Page last updated: 2024-08-07 13:06:01
Diamine acetyltransferase 1
A diamine acetyltransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21673]
Synonyms
EC 2.3.1.57;
Polyamine N-acetyltransferase 1;
Putrescine acetyltransferase;
Spermidine/spermine N(1)-acetyltransferase 1;
SSAT;
SSAT-1
Research
Bioassay Publications (2)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
diminazene | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
pentamidine | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
Drugs with Other Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
trientine | Homo sapiens (human) | Km | 83.0000 | 1 | 1 |
Enables
This protein enables 5 target(s):
Target | Category | Definition |
diamine N-acetyltransferase activity | molecular function | Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. [EC:2.3.1.57] |
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
N-acetyltransferase activity | molecular function | Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. [GOC:ai] |
identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
spermidine binding | molecular function | Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai] |
Located In
This protein is located in 1 target(s):
Target | Category | Definition |
cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 4 target(s):
Target | Category | Definition |
angiogenesis | biological process | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453] |
polyamine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732] |
putrescine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. [GOC:ai] |
spermidine acetylation | biological process | The modification of spermidine by addition of acetyl groups. [GOC:mlg] |