[no definition available]
pp1a;
ORF1a polyprotein
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| bithionol | Severe acute respiratory syndrome-related coronavirus | IC50 | 46.0000 | 1 | 1 |
| carmofur | Severe acute respiratory syndrome-related coronavirus | IC50 | 1.8200 | 1 | 1 |
| chloroquine | Severe acute respiratory syndrome-related coronavirus | IC50 | 5.4700 | 1 | 1 |
| chlorpromazine | Severe acute respiratory syndrome-related coronavirus | IC50 | 11.2400 | 1 | 2 |
| disulfiram | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 1 | 1 |
| ebselen | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.6700 | 1 | 1 |
| emodin | Severe acute respiratory syndrome-related coronavirus | IC50 | 10.0000 | 1 | 1 |
| ethacrynic acid | Severe acute respiratory syndrome-related coronavirus | Ki | 375.0000 | 1 | 1 |
| fluphenazine | Severe acute respiratory syndrome-related coronavirus | IC50 | 11.8000 | 1 | 2 |
| hexachlorophene | Severe acute respiratory syndrome-related coronavirus | Ki | 4.0000 | 1 | 1 |
| niclosamide | Severe acute respiratory syndrome-related coronavirus | IC50 | 50.0000 | 2 | 2 |
| promethazine | Severe acute respiratory syndrome-related coronavirus | IC50 | 13.6450 | 1 | 2 |
| ficusin | Severe acute respiratory syndrome-related coronavirus | IC50 | 150.0000 | 1 | 1 |
| angelicin | Severe acute respiratory syndrome-related coronavirus | IC50 | 150.0000 | 1 | 1 |
| pyrithione zinc | Severe acute respiratory syndrome-related coronavirus | Ki | 0.1700 | 1 | 1 |
| zinc ethylphenyldithiocarbamate | Severe acute respiratory syndrome-related coronavirus | Ki | 1.0000 | 1 | 1 |
| bithionol sulfoxide | Severe acute respiratory syndrome-related coronavirus | IC50 | 7.6000 | 1 | 1 |
| tanshinone | Severe acute respiratory syndrome-related coronavirus | IC50 | 14.9250 | 4 | 4 |
| tanshinone | Severe acute respiratory syndrome-related coronavirus | Ki | 13.7000 | 1 | 1 |
| miltirone | Severe acute respiratory syndrome-related coronavirus | IC50 | 47.5500 | 4 | 4 |
| miltirone | Severe acute respiratory syndrome-related coronavirus | Ki | 21.5000 | 1 | 1 |
| cryptotanshinone | Severe acute respiratory syndrome-related coronavirus | IC50 | 81.3000 | 4 | 4 |
| cryptotanshinone | Severe acute respiratory syndrome-related coronavirus | Ki | 9.0000 | 1 | 1 |
| tanshinone ii a | Severe acute respiratory syndrome-related coronavirus | IC50 | 27.1500 | 4 | 4 |
| tanshinone ii a | Severe acute respiratory syndrome-related coronavirus | Ki | 11.2000 | 1 | 1 |
| 1-methylpropyl-2-imidazolyl disulfide | Severe acute respiratory syndrome-related coronavirus | IC50 | 21.0000 | 1 | 2 |
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.3700 | 2 | 2 |
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | Severe acute respiratory syndrome-related coronavirus | Ki | 0.1201 | 1 | 2 |
| hirsutanone | Severe acute respiratory syndrome-related coronavirus | IC50 | 4.1000 | 1 | 1 |
| CID 2131972 | Severe acute respiratory syndrome-related coronavirus | Ki | 9.1100 | 1 | 1 |
| 5-(4-Chloro-benzenesulfonyl)-pyrimidine-2,4-diamine | Severe acute respiratory syndrome-related coronavirus | IC50 | 6.0000 | 1 | 1 |
| S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate | Severe acute respiratory syndrome-related coronavirus | IC50 | 3.0000 | 3 | 3 |
| N-(4-Butan-2-ylphenyl)-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-3-ylethyl]furan-2-carboxamide | Severe acute respiratory syndrome-related coronavirus | IC50 | 18.1000 | 2 | 4 |
| 8-(Trifluoromethyl)-9H-purin-6-amine | Severe acute respiratory syndrome-related coronavirus | IC50 | 13.9000 | 1 | 1 |
| ginkgetin | Severe acute respiratory syndrome-related coronavirus | IC50 | 32.7000 | 1 | 1 |
| apigenin | Severe acute respiratory syndrome-related coronavirus | IC50 | 280.0000 | 1 | 1 |
