Page last updated: 2024-08-07 15:30:47
Glutathione reductase, mitochondrial
A glutathione reductase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00390]
Synonyms
GR;
GRase;
EC 1.8.1.7
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (24)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| quinacrine | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 4-phenyl-3-furoxancarbonitrile | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| carmustine | Homo sapiens (human) | IC50 | 8.1000 | 1 | 1 |
| ketotifen | Homo sapiens (human) | Ki | 0.8000 | 1 | 1 |
| vitamin k 3 | Homo sapiens (human) | Ki | 14.1000 | 2 | 2 |
| nifedipine | Homo sapiens (human) | IC50 | 23.4000 | 1 | 1 |
| nifedipine | Homo sapiens (human) | Ki | 17.4000 | 1 | 1 |
| lysine | Homo sapiens (human) | IC50 | 61.2000 | 1 | 1 |
| lysine | Homo sapiens (human) | Ki | 54.6000 | 1 | 1 |
| methylene blue | Homo sapiens (human) | IC50 | 16.2000 | 2 | 2 |
| nitrobenzene | Homo sapiens (human) | IC50 | 546.8000 | 1 | 1 |
| nitrobenzene | Homo sapiens (human) | Ki | 274.1000 | 1 | 1 |
| phenyramidol | Homo sapiens (human) | Ki | 434.0000 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | IC50 | 53.7000 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | Ki | 42.7000 | 1 | 1 |
| cefoperazone | Homo sapiens (human) | Ki | 28.7200 | 1 | 1 |
| 10-(4'-chlorophenyl)-3-methylflavin | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| 3-anilino-1-(3-nitrophenyl)-1-propanone | Homo sapiens (human) | IC50 | 58.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 218.0000 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | IC50 | 22.8000 | 1 | 1 |
| cefuroxime | Homo sapiens (human) | Ki | 10.4200 | 1 | 1 |
| ceftriaxone | Homo sapiens (human) | Ki | 17.3400 | 1 | 1 |
| ceftizoxime | Homo sapiens (human) | Ki | 22.7600 | 1 | 1 |
| chlorhexidine | Homo sapiens (human) | Ki | 192.0000 | 1 | 1 |
| mobic | Homo sapiens (human) | Ki | 6.1000 | 1 | 1 |
| flavellagic acid | Homo sapiens (human) | IC50 | 26.7000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| vitamin k 3 | Homo sapiens (human) | Km | 31.2000 | 1 | 1 |
| methylene blue | Homo sapiens (human) | Km | 6.3000 | 1 | 1 |
| diallyl trisulfide | Homo sapiens (human) | Km | 160.0000 | 1 | 1 |
| ajoene | Homo sapiens (human) | Km | 800.0000 | 1 | 1 |
| chlorhexidine | Homo sapiens (human) | Ki' | 210.0000 | 1 | 1 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| electron transfer activity | molecular function | A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer] |
| NADP binding | molecular function | Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai] |
| glutathione-disulfide reductase (NADPH) activity | molecular function | Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. [PMID:36771108, RHEA:11740] |
| flavin adenine dinucleotide binding | molecular function | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| cellular oxidant detoxification | biological process | Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. [GOC:dos, GOC:vw] |
| cellular response to oxidative stress | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah] |
| glutathione metabolic process | biological process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. [ISBN:0198506732] |
| cell redox homeostasis | biological process | Any process that maintains the redox environment of a cell or compartment within a cell. [GOC:ai, GOC:dph, GOC:tb] |