Proteins > Histone deacetylase 4
Page last updated: 2024-08-07 16:52:11

Histone deacetylase 4

A histone deacetylase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56524]

Synonyms

HD4;
EC 3.5.1.98

Research

Bioassay Publications (288)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.35)18.2507
2000's67 (23.26)29.6817
2010's162 (56.25)24.3611
2020's58 (20.14)2.80

Compounds (86)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidHomo sapiens (human)Ki8.190011
butyric acidHomo sapiens (human)IC502,000.000011
butyric acidHomo sapiens (human)Ki136.000011
celecoxibHomo sapiens (human)IC501.637011
ci 994Homo sapiens (human)IC5023.2175512
ci 994Homo sapiens (human)Ki0.095013
clioquinolHomo sapiens (human)IC5071.0857114
valproic acidHomo sapiens (human)IC502,808.750044
valproic acidHomo sapiens (human)Ki564.000011
fluconazoleHomo sapiens (human)IC5040.000011
beta-thujaplicinHomo sapiens (human)Ki20.000011
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)IC500.833022
entinostatHomo sapiens (human)IC5011.49803755
4-phenylbutyric acidHomo sapiens (human)IC502,000.000011
4-phenylbutyric acidHomo sapiens (human)Ki2.800011
pomiferinHomo sapiens (human)IC501.050011
pyroxamideHomo sapiens (human)IC505.100022
scriptaidHomo sapiens (human)IC500.430022
scriptaidHomo sapiens (human)Ki7.500011
4-phenylbutyric acid, sodium saltHomo sapiens (human)Ki6.340011
fenofibrateHomo sapiens (human)IC5075.000011
vorinostatHomo sapiens (human)IC507.1129225258
vorinostatHomo sapiens (human)Ki12.501066
benzohydroxamic acidHomo sapiens (human)IC5033.330011
acetylcysteineHomo sapiens (human)IC503,160.000011
camptothecinHomo sapiens (human)IC500.050011
bendamustineHomo sapiens (human)IC500.010011
osajinHomo sapiens (human)IC506.530011
lapatinibHomo sapiens (human)IC50100.000011
N-hydroxy-2-phenylacetamideHomo sapiens (human)IC5033.330011
n-hydroxy-2,2-diphenylacetamideHomo sapiens (human)IC5013.621288
trapoxin aHomo sapiens (human)IC500.004733
e-z cinnamic acidHomo sapiens (human)Ki0.008211
trichostatin aHomo sapiens (human)IC500.85525474
trichostatin aHomo sapiens (human)Ki3.650255
caffeic acidHomo sapiens (human)IC502,540.000011
caffeic acidHomo sapiens (human)Ki10.840011
curcuminHomo sapiens (human)IC50187.000011
chlorogenic acidHomo sapiens (human)IC50258.333333
chlorogenic acidHomo sapiens (human)Ki0.135011
zd 6474Homo sapiens (human)IC5010.000033
desmethylanethol trithioneHomo sapiens (human)IC500.450022
5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinolHomo sapiens (human)IC5025.195018
ex 527Homo sapiens (human)IC50100.000011
sodium butyrateHomo sapiens (human)IC50360.000033
sodium butyrateHomo sapiens (human)Ki365.000011
5'-o-caffeoylquinic acidHomo sapiens (human)IC50185.200022
harmineHomo sapiens (human)IC5010.000033
aureusidinHomo sapiens (human)IC5018.500011
romidepsinHomo sapiens (human)IC506.47481111
romidepsinHomo sapiens (human)Ki0.020522
cinnamoylhydroxamic acidHomo sapiens (human)IC5019.460011
3',4'-dihydroxyauroneHomo sapiens (human)IC508.200011
psammaplin aHomo sapiens (human)IC500.027022
trichostatin cHomo sapiens (human)IC5023.630011
laq824Homo sapiens (human)IC500.08481418
laq824Homo sapiens (human)Ki2.250022
indigo carmineHomo sapiens (human)IC50321.620022
tanespimycinHomo sapiens (human)IC501,000.000011
pd 404182Homo sapiens (human)IC509.000011
tubacinHomo sapiens (human)IC5017.300044
tubacinHomo sapiens (human)Ki13.062122
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)IC501.03351212
belinostatHomo sapiens (human)IC504.40381022
belinostatHomo sapiens (human)Ki0.258333
sk-7041Homo sapiens (human)IC500.172011
panobinostatHomo sapiens (human)IC500.79631624
panobinostatHomo sapiens (human)Ki0.382155
hdac-42Homo sapiens (human)IC500.016011
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)IC507.6678624
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)Ki0.167213
n1-(2-aminophenyl)-n7-phenylheptanediamideHomo sapiens (human)IC50129.000022
bml 210Homo sapiens (human)IC5091.400055
n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamideHomo sapiens (human)IC501.060033
givinostatHomo sapiens (human)IC501.000011
givinostatHomo sapiens (human)Ki1.050022
mocetinostatHomo sapiens (human)IC506.2287515
methyl 3,5-di-o-caffeoyl quinateHomo sapiens (human)IC506.290022
r 306465Homo sapiens (human)IC500.005322
quisinostatHomo sapiens (human)IC500.002644
quisinostatHomo sapiens (human)Ki0.003522
abexinostatHomo sapiens (human)IC500.060011
chidamideHomo sapiens (human)IC505.789032
hc toxinHomo sapiens (human)IC500.430011
azumamide eHomo sapiens (human)IC502.280011
cnf 2024Homo sapiens (human)IC501.000022
pci 34051Homo sapiens (human)IC5048.000055
cudc 101Homo sapiens (human)IC500.156774
largazoleHomo sapiens (human)IC505.333333
N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl esterHomo sapiens (human)IC500.050011
trichostatin rkHomo sapiens (human)IC50100.000011
jq1 compoundHomo sapiens (human)IC500.291011
tubastatin aHomo sapiens (human)IC5021.35951423
tubastatin aHomo sapiens (human)Ki5.380011
pracinostatHomo sapiens (human)IC505.063022
pracinostatHomo sapiens (human)Ki0.016011
acy-1215Homo sapiens (human)IC504.90911111
cudc-907Homo sapiens (human)IC500.323366
rg2833Homo sapiens (human)IC50180.000011
mi-192Homo sapiens (human)IC505.000011
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)IC5012.095044
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)Ki7.570011
osimertinibHomo sapiens (human)IC501.000011
santacruzamate aHomo sapiens (human)IC503.000022

