Proteins > 5-hydroxytryptamine receptor 2A
Page last updated: 2024-08-07 15:59:34
5-hydroxytryptamine receptor 2A
A 5-hydroxytryptamine receptor 2A that is encoded in the genome of rat. [OMA:P14842, PRO:DNx]
Synonyms
5-HT-2;
5-HT-2A;
Serotonin receptor 2A
Research
Bioassay Publications (206)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 25 (12.14) | 18.7374 |
| 1990's | 89 (43.20) | 18.2507 |
| 2000's | 58 (28.16) | 29.6817 |
| 2010's | 30 (14.56) | 24.3611 |
| 2020's | 4 (1.94) | 2.80 |
Compounds (259)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Ki | 13.4100 | 2 | 2 |
| tryptamine | Rattus norvegicus (Norway rat) | Ki | 1.4725 | 2 | 2 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | IC50 | 5.5000 | 2 | 2 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 3.7859 | 8 | 8 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Ki | 0.0129 | 5 | 6 |
| 1-(1-naphthyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0180 | 2 | 2 |
| 1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 2.2500 | 2 | 2 |
| 1-(3-chlorophenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 1 | 1 |
| 2-methyl-5-ht | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 2.8075 | 1 | 2 |
| 5-carboxamidotryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| methylbufotenin | Rattus norvegicus (Norway rat) | IC50 | 0.9725 | 4 | 4 |
| methylbufotenin | Rattus norvegicus (Norway rat) | Ki | 0.6915 | 7 | 8 |
| 5-methoxytryptamine | Rattus norvegicus (Norway rat) | Ki | 0.5571 | 7 | 7 |
| 6-methoxytryptoline | Rattus norvegicus (Norway rat) | Ki | 3.0900 | 2 | 2 |
| tacrine | Rattus norvegicus (Norway rat) | IC50 | 0.0780 | 1 | 1 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0103 | 3 | 3 |
| alpha-methylserotonin | Rattus norvegicus (Norway rat) | Ki | 0.5025 | 2 | 2 |
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| bmy 7378 | Rattus norvegicus (Norway rat) | Ki | 0.4898 | 1 | 1 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 3.5650 | 4 | 4 |
| buspirone | Rattus norvegicus (Norway rat) | Ki | 1.0543 | 3 | 3 |
| cgs 12066 | Rattus norvegicus (Norway rat) | IC50 | 6.8000 | 1 | 1 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0024 | 3 | 3 |
| cisapride | Rattus norvegicus (Norway rat) | IC50 | 0.0098 | 1 | 1 |
| clebopride | Rattus norvegicus (Norway rat) | Ki | 0.0890 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | Ki | 0.0083 | 1 | 1 |
| cyproheptadine | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 1 | 1 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0016 | 1 | 1 |
| desipramine | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| amphetamine | Rattus norvegicus (Norway rat) | Ki | 18.2500 | 4 | 4 |
| dichlorphenamide | Rattus norvegicus (Norway rat) | Ki | 0.0380 | 2 | 2 |
| doxepin | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| emodin | Rattus norvegicus (Norway rat) | IC50 | 36.4000 | 1 | 1 |
| ethoxzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0080 | 2 | 2 |
| fluoxetine | Rattus norvegicus (Norway rat) | IC50 | 0.1000 | 1 | 1 |
| fluoxetine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| granisetron | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.1467 | 10 | 10 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 0.0483 | 20 | 21 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| imipramine | Rattus norvegicus (Norway rat) | Ki | 0.0230 | 1 | 1 |
| indirubin-3'-monoxime | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| jl 18 | Rattus norvegicus (Norway rat) | Ki | 0.0750 | 3 | 3 |
| nsc 664704 | Rattus norvegicus (Norway rat) | IC50 | 15.0000 | 1 | 1 |
| ketanserin | Rattus norvegicus (Norway rat) | IC50 | 0.0021 | 4 | 4 |
| ketanserin | Rattus norvegicus (Norway rat) | Ki | 0.0033 | 17 | 17 |
| ketoconazole | Rattus norvegicus (Norway rat) | IC50 | 1.0670 | 1 | 1 |
| mafenide | Rattus norvegicus (Norway rat) | Ki | 0.1700 | 1 | 1 |
| mescaline | Rattus norvegicus (Norway rat) | Ki | 3.7867 | 3 | 3 |
| methazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0123 | 3 | 3 |
| metoclopramide | Rattus norvegicus (Norway rat) | IC50 | 13.2000 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 0.0065 | 5 | 5 |
| mirtazapine | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 1 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.1170 | 3 | 3 |
| nafamostat | Rattus norvegicus (Norway rat) | IC50 | 12.0000 | 1 | 1 |
| nefazodone | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 1 | 1 |
| nemonapride | Rattus norvegicus (Norway rat) | IC50 | 0.0490 | 1 | 2 |
| nifedipine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| nifedipine | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| nitrendipine | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| nortriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| olomoucine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| pimethixene | Rattus norvegicus (Norway rat) | Ki | 0.0025 | 1 | 1 |
| pindolol | Rattus norvegicus (Norway rat) | Ki | 114.7500 | 2 | 2 |
| pirenperone | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 2 | 2 |
| prazosin | Rattus norvegicus (Norway rat) | IC50 | 42.0000 | 1 | 1 |
| psilocin | Rattus norvegicus (Norway rat) | Ki | 0.2820 | 3 | 4 |
| quipazine | Rattus norvegicus (Norway rat) | IC50 | 1.4000 | 1 | 1 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.6038 | 9 | 9 |
| risperidone | Rattus norvegicus (Norway rat) | IC50 | 0.0991 | 6 | 6 |
| risperidone | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 10 | 11 |
| ritanserin | Rattus norvegicus (Norway rat) | IC50 | 0.0010 | 6 | 7 |
| ritanserin | Rattus norvegicus (Norway rat) | Ki | 0.0079 | 4 | 5 |
| rizatriptan | Rattus norvegicus (Norway rat) | IC50 | 6.3096 | 1 | 1 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 7 | 7 |
| spiroxatrine | Rattus norvegicus (Norway rat) | Ki | 0.4855 | 1 | 2 |
| sulfamethoxazole | Rattus norvegicus (Norway rat) | IC50 | 4.7000 | 1 | 1 |
| sulfanilamide | Rattus norvegicus (Norway rat) | Ki | 0.3000 | 2 | 2 |
| sulfathiazole | Rattus norvegicus (Norway rat) | IC50 | 2.5000 | 1 | 1 |
| sumatriptan | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.0390 | 2 | 2 |
| trazodone | Rattus norvegicus (Norway rat) | IC50 | 0.0170 | 1 | 2 |
| trimethoprim | Rattus norvegicus (Norway rat) | IC50 | 15.0000 | 1 | 1 |
| trimetrexate | Rattus norvegicus (Norway rat) | IC50 | 0.0260 | 2 | 2 |
| wb 4101 | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| whi p180 | Rattus norvegicus (Norway rat) | IC50 | 168.0000 | 1 | 1 |
| lysergic acid diethylamide | Rattus norvegicus (Norway rat) | Ki | 0.0036 | 6 | 6 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Ki | 1.6360 | 1 | 1 |
| phenylpiperazine | Rattus norvegicus (Norway rat) | Ki | 1.3840 | 2 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 43.3000 | 1 | 1 |
| carzenide | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 1 | 1 |
| indopan | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| bufotenin | Rattus norvegicus (Norway rat) | Ki | 0.3800 | 1 | 1 |
| 1,2-Dihydroquinolin-2-imine | Rattus norvegicus (Norway rat) | Ki | 79.0000 | 1 | 1 |
| fluanisone | Rattus norvegicus (Norway rat) | Ki | 0.0520 | 2 | 2 |
| 11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.0390 | 1 | 1 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 1 | 1 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.0035 | 3 | 3 |
| clothiapine | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 2 | 2 |
| benzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 2 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Ki | 0.1000 | 3 | 3 |
| metergoline | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 2 | 2 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Ki | 0.9484 | 6 | 7 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 33.6000 | 1 | 1 |
| 1-(3-chloro-5-benzo[b][1]benzoxepinyl)-4-methylpiperazine | Rattus norvegicus (Norway rat) | Ki | 0.0030 | 2 | 2 |
| lenperone | Rattus norvegicus (Norway rat) | Ki | 0.0042 | 2 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Ki | 11.1000 | 1 | 1 |
| w-a 335 | Rattus norvegicus (Norway rat) | IC50 | 0.0026 | 1 | 1 |
| buspirone hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.7400 | 1 | 1 |
| 5-methoxy-alpha-methyltryptamine | Rattus norvegicus (Norway rat) | Ki | 0.3450 | 1 | 1 |
| eniluracil | Rattus norvegicus (Norway rat) | IC50 | 0.0140 | 1 | 1 |
| staurosporine | Rattus norvegicus (Norway rat) | IC50 | 4.0000 | 1 | 1 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.3850 | 1 | 1 |
| fluperlapine | Rattus norvegicus (Norway rat) | Ki | 0.0038 | 2 | 2 |
| rimcazole | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| piritrexim | Rattus norvegicus (Norway rat) | IC50 | 0.0380 | 1 | 1 |
| quinpirole | Rattus norvegicus (Norway rat) | Ki | 1.5000 | 1 | 1 |
| tiospirone | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 1 |
| tiospirone | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| ipsapirone | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| ipsapirone | Rattus norvegicus (Norway rat) | Ki | 0.0034 | 1 | 1 |
| sertindole | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 5 | 6 |
