tRNA (cytosine(38)-C(5))-methyltransferase

A tRNA (cytosine-5-)-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14717]

Synonyms

EC 2.1.1.204;
DNA (cytosine-5)-methyltransferase-like protein 2;
Dnmt2;
DNA methyltransferase homolog HsaIIP;
DNA MTase homolog HsaIIP;
M.HsaIIP;
PuMet

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sinefungin	Homo sapiens (human)	IC50	13.2000	1	1
s-adenosylhomocysteine	Homo sapiens (human)	IC50	15.8000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sinefungin	Homo sapiens (human)	Kd	7.5000	1	1
s-adenosylhomocysteine	Homo sapiens (human)	Kd	13.6000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
tRNA methyltransferase activity	molecular function	Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. [GOC:mah]
tRNA (cytidine-5-)-methyltransferase activity	molecular function	Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49). [RHEA:61468]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 3 target(s):

Target	Category	Definition
response to amphetamine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef]
tRNA modification	biological process	The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. [GOC:curators]
tRNA stabilization	biological process	Prevention of degradation of tRNA molecules. [GOC:aa, GOC:bf, PMID:20459084]