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ci 994Homo sapiens (human)EC503.810011
entinostatHomo sapiens (human)EC501.000011
imatinibHomo sapiens (human)EC50100.000011
vorinostatHomo sapiens (human)EC503.430066
trichostatin aHomo sapiens (human)EC502.500012
belinostatHomo sapiens (human)EC500.072522
kd 5170Homo sapiens (human)EC500.045011
tasquinimodHomo sapiens (human)Kd0.010022

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)AC502.100011
pyroxamideHomo sapiens (human)AC507.900011
vorinostatHomo sapiens (human)AC503.100011
vorinostatHomo sapiens (human)INH0.188522
vorinostatHomo sapiens (human)Inhibition0.080011
trapoxin aHomo sapiens (human)AC500.010011
trichostatin aHomo sapiens (human)AC500.400011
trichostatin aHomo sapiens (human)EC10000.020011
trichostatin aHomo sapiens (human)Inhibition0.003511
romidepsinHomo sapiens (human)INH0.024411
largazoleHomo sapiens (human)INH0.572011

Enables

This protein enables 12 target(s):

TargetCategoryDefinition
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
histone deacetylase activitymolecular functionCatalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
SUMO transferase activitymolecular functionCatalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. [GOC:rn, PMID:11031248, PMID:11265250]
potassium ion bindingmolecular functionBinding to a potassium ion (K+). [GOC:mah]
protein lysine deacetylase activitymolecular functionCatalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
histone deacetylase bindingmolecular functionBinding to histone deacetylase. [GOC:jl]
molecular adaptor activitymolecular functionThe binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]
RNA polymerase II-specific DNA-binding transcription factor bindingmolecular functionBinding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]
DNA-binding transcription factor bindingmolecular functionBinding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear speckcellular componentA discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
histone deacetylase complexcellular componentA protein complex that possesses histone deacetylase activity. [GOC:mah]
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
transcription repressor complexcellular componentA protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah]

Involved In

This protein is involved in 24 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
chromatin remodelingbiological processA dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
protein deacetylationbiological processThe removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]
inflammatory responsebiological processThe immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
nervous system developmentbiological processThe process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
negative regulation of myotube differentiationbiological processAny process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]
negative regulation of transcription by competitive promoter bindingbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site. [GOC:tb]
response to denervation involved in regulation of muscle adaptationbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation. [GOC:mtg_muscle]
cardiac muscle hypertrophy in response to stressbiological processThe physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
protein sumoylationbiological processThe process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. [GOC:jl, PMID:11265250]
B cell differentiationbiological processThe process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah]
positive regulation of protein sumoylationbiological processAny process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]
peptidyl-lysine deacetylationbiological processThe removal of an acetyl group from an acetylated lysine residue in a peptide or protein. [GOC:BHF, GOC:mah]
B cell activationbiological processThe change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]
regulation of protein bindingbiological processAny process that modulates the frequency, rate or extent of protein binding. [GOC:go_curators]
negative regulation of DNA-binding transcription factor activitybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl]
negative regulation of gene expression, epigeneticbiological processAn epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. [PMID:22243696]
negative regulation of glycolytic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. [GOC:go_curators]
positive regulation of DNA-templated transcriptionbiological processAny process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-binding transcription factor activitybiological processAny process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]
type I interferon-mediated signaling pathwaybiological processThe series of molecular signals initiated by type I interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:dph, GOC:signaling, PMID:32464097]
response to interleukin-1biological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:BHF, GOC:mah]