STE20/SPS1-related proline-alanine-rich protein kinase

A STE20/SPS1-related proline-alanine-rich protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UEW8]

Synonyms

Ste-20-related kinase;
EC 2.7.11.1;
DCHT;
Serine/threonine-protein kinase 39

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (69)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
staurosporine	Homo sapiens (human)	IC50	0.0158	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
imatinib	Homo sapiens (human)	Kd	10.0000	1	1
staurosporine	Homo sapiens (human)	Kd	0.1300	1	1
gefitinib	Homo sapiens (human)	Kd	10.0000	1	1
lestaurtinib	Homo sapiens (human)	Kd	1.1000	2	2
vatalanib	Homo sapiens (human)	Kd	10.0000	1	1
ruboxistaurin	Homo sapiens (human)	Kd	10.0000	1	1
canertinib	Homo sapiens (human)	Kd	10.0000	1	1
birb 796	Homo sapiens (human)	Kd	10.0000	1	1
sb 203580	Homo sapiens (human)	Kd	10.0000	1	1
enzastaurin	Homo sapiens (human)	Kd	10.0000	1	1
erlotinib	Homo sapiens (human)	Kd	10.0000	1	1
lapatinib	Homo sapiens (human)	Kd	10.0000	1	1
sorafenib	Homo sapiens (human)	Kd	10.0000	2	2
pd 173955	Homo sapiens (human)	Kd	10.0000	1	1
s 1033	Homo sapiens (human)	Kd	10.0000	1	1
bms 387032	Homo sapiens (human)	Kd	10.0000	1	1
tandutinib	Homo sapiens (human)	Kd	10.0000	2	2
vx-745	Homo sapiens (human)	Kd	10.0000	1	1
dasatinib	Homo sapiens (human)	Kd	10.0000	1	1
zd 6474	Homo sapiens (human)	Kd	10.0000	1	1
alvocidib	Homo sapiens (human)	Kd	10.0000	1	1
bosutinib	Homo sapiens (human)	Kd	3.7000	1	1
su 11248	Homo sapiens (human)	Kd	0.1400	2	2
vx680	Homo sapiens (human)	Kd	10.0000	1	1
axitinib	Homo sapiens (human)	Kd	10.0000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
midostaurin	Homo sapiens (human)	Kd	10.0000	2	2
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
pi103	Homo sapiens (human)	Kd	10.0000	1	1
hki 272	Homo sapiens (human)	Kd	10.0000	1	1
tofacitinib	Homo sapiens (human)	Kd	10.0000	1	1
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	10.0000	1	1
masitinib	Homo sapiens (human)	Kd	10.0000	1	1
pazopanib	Homo sapiens (human)	Kd	10.0000	1	1
azd 6244	Homo sapiens (human)	Kd	10.0000	1	1
su 14813	Homo sapiens (human)	Kd	0.4300	1	1
bibw 2992	Homo sapiens (human)	Kd	10.0000	1	1
tg100-115	Homo sapiens (human)	Kd	10.0000	1	1
pha 665752	Homo sapiens (human)	Kd	10.0000	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	10.0000	1	1
brivanib	Homo sapiens (human)	Kd	10.0000	1	1
at 7519	Homo sapiens (human)	Kd	10.0000	1	1
bi 2536	Homo sapiens (human)	Kd	10.0000	1	1
nvp-ast487	Homo sapiens (human)	Kd	1.5000	1	1
kw 2449	Homo sapiens (human)	Kd	0.8900	1	1
abt 869	Homo sapiens (human)	Kd	10.0000	1	1
gw 2580	Homo sapiens (human)	Kd	10.0000	1	1
crizotinib	Homo sapiens (human)	Kd	10.0000	1	1
chir-265	Homo sapiens (human)	Kd	10.0000	1	1
motesanib	Homo sapiens (human)	Kd	10.0000	1	1
mln8054	Homo sapiens (human)	Kd	10.0000	1	1
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	10.0000	1	1
azd 1152-hqpa	Homo sapiens (human)	Kd	10.0000	1	1
nvp-tae684	Homo sapiens (human)	Kd	0.1500	1	1
fedratinib	Homo sapiens (human)	Kd	1.6000	1	1
gsk690693	Homo sapiens (human)	Kd	10.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	10.0000	1	1
plx 4720	Homo sapiens (human)	Kd	10.0000	1	1
sgx 523	Homo sapiens (human)	Kd	10.0000	1	1
quizartinib	Homo sapiens (human)	Kd	10.0000	2	2
incb-018424	Homo sapiens (human)	Kd	1.9000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1363089	Homo sapiens (human)	Kd	10.0000	1	1
chir 258	Homo sapiens (human)	Kd	0.5300	1	1
nintedanib	Homo sapiens (human)	Kd	0.5200	1	1
pp242	Homo sapiens (human)	Kd	10.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
protein serine/threonine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
kinase activity	molecular function	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cell cortex	cellular component	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. [GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
cell body	cellular component	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. [GOC:go_curators]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 31 target(s):

Target	Category	Definition
response to dietary excess	biological process	The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. [GOC:pg, GOC:pr, PMID:12161655]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
cell volume homeostasis	biological process	Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. [GOC:dph, GOC:go_curators, GOC:tb]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
regulation of blood pressure	biological process	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
positive regulation of T cell chemotaxis	biological process	Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]
peptidyl-serine phosphorylation	biological process	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]
peptidyl-threonine phosphorylation	biological process	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [RESID:AA0038]
intracellular chloride ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell. [GOC:mah]
positive regulation of ion transmembrane transporter activity	biological process	Any process that activates or increases the activity of an ion transporter. [GOC:mah, GOC:tb]
intracellular signal transduction	biological process	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
sodium ion transmembrane transport	biological process	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
cellular response to potassium ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. [GOC:yaf]
maintenance of lens transparency	biological process	A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina. [GOC:nhn, PMID:22095752]
chemokine (C-X-C motif) ligand 12 signaling pathway	biological process	The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, Wikipedia:Stromal_cell-derived_factor-1]
macrophage activation	biological process	A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]
positive regulation of potassium ion transport	biological process	Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]
protein autophosphorylation	biological process	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]
regulation of inflammatory response	biological process	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai]
renal sodium ion absorption	biological process	A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:dph, GOC:mah]
cellular hyperosmotic response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. [GOC:mah]
cellular hypotonic response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. [GOC:mah]
negative regulation of pancreatic juice secretion	biological process	Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of p38MAPK cascade	biological process	Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie]
negative regulation of potassium ion transmembrane transporter activity	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]
negative regulation of potassium ion transmembrane transport	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie]
response to aldosterone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17644563]
negative regulation of creatine transmembrane transporter activity	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585]
cellular response to chemokine	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. [PMID:11113082]
negative regulation of sodium ion transmembrane transporter activity	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]