Page last updated: 2024-08-07 13:06:01

Diamine acetyltransferase 1

A diamine acetyltransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21673]

Synonyms

EC 2.3.1.57;
Polyamine N-acetyltransferase 1;
Putrescine acetyltransferase;
Spermidine/spermine N(1)-acetyltransferase 1;
SSAT;
SSAT-1

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (3)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
diminazeneHomo sapiens (human)Ki2.400011
pentamidineHomo sapiens (human)Ki2.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
trientineHomo sapiens (human)Km83.000011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
diamine N-acetyltransferase activitymolecular functionCatalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. [EC:2.3.1.57]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
N-acetyltransferase activitymolecular functionCatalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. [GOC:ai]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
spermidine bindingmolecular functionBinding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
angiogenesisbiological processBlood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
polyamine biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]
putrescine catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. [GOC:ai]
spermidine acetylationbiological processThe modification of spermidine by addition of acetyl groups. [GOC:mlg]