Page last updated: 2024-08-07 13:01:00
Urease subunit alpha
[no definition available]
Synonyms
EC 3.5.1.5;
Urea amidohydrolase subunit alpha
Research
Bioassay Publications (17)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
Compounds (24)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| taxifolin | Helicobacter pylori 26695 | IC50 | 43.7000 | 1 | 1 |
| naringenin | Helicobacter pylori 26695 | IC50 | 328.0000 | 1 | 1 |
| urea | Helicobacter pylori 26695 | Ki | 6,470.0000 | 1 | 1 |
| acetohydroxamic acid | Helicobacter pylori 26695 | IC50 | 61.0238 | 24 | 24 |
| acetohydroxamic acid | Helicobacter pylori 26695 | Ki | 96.0000 | 1 | 1 |
| ebselen | Helicobacter pylori 26695 | IC50 | 30.4725 | 4 | 4 |
| ebselen | Helicobacter pylori 26695 | Ki | 0.2260 | 1 | 1 |
| hydroxyurea | Helicobacter pylori 26695 | IC50 | 100.0000 | 1 | 1 |
| rabeprazole | Helicobacter pylori 26695 | IC50 | 0.2900 | 1 | 1 |
| tangeretin | Helicobacter pylori 26695 | IC50 | 4,628.0000 | 1 | 1 |
| 4-ethylcatechol | Helicobacter pylori 26695 | IC50 | 11.1000 | 2 | 2 |
| 5,7-dimethoxyflavone | Helicobacter pylori 26695 | IC50 | 2,185.0000 | 1 | 1 |
| bis(2-(n-phenylcarboxamido)phenyl)diselenide | Helicobacter pylori 26695 | IC50 | 35.8250 | 4 | 4 |
| bis(2-(n-phenylcarboxamido)phenyl)diselenide | Helicobacter pylori 26695 | Ki | 0.6510 | 1 | 1 |
| 7,4'-Di-O-methyldaidzein | Helicobacter pylori 26695 | IC50 | 3,527.0000 | 1 | 1 |
| 2',6'-dihydroxy-4'-methoxydihydrochalcone | Helicobacter pylori 26695 | IC50 | 978.0000 | 1 | 1 |
| thiourea | Helicobacter pylori 26695 | IC50 | 23.0000 | 1 | 1 |
| Angolensin | Helicobacter pylori 26695 | IC50 | 1,050.0000 | 1 | 1 |
| quercetin | Helicobacter pylori 26695 | IC50 | 11.1333 | 3 | 3 |
| quercetin | Helicobacter pylori 26695 | Ki | 9.3400 | 1 | 1 |
| formononetin | Helicobacter pylori 26695 | IC50 | 2,003.0000 | 1 | 1 |
| apigenin | Helicobacter pylori 26695 | IC50 | 138.0000 | 1 | 1 |
| luteolin | Helicobacter pylori 26695 | IC50 | 35.4000 | 1 | 1 |
| baicalein | Helicobacter pylori 26695 | IC50 | 291.0000 | 1 | 1 |
| chrysin | Helicobacter pylori 26695 | IC50 | 302.0000 | 1 | 1 |
| daidzein | Helicobacter pylori 26695 | IC50 | 556.0000 | 1 | 1 |
| flavokawain b | Helicobacter pylori 26695 | IC50 | 1,220.0000 | 1 | 1 |
| 4',7,8-trihydroxyisoflavone | Helicobacter pylori 26695 | IC50 | 1,033.3333 | 3 | 3 |
Synthesis, evaluation and mechanism exploration of 2-(N-(3-nitrophenyl)-N-phenylsulfonyl)aminoacetohydroxamic acids as novel urease inhibitors.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 78, 2022
[no title available]European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Design, synthesis, molecular docking, anti-Proteus mirabilis and urease inhibition of new fluoroquinolone carboxylic acid derivatives.Bioorganic chemistry, , Volume: 70, 2017
3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation.Bioorganic & medicinal chemistry, , 10-01, Volume: 24, Issue:19, 2016
1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors.Journal of medicinal chemistry, , 09-08, Volume: 59, Issue:17, 2016
Synthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-gastric ulcer agent.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Synthesis and evaluation of N-analogs of 1,2-diarylethane as Helicobacter pylori urease inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors.European journal of medicinal chemistry, , Volume: 68, 2013
Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors.European journal of medicinal chemistry, , Volume: 63, 2013
Synthesis, biological evaluation, and molecular docking studies of 2,5-substituted-1,4-benzoquinone as novel urease inhibitors.Bioorganic & medicinal chemistry, , Aug-15, Volume: 20, Issue:16, 2012
The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:11, 2010
Synthesis, molecular docking and biological evaluation of metronidazole derivatives as potent Helicobacter pylori urease inhibitors.Bioorganic & medicinal chemistry, , Nov-01, Volume: 17, Issue:21, 2009
Amines and oximes derived from deoxybenzoins as Helicobacter pylori urease inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:5, 2009
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease.Bioorganic & medicinal chemistry, , Jun-01, Volume: 15, Issue:11, 2007
Quercetin derivatives: Drug design, development, and biological activities, a review.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors.European journal of medicinal chemistry, , Volume: 68, 2013
Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors.European journal of medicinal chemistry, , Volume: 63, 2013