| isobavachalcone | Severe acute respiratory syndrome-related coronavirus | Ki | 7.0000 | 1 | 2 |
| amentoflavone | Severe acute respiratory syndrome-related coronavirus | IC50 | 8.3000 | 1 | 1 |
| hyperoside | Severe acute respiratory syndrome-related coronavirus | IC50 | 42.7000 | 1 | 1 |
| sciadopitysin | Severe acute respiratory syndrome-related coronavirus | IC50 | 38.4000 | 1 | 1 |
| psoralidin | Severe acute respiratory syndrome-related coronavirus | Ki | 2.9500 | 1 | 2 |
| savinin | Severe acute respiratory syndrome-related coronavirus | IC50 | 25.0000 | 1 | 1 |
| broussochalcone a | Severe acute respiratory syndrome-related coronavirus | IC50 | 25.6500 | 1 | 2 |
| rupintrivir | Severe acute respiratory syndrome-related coronavirus | IC50 | 410.0000 | 1 | 2 |
| rupintrivir | Severe acute respiratory syndrome-related coronavirus | Ki | 10.0000 | 1 | 2 |
| Ethyl (E,4S)-4-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-3-phenylpropanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate | Severe acute respiratory syndrome-related coronavirus | Ki | 2.2600 | 1 | 1 |
| 5-Chloro-3-pyridinyl 2-furoate | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.0600 | 3 | 3 |
| np 031112 | Severe acute respiratory syndrome-related coronavirus | IC50 | 1.5500 | 1 | 1 |
| Dihydrotanshinone I | Severe acute respiratory syndrome-related coronavirus | IC50 | 7.8000 | 4 | 4 |
| Dihydrotanshinone I | Severe acute respiratory syndrome-related coronavirus | Ki | 11.2000 | 1 | 1 |
| Benzotriazol-1-yl 1H-indole-5-carboxylate | Severe acute respiratory syndrome-related coronavirus | Ki | 0.0075 | 1 | 1 |
| 5-Bromopyridin-3-yl furan-2-carboxylate | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.0500 | 2 | 2 |
| 5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.0630 | 3 | 3 |
| (5-Chloropyridin-3-yl) 1H-indole-5-carboxylate | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.3100 | 2 | 2 |
| 5-Chloropyridin-3-yl 1H-indole-2-carboxylate | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.0650 | 3 | 3 |
| phenylmercuric acetate | Severe acute respiratory syndrome-related coronavirus | Ki | 0.7000 | 1 | 1 |
| GRL-0617 | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.6000 | 1 | 1 |
| (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.0300 | 2 | 2 |
| KOM70144 | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.5600 | 1 | 1 |
| Benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(1,3-thiazol-2-yl)propan-2-yl]amino]pentan-2-yl]amino]-1-oxobutan-2-yl]carbamate | Severe acute respiratory syndrome-related coronavirus | Ki | 2.2000 | 1 | 1 |
| N-[(1R)-2-(tert-butylamino)-2-oxo-1-(3-pyridinyl)ethyl]-N-(4-tert-butylphenyl)-2-furancarboxamide | Severe acute respiratory syndrome-related coronavirus | IC50 | 1.5000 | 2 | 2 |
| N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.0500 | 1 | 1 |
| 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.0400 | 1 | 1 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| amodiaquine | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.1933 | 1 | 3 |
| astemizole | Severe acute respiratory syndrome-related coronavirus | EC50 | 5.2350 | 1 | 2 |
| camostat | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.0000 | 1 | 2 |
| chloroquine | Severe acute respiratory syndrome-related coronavirus | EC50 | 5.3333 | 1 | 6 |
| chlorpromazine | Severe acute respiratory syndrome-related coronavirus | EC50 | 7.7360 | 1 | 5 |
| clomipramine | Severe acute respiratory syndrome-related coronavirus | EC50 | 11.2800 | 1 | 2 |
| ebselen | Severe acute respiratory syndrome-related coronavirus | EC50 | 4.6700 | 1 | 1 |
| emodin | Severe acute respiratory syndrome-related coronavirus | EC50 | 200.0000 | 1 | 2 |
| fluphenazine | Severe acute respiratory syndrome-related coronavirus | EC50 | 16.2400 | 1 | 3 |
| fluspirilene | Severe acute respiratory syndrome-related coronavirus | EC50 | 6.7150 | 1 | 2 |
| hydroxychloroquine | Severe acute respiratory syndrome-related coronavirus | EC50 | 5.6567 | 1 | 3 |
| hydroxyzine | Severe acute respiratory syndrome-related coronavirus | EC50 | 14.4000 | 1 | 1 |
| loperamide | Severe acute respiratory syndrome-related coronavirus | EC50 | 5.0800 | 1 | 5 |
| meclofenamic acid | Severe acute respiratory syndrome-related coronavirus | Kd | 220.0000 | 1 | 1 |
| mefloquine hydrochloride | Severe acute respiratory syndrome-related coronavirus | EC50 | 11.4800 | 1 | 2 |
| oxaprozin | Severe acute respiratory syndrome-related coronavirus | Kd | 1,000.0000 | 1 | 1 |
| promethazine | Severe acute respiratory syndrome-related coronavirus | EC50 | 9.6700 | 1 | 2 |
| imatinib | Severe acute respiratory syndrome-related coronavirus | EC50 | 12.5000 | 1 | 3 |
| thiethylperazine | Severe acute respiratory syndrome-related coronavirus | EC50 | 7.8600 | 1 | 1 |
| triflupromazine | Severe acute respiratory syndrome-related coronavirus | EC50 | 6.0700 | 1 | 2 |
| cycloheximide | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.1145 | 1 | 2 |
| chlorphenoxamine | Severe acute respiratory syndrome-related coronavirus | EC50 | 16.3350 | 1 | 2 |
| triparanol | Severe acute respiratory syndrome-related coronavirus | EC50 | 5.2800 | 1 | 1 |
| emetine | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0325 | 1 | 2 |
| acetophenazine | Severe acute respiratory syndrome-related coronavirus | EC50 | 23.6000 | 1 | 1 |
| ribavirin | Severe acute respiratory syndrome-related coronavirus | EC50 | 109.5000 | 1 | 1 |
| gemcitabine | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.0800 | 1 | 2 |
| methotrimeprazine | Severe acute respiratory syndrome-related coronavirus | EC50 | 2.5000 | 1 | 1 |
| lopinavir | Severe acute respiratory syndrome-related coronavirus | EC50 | 12.8200 | 1 | 5 |
| nutlin 3 | Severe acute respiratory syndrome-related coronavirus | EC50 | 36.9000 | 1 | 1 |
| anisomycin | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0965 | 1 | 2 |
| homoharringtonine | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0710 | 1 | 1 |
| terconazole | Severe acute respiratory syndrome-related coronavirus | EC50 | 13.7600 | 1 | 2 |
| thiothixene | Severe acute respiratory syndrome-related coronavirus | EC50 | 7.3000 | 1 | 2 |
| benztropine | Severe acute respiratory syndrome-related coronavirus | EC50 | 19.1150 | 1 | 2 |
| tamoxifen | Severe acute respiratory syndrome-related coronavirus | EC50 | 51.4950 | 1 | 2 |
| toremifene | Severe acute respiratory syndrome-related coronavirus | EC50 | 12.4350 | 1 | 2 |
| dasatinib | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0325 | 1 | 2 |
| quercetin | Severe acute respiratory syndrome-related coronavirus | EC50 | 83.4000 | 2 | 2 |
| luteolin | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.6000 | 2 | 2 |
| dothiepin hydrochloride | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.4000 | 1 | 1 |
| sotrastaurin | Severe acute respiratory syndrome-related coronavirus | EC50 | 9.7000 | 1 | 1 |
| saracatinib | Severe acute respiratory syndrome-related coronavirus | EC50 | 2.9000 | 1 | 1 |
| (5-Chloropyridin-3-yl) 1H-indole-5-carboxylate | Severe acute respiratory syndrome-related coronavirus | EC50 | 24.0000 | 2 | 2 |
| (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate | Severe acute respiratory syndrome-related coronavirus | EC50 | 6.9000 | 2 | 2 |
| s 8932 | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.7700 | 1 | 1 |
| N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.4200 | 1 | 1 |
| molnupiravir | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.1540 | 1 | 1 |
| 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.3300 | 1 | 1 |