Betulin is a pentacyclic triterpene found in the bark of birch trees. It has been studied for its potential medicinal properties, including anti-inflammatory, antiviral, and anticancer effects. Betulin is also a precursor to betulinic acid, which is a more potent anti-cancer agent. Research on betulin has focused on its ability to inhibit the growth of tumor cells, its potential to reduce inflammation, and its role in protecting cells from oxidative damage. Studies have shown that betulin can be synthesized through various methods, including chemical extraction from birch bark and biotransformation using microbial enzymes. The widespread availability of betulin in birch trees makes it a promising source for the development of new therapeutic agents.'
betulin: isolated from various white birch bark (BETULA) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 72326 |
| CHEMBL ID | 23236 |
| CHEBI ID | 3086 |
| SCHEMBL ID | 131739 |
| MeSH ID | M0043133 |
| Synonym |
|---|
| BRD-K64874225-001-01-3 |
| nsc-4644 |
| betulinol |
| betuline |
| betulol |
| trochol |
| MEGXP0_001726 |
| betulinic alcohol |
| lup-20(30)-ene-3beta,28-diol |
| einecs 207-475-5 |
| ai3-62999 |
| lup-20(29)-ene-3,28-diol, (3beta)- |
| lup-20(29)-ene-3 beta,28-diol |
| nsc 4644 |
| lup-20(29)-ene-3beta,28-diol |
| (1r,2r,5s,8r,9r,10r,13r,14r,17s,19r)-5-(hydroxymethyl)-1,2,14,18,18-pentamethyl-8-(prop-1-en-2-yl)pentacyclo[11.8.0.0^{2,10}.0^{5,9}.0^{14,19}]henicosan-17-ol |
| bdbm23207 |
| betulin, 23 |
| BPBIO1_001165 |
| ACON1_000091 |
| BSPBIO_001059 |
| PRESTWICK3_000990 |
| (3.beta.)-lup-20(29)-ene-3,28-diol |
| (1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br)-3a-(hydroxymethyl)-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol |
| AB00513988 |
| C08618 |
| betulin |
| 473-98-3 |
| nsc-692218 |
| NCGC00168803-01 |
| NCGC00168803-02 |
| betulin, >=98% |
| B0803 |
| chebi:3086 , |
| CHEMBL23236 |
| (1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol |
| AKOS005267212 |
| HMS2098E21 |
| LMPR0106140005 |
| (3as,5br,9s,11ar)-3a-(hydroxymethyl)-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol;betulin |
| A827211 |
| (3beta)-lup-20(29)-ene-3,28-diol |
| S4754 |
| 6w70hn7x7o , |
| unii-6w70hn7x7o |
| lup-20(29)-ene-3 ,28-diol |
| (+)-betulin |
| (1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1h-cyclopenta[a]chrysen-9-ol |
| lup-20(29)-ene-3,28-diol, (3.beta.)- |
| cp betulin |
| betulin [inci] |
| betulin [mi] |
| oristract btl |
| lup-20(29)-ene-3b,28-diol |
| CCG-208619 |
| SCHEMBL131739 |
| FVWJYYTZTCVBKE-ROUWMTJPSA-N |
| (1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br)-3 a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1h-cyclopenta[a]chrysen-9-ol |
| Q-100501 |
| mfcd00016802 |
| CS-6156 |
| HY-N0083 |
| betulin, analytical standard |
| GS-3254 |
| sr-05000002167 |
| SR-05000002167-3 |
| SR-05000002167-2 |
| betulinol (obsol.) |
| lup-20(29)-ene-3beta ,28-diol |
| lup-20(30)-ene-3beta ,28-diol |
| lup-20(29)-ene-3,28-diol, (3beta )- |
| NCGC00168803-04 |
| Q419726 |
| betulinol (obsol pound(c) |
| DTXSID101019934 |
| EX-A3354 |
| 7372-31-8 |
Betulin is an important triterpenoid substance isolated from birch bark, which, together with its sulfates, exhibits important bioactive properties. Betulin is a pentacyclic triterpene with demonstrated healing properties in mid-dermal wounds.
Betulinic acid has been modified to ionic derivatives (2-5) to improve its water solubility and biological activities. The toxicity of the derivatives has been evaluated against cultured human melanoma (MEL-2) and human epidermoid carcinoma of the mouth (KB) cell lines.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Betulin also inhibit skin tumor apparition and promotion, proved by histological results and VEGF (vascular endothelial growth factor) expression correlated to non-invasive measurements." | ( Anti-angiogenic and anti-cancer evaluation of betulin nanoemulsion in chicken chorioallantoic membrane and skin carcinoma in Balb/c mice. Amiji, MM; Cimpean, AM; Dehelean, CA; Feflea, S; Ganta, S; Gheorgheosu, D; Muntean, D, 2013) | 1.37 |
Betulin treatment was revealed to have noteworthy antiasthmatic effects mediated by the suppression of production of inflammatory cells and the expression of other inflammatory markers. Betulin treatment significantly improved the survival rate of septic rats, and attenuated lung and liver injury in sepsis.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Betulin treatment was revealed to have noteworthy antiasthmatic effects mediated by the suppression of production of inflammatory cells and the expression of other inflammatory markers." | ( Effect of Betulin on Inflammatory Biomarkers and Oxidative Status of Ova-Induced Murine Asthma. Wang, L; Zhong, D, 2020) | 1.68 |
| "Betulin treatment down-regulated the expression of MMP-9, tTG and TGF-β1 genes; moreover, betulin treatment effectively down-regulated the TREM-1, p-IκB-α and NF-κBp65 proteins level in lung." | ( Triterpenoid compound betulin attenuates allergic airway inflammation by modulating antioxidants, inflammatory cytokines and tissue transglutaminase in ovalbumin-induced asthma mice model. Chinnaiyan, U; Dhayalan, S; Kamaraj, Y; Kumar, D; Kumaresan, V; Muniyandi, K; Punamalai, G; Subramaniyan, S, 2021) | 1.66 |
| "Betulin treatment of amastigotes cultured within macrophages, resulted in a reduced number of amastigotes, with no substantive cytotoxic damage to the host macrophage cells at leishmanicidal drug concentrations." | ( Molecular mechanisms of in vitro betulin-induced apoptosis of Leishmania donovani. Dubey, VK; Saudagar, P, 2014) | 1.41 |
| "Betulin treatment significantly improved the survival rate of septic rats, and attenuated lung and liver injury in sepsis, including the reduction of lung wet/dry weight ratio and activities of alanine aminotransferase and aspartate aminotransferase in the serum." | ( Betulin attenuates lung and liver injuries in sepsis. Han, X; Liu, W; Liu, Z; Zhao, H; Zhao, M, 2016) | 2.6 |
| "The treatment with betulin (50 and 100 mg/kg b.w., intragastric) during this period attenuated the histological signs of steatohepatitis and lowered the serum and liver triglyceride contents, as well as the serum activities of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase." | ( Betulin attenuated liver damage by prevention of hepatic mitochondrial dysfunction in rats with alcoholic steatohepatitis. Belonovskaya, E; Buko, V; Ilyich, T; Kirko, S; Kuzmitskaya, I; Lukivskaya, O; Naruta, E; Shlyahtun, A; Zakreska, A; Zavodnik, I, 2019) | 2.28 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Moreover, when HepG2 cells were incubated with betulin and then incubated in fresh betulin-free medium before the addition of CdCl(2), the toxic effects of cadmium were reduced." | ( Protective effects of triterpene compounds against the cytotoxicity of cadmium in HepG2 cells. Matsumoto, Y; Miura, N; Miyairi, S; Naganuma, A; Nishiyama, S, 1999) | 0.56 |
| " The literature describes it as selectively toxic to neoplastic cells but safe for normal cells." | ( High cytotoxicity of betulin towards fish and murine fibroblasts: Is betulin safe for nonneoplastic cells? Kaczorek-Łukowska, E; Kazuń, B; Małaczewska, J, 2021) | 0.94 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The use of every of the compounds in combination with rimantadine resulted in a 2-16 times decrease of their EC50 and correction of the concentration-effect relation of rimantadine." | ( [New betulin derivatives in combination with rimantadine for inhibition of influenza virus reproduction]. Boreko, EI; Pavlova, NI; Savinova, OV, 2009) | 0.87 |
Both betulinic acid and its metabolic precursor, betulin, are very poorly soluble in aqueous buffers. Their bioavailability and bio-distribution are insufficient in terms of medical applications.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Administration of BA or BT significantly decreased CYP2E1 activities and expression of SREBP-1caused by ethanol, however, lower dosage of BA or BT showed slight effects on CYP2E1 activity or expression of SREBP-1c." | ( Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro. Bai, T; Cui, PH; Jiang, S; Jin, XJ; Lian, LH; Nan, JX; Sun, XT; Wan, Y; Wu, YL, 2013) | 1.83 |
| Role | Description |
|---|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| antiviral agent | A substance that destroys or inhibits replication of viruses. |
| analgesic | An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| anti-inflammatory agent | Any compound that has anti-inflammatory effects. |
| antineoplastic agent | A substance that inhibits or prevents the proliferation of neoplasms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| pentacyclic triterpenoid | |
| diol | A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| betulinate biosynthesis | 1 | 6 |
| betulinate biosynthesis | 0 | 7 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | IC50 (µMol) | 21.8965 | 0.0140 | 5.9324 | 9.0000 | AID1798302; AID404873; AID549503; AID603224 |
| Pancreatic alpha-amylase | Sus scrofa (pig) | IC50 (µMol) | 200.0000 | 1.3530 | 4.3108 | 8.9300 | AID1465050 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 (µMol) | 150.0000 | 0.0001 | 0.5542 | 10.0000 | AID333024 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 (µMol) | 38.6000 | 0.4800 | 4.3564 | 9.9400 | AID358918 |
| 5'-nucleotidase | Homo sapiens (human) | IC50 (µMol) | 22.6600 | 0.0500 | 2.2411 | 8.2000 | AID1693837; AID1889898 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Mus musculus (house mouse) | IC50 (µMol) | 49.7600 | 0.5000 | 1.0300 | 1.5600 | AID1693839 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 (µMol) | 150.0000 | 0.0001 | 0.8029 | 10.0000 | AID333025 |
| Transcription factor p65 | Homo sapiens (human) | IC50 (µMol) | 8.8000 | 0.0001 | 1.8981 | 8.8000 | AID1398545 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | IC50 (µMol) | 109.0000 | 1.0000 | 5.9267 | 9.6000 | AID1896150 |
| 5'-nucleotidase | Mus musculus (house mouse) | IC50 (µMol) | 50.3200 | 0.0400 | 3.1000 | 4.6300 | AID1693838 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| G-protein coupled bile acid receptor 1 | Homo sapiens (human) | EC50 (µMol) | 10.0000 | 0.0237 | 2.5259 | 8.9000 | AID444761 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1401981 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by microplate alamar blue assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes. |
| AID1668314 | Inhibition of LPS-induced iNOS expression in human BV2 cells at 250 ug/ml preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by Western blot analysis | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1314824 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as TNF mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315127 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as IL2 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314830 | Effect on transcription factor related gene expression in non-diabetic young human primary keratinocytes assessed as JUN mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314946 | Effect on growth factor related gene expression in non-diabetic adult human primary fibroblasts assessed as GDF15 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402655 | Antibacterial activity against Pseudomonas aeruginosa AK 958 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314899 | Effect on growth factor related gene expression in non-diabetic adult human primary keratinocytes assessed as PDGFB mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1668318 | Inhibition of LPS-induced JNK-46 activation in human BV2 cells preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by Western blot analysis | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1315070 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as IL10 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315037 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as upregulation of IL8 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1597609 | Antiproliferative activity against human T47D cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme. |
| AID1315103 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of soluble TNFR1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314960 | Effect on growth factor related gene expression in diabetic adult human primary fibroblasts assessed as GDF15 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1298841 | Cytotoxicity against human HeLa cells after 96 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates. |
| AID1314928 | Effect on chemokines related gene expression in non-diabetic young human primary fibroblasts assessed as CCL2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314947 | Effect on growth factor related gene expression in non-diabetic adult human primary fibroblasts assessed as VEGFA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314842 | Effect on antiinflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as NFKBIA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1617255 | Cytotoxicity against nutrient-rich DMEM cultured human PANC1 cells at PC50 incubated for 24 hrs by WST-8 assay | |||
| AID1066591 | Cytotoxicity against human A2780 cells after 96 hrs by MTT assay | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Lupane triterpenoids from the stems of Euonymus carnosus. |
| AID358918 | Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophoresis | 2001 | Journal of natural products, Dec, Volume: 64, Issue:12 | Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. |
| AID1315012 | Effect on growth factors related gene expression in non-diabetic adult human primary fibroblasts assessed as FGF2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1349607 | Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3 | Antineoplastic Agents. 606. The Betulastatins. |
