah]