Page last updated: 2024-08-07 20:01:10
Chitinase B
[no definition available]
Synonyms
EC 3.2.1.14
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| erythromycin | Serratia marcescens | IC50 | 300.0000 | 1 | 1 |
| allosamidin | Serratia marcescens | IC50 | 0.0900 | 1 | 1 |
| argadin | Serratia marcescens | IC50 | 0.1374 | 3 | 4 |
| argadin | Serratia marcescens | Ki | 0.0200 | 1 | 1 |
| argifin | Serratia marcescens | IC50 | 4.7125 | 7 | 8 |
| argifin | Serratia marcescens | Ki | 33.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| argadin | Serratia marcescens | Kd | 3.6500 | 1 | 8 |
| argifin | Serratia marcescens | Kd | 5.9975 | 2 | 8 |
Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.Journal of medicinal chemistry, , Jun-25, Volume: 58, Issue:12, 2015
Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.Chemistry & biology, , Volume: 12, Issue:1, 2005
Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.Journal of medicinal chemistry, , Jun-25, Volume: 58, Issue:12, 2015
NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin.Bioorganic & medicinal chemistry, , Aug-15, Volume: 18, Issue:16, 2010
Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Argifin; efficient solid phase total synthesis and evaluation of analogues of acyclic peptide.Bioorganic & medicinal chemistry, , Apr-01, Volume: 17, Issue:7, 2009
Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.Chemistry & biology, , Volume: 12, Issue:1, 2005