| AID1315010 | Effect on antioxidant related gene expression in diabetic adult human primary fibroblasts assessed as NFE2L2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315137 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as MIP1alpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315023 | Effect on adhesion molecules related gene expression in non-diabetic young human primary fibroblasts assessed as VCAM1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314891 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as IL1R1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1693843 | Cytotoxicity against human MIA PaCa-2 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay | 2021 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 34 | Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor. |
| AID1315042 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as upregulation of IL8 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402650 | Antibacterial activity against Bacillus megaterium CECT 44 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1315139 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as MIP1beta protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1770395 | Antiproliferative activity against human Z138 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1315009 | Effect on antioxidant related gene expression in non-diabetic adult human primary fibroblasts assessed as NFE2L2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID255930 | Concentration required to kill 50 % of human chronic myelogenous leukemia cell line K562 | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Correlation of cytotoxic activity of betulinines and their hydroxy analogues. |
| AID1315157 | Effect on actin cytoskeleton in human diabetic primary keratinocytes assessed as formation of cellular protrusions at 10 nM after 2 hrs by rhodamine phalloidin-staining based fluorescence microscopic analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315049 | Upregulation of wound healing activity related MCP1 protein levels in non-diabetic adult human primary keratinocytes at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID283803 | Cytotoxicity against human CEM cells after 72 hrs by MTT assay | 2007 | Journal of natural products, Apr, Volume: 70, Issue:4 | Triterpenoid pyrazines and benzopyrazines with cytotoxic activity. |
| AID1519644 | Cytotoxicity against MDCK cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis, and biological evaluation of ligustrazine - betulin amino-acid/dipeptide derivatives as anti-tumor agents. |
| AID403269 | Cytotoxicity against human LNCAP cells | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. |
| AID1314851 | Effect on cellular connection related gene expression in diabetic adult human primary keratinocytes assessed as GJB2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1349606 | Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3 | Antineoplastic Agents. 606. The Betulastatins. |
| AID1315140 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as MIP1beta protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315163 | Effect on actin cytoskeleton in diabetic adult human primary keratinocytes assessed as formation of cellular protrusions at 10 nM after 2 hrs in presence of p-38 MAPK inhibitor LN 950 by rhodamine phalloidin-staining based fluorescence microscopic analysi | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315060 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as increase in soluble VCAM1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504288 | Antiproliferative activity in human MCF7 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1246834 | Cytotoxicity against human Bcap37 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and in vitro antitumor evaluation of betulin acid ester derivatives as novel apoptosis inducers. |
| AID1314956 | Effect on chemokines related gene expression in non-diabetic young human primary fibroblasts assessed as WDR26 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315089 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as FGF23 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1773423 | Antiviral activity against Vesicular stomatitis virus Indiana infected in A549 cells assessed as inhibition of viral adsorption at early stage of replication treated for 1 hr during viral infection followed by replacement with fresh medium and measured af | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID1315159 | Effect on actin cytoskeleton in human non-diabetic primary fibroblasts assessed as formation of thin elongated cellular body at 10 nM after 2 hrs by rhodamine phalloidin-staining based fluorescence microscopic analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID333025 | Inhibition of PKC epsilon | 1994 | Journal of natural products, Feb, Volume: 57, Issue:2 | Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. |
| AID1315093 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as leptin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314911 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as TNF mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1573775 | Antiviral activity against recombinant HCMV AD169 expressing GFP infected in human foreskin fibroblasts measured after 7 days by GFP-based multi-round replication assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1 | Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities. |
| AID1504266 | Cytotoxic activity in human MDA-MB-231 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1314925 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as IL1B mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314872 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as IL1B mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314871 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as PTGS2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315138 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as MIP1alpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1597606 | Antiproliferative activity against human COLO829 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme. |
| AID1315048 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as upregulation of IL1RA protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314958 | Effect on antiinflammatory related gene expression in diabetic adult human primary fibroblasts assessed as NFKBIA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402648 | Antibacterial activity against Bacillus cereus CECT 496 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314943 | Effect on chemokines related gene expression in non-diabetic adult human primary fibroblasts assessed as IL8 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314912 | Effect on chemokines related gene expression in diabetic adult human primary keratinocytes assessed as CXCL10 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID468092 | Antiviral activity against SFV infected in BHK cells assessed as surviving virus fraction at 50 uM after 14 hrs by luciferase reporter gene assay | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Betulin-derived compounds as inhibitors of alphavirus replication. |
| AID417595 | Cytotoxicity against human MCF7 cells by resazurin reduction test | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. |
| AID1314915 | Effect on antioxidant related gene expression in diabetic adult human primary keratinocytes assessed as SOD2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1315131 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as IL10 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID255925 | Concentration required to kill 50 % of human T-lymphoblastic leukemia cell line (CEM) | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Correlation of cytotoxic activity of betulinines and their hydroxy analogues. |
| AID1315044 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as upregulation of TNFalpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314826 | Effect on chemokines related gene expression in non-diabetic young human primary keratinocytes assessed as IL8 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID393219 | Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test | 2009 | Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5 | Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. |
| AID1315102 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of MIF protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402646 | Antibacterial activity against Enterococcus faecalis CECT 795 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1315001 | Effect on growth factor related gene expression in diabetic adult human primary fibroblasts assessed as GDF15 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID338358 | Cytotoxicity against human Raji cells assessed as cell viability at 10 mol ratio after 48 hrs relative to TPA | |||
| AID402660 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1315002 | Effect on growth factor related gene expression in diabetic adult human primary fibroblasts assessed as VEGFA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314963 | Effect on MMP1 mRNA expression levels in diabetic adult human primary fibroblasts at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID333024 | Inhibition of PKC beta2 | 1994 | Journal of natural products, Feb, Volume: 57, Issue:2 | Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. |
| AID1773419 | Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID1578453 | Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids. |
| AID1446278 | Cytotoxicity against human ECA109 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms. |
| AID549503 | Inhibition of rabbit muscle glycogen phosphorylase a | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. |
| AID402661 | Cytotoxicity against human Hep2 cells after 48 hrs by MTT assay | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314865 | Effect on transcription factor related gene expression in diabetic adult human primary keratinocytes assessed as JUN mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314978 | Effect on MMP1 mRNA expression levels in non-diabetic young human primary fibroblasts at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1238536 | Selectivity index, ratio of CC50 for African green monkey RC-37 cells to IC50 for HSV-1 KOS | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
| AID1315135 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as IL17A protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315033 | Upregulation of adhesion molecules related ICAM1 mRNA expression in non-diabetic adult human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID393221 | Cytotoxicity against human WS1 cells after 48 hrs by resazurin reduction test | 2009 | Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5 | Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. |
| AID1315074 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as IL17A protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314816 | Effect on cellular connection related gene expression in non-diabetic young human primary keratinocytes assessed as GJB2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504292 | Antiproliferative activity in human Hep2 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1315028 | Effect on adhesion molecules related gene expression in diabetic adult human primary fibroblasts assessed as VCAM1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314909 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as IL1R1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315107 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of soluble VCAM1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315123 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as INFgamma protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315014 | Effect on growth factors related gene expression in non-diabetic young human primary fibroblasts assessed as FGF2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315165 | Activation of Cdc42 in human diabetic primary keratinocytes at 10 nM after 20 mins by immunoblot method | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315015 | Effect on growth factors related gene expression in non-diabetic adult human primary fibroblasts assessed as FGF2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID255881 | Concentration required to kill 50 % of human melanoma SK-MEL2 cells | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Correlation of cytotoxic activity of betulinines and their hydroxy analogues. |
| AID1314986 | Effect on antioxidant related gene expression in non-diabetic adult human primary fibroblasts assessed as SOD2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1773438 | Antiviral activity against Human adenovirus 5 Adenoid 75 infected in A549 cells assessed as reduction in virus titer preincubated for 24 hrs followed by viral infection and measured after 72 hrs by microscopic analysis | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID1314867 | Effect on AQP3 mRNA expression levels in diabetic adult human primary keratinocytes at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315000 | Effect on antioxidant related gene expression in diabetic adult human primary fibroblasts assessed as SOD2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315025 | Effect on adhesion molecules related gene expression in diabetic adult human primary fibroblasts assessed as VCAM1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID433125 | Induction of apoptosis in human EPP85-181P cells assessed as normal cells after 24 hrs by comet assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1314866 | Effect on MMP1 mRNA expression levels in diabetic adult human primary keratinocytes at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314868 | Effect on cellular connection related gene expression in non-diabetic young human primary keratinocytes assessed as CLDN4 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1398545 | Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISA | 2018 | Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15 | Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. |
| AID338353 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation at 10 mol ratio after 48 hrs relative to TPA | |||