| besipirdine | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| fananserin | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 5 | 5 |
| aripiprazole | Rattus norvegicus (Norway rat) | Ki | 0.0091 | 4 | 4 |
| ziprasidone | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Ki | 0.0225 | 17 | 18 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 4.1119 | 9 | 10 |
| 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose | Rattus norvegicus (Norway rat) | Ki | 3.9000 | 1 | 1 |
| irindalone | Rattus norvegicus (Norway rat) | IC50 | 0.1325 | 3 | 4 |
| lerisetron | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| isocytosine | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.0750 | 1 | 1 |
| spiramide | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| disulphane | Rattus norvegicus (Norway rat) | Ki | 0.0460 | 1 | 1 |
| setoperone | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| brinzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0030 | 2 | 2 |
| etisulergine | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 2 | 2 |
| mesulergine | Rattus norvegicus (Norway rat) | Ki | 0.0030 | 2 | 2 |
| diclofensine | Rattus norvegicus (Norway rat) | Ki | 0.0370 | 1 | 1 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| 5-iodouracil | Rattus norvegicus (Norway rat) | IC50 | 0.2200 | 1 | 1 |
| spirodecanone | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| tefludazine | Rattus norvegicus (Norway rat) | IC50 | 0.0048 | 3 | 3 |
| hp 873 | Rattus norvegicus (Norway rat) | IC50 | 0.0090 | 1 | 1 |
| mdl 11939 | Rattus norvegicus (Norway rat) | Ki | 0.0075 | 2 | 2 |
| 2-aminobenzenesulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.2950 | 1 | 1 |
| 1-benzylpiperazine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Ki | 2.8800 | 3 | 3 |
| 5-cyanouracil | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.0600 | 1 | 1 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Ki | 0.1000 | 3 | 3 |
| aminozolamide | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 1 | 1 |
| 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine | Rattus norvegicus (Norway rat) | Ki | 0.0170 | 3 | 3 |
| 5-vinyluracil | Rattus norvegicus (Norway rat) | IC50 | 0.0890 | 1 | 1 |
| u 69593 | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Ki | 0.3000 | 1 | 1 |
| tryptoline | Rattus norvegicus (Norway rat) | Ki | 3.5333 | 3 | 3 |
| 1-hydroxymethylmidazolam | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| 6-chloro-2-(1-piperazinyl)pyrazine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | Rattus norvegicus (Norway rat) | Ki | 0.8973 | 3 | 3 |
| alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol | Rattus norvegicus (Norway rat) | IC50 | 0.8300 | 1 | 1 |
| parthenolide | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| 3-n-methylspiperone | Rattus norvegicus (Norway rat) | IC50 | 0.0013 | 1 | 1 |
| 3-n-methylspiperone | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 2 | 2 |
| mosapride | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| a 68930 | Rattus norvegicus (Norway rat) | Ki | 4.9400 | 1 | 1 |
| cp 93129 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| l 687384 | Rattus norvegicus (Norway rat) | IC50 | 7.1000 | 1 | 1 |
| 4-ethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| mcn 5707 | Rattus norvegicus (Norway rat) | Ki | 0.1403 | 1 | 3 |
| methotrexate | Rattus norvegicus (Norway rat) | IC50 | 0.0011 | 1 | 1 |
| fluoroclebopride | Rattus norvegicus (Norway rat) | Ki | 0.2830 | 1 | 1 |
| l 694247 | Rattus norvegicus (Norway rat) | IC50 | 0.3162 | 1 | 2 |
| 4-(3-(benzotriazol-1-yl)propyl)-1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 1.0400 | 1 | 1 |
| sonepiprazole | Rattus norvegicus (Norway rat) | Ki | 1.8000 | 1 | 1 |
| n-methylserotonin | Rattus norvegicus (Norway rat) | Ki | 0.1800 | 1 | 1 |
| 3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole | Rattus norvegicus (Norway rat) | Ki | 0.0670 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 9.2833 | 3 | 3 |
| moracin c | Rattus norvegicus (Norway rat) | IC50 | 2.3500 | 1 | 1 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Ki | 9.3767 | 3 | 3 |
| cyc 202 | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| 6-hydroxytryptamine | Rattus norvegicus (Norway rat) | Ki | 11.5000 | 1 | 1 |
| harmalan | Rattus norvegicus (Norway rat) | Ki | 1.1500 | 1 | 1 |
| naphthalenesulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.1330 | 1 | 1 |
| 5-methoxytryptoline | Rattus norvegicus (Norway rat) | Ki | 0.1025 | 2 | 2 |
| 4,9-dihydro-7-methoxy-3h-pyrido(3,4b)indole | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| 4-(2-aminoethyl)benzenesulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.1600 | 1 | 1 |
| n,n-di-n-propylserotonin | Rattus norvegicus (Norway rat) | Ki | 0.2255 | 2 | 2 |
| 8-methoxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 1.6650 | 2 | 2 |
| bifeprunox | Rattus norvegicus (Norway rat) | Ki | 3.3113 | 1 | 1 |
| lurasidone | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| 1-methyl-6-methoxy-dihydro-beta-carboline | Rattus norvegicus (Norway rat) | Ki | 5.6000 | 1 | 1 |
| Pedunculagin | Rattus norvegicus (Norway rat) | Ki | 0.0420 | 1 | 1 |
| gluco-obtusifolin | Rattus norvegicus (Norway rat) | IC50 | 24.3000 | 1 | 1 |
| cocaine | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| valine-pyrrolidide | Rattus norvegicus (Norway rat) | IC50 | 4.0000 | 1 | 1 |
| purvalanol a | Rattus norvegicus (Norway rat) | IC50 | 26.0000 | 1 | 1 |
| rubrofusarin gentiobioside | Rattus norvegicus (Norway rat) | IC50 | 37.5000 | 1 | 1 |
| 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| levosulpiride | Rattus norvegicus (Norway rat) | Ki | 27.0000 | 1 | 1 |
| n-phenyl-n'-2-pyridylthiourea | Rattus norvegicus (Norway rat) | IC50 | 23.3600 | 1 | 1 |
| 1-(2,5-dimethoxyphenyl)-3-phenylthiourea | Rattus norvegicus (Norway rat) | IC50 | 29.9300 | 1 | 1 |
| thiourea | Rattus norvegicus (Norway rat) | IC50 | 21.0000 | 1 | 1 |
| altanserin | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 4 | 4 |
| mcn 5652 | Rattus norvegicus (Norway rat) | Ki | 0.4297 | 1 | 3 |
| sch 23390 | Rattus norvegicus (Norway rat) | Ki | 0.0130 | 1 | 1 |
| quinagolide | Rattus norvegicus (Norway rat) | IC50 | 5.6000 | 2 | 4 |
| 3-[(3-fluorophenyl)methyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Rattus norvegicus (Norway rat) | Ki | 0.0053 | 1 | 1 |
| alsterpaullone | Rattus norvegicus (Norway rat) | IC50 | 51.0000 | 1 | 1 |
| harmine | Rattus norvegicus (Norway rat) | Ki | 7.7900 | 1 | 1 |
| dorzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 3 | 3 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 2.1000 | 1 | 1 |
| l 365260 | Rattus norvegicus (Norway rat) | IC50 | 0.0081 | 1 | 1 |
| mdl 100907 | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 6 | 7 |
| romidepsin | Rattus norvegicus (Norway rat) | IC50 | 0.0180 | 1 | 1 |
| cinanserin | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 1 |
| cinanserin | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 3 | 3 |
| 7-chloro-4-hydroxy-2-phenyl-1,8-naphthyridine | Rattus norvegicus (Norway rat) | Ki | 0.0016 | 1 | 1 |
| 1-methyl-d-lysergic acid butanolamide | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 2 | 2 |
| gw2974 | Rattus norvegicus (Norway rat) | IC50 | 8.0000 | 1 | 1 |
| 6-hydroxybenzothiazide-2-sulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.0080 | 2 | 2 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 8.9000 | 2 | 2 |
| vilazodone | Rattus norvegicus (Norway rat) | IC50 | 1.5100 | 1 | 1 |
| sarizotan | Rattus norvegicus (Norway rat) | Ki | 2.1380 | 1 | 1 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| 5-methoxy-2-phenyl-n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Ki | 0.4700 | 1 | 1 |
| ms-245 | Rattus norvegicus (Norway rat) | Ki | 0.0975 | 2 | 2 |
| talabostat | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| lu 28-179 | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0100 | 1 | 2 |
| slv 313 | Rattus norvegicus (Norway rat) | Ki | 0.7244 | 1 | 1 |
| ngb 2904 | Rattus norvegicus (Norway rat) | Ki | 0.2230 | 1 | 1 |
| mart-1 antigen | Rattus norvegicus (Norway rat) | IC50 | 0.2624 | 1 | 2 |
| plomestane | Rattus norvegicus (Norway rat) | Ki | 0.0152 | 1 | 1 |
| mdl 105725 | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| pnu 96415e | Rattus norvegicus (Norway rat) | Ki | 0.0058 | 1 | 1 |
| n,n-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| linagliptin | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| 2-(4-iodo-2,5-dimethoxyphenyl)-n-(2-methoxybenzyl)ethanamine | Rattus norvegicus (Norway rat) | Ki | 0.0022 | 1 | 1 |
| lassbio-581 | Rattus norvegicus (Norway rat) | Ki | 5.4605 | 2 | 2 |
| 9-(aminomethyl)-9,10-dihydroanthracene | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 2 | 2 |
| 1-(2,4-difluorophenethyl)-4-(4-fluorophenylsulfonyl)piperidine | Rattus norvegicus (Norway rat) | Ki | 0.0019 | 1 | 1 |
| lassbio-579 | Rattus norvegicus (Norway rat) | Ki | 4.5700 | 2 | 2 |
| 2,5-dimethoxy-4-methylamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0625 | 2 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0121 | 8 | 8 |
| octoclothepine, (s)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| rs 39604 | Rattus norvegicus (Norway rat) | Ki | 0.0039 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.1093 | 4 | 4 |
| niraparib | Rattus norvegicus (Norway rat) | IC50 | 0.0021 | 1 | 1 |
| niraparib | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| dynorphins | Rattus norvegicus (Norway rat) | Ki | 0.0034 | 1 | 1 |
| n,n-diallyl-5-methoxytryptamine | Rattus norvegicus (Norway rat) | Ki | 0.5012 | 1 | 1 |
| butyrolactone i | Rattus norvegicus (Norway rat) | IC50 | 94.0000 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 0.0886 | 11 | 11 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.0123 | 22 | 23 |
| olanzapine | Rattus norvegicus (Norway rat) | IC50 | 0.0470 | 1 | 1 |
| olanzapine | Rattus norvegicus (Norway rat) | Ki | 0.0058 | 5 | 5 |
| methylaplysinopsin | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Kd | 5.4954 | 2 | 4 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | EC50 | 0.0570 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.0324 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.3548 | 1 | 2 |
| methylbufotenin | Rattus norvegicus (Norway rat) | EC50 | 0.4620 | 1 | 1 |
| alpha-methylserotonin | Rattus norvegicus (Norway rat) | EC50 | 0.1210 | 2 | 2 |
| amphetamine | Rattus norvegicus (Norway rat) | Kd | 5.3703 | 3 | 5 |
| ketanserin | Rattus norvegicus (Norway rat) | Kd | 0.0015 | 2 | 2 |
| mescaline | Rattus norvegicus (Norway rat) | EC50 | 5.9667 | 3 | 3 |
| mescaline | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| o-methyltyramine | Rattus norvegicus (Norway rat) | Kd | 7.9433 | 1 | 2 |
| psilocin | Rattus norvegicus (Norway rat) | EC50 | 2.3000 | 1 | 1 |
| ritanserin | Rattus norvegicus (Norway rat) | Kd | 0.0016 | 1 | 1 |
| spiperone | Rattus norvegicus (Norway rat) | Kd | 0.0001 | 1 | 1 |
| trifluoperazine | Rattus norvegicus (Norway rat) | Kd | 0.0010 | 1 | 1 |
| tyramine | Rattus norvegicus (Norway rat) | Kd | 8.5114 | 1 | 2 |
| lysergic acid diethylamide | Rattus norvegicus (Norway rat) | EC50 | 0.0098 | 2 | 2 |
| dextroamphetamine | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Kd | 1.0000 | 1 | 1 |
| dimethoxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 4.3652 | 1 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 3.5481 | 1 | 2 |
| 3-phenylpropylamine | Rattus norvegicus (Norway rat) | Kd | 11.7490 | 1 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0661 | 2 | 3 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.1549 | 2 | 3 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 7.0795 | 2 | 3 |
| l-amphetamine | Rattus norvegicus (Norway rat) | Kd | 6.9183 | 1 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Kd | 2.4547 | 1 | 2 |
| 5-methoxy-alpha-methyltryptamine | Rattus norvegicus (Norway rat) | EC50 | 0.1662 | 2 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | EC50 | 0.0565 | 4 | 4 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0447 | 2 | 3 |
| cathinone | Rattus norvegicus (Norway rat) | Kd | 3.0200 | 1 | 2 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.1479 | 2 | 3 |
| 3,4-methylenedioxyphenethylamine | Rattus norvegicus (Norway rat) | Kd | 0.7943 | 1 | 2 |
| 3-methoxy-4-hydroxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 1.2882 | 1 | 2 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Kd | 0.1412 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0753 | 2 | 3 |
| 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine | Rattus norvegicus (Norway rat) | EC50 | 0.0270 | 1 | 1 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Kd | 0.0851 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 3 | 4 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Kd | 2.8840 | 2 | 3 |
| cannabidiol | Rattus norvegicus (Norway rat) | EC50 | 32.0000 | 1 | 1 |
| sincalide | Rattus norvegicus (Norway rat) | EC50 | 0.0001 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | EC50 | 0.0218 | 3 | 3 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.0234 | 1 | 1 |
| methylhistaprodifen | Rattus norvegicus (Norway rat) | Kd | 4.0738 | 1 | 1 |
| histaprodifen | Rattus norvegicus (Norway rat) | Kd | 6.4565 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.1175 | 1 | 1 |
| vu0357017 | Rattus norvegicus (Norway rat) | EC50 | 95.7200 | 1 | 0 |
Drugs with Other Measurements
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Serotonin receptor affinity of cathinone and related analogues.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.Bioorganic & medicinal chemistry letters, , Mar-06, Volume: 10, Issue:5, 2000
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.Journal of medicinal chemistry, , Dec-06, Volume: 39, Issue:25, 1996
Synthesis and structure activity relationships of cis- and trans-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes.Journal of medicinal chemistry, , Jan-07, Volume: 37, Issue:1, 1994
N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.Journal of medicinal chemistry, , 07-27, Volume: 60, Issue:14, 2017
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.Journal of medicinal chemistry, , Jun-25, Volume: 58, Issue:12, 2015
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006
Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Benzofuran bioisosteres of hallucinogenic tryptamines.Journal of medicinal chemistry, , May-29, Volume: 35, Issue:11, 1992
1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.Journal of medicinal chemistry, , Oct-02, Volume: 35, Issue:20, 1992
Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.Journal of medicinal chemistry, , Nov-13, Volume: 35, Issue:23, 1992
N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents.Journal of medicinal chemistry, , Dec-16, Volume: 42, Issue:25, 1999
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.Journal of medicinal chemistry, , Dec-06, Volume: 39, Issue:25, 1996
Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Synthesis and structure activity relationships of cis- and trans-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes.Journal of medicinal chemistry, , Jan-07, Volume: 37, Issue:1, 1994
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Pyrrole mannich bases as potential antipsychotic agents.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Serotonin receptor affinity of cathinone and related analogues.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
New arylpiperazine derivatives with high affinity for alpha1A, D2 and 5-HT2A receptors.Bioorganic & medicinal chemistry letters, , Jan-20, Volume: 13, Issue:2, 2003
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.Journal of medicinal chemistry, , Nov-07, Volume: 45, Issue:23, 2002
GRid-INdependent descriptors (GRIND): a novel class of alignment-independent three-dimensional molecular descriptors.Journal of medicinal chemistry, , Aug-24, Volume: 43, Issue:17, 2000
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.Bioorganic & medicinal chemistry letters, , Mar-06, Volume: 10, Issue:5, 2000
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical anJournal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).Journal of medicinal chemistry, , Dec-31, Volume: 41, Issue:27, 1998
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.Bioorganic & medicinal chemistry letters, , Apr-21, Volume: 8, Issue:8, 1998
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873).Journal of medicinal chemistry, , Mar-31, Volume: 38, Issue:7, 1995
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.Journal of medicinal chemistry, , May-26, Volume: 38, Issue:11, 1995
Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Jul-22, Volume: 37, Issue:15, 1994
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents.Journal of medicinal chemistry, , Aug-05, Volume: 37, Issue:16, 1994
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Pyrrole mannich bases as potential antipsychotic agents.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Antipsychotic activity of substituted gamma-carbolines.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.Journal of medicinal chemistry, , Nov-07, Volume: 45, Issue:23, 2002
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.Journal of medicinal chemistry, , Jun-21, Volume: 39, Issue:13, 1996
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022
New 5-HTBioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.European journal of medicinal chemistry, , Mar-03, Volume: 110, 2016
5-HT2 receptor affinity, docking studies and pharmacological evaluation of a series of 1,3-disubstituted thiourea derivatives.European journal of medicinal chemistry, , Jun-30, Volume: 116, 2016
New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation.European journal of medicinal chemistry, , Volume: 47, Issue:1, 2012
Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.Bioorganic & medicinal chemistry, , Dec-15, Volume: 15, Issue:24, 2007
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.Bioorganic & medicinal chemistry letters, , May-07, Volume: 11, Issue:9, 2001
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.Bioorganic & medicinal chemistry letters, , Mar-06, Volume: 10, Issue:5, 2000
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.Journal of medicinal chemistry, , Dec-06, Volume: 39, Issue:25, 1996
Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives.Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.Journal of medicinal chemistry, , Volume: 31, Issue:12, 1988
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor.Journal of medicinal chemistry, , Jul-13, Volume: 49, Issue:14, 2006
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.Journal of medicinal chemistry, , Jul-31, Volume: 46, Issue:16, 2003
Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Synthesis and biological investigation of new equatorial (β) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.Journal of medicinal chemistry, , Volume: 32, Issue:5, 1989
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.Journal of medicinal chemistry, , Volume: 29, Issue:5, 1986
Design and synthesis of a new fluorescent probe for cytochrome P450 3A4 (CYP 3A4).Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11- dicarboxylates as calcium entry antagonists: new conformationally restrained analogues of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformationJournal of medicinal chemistry, , Volume: 30, Issue:4, 1987
Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11- dicarboxylates as calcium entry antagonists: new conformationally restrained analogues of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformationJournal of medicinal chemistry, , Volume: 30, Issue:4, 1987
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.Journal of medicinal chemistry, , Jul-31, Volume: 46, Issue:16, 2003
Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.Journal of medicinal chemistry, , Jun-11, Volume: 52, Issue:11, 2009
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.Journal of medicinal chemistry, , Nov-12, Volume: 52, Issue:21, 2009
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.Journal of medicinal chemistry, , May-06, Volume: 42, Issue:9, 1999
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.Journal of medicinal chemistry, , Volume: 29, Issue:11, 1986
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical anJournal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).Journal of medicinal chemistry, , Dec-31, Volume: 41, Issue:27, 1998
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.Bioorganic & medicinal chemistry letters, , Apr-21, Volume: 8, Issue:8, 1998
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873).Journal of medicinal chemistry, , Mar-31, Volume: 38, Issue:7, 1995
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.Journal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Jul-22, Volume: 37, Issue:15, 1994
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation.Journal of medicinal chemistry, , Feb-14, Volume: 40, Issue:4, 1997
Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans.Journal of medicinal chemistry, , Sep-17, Volume: 36, Issue:19, 1993
Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.Journal of medicinal chemistry, , Volume: 31, Issue:12, 1988
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding.Journal of medicinal chemistry, , Dec-03, Volume: 41, Issue:25, 1998
Activity of Parthenolide at 5HT2A receptors.Journal of natural products, , Volume: 60, Issue:6, 1997
Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.Journal of medicinal chemistry, , Nov-07, Volume: 45, Issue:23, 2002
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.Journal of medicinal chemistry, , Oct-15, Volume: 36, Issue:21, 1993
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor.Journal of medicinal chemistry, , Jul-13, Volume: 49, Issue:14, 2006
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.Journal of medicinal chemistry, , Jul-31, Volume: 46, Issue:16, 2003
Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.Journal of medicinal chemistry, , Jul-19, Volume: 39, Issue:15, 1996
Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 13, Issue:15, 2003
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.Journal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 29, Issue:21, 2019
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022
[no title available]Bioorganic & medicinal chemistry, , 08-01, Volume: 27, Issue:15, 2019
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Current and novel approaches to the drug treatment of schizophrenia.Journal of medicinal chemistry, , Feb-15, Volume: 44, Issue:4, 2001
Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 18, Issue:5, 2010
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines.Bioorganic & medicinal chemistry, , Jun-01, Volume: 16, Issue:11, 2008
