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D(1B) dopamine receptor
A D(1B) dopamine receptor that is encoded in the genome of rat. [OMA:P25115, PRO:DNx]
Synonyms
D(5) dopamine receptor;
Dopamine D5 receptor
Research
Bioassay Publications (33)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 24 (72.73) | 18.7374 |
| 1990's | 4 (12.12) | 18.2507 |
| 2000's | 4 (12.12) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (55)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| octoclothepine | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 3 |
| bmy 7378 | Rattus norvegicus (Norway rat) | IC50 | 0.0910 | 1 | 2 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 1 | 2 |
| chlorpromazine | Rattus norvegicus (Norway rat) | IC50 | 0.0416 | 7 | 12 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0140 | 1 | 1 |
| clonidine | Rattus norvegicus (Norway rat) | Ki | 4.0000 | 1 | 2 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| adtn | Rattus norvegicus (Norway rat) | IC50 | 0.0024 | 2 | 2 |
| granisetron | Rattus norvegicus (Norway rat) | Ki | 0.0091 | 1 | 2 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.0067 | 4 | 5 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 0.0017 | 2 | 2 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.8100 | 1 | 1 |
| metoclopramide | Rattus norvegicus (Norway rat) | Ki | 0.2291 | 1 | 2 |
| nomifensine | Rattus norvegicus (Norway rat) | IC50 | 2.7240 | 2 | 2 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| phenoxybenzamine | Rattus norvegicus (Norway rat) | Ki | 0.1200 | 1 | 2 |
| promazine | Rattus norvegicus (Norway rat) | IC50 | 1.0400 | 1 | 2 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 2 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| sulpiride | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.0850 | 1 | 2 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.1432 | 7 | 7 |
| yohimbine | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 2 |
| apomorphine hydrochloride, anhydrous | Rattus norvegicus (Norway rat) | Ki | 0.0037 | 1 | 1 |
| apocodeine | Rattus norvegicus (Norway rat) | IC50 | 6.2000 | 2 | 2 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | IC50 | 0.7580 | 1 | 1 |
| pimozide | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 4 |
| bromocriptine | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| penfluridol | Rattus norvegicus (Norway rat) | IC50 | 0.0620 | 1 | 2 |
| butaclamol | Rattus norvegicus (Norway rat) | IC50 | 0.0053 | 2 | 3 |
| butaclamol | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 2 |
| butaclamol | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 2 | 3 |
| flutroline | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 1 | 2 |
| gepirone | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| sertraline hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.0700 | 1 | 1 |
| lerisetron | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| sertraline | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 2 |
| mezilamine | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 2 | 3 |
| 2-(n,n-dipropyl)amino-5,6-dihydroxytetralin | Rattus norvegicus (Norway rat) | IC50 | 0.1355 | 2 | 3 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | IC50 | 34.4300 | 1 | 1 |
| dexmethylphenidate hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.1235 | 2 | 2 |
| chloroethylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 5.1970 | 2 | 2 |
| n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.2394 | 2 | 4 |
| preclamol | Rattus norvegicus (Norway rat) | IC50 | 0.9300 | 1 | 1 |
| tropisetron | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 2 |
| flupenthixol | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 3 |
| l 745870 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| fluvoxamine | Rattus norvegicus (Norway rat) | IC50 | 0.5400 | 1 | 1 |
| zimeldine | Rattus norvegicus (Norway rat) | IC50 | 4.5000 | 1 | 1 |
| morphine chloride | Rattus norvegicus (Norway rat) | IC50 | 0.0340 | 2 | 4 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | IC50 | 2.2050 | 2 | 2 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | IC50 | 0.3125 | 2 | 2 |
| dihydrexidine | Rattus norvegicus (Norway rat) | Ki | 0.0160 | 1 | 1 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.3680 | 2 | 2 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.1742 | 2 | 2 |
| flumezapine | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.Journal of medicinal chemistry, , Volume: 27, Issue:2, 1984
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Preparation of some 10-[3-(dimethylamino)-1-propyl]-10H-pyrazino[2,3-b][1,4] benzothiazines as potential neuroleptics.Journal of medicinal chemistry, , Volume: 26, Issue:4, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine.Journal of medicinal chemistry, , Volume: 23, Issue:8, 1980
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.Bioorganic & medicinal chemistry letters, , Oct-18, Volume: 14, Issue:20, 2004
Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines.Journal of medicinal chemistry, , Volume: 29, Issue:1, 1986
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Dopamine autoreceptor agonists as potential antipsychotics. 1. (Aminoalkoxy)anilines.Journal of medicinal chemistry, , Volume: 31, Issue:8, 1988
Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analogue of apomorphine.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.Journal of medicinal chemistry, , Volume: 26, Issue:3, 1983
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.Journal of medicinal chemistry, , Volume: 27, Issue:2, 1984
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.Journal of medicinal chemistry, , Volume: 26, Issue:3, 1983
Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.Bioorganic & medicinal chemistry letters, , Oct-18, Volume: 14, Issue:20, 2004
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
1-[3-(Diarylamino)propyl]piperidines and related compounds, potential antipsychotic agents with low cataleptogenic profiles.Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.Journal of medicinal chemistry, , Volume: 24, Issue:9, 1981