| AID338352 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation at 100 mol ratio after 48 hrs relative to TPA | |||
| AID1315117 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as PLA2G7 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314921 | Effect on AQP3 mRNA expression levels in diabetic adult human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314856 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as IL6 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314889 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as PTGS2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1378819 | Induction of cell cycle arrest in in human PC3 cells assessed as effect on G0/G1 phase at cytotoxic IC50 after 48 hrs by propidium iodide staining based flow cytometry | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin. |
| AID1314853 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as PTGS2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID255897 | Concentration required to kill 50 % of human colon cancer cell line HT-29 | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Correlation of cytotoxic activity of betulinines and their hydroxy analogues. |
| AID1298840 | Cytotoxicity against human A549 cells after 96 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates. |
| AID1265353 | Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds. |
| AID311138 | Antitrypanosomal activity against Trypanosoma brucei brucei bloodstream trypomastigotes by alamar blue assay | 2007 | Journal of natural products, Aug, Volume: 70, Issue:8 | Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. |
| AID1315026 | Effect on adhesion molecules related gene expression in non-diabetic young human primary fibroblasts assessed as VCAM1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314982 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as IL6 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314994 | Effect on pro-inflammatory related gene expression in diabetic adult human primary fibroblasts assessed as IL1B mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1349605 | Growth inhibition of human SF268 cells after 48 hrs by SRB assay | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3 | Antineoplastic Agents. 606. The Betulastatins. |
| AID1315149 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as leptin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314845 | Effect on growth factor related gene expression in non-diabetic adult human primary keratinocytes assessed as PDGFB mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1228702 | Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth at 10 uM measured 48 hrs post infection by luminometry | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina. |
| AID1664594 | Cytotoxicity against human PANC1 cells in nutrient-deprived medium | 2020 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 30, Issue:16 | Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line. |
| AID1668316 | Inhibition of LPS-induced JNK-46 phosphorylation in human BV2 cells at 62.5 to 250 ug/ml preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by Western blot analysis | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1770427 | Antibacterial activity against Staphylococcus aureus ATCC65385 assessed as growth inhibition after 20 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1770387 | Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1314819 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as IL1B mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315084 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as MIP1beta protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID433121 | Cytotoxicity against human EPG85-257P cells after 24 hrs by SRB method | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1314913 | Effect on chemokines related gene expression in diabetic adult human primary keratinocytes assessed as IL8 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315142 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as soluble CD40L protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315076 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as IFNgamma protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315129 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as IL4 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID338351 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation at 1000 mol ratio after 48 hrs relative to TPA | |||
| AID311139 | Cytotoxicity against mouse J774 cells by alamar blue assay | 2007 | Journal of natural products, Aug, Volume: 70, Issue:8 | Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. |
| AID1314840 | Effect on chemokines related gene expression in non-diabetic adult human primary keratinocytes assessed as CXCL10 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314992 | Effect on chemokines related gene expression in diabetic adult human primary fibroblasts assessed as CCL2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1597607 | Antiproliferative activity against human C32 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme. |
| AID1246832 | Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and in vitro antitumor evaluation of betulin acid ester derivatives as novel apoptosis inducers. |
| AID1578455 | Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids. |
| AID1315007 | Effect on antioxidant related gene expression in diabetic adult human primary fibroblasts assessed as NFE2L2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314854 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as IL1B mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314948 | Effect on transcription factor related gene expression in non-diabetic adult human primary fibroblasts assessed as JUN mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314814 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of RANTES protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314973 | Effect on antioxidant related gene expression in non-diabetic young human primary fibroblasts assessed as SOD2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315072 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as IL12p40 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315080 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as soluble RAGE protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1066594 | Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Lupane triterpenoids from the stems of Euonymus carnosus. |
| AID1315035 | Effect on chemokines related gene expression in human primary keratinocytes assessed as MIP2 mRNA levels at1.96 to 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314825 | Effect on chemokines related gene expression in non-diabetic young human primary keratinocytes assessed as CXCL10 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314860 | Effect on antiinflammatory related gene expression in diabetic adult human primary keratinocytes assessed as NFKBIA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315155 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of IL8 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315106 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of soluble ICAM1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402643 | Antibacterial activity against Staphylococcus aureus ATCC 6538 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314844 | Effect on growth factor related gene expression in non-diabetic adult human primary keratinocytes assessed as GDF15 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314864 | Effect on growth factor related gene expression in diabetic adult human primary keratinocytes assessed as VEGFA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504271 | Cytotoxic activity in HEK293 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1398543 | Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay | 2018 | Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15 | Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. |
| AID1770428 | Antibacterial activity against Escherichia coli ATCC47076 assessed as growth inhibition after 20 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1315043 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as upregulation of MIP1alpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315083 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as PLA2G7 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1693842 | Cytotoxicity against human MDA-MB-231 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay | 2021 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 34 | Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor. |
| AID106299 | Cytotoxicity against cultured human melanoma (MEL-2) cell line. | 1998 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13 | Synthesis of betulinic acid derivatives with activity against human melanoma. |
| AID1668317 | Inhibition of LPS-induced JNK-54 activation in human BV2 cells preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by Western blot analysis | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1238525 | Antiviral activity against HSV-2 G infected in African green monkey Vero cells after 2 days by plaque reduction assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
| AID1446276 | Cytotoxicity against human K562 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms. |
| AID433119 | Cytotoxicity against human EPP85-181P cells after 24 hrs by SRB method | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1314937 | Effect on antiinflammatory related gene expression in diabetic adult human primary fibroblasts assessed as SOCS3 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1230153 | Cytotoxicity against human HT-29 cells by SRB assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Simple structural modifications confer cytotoxicity to allobetulin. |
| AID1315027 | Effect on adhesion molecules related gene expression in non-diabetic adult human primary fibroblasts assessed as VCAM1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1519643 | Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis, and biological evaluation of ligustrazine - betulin amino-acid/dipeptide derivatives as anti-tumor agents. |
| AID433124 | Induction of apoptosis in human EPP85-181P cells assessed as cell accumulation at apoptotic phase after 24 hrs by comet assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1127025 | Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer. |
| AID1315124 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as INFgamma protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314926 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as IL1R1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315057 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as increase in soluble TNF1 receptor protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314812 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as upregulation of RANTES protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315021 | Effect on adhesion molecules related gene expression in non-diabetic adult human primary fibroblasts assessed as ICAM1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315166 | Activation of Rac1 in human diabetic primary keratinocytes at 10 nM after 20 mins by immunoblot method | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315054 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as effect on soluble ICAM1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1446277 | Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms. |
| AID1770392 | Antiproliferative activity against human DND41 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1314934 | Effect on growth factor related gene expression in non-diabetic young human primary fibroblasts assessed as VEGFA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315095 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as osteocalcin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID417593 | Cytotoxicity against human A549 cells by resazurin reduction test | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. |
| AID1315006 | Effect on antioxidant related gene expression in non-diabetic adult human primary fibroblasts assessed as NFE2L2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315019 | Effect on adhesion molecules related gene expression in diabetic adult human primary fibroblasts assessed as ICAM1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1617250 | Anti-austerity activity against nutrient-deprived human PANC1 cells assessed as cell death incubated for 24 hrs by WST-8 assay | |||
| AID1315068 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as IL4 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1066592 | Cytotoxicity against human A549 cells after 96 hrs by MTT assay | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Lupane triterpenoids from the stems of Euonymus carnosus. |
| AID1315147 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as insulin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314883 | Effect on transcription factor related gene expression in non-diabetic young human primary keratinocytes assessed as JUN mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315090 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as insulin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314951 | Effect on chemokines related gene expression in non-diabetic adult human primary fibroblasts assessed as WDR26 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1238531 | Cytotoxicity against African green monkey Vero cells after 2 days by neutral red uptake assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
| AID1315082 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as PLA2G7 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315085 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as MIP1beta protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504267 | Cytotoxic activity in human DU145 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1315116 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as soluble E-selectin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1578450 | Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids. |
