Compounds > arl 17477
Page last updated: 2024-09-27

arl 17477

Description

ARL 17477: a potent & selective neuronal nitric oxide synthase inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9824646
MeSH IDM0267524
PubMed CID449021
CHEMBL ID544052
CHEMBL ID293212
SCHEMBL ID122445
MeSH IDM0267524

Synonyms (27)

Synonym
arl 17477 dihydrochloride
866914-87-6
AKOS024457549
180983-17-9
J-011553
arl17477dihydrochloride
n/'-[4-[2-[(3-chlorophenyl)methylamino]ethyl]phenyl]thiophene-2-carboximidamide;dihydrochloride
n-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamidedihydrochloride
n'-[4-[2-[(3-chlorophenyl)methylamino]ethyl]phenyl]thiophene-2-carboximidamide;dihydrochloride
arl 17477
HY-107720
CS-0029306
n-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide
DB03449
n-(4-(2-((3-chlorophenylmethyl)amino)ethyl)phenyl)-2-thiophecarboxamidine
n-{4-[2-(3-chloro-benzylamino)-ethyl]-phenyl}-thiophene-2-carboxamidine; hydrochloride
bdbm50122307
chembl544052
CHEMBL293212 ,
SCHEMBL122445
bdbm196649
us9212144, 4
NCGC00370813-01
arl17477
Q27094374
HMS3742G21
PD007523

Protein Targets (10)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency0.67410.01237.983543.2770AID1645841
GVesicular stomatitis virusPotency11.98770.01238.964839.8107AID1645842
cytochrome P450 2D6Homo sapiens (human)Potency0.47720.00108.379861.1304AID1645840
Interferon betaHomo sapiens (human)Potency11.98770.00339.158239.8107AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency11.98770.01238.964839.8107AID1645842
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency11.98770.01238.964839.8107AID1645842
cytochrome P450 2C9, partialHomo sapiens (human)Potency11.98770.01238.964839.8107AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Nitric oxide synthase, endothelialHomo sapiens (human)IC50 (µMol)3.50000.07202.58738.7000AID68139
Nitric oxide synthase, brainHomo sapiens (human)IC50 (µMol)0.03500.03502.711910.0000AID225704
Nitric oxide synthase, inducibleHomo sapiens (human)IC50 (µMol)5.00000.00022.319010.0000AID92007
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (133)

Processvia Protein(s)Taxonomy
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
adaptive immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of T cell anergyHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
defense responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
detection of bacteriumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-12 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-6 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protection from natural killer cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
innate immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of dendritic cell differentiationHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class IbHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
positive regulation of gene expressionNitric oxide synthase, endothelialHomo sapiens (human)
angiogenesisNitric oxide synthase, endothelialHomo sapiens (human)
ovulation from ovarian follicleNitric oxide synthase, endothelialHomo sapiens (human)
in utero embryonic developmentNitric oxide synthase, endothelialHomo sapiens (human)
blood vessel remodelingNitric oxide synthase, endothelialHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
regulation of the force of heart contraction by chemical signalNitric oxide synthase, endothelialHomo sapiens (human)
regulation of systemic arterial blood pressure by endothelinNitric oxide synthase, endothelialHomo sapiens (human)
aortic valve morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
pulmonary valve morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
endocardial cushion morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
arginine catabolic processNitric oxide synthase, endothelialHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, endothelialHomo sapiens (human)
potassium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
calcium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
mitochondrion organizationNitric oxide synthase, endothelialHomo sapiens (human)
regulation of blood pressureNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of cell population proliferationNitric oxide synthase, endothelialHomo sapiens (human)
response to heatNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of platelet activationNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of muscle hyperplasiaNitric oxide synthase, endothelialHomo sapiens (human)
smooth muscle hyperplasiaNitric oxide synthase, endothelialHomo sapiens (human)
removal of superoxide radicalsNitric oxide synthase, endothelialHomo sapiens (human)
lung developmentNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, endothelialHomo sapiens (human)
regulation of nervous system processNitric oxide synthase, endothelialHomo sapiens (human)
lipopolysaccharide-mediated signaling pathwayNitric oxide synthase, endothelialHomo sapiens (human)
response to fluid shear stressNitric oxide synthase, endothelialHomo sapiens (human)
vasodilationNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of blood vessel endothelial cell migrationNitric oxide synthase, endothelialHomo sapiens (human)
endothelial cell migrationNitric oxide synthase, endothelialHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of Notch signaling pathwayNitric oxide synthase, endothelialHomo sapiens (human)
positive regulation of angiogenesisNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of smooth muscle cell proliferationNitric oxide synthase, endothelialHomo sapiens (human)
homeostasis of number of cells within a tissueNitric oxide synthase, endothelialHomo sapiens (human)
establishment of localization in cellNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, endothelialHomo sapiens (human)
ventricular septum morphogenesisNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of biomineral tissue developmentNitric oxide synthase, endothelialHomo sapiens (human)
blood vessel diameter maintenanceNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsNitric oxide synthase, endothelialHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, endothelialHomo sapiens (human)
response to hormoneNitric oxide synthase, endothelialHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, endothelialHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, endothelialHomo sapiens (human)
response to hypoxiaNitric oