Page last updated: 2024-08-08 00:13:46
Serine/threonine-protein kinase 33
A serine/threonine-protein kinase 33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BYT3]
Synonyms
EC 2.7.11.1
Research
Bioassay Publications (8)
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (25.00) | 29.6817 |
2010's | 5 (62.50) | 24.3611 |
2020's | 1 (12.50) | 2.80 |
Compounds (78)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
staurosporine | Homo sapiens (human) | IC50 | 0.0373 | 2 | 2 |
birb 796 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
N-[2-(3-oxo-4H-quinoxalin-2-yl)phenyl]-2-thiophenecarboxamide | Homo sapiens (human) | IC50 | 0.2800 | 1 | 1 |
Mps1-IN-2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 0 |
N-[2-(3-oxo-4H-quinoxalin-2-yl)-4-propan-2-ylphenyl]-2-thiophenecarboxamide | Homo sapiens (human) | IC50 | 0.0140 | 2 | 2 |
Drugs with Activation Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
sb 202190 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
imatinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
staurosporine | Homo sapiens (human) | Kd | 0.0018 | 2 | 2 |
gefitinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
lestaurtinib | Homo sapiens (human) | Kd | 0.0260 | 2 | 2 |
vatalanib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
ruboxistaurin | Homo sapiens (human) | Kd | 2.8500 | 2 | 2 |
canertinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
birb 796 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
cyc 202 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
sb 203580 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
enzastaurin | Homo sapiens (human) | Kd | 4.9000 | 1 | 1 |
erlotinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
lapatinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
sorafenib | Homo sapiens (human) | Kd | 2.4000 | 3 | 3 |
pd 173955 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
s 1033 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
bms 387032 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
tandutinib | Homo sapiens (human) | Kd | 10.0000 | 3 | 3 |
vx-745 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
dasatinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
zd 6474 | Homo sapiens (human) | Kd | 1.4000 | 2 | 2 |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
alvocidib | Homo sapiens (human) | Kd | 1.7000 | 2 | 2 |
bosutinib | Homo sapiens (human) | Kd | 0.0370 | 1 | 1 |
su 11248 | Homo sapiens (human) | Kd | 0.0170 | 3 | 3 |
jnj-7706621 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
vx680 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
ekb 569 | Homo sapiens (human) | Kd | 4.5000 | 1 | 1 |
axitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pd 184352 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
bms345541 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
midostaurin | Homo sapiens (human) | Kd | 6.7300 | 3 | 3 |
ki 20227 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
cp 724714 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pi103 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
hki 272 | Homo sapiens (human) | Kd | 0.9400 | 1 | 1 |
tofacitinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
cediranib | Homo sapiens (human) | Kd | 0.5400 | 1 | 1 |
masitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pazopanib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
azd 6244 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
su 14813 | Homo sapiens (human) | Kd | 0.1300 | 2 | 2 |
bibw 2992 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
tg100-115 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pha 665752 | Homo sapiens (human) | Kd | 0.8400 | 1 | 1 |
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Homo sapiens (human) | Kd | 0.9700 | 1 | 1 |
brivanib | Homo sapiens (human) | Kd | 3.2000 | 1 | 1 |
at 7519 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
bi 2536 | Homo sapiens (human) | Kd | 1.1000 | 1 | 1 |
nvp-ast487 | Homo sapiens (human) | Kd | 1.2000 | 2 | 2 |
kw 2449 | Homo sapiens (human) | Kd | 0.1400 | 1 | 1 |
abt 869 | Homo sapiens (human) | Kd | 3.8000 | 2 | 2 |
gw 2580 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
crizotinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
chir-265 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
motesanib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
mln8054 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
GDC-0879 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
gsk 461364 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
azd 1152-hqpa | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
nvp-tae684 | Homo sapiens (human) | Kd | 0.0032 | 1 | 1 |
fedratinib | Homo sapiens (human) | Kd | 0.2200 | 1 | 1 |
gsk690693 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
gdc 0941 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
plx 4720 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
sgx 523 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
quizartinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
incb-018424 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
gsk 1838705a | Homo sapiens (human) | Kd | 0.0700 | 1 | 1 |
gsk 1363089 | Homo sapiens (human) | Kd | 0.0980 | 1 | 1 |
chir 258 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
nintedanib | Homo sapiens (human) | Kd | 1.1000 | 1 | 1 |
pp242 | Homo sapiens (human) | Kd | 4.5000 | 1 | 1 |
Enables
This protein enables 3 target(s):
Target | Category | Definition |
---|---|---|
protein serine/threonine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925] |
ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
protein serine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989] |
Located In
This protein is located in 1 target(s):
Target | Category | Definition |
---|---|---|
perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
Active In
This protein is active in 2 target(s):
Target | Category | Definition |
---|---|---|
nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 2 target(s):
Target | Category | Definition |
---|---|---|
protein autophosphorylation | biological process | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732] |
mitotic DNA damage checkpoint signaling | biological process | A signal transduction process involved in mitotic DNA damage checkpoint. [GOC:mtg_cell_cycle, GOC:TermGenie] |