| AID1398546 | Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay | 2018 | Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15 | Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. |
| AID1315111 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of soluble IL6R protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314861 | Effect on antioxidant related gene expression in diabetic adult human primary keratinocytes assessed as SOD2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314941 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as IL1R1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID79307 | Compound was evaluated for cytotoxicity in H9 lymphocytes | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives. |
| AID549501 | Cytotoxicity against human MT4 lymphocytes after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. |
| AID697853 | Inhibition of horse BChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID433123 | Aqueous solubility in DMSO solution at 1 mg | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1314917 | Effect on growth factor related gene expression in diabetic adult human primary keratinocytes assessed as PDGFB mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1446279 | Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms. |
| AID1314902 | Effect on MMP1 mRNA expression levels in non-diabetic adult human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315066 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as IL2 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504293 | Antiproliferative activity in African green monkey Vero cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1315097 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as osteopontin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314859 | Effect on chemokines related gene expression in diabetic adult human primary keratinocytes assessed as IL8 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID377094 | Antiinflammatory activity against human A549 cells assessed as inhibition of IL-1-alpha-induced ICAM1 expression treated after 1 hr before IL1alpha challenge | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. |
| AID1773418 | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID1314839 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as TNF mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314829 | Effect on growth factor related gene expression in non-diabetic young human primary keratinocytes assessed as GDF15 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315150 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as leptin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315003 | Effect on transcription factor related gene expression in diabetic adult human primary fibroblasts assessed as JUN mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314945 | Effect on antioxidant related gene expression in non-diabetic adult human primary fibroblasts assessed as SOD2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1398541 | Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay | 2018 | Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15 | Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. |
| AID1314897 | Effect on antioxidant related gene expression in non-diabetic adult human primary keratinocytes assessed as SOD2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314936 | Effect on MMP1 mRNA expression levels in non-diabetic young human primary fibroblasts at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1770394 | Antiproliferative activity against human K562 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1314996 | Effect on pro-inflammatory related gene expression in diabetic adult human primary fibroblasts assessed as IL6 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID433126 | Induction of apoptosis in human EPG85-257P cells assessed as cell accumulation at apoptotic phase after 24 hrs by comet assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1315078 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as soluble TNFR2 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314893 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as TNF mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314863 | Effect on growth factor related gene expression in diabetic adult human primary keratinocytes assessed as PDGFB mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315005 | Effect on antioxidant related gene expression in non-diabetic young human primary fibroblasts assessed as NFE2L2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID338356 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 mol ratio after 48 hrs relative to TPA | |||
| AID255945 | Concentration required to kill 50 % of human paclitaxel-resistant subline of K562 cells (K-562-Tax) | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Correlation of cytotoxic activity of betulinines and their hydroxy analogues. |
| AID417596 | Cytotoxicity against human PC3 cells by resazurin reduction test | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. |
| AID1750790 | Cytotoxicity against mock-infected human embryonic lung fibroblast cells incubated for 5 days by MTS assay | 2021 | Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9 | Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease. |
| AID354974 | Inhibition of recombinant protein farnesyltransferase-mediated [3H]FPP transfer after 30 mins by scintillation counting | 1996 | Journal of natural products, Jul, Volume: 59, Issue:7 | Lupane derivatives from Lophopetalum wallichii with farnesyl protein transferase inhibitory activity. |
| AID1315020 | Effect on adhesion molecules related gene expression in non-diabetic young human primary fibroblasts assessed as ICAM1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1378821 | Induction of cell cycle arrest in in human PC3 cells assessed as effect on G2/M phase at cytotoxic IC50 after 48 hrs by propidium iodide staining based flow cytometry | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin. |
| AID79295 | Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%. | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23 | Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. |
| AID1465050 | Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by dinitrosalicylic acid reagent based assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose. |
| AID1315118 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as PLA2G7 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314890 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as IL1B mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315008 | Effect on antioxidant related gene expression in non-diabetic young human primary fibroblasts assessed as NFE2L2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314870 | Effect on ECM related gene expression in non-diabetic young human primary keratinocytes assessed as FBN1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID393220 | Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test | 2009 | Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5 | Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. |
| AID1314857 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as TNF mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1296098 | Antiinflammatory activity against mouse J774 cells assessed as inhibition of LPS-induced MCP-1 production measured as remaining MCP-1 levels at 10 uM after 24 hrs by ELISA | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo. |
| AID1315055 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as increase in soluble IL6 receptor protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1519642 | Antiproliferative activity against human BGC823 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis, and biological evaluation of ligustrazine - betulin amino-acid/dipeptide derivatives as anti-tumor agents. |
| AID79309 | Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound toxic to 50% of mock-infected H9 cells. | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23 | Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. |
| AID1314954 | Effect on pro-inflammatory related gene expression in diabetic adult human primary fibroblasts assessed as IL1R1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315092 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as leptin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314924 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as PTGS2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1238535 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for HSV-2 G | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
| AID1315168 | Effect on actin cytoskeleton in non-diabetic adult human primary keratinocytes assessed as formation of cellular protrusions at 10 nM after 2 hrs in presence of p-38 MAPK inhibitor LN 950 by rhodamine phalloidin-staining based fluorescence microscopic ana | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1296095 | Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced iNOS expression measured as remaining protein levels at 10 uM after 24 hrs by Western blot analysis | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo. |
| AID402654 | Antibacterial activity against Salmonella sp. CECT 456 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1315050 | Upregulation of wound healing activity related MCP1 protein levels in diabetic adult human primary keratinocytes at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1398542 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay | 2018 | Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15 | Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. |
| AID697852 | Inhibition of electric eel AChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1314985 | Effect on antiinflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as NFKBIA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314949 | Effect on MMP1 mRNA expression levels in non-diabetic adult human primary fibroblasts at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314988 | Effect on growth factor related gene expression in non-diabetic adult human primary fibroblasts assessed as VEGFA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314823 | Effect on growth factor related gene expression in non-diabetic young human primary keratinocytes assessed as VEGFA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315119 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as soluble RAGE protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315144 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as TNFalpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID400568 | Cytotoxicity against vincristine-sensitive human KB cells after 72 hrs by alamar blue assay | 2004 | Journal of natural products, Mar, Volume: 67, Issue:3 | Four new triterpenoids from Maytenus ilicifolia. |
| AID1773425 | Antiviral activity against Enterovirus E LCR-4 infected in A549 cells assessed as inhibition of viral adsorption at early stage of replication treated for 1 hr during viral infection followed by replacement with fresh medium and measured after 72 hrs by M | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID1896151 | Selectivity index, ratio of IC50 for inhibition of human NTCP mediated TCA uptake in HEK293 cells overexpressing NTCP to IC50 for inhibition of HBV subgenotype D3 [3H]-myr-preS1 (2 to 48 residues) peptide binding to human NTCP in HEK293 cells overexpressi | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19 | Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential. |
| AID1315029 | Effect on extracellular matrix related gene expression in diabetic adult human primary keratinocytes assessed as MMP2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314940 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as IL1B mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314920 | Effect on MMP1 mRNA expression levels in diabetic adult human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315063 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as increase in soluble gp130 part of IL6 receptor protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314916 | Effect on growth factor related gene expression in diabetic adult human primary keratinocytes assessed as GDF15 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID391574 | Antiproliferative activity against mouse +SA mammary epithelial cells after 4 days by MTT assay | 2008 | Journal of natural products, Oct, Volume: 71, Issue:10 | Antiproliferative triterpenes from Melaleuca ericifolia. |
| AID1314976 | Effect on growth factor related gene expression in non-diabetic young human primary fibroblasts assessed as VEGFA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315156 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of IL8 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315024 | Effect on adhesion molecules related gene expression in non-diabetic adult human primary fibroblasts assessed as VCAM1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID338355 | Cytotoxicity against human Raji cells assessed as cell viability at 5000 mol ratio after 48 hrs relative to TPA | |||
| AID1446280 | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms. |
| AID1314873 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as IL1R1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID338354 | Inhibition of EBV-early antigen activation in human Raji cells assessed as early antigen activation at 1 uM ratio after 48 hrs | |||
| AID1314898 | Effect on growth factor related gene expression in non-diabetic adult human primary keratinocytes assessed as GDF15 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1573776 | Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected in type A-positive human erythrocytes after 72 hrs by SYBR green 1 dye-based fluorescence assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1 | Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities. |
| AID95520 | Cytotoxicity against human epidermoid carcinoma of the mouth (KB) cell line. | 1998 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13 | Synthesis of betulinic acid derivatives with activity against human melanoma. |
| AID1230156 | Cytotoxicity against human 8505C cells by SRB assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Simple structural modifications confer cytotoxicity to allobetulin. |
| AID1504269 | Cytotoxic activity in human Hep2 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID468093 | Antiviral activity against SFV infected in BHK cells after 14 hrs by luciferase reporter gene assay | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Betulin-derived compounds as inhibitors of alphavirus replication. |
| AID1296096 | Antiinflammatory activity against mouse J774 cells assessed as inhibition of LPS-induced COX-2 expression measured as remaining protein levels at 10 uM after 24 hrs by Western blot analysis | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo. |
| AID471324 | Inhibition of GST-tagged human PTP1B | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Chemical Constituents of the Roots of Euphorbia micractina. |
| AID1349603 | Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3 | Antineoplastic Agents. 606. The Betulastatins. |
| AID404873 | Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12 | Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. |
| AID1315061 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as increase in soluble VCAM1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314887 | Effect on cellular connection related gene expression in non-diabetic adult human primary keratinocytes assessed as GJB2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314811 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as increase in soluble TNF1 receptor protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315108 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of soluble VCAM1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314908 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as IL1B mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID403268 | Cytotoxicity against human Lu1 cells | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. |
| AID1314837 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as IL1R1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID665419 | Solubility of the compound in water | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Alkylidene branched lupane derivatives: synthesis and antitumor activity. |
| AID255891 | Concentration required to kill 50 % of human prostate cancer PC3 cells | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Correlation of cytotoxic activity of betulinines and their hydroxy analogues. |
| AID1314964 | Effect on chemokines related gene expression in diabetic adult human primary fibroblasts assessed as WDR26 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID398517 | Cytotoxicity against human HOG.R5 cells | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. |
| AID1314984 | Effect on chemokines related gene expression in non-diabetic adult human primary fibroblasts assessed as IL8 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315011 | Effect on growth factors related gene expression in non-diabetic young human primary fibroblasts assessed as FGF2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1578452 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids. |
| AID334272 | Growth inhibition of mouse B16 2F2 cells after 3 days | 2002 | Journal of natural products, May, Volume: 65, Issue:5 | Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line. |
| AID1896150 | Inhibition of HBV subgenotype D3 [3H]-myr-preS1 (2 to 48 residues) peptide binding to human NTCP in HEK293 cells preincubated for 5 mins followed by substrate addition and measured after 10 mins using by microplate scintillation counter analysis | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19 | Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential. |
| AID1504265 | Cytotoxic activity in human MCF7 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1315151 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as osteocalcin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402656 | Antifungal activity against Candida albicans UBC1 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1315013 | Effect on growth factors related gene expression in diabetic adult human primary fibroblasts assessed as FGF2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315030 | Effect on extracellular matrix related gene expression in diabetic adult human primary keratinocytes assessed as FN1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402644 | Antibacterial activity against Staphylococcus epidermidis CECT 232 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1315158 | Effect on actin cytoskeleton in human diabetic primary fibroblasts assessed as formation of thin elongated cellular body at 10 nM after 2 hrs by rhodamine phalloidin-staining based fluorescence microscopic analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID664934 | Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11 | Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. |
| AID1378820 | Induction of cell cycle arrest in in human PC3 cells assessed as effect on S phase at cytotoxic IC50 after 48 hrs by propidium iodide staining based flow cytometry | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin. |
| AID423006 | Cytotoxicity against human A549 cells after 48 hrs | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1 | Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. |
| AID1314879 | Effect on antioxidant related gene expression in non-diabetic young human primary keratinocytes assessed as SOD2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315132 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as IL10 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314977 | Effect on transcription factor related gene expression in non-diabetic young human primary fibroblasts assessed as JUN mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315112 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of soluble IL6R protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID603224 | Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies. |
| AID1314998 | Effect on chemokines related gene expression in diabetic adult human primary fibroblasts assessed as IL8 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1246833 | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and in vitro antitumor evaluation of betulin acid ester derivatives as novel apoptosis inducers. |
| AID1315099 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as GROalpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1773436 | Antiviral activity against Vesicular stomatitis virus Indiana infected in A549 cells assessed as reduction in virus titer preincubated for 24 hrs followed by viral infection and measured after 72 hrs by microscopic analysis | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID338350 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation at 5000 mol ratio after 48 hrs relative to TPA | |||
| AID1230154 | Cytotoxicity against human MCF7 cells by SRB assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Simple structural modifications confer cytotoxicity to allobetulin. |
| AID1770390 | Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1668312 | Inhibition of LPS-induced IL6 production in human BV2 cells preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by ELISA | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1597605 | Antiproliferative activity against human SNB19 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme. |
| AID377098 | Cytotoxicity against human Hep G2 cells after 48 hrs by WST-8 assay | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. |
| AID1314827 | Effect on antiinflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as NFKBIA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315145 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as FGF23 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1238532 | Cytotoxicity against African green monkey RC-37 cells assessed as cell viability after 3 days by neutral red uptake assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
| AID1127026 | Cytotoxicity against human DU145 cells after 48 hrs by SRB assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer. |
| AID1314938 | Effect on antiinflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as SOCS3 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314999 | Effect on antiinflammatory related gene expression in diabetic adult human primary fibroblasts assessed as NFKBIA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1230157 | Cytotoxicity against human A2780 cells by SRB assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Simple structural modifications confer cytotoxicity to allobetulin. |
| AID1315081 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as soluble RAGE protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314852 | Effect on ECM related gene expression in diabetic adult human primary keratinocytes assessed as FBN1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1265355 | Cytotoxicity against human A549 cells after 96 hrs by SRB assay | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds. |
| AID1315052 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as GM-CSF protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314813 | Effect on cellular connection related gene expression in non-diabetic adult human primary keratinocytes assessed as CLDN4 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314850 | Effect on cellular connection related gene expression in diabetic adult human primary keratinocytes assessed as CLDN4 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID400572 | Reversal of vincristine resistance in human KB/VJ300 cells | 2004 | Journal of natural products, Mar, Volume: 67, Issue:3 | Four new triterpenoids from Maytenus ilicifolia. |
| AID1314849 | Effect on AQP3 mRNA expression levels in non-diabetic adult human primary keratinocytes at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID417594 | Cytotoxicity against human DLD1 cells by resazurin reduction test | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. |
| AID1504287 | Antiproliferative activity in human SiHa cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1127023 | Cytotoxicity against human SF268 cells after 48 hrs by SRB assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer. |
| AID1315164 | Activation of RhoA in human diabetic primary keratinocytes at 10 nM after 3 hrs by immunoblot method | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1770393 | Antiproliferative activity against human HL-60 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID667667 | Inhibition of R5-tropic HIV1 envelope glycoprotein-mediated cell-cell fusion between viral envelope expressing human virus-infected HeLa ADA cells to human HeLa P5 cells at 5 uM after 16 hrs by beta-galactosidase reporter gene assay using chemiluminescenc | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Synthesis and anti-HIV activity of lupane and olean-18-ene derivatives. Absolute configuration of 19,20-epoxylupanes by VCD. |
| AID1314876 | Effect on chemokines related gene expression in non-diabetic young human primary keratinocytes assessed as CXCL10 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314907 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as PTGS2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315146 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as FGF23 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID377097 | Cytotoxicity against human VA13 cells after 48 hrs by WST-8 assay | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. |
| AID393218 | Toxicity in sheep erythrocytes assessed as induction of hemolysis | 2009 | Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5 | Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. |
| AID1315098 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as GROalpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314965 | Effect on chemokines related gene expression in non-diabetic adult human primary fibroblasts assessed as WDR26 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314981 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as IL1R1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314972 | Effect on antiinflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as NFKBIA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314927 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as IL6 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402649 | Antibacterial activity against Bacillus pumilus CECT 29 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314991 | Effect on chemokines related gene expression in non-diabetic young human primary fibroblasts assessed as CCL2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504291 | Antiproliferative activity in human KB cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1314834 | Effect on ECM related gene expression in non-diabetic adult human primary keratinocytes assessed as FBN1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID423008 | Cytotoxicity against human MCF7 cells after 48 hrs | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1 | Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. |
| AID1315148 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as insulin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504264 | Cytotoxic activity in human SiHa cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1315041 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as upregulation of RANTES protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314990 | Effect on MMP1 mRNA expression levels in non-diabetic adult human primary fibroblasts at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1127024 | Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer. |
| AID1315088 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as FGF23 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315143 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as TNFalpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1256624 | Effect on neurite outgrowth in rat PC12 cells at 10 and 20 uM after 48 hrs by inverted microscopic analysis | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells. |
| AID1314847 | Effect on transcription factor related gene expression in non-diabetic adult human primary keratinocytes assessed as JUN mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID400571 | Induction of human HL60 cell differentiation assessed as morphological change at 0.05 to 25 ug/ml by phase-contrast microscopy | 2004 | Journal of natural products, Mar, Volume: 67, Issue:3 | Four new triterpenoids from Maytenus ilicifolia. |
| AID1314929 | Effect on chemokines related gene expression in non-diabetic young human primary fibroblasts assessed as IL8 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315136 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as IL17A protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504263 | Cytotoxic activity in human HeLa cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1314919 | Effect on transcription factor related gene expression in diabetic adult human primary keratinocytes assessed as JUN mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1230155 | Cytotoxicity against human A549 cells by SRB assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Simple structural modifications confer cytotoxicity to allobetulin. |
| AID1314961 | Effect on growth factor related gene expression in diabetic adult human primary fibroblasts assessed as VEGFA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314835 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as PTGS2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1750789 | Antiviral activity against Human coronavirus 229E infected in human embryonic lung fibroblast cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by microscopy | 2021 | Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9 | Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease. |
| AID1465051 | Inhibition of yeast alpha-glucosidase using 4-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose. |
| AID1315134 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as IL12p40 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314989 | Effect on transcription factor related gene expression in non-diabetic adult human primary fibroblasts assessed as JUN mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315069 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as IL4 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314995 | Effect on pro-inflammatory related gene expression in diabetic adult human primary fibroblasts assessed as IL1R1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315105 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of soluble ICAM1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID377096 | Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. |
| AID1315154 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as osteopontin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1238534 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for HSV-1 F | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
| AID1889898 | Inhibition of human CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr followed by substrate addition and measured after 2 hrs by malachite green reagent based colorimetric ass | 2022 | Bioorganic & medicinal chemistry, 04-01, Volume: 59 | Discovery and optimization of betulinic acid derivatives as novel potent CD73 inhibitors. |
| AID1504290 | Antiproliferative activity in human DU145 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1597611 | Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme. |
| AID1314983 | Effect on chemokines related gene expression in non-diabetic adult human primary fibroblasts assessed as CCL2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315004 | Effect on MMP1 mRNA expression levels in diabetic adult human primary fibroblasts at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1578451 | Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids. |
| AID1314969 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as IL1R1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1578454 | Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids. |
| AID1315101 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of MIF protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314886 | Effect on cellular connection related gene expression in non-diabetic adult human primary keratinocytes assessed as CLDN4 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314935 | Effect on transcription factor related gene expression in non-diabetic young human primary fibroblasts assessed as JUN mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315086 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as soluble CD40L protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315062 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as increase in soluble gp130 part of IL6 receptor protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID491634 | Cytotoxicity against human CEM/ADR5000 by XTT assay | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Cytotoxicity of artesunic acid homo- and heterodimer molecules toward sensitive and multidrug-resistant CCRF-CEM leukemia cells. |
| AID1315128 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as IL2 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314846 | Effect on growth factor related gene expression in non-diabetic adult human primary keratinocytes assessed as VEGFA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1256621 | Cytotoxicity against rat PC12 cells assessed as cell viability at 10 and 20 uM after 72 hrs by SRB assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells. |
| AID1315056 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as increase in soluble IL6 receptor protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315141 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as soluble CD40L protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1127022 | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer. |
| AID1314950 | Effect on chemokines related gene expression in diabetic adult human primary fibroblasts assessed as WDR26 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314910 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as IL6 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1298839 | Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates. |
| AID338357 | Cytotoxicity against human Raji cells assessed as cell viability at 100 mol ratio after 48 hrs relative to TPA | |||
| AID1314980 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as IL1B mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314832 | Effect on AQP3 mRNA expression levels in non-diabetic young human primary keratinocytes at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314878 | Effect on antiinflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as NFKBIA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID471325 | Antiviral activity against HIV-1 NL4-3 expressing VSV-G envelope infected in human 293T cells assessed as inhibition of viral replication after 48 hrs by Luciferase reporter gene assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Chemical Constituents of the Roots of Euphorbia micractina. |
| AID1315091 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as insulin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1668319 | Inhibition of LPS-induced NF-kappaB/p65 nuclear translocation in human BV2 cells assessed as reduction in p65/NFkappaB level at 250 ug/ml by DAPI staining based fluorescence microscopic analysis | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1066595 | Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Lupane triterpenoids from the stems of Euonymus carnosus. |
| AID1314869 | Effect on cellular connection related gene expression in non-diabetic young human primary keratinocytes assessed as GJB2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314905 | Effect on cellular connection related gene expression in diabetic adult human primary keratinocytes assessed as GJB2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314833 | Effect on cellular connection related gene expression in non-diabetic adult human primary keratinocytes assessed as GJB2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315125 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as IL-1beta protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID358916 | Inhibition of human topoisomerase 1 assessed as relaxation of supercoiled pBR322 DNA up to 200 uM by agarose gel electrophoresis | 2001 | Journal of natural products, Dec, Volume: 64, Issue:12 | Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. |
| AID393224 | Cell membrane permeabilization in human WS1 cells assessed as drug level causing decrease in calcein fluorescence | 2009 | Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5 | Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. |
| AID1315038 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as upregulation of MIP1alpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315100 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of RANTES protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315152 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as osteocalcin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314838 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as IL6 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1770389 | Antiproliferative activity against human LN-229 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1314931 | Effect on antiinflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as SOCS3 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID423010 | Cytotoxicity against human WS1 cells after 48 hrs | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1 | Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. |
| AID1315110 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of soluble MCP1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1693838 | Inhibition of mouse CD73 | 2021 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 34 | Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor. |
| AID1314892 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as IL6 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315079 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as soluble TNFR2 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1127021 | Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer. |
| AID393222 | Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence | 2009 | Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5 | Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. |
| AID1315120 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as soluble RAGE protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315121 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as GM-CSF protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314975 | Effect on chemokines related gene expression in diabetic adult human primary fibroblasts assessed as CCL2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315115 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as soluble E-selectin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315065 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as IL1beta protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314968 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as IL1B mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504294 | Antiproliferative activity in HEK293 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1315017 | Effect on adhesion molecules related gene expression in non-diabetic young human primary fibroblasts assessed as ICAM1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314918 | Effect on growth factor related gene expression in diabetic adult human primary keratinocytes assessed as VEGFA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314974 | Effect on growth factor related gene expression in non-diabetic young human primary fibroblasts assessed as GDF15 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1668315 | Inhibition of LPS-induced JNK-54 phosphorylation in human BV2 cells at 62.5 to 250 ug/ml preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by Western blot analysis | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1315114 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of soluble Fas protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315047 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as upregulation of IL1RA protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314966 | Effect on chemokines related gene expression in non-diabetic young human primary fibroblasts assessed as WDR26 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314906 | Effect on ECM related gene expression in diabetic adult human primary keratinocytes assessed as FBN1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314953 | Effect on pro-inflammatory related gene expression in diabetic adult human primary fibroblasts assessed as IL1B mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315022 | Effect on adhesion molecules related gene expression in diabetic adult human primary fibroblasts assessed as ICAM1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504268 | Cytotoxic activity in human KB cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID333022 | Cytotoxicity against human H9 cells after 3 days | 1994 | Journal of natural products, Feb, Volume: 57, Issue:2 | Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. |
| AID1314836 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as IL1B mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504270 | Cytotoxic activity in African green monkey Vero cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1314997 | Effect on chemokines related gene expression in non-diabetic adult human primary fibroblasts assessed as CCL2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402651 | Antibacterial activity against Mycobacterium smegmatis CECT 3032 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1265354 | Cytotoxicity against human A2780 cells after 96 hrs by SRB assay | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds. |
| AID377095 | Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. |
| AID1317963 | Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTS assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells. |
| AID1770388 | Antiproliferative activity against human HAP1 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID444761 | Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. |
| AID1314970 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as IL6 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315130 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as IL4 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314896 | Effect on antiinflammatory related gene expression in non-diabetic adult human primary keratinocytes assessed as NFKBIA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1238524 | Antiviral activity against HSV-1 F infected in African green monkey Vero cells after 2 days by plaque reduction assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
| AID423009 | Cytotoxicity against human PC3 cells after 48 hrs | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1 | Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. |
| AID1238526 | Antiviral activity against HSV-1 KOS infected in African green monkey RC-37 cells assessed as inhibition of viral replication incubated with virus for 1 hr followed by viral adsorbtion to cells for 1 hr measured after 3 days by plaque reduction assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
| AID1314894 | Effect on chemokines related gene expression in non-diabetic adult human primary keratinocytes assessed as CXCL10 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315122 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as GM-CSF protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315077 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as IFNgamma protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314815 | Effect on cellular connection related gene expression in non-diabetic young human primary keratinocytes assessed as CLDN4 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID235238 | Therapeutic index was evaluated as ratio of IC50 to that of EC50 | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives. |
| AID417597 | Cytotoxicity against human WS1 cells by resazurin reduction test | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. |
| AID1349604 | Growth inhibition of human MCF7 cells after 48 hrs by SRB assay | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3 | Antineoplastic Agents. 606. The Betulastatins. |
| AID1315053 | Upregulation of wound healing activity related soluble ICAM1 protein levels in non-diabetic adult human primary keratinocytes at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314922 | Effect on antiinflammatory related gene expression in diabetic adult human primary fibroblasts assessed as SOCS3 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1770391 | Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1378817 | Induction of mitochondrial membrane potential loss in human PC3 cells assessed as fluorescence intensity at cytotoxic IC50 after 48 hrs by TMRE dye-based fluorescence assay based flow cytometry (Rvb = 210.8 No_unit) | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8 | Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin. |
| AID468096 | Cytotoxicity against human HuH7 cells assessed as cell viability at 500 uM after 24 hrs | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Betulin-derived compounds as inhibitors of alphavirus replication. |
| AID1315096 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as osteopontin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314962 | Effect on transcription factor related gene expression in diabetic adult human primary fibroblasts assessed as JUN mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314843 | Effect on antioxidant related gene expression in non-diabetic adult human primary keratinocytes assessed as SOD2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1246836 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and in vitro antitumor evaluation of betulin acid ester derivatives as novel apoptosis inducers. |
| AID1315113 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of soluble Fas protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315045 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as upregulation of MIF protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315087 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as soluble CD40L protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314877 | Effect on chemokines related gene expression in non-diabetic young human primary keratinocytes assessed as IL8 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314875 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as TNF mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1349608 | Growth inhibition of human DU145 cells after 48 hrs by SRB assay | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3 | Antineoplastic Agents. 606. The Betulastatins. |
| AID1314914 | Effect on antiinflammatory related gene expression in diabetic adult human primary keratinocytes assessed as NFKBIA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID383183 | Inhibition of Saccharomyces sp. alpha-glucosidase | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus. |
| AID1314952 | Effect on pro-inflammatory related gene expression in diabetic adult human primary fibroblasts assessed as PTGS2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314932 | Effect on growth factor related gene expression in non-diabetic young human primary fibroblasts assessed as GDF15 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315018 | Effect on adhesion molecules related gene expression in non-diabetic adult human primary fibroblasts assessed as ICAM1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314993 | Effect on pro-inflammatory related gene expression in diabetic adult human primary fibroblasts assessed as PTGS2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1265356 | Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds. |
| AID1315153 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as osteopontin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1750788 | Antiviral activity against Human coronavirus 229E infected in human embryonic lung fibroblast cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTS cell viability assay | 2021 | Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9 | Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease. |
| AID1315016 | Effect on growth factors related gene expression in diabetic adult human primary fibroblasts assessed as FGF2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID417592 | Toxicity in sheep erythrocytes assessed as induction of hemolysis | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. |
| AID311143 | Selectivity index, ratio of IC50 for mouse J774 cells to IC50 for Trypanosoma brucei brucei bloodstream trypomastigotes | 2007 | Journal of natural products, Aug, Volume: 70, Issue:8 | Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. |
| AID1668313 | Inhibition of LPS-induced NO release in human BV2 cells at 62.5 to 250 ug/ml preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1315109 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as upregulation of soluble MCP1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1246835 | Cytotoxicity against human A375 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and in vitro antitumor evaluation of betulin acid ester derivatives as novel apoptosis inducers. |
| AID1314939 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as PTGS2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1693837 | Inhibition of human CD73 | 2021 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 34 | Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor. |
| AID333020 | Therapeutic index, IC50 for human H9 cells to EC50 for HIV1 3B | 1994 | Journal of natural products, Feb, Volume: 57, Issue:2 | Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. |
| AID1314862 | Effect on growth factor related gene expression in diabetic adult human primary keratinocytes assessed as GDF15 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1668309 | Inhibition of LPS-induced IL-1beta production in human BV2 cells preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by ELISA | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1519641 | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis, and biological evaluation of ligustrazine - betulin amino-acid/dipeptide derivatives as anti-tumor agents. |
| AID1314959 | Effect on antioxidant related gene expression in diabetic adult human primary fibroblasts assessed as SOD2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314848 | Effect on MMP1 mRNA expression levels in non-diabetic adult human primary keratinocytes at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314987 | Effect on growth factor related gene expression in non-diabetic adult human primary fibroblasts assessed as GDF15 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID210597 | Therapeutic Index is the average of the IC50 to that of EC50 | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23 | Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. |
| AID79291 | Compound was evaluated for anti-HIV activity in H9 lymphocytes | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives. |
| AID1314901 | Effect on transcription factor related gene expression in non-diabetic adult human primary keratinocytes assessed as JUN mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314942 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as IL6 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314979 | Effect on pro-inflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as PTGS2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1296097 | Antiinflammatory activity against mouse J774 cells assessed as inhibition of LPS-induced IL-6 production measured as remaining IL-6 levels at 10 uM after 24 hrs by ELISA | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo. |
| AID1314841 | Effect on chemokines related gene expression in non-diabetic adult human primary keratinocytes assessed as IL8 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1315073 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as IL12p40 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315058 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as increase in soluble Fas protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314821 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as IL6 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402645 | Antibacterial activity against Staphylococcus saprophyticus CECT 235 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314828 | Effect on antioxidant related gene expression in non-diabetic young human primary keratinocytes assessed as SOD2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315126 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as IL-1beta protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID433120 | Cytotoxicity against daunorubicin-resistant human EPP85-181RDB cells after 24 hrs by SRB method | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1773437 | Antiviral activity against Human herpesvirus 1 MacIntyre infected in A549 cells assessed as reduction in virus titer preincubated for 24 hrs followed by viral infection and measured after 72 hrs by microscopic analysis | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID1504286 | Antiproliferative activity in human HeLa cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1315133 | Effect on wound healing activity in non-diabetic adult human primary fibroblasts assessed as IL12p40 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1773424 | Antiviral activity against Human herpesvirus-1 MacIntyre infected in A549 cells assessed as inhibition of viral adsorption at early stage of replication treated for 1 hr during viral infection followed by replacement with fresh medium and measured after 4 | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID1315104 | Effect on wound healing activity in diabetic adult human primary fibroblasts assessed as upregulation of soluble TNFR1 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID398515 | Selectivity index, ratio of CC50 for HOG.R5 cells to IC50 for HIV1 3B | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. |
| AID1066593 | Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Lupane triterpenoids from the stems of Euonymus carnosus. |
| AID1315059 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as increase in soluble Fas protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID403267 | Cytotoxicity against human KB cells | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. |