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.Journal of medicinal chemistry, , Jul-31, Volume: 46, Issue:16, 2003
Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 13, Issue:15, 2003
1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists.Journal of medicinal chemistry, , Mar-15, Volume: 44, Issue:6, 2001
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.Journal of medicinal chemistry, , Jul-19, Volume: 39, Issue:15, 1996
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 13, Issue:15, 2003
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans.Journal of medicinal chemistry, , Sep-17, Volume: 36, Issue:19, 1993
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.Journal of medicinal chemistry, , Volume: 31, Issue:12, 1988
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.Journal of medicinal chemistry, , Volume: 31, Issue:12, 1988
Ketanserin analogues: the effect of structural modification on 5-HT2 serotonin receptor binding.Journal of medicinal chemistry, , Mar-31, Volume: 38, Issue:7, 1995
Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists.Journal of medicinal chemistry, , Sep-21, Volume: 49, Issue:19, 2006
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Binding of beta-carbolines at 5-HT(2) serotonin receptors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003
Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods.Journal of medicinal chemistry, , Dec-10, Volume: 36, Issue:25, 1993
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
(-)-3 beta-Substituted ecgonine methyl esters as inhibitors for cocaine binding and dopamine uptake.Journal of medicinal chemistry, , Mar-12, Volume: 41, Issue:6, 1998
Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporter.Journal of medicinal chemistry, , Jul-08, Volume: 37, Issue:14, 1994
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009
Total synthesis and evaluation of [18F]MHMZ.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 18, Issue:4, 2008
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009
Total synthesis and evaluation of [18F]MHMZ.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 18, Issue:4, 2008
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 15, Issue:16, 2005
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Current and novel approaches to the drug treatment of schizophrenia.Journal of medicinal chemistry, , Feb-15, Volume: 44, Issue:4, 2001
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.Bioorganic & medicinal chemistry letters, , Oct-16, Volume: 10, Issue:20, 2000
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 17, Issue:11, 2007
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 18, Issue:5, 2010
Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 13, Issue:15, 2003
Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.European journal of medicinal chemistry, , Volume: 62, 2013
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 18, Issue:5, 2010
The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.European journal of medicinal chemistry, , Volume: 44, Issue:2, 2009
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.Journal of medicinal chemistry, , Nov-07, Volume: 45, Issue:23, 2002
Application of similarity matrices and genetic neural networks in quantitative structure-activity relationships of 2- or 4-(4-Methylpiperazino)pyrimidines: 5-HT(2A) receptor antagonists.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical anJournal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).Journal of medicinal chemistry, , Dec-31, Volume: 41, Issue:27, 1998
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.Journal of medicinal chemistry, , Jun-21, Volume: 39, Issue:13, 1996
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873).Journal of medicinal chemistry, , Mar-31, Volume: 38, Issue:7, 1995
Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity.Journal of medicinal chemistry, , Oct-27, Volume: 38, Issue:22, 1995
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.Journal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Jul-22, Volume: 37, Issue:15, 1994
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents.Journal of medicinal chemistry, , Aug-05, Volume: 37, Issue:16, 1994
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Pyrrole mannich bases as potential antipsychotic agents.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Antipsychotic activity of substituted gamma-carbolines.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.Bioorganic & medicinal chemistry, , Jan-01, Volume: 23, Issue:1, 2015
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996