| AID1315162 | Effect on actin cytoskeleton in human non-diabetic primary fibroblasts assessed as formation of thin elongated cellular body at 10 nM after 2 hrs in presence of p-38 MAPK inhibitor LN 950 by rhodamine phalloidin-staining based fluorescence microscopic ana | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402653 | Antibacterial activity against Proteus mirabilis CECT170 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1315034 | Upregulation of adhesion molecules related ICAM1 mRNA expression in diabetic adult human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314971 | Effect on chemokines related gene expression in non-diabetic young human primary fibroblasts assessed as IL8 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID433127 | Induction of apoptosis in human EPG85-257P cells assessed as normal cells after 24 hrs by comet assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1315064 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as IL1beta protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID334273 | Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days | 2002 | Journal of natural products, May, Volume: 65, Issue:5 | Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line. |
| AID1314900 | Effect on growth factor related gene expression in non-diabetic adult human primary keratinocytes assessed as VEGFA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314882 | Effect on growth factor related gene expression in non-diabetic young human primary keratinocytes assessed as VEGFA mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402662 | Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314904 | Effect on cellular connection related gene expression in diabetic adult human primary keratinocytes assessed as CLDN4 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1668307 | Cytotoxicity against human BV2 cells assessed as survival rate at 125 ug/ml | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID471323 | Cytotoxicity against human A2780 cells after 4 days by MTT assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Chemical Constituents of the Roots of Euphorbia micractina. |
| AID1446281 | Cytotoxicity against human HL-7702 cells assessed as cell growth inhibition after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms. |
| AID433122 | Cytotoxicity against daunorubicin-resistant human EPG85-257RDB cells after 24 hrs by SRB method | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. |
| AID1315046 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as upregulation of soluble E-selectin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1597608 | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme. |
| AID1668308 | Inhibition of LPS-induced TNF-alpha production in human BV2 cells preincubated for 4 hrs followed by LPS stimulation and measured after 24 hrs by ELISA | 2020 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 30, Issue:12 | Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. |
| AID1398544 | Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay | 2018 | Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15 | Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. |
| AID1314903 | Effect on AQP3 mRNA expression levels in non-diabetic adult human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314930 | Effect on antiinflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as NFKBIA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315067 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as IL2 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315039 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as upregulation of TNFalpha protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314818 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as PTGS2 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314933 | Effect on antiinflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as SOCS3 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314880 | Effect on growth factor related gene expression in non-diabetic young human primary keratinocytes assessed as GDF15 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1298836 | Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates. |
| AID1314881 | Effect on growth factor related gene expression in non-diabetic young human primary keratinocytes assessed as PDGFB mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1265357 | Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds. |
| AID1314817 | Effect on ECM related gene expression in non-diabetic young human primary keratinocytes assessed as FBN1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1519640 | Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Design, synthesis, and biological evaluation of ligustrazine - betulin amino-acid/dipeptide derivatives as anti-tumor agents. |
| AID1597610 | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme. |
| AID1770429 | Antibacterial activity against Salmonella enterica subsp.enterica ATCC13076 assessed as growth inhibition after 20 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID1315051 | Upregulation of wound healing activity related GM-CSF protein levels in non-diabetic adult human primary keratinocytes at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID336478 | Inhibition of COX2 at 100 uM by scintillation proximity assay | 2002 | Journal of natural products, Nov, Volume: 65, Issue:11 | Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. |
| AID1314957 | Effect on chemokines related gene expression in diabetic adult human primary fibroblasts assessed as IL8 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315036 | Upregulation of chemokines related MCP1 mRNA expression in human primary keratinocytes at 1.96 to 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314885 | Effect on AQP3 mRNA expression levels in non-diabetic young human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID423007 | Cytotoxicity against human DLD1 cells after 48 hrs | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1 | Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. |
| AID1314858 | Effect on chemokines related gene expression in diabetic adult human primary keratinocytes assessed as CXCL10 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315071 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as IL10 protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1504289 | Antiproliferative activity in human MDA-MB-231 cells by sulforhodamine B assay | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Lupane-Type Triterpenes of Phoradendron vernicosum. |
| AID1230152 | Cytotoxicity against human 518A2 cells by SRB assay | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Simple structural modifications confer cytotoxicity to allobetulin. |
| AID403270 | Cytotoxicity against human HUVEC | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. |
| AID398516 | Antiviral activity against HIV1 3B infected in human HOG.R5 assessed as inhibition of viral replication by microtiter assay | 2003 | Journal of natural products, Feb, Volume: 66, Issue:2 | Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. |
| AID1693839 | Inhibition of mouse CD39 | 2021 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 34 | Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor. |
| AID1314884 | Effect on MMP1 mRNA expression levels in non-diabetic young human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314888 | Effect on ECM related gene expression in non-diabetic adult human primary keratinocytes assessed as FBN1 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID549500 | Antiviral activity against Human immunodeficiency virus 1 NL4-3 infected in MT4 lymphocytes assessed as p24 antigen level by ELISA | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. |
| AID1315031 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as upregulation of MIF protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315167 | Effect on actin cytoskeleton in non-diabetic young human primary keratinocytes assessed as formation of cellular protrusions at 10 nM after 2 hrs in presence of p-38 MAPK inhibitor LN 950 by rhodamine phalloidin-staining based fluorescence microscopic ana | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314822 | Effect on growth factor related gene expression in non-diabetic young human primary keratinocytes assessed as PDGFB mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID393223 | Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence | 2009 | Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5 | Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. |
| AID1066590 | Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Lupane triterpenoids from the stems of Euonymus carnosus. |
| AID1298837 | Cytotoxicity against human A2780 cells after 96 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates. |
| AID397122 | Inhibition of HIV1 RT | |||
| AID444763 | Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. |
| AID1773426 | Antiviral activity against Human adenovirus 5 Adenoid 75 infected in A549 cells assessed as inhibition of viral adsorption at early stage of replication treated for 1 hr during viral infection followed by replacement with fresh medium and measured after 7 | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study. |
| AID491633 | Cytotoxicity against human CCRF-CEM by XTT assay | 2010 | Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13 | Cytotoxicity of artesunic acid homo- and heterodimer molecules toward sensitive and multidrug-resistant CCRF-CEM leukemia cells. |
| AID1314944 | Effect on antiinflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as NFKBIA mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID667668 | Inhibition of X4-tropic HIV1 envelope glycoprotein-mediated cell-cell fusion between viral envelope expressing human virus-infected HeLa ADA cells to human HeLa P5 cells at 5 uM after 16 hrs by beta-galactosidase reporter gene assay using chemiluminescenc | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Synthesis and anti-HIV activity of lupane and olean-18-ene derivatives. Absolute configuration of 19,20-epoxylupanes by VCD. |
| AID1314955 | Effect on pro-inflammatory related gene expression in diabetic adult human primary fibroblasts assessed as IL6 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1315032 | Upregulation of adhesion molecules related VCAM1 mRNA expression in non-diabetic adult human primary keratinocytes at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID444762 | Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay relative to litocholic acid | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. |
| AID1314874 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as IL6 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID358919 | Inhibition of 1 unit human topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA at 100 uM by agarose gel electrophoresis | 2001 | Journal of natural products, Dec, Volume: 64, Issue:12 | Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. |
| AID1315075 | Effect on wound healing activity in diabetic adult human primary keratinocytes assessed as IL17A protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314820 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary keratinocytes assessed as IL1R1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402652 | Antibacterial activity against Escherichia coli CECT 99 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314923 | Effect on antiinflammatory related gene expression in non-diabetic adult human primary fibroblasts assessed as SOCS3 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314895 | Effect on chemokines related gene expression in non-diabetic adult human primary keratinocytes assessed as IL8 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1314967 | Effect on pro-inflammatory related gene expression in non-diabetic young human primary fibroblasts assessed as PTGS2 mRNA levels at 9.81 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1770430 | Antibacterial activity against Listeria innocua LMG11387 assessed as growth inhibition after 20 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. |
| AID333023 | Antiviral activity against HIV1 3B in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay | 1994 | Journal of natural products, Feb, Volume: 57, Issue:2 | Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. |
| AID1315040 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as upregulation of soluble E-selectin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1296094 | Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced nitric oxide production measured as remaining nitric oxide levels at 10 uM by Griess assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo. |
| AID1298838 | Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates. |
| AID1315094 | Effect on wound healing activity in non-diabetic adult human primary keratinocytes assessed as osteocalcin protein levels at 1.96 uM after 24 hrs by bead-based suspension array analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID402647 | Antibacterial activity against Bacillus subtilis CECT 39 up to 40 ug/mL by broth microdilution method | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Lupane triterpenoids from Maytenus species. |
| AID1314831 | Effect on MMP1 mRNA expression levels in non-diabetic young human primary keratinocytes at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID468095 | Cytotoxicity against human HuH7 cells assessed as cell viability at 50 uM after 24 hrs | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Betulin-derived compounds as inhibitors of alphavirus replication. |
| AID1314855 | Effect on pro-inflammatory related gene expression in diabetic adult human primary keratinocytes assessed as IL1R1 mRNA levels at 1.96 uM after 6 hrs by qPCR analysis | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. |
| AID1798302 | Enzyme Inhibition Assay from Article 10.1021/jm8000949: \\Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure-Activity Relationships, and X-ray Crystallographic Studies.\\ | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12 | Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (0.50) | 18.7374 |
| 1990's | 13 (3.26) | 18.2507 |
| 2000's | 75 (18.80) | 29.6817 |
| 2010's | 216 (54.14) | 24.3611 |
| 2020's | 93 (23.31) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (62.22) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 8 (1.90%) | 5.53% |
| Reviews | 19 (4.50%) | 6.00% |
| Case Studies | 2 (0.47%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 393 (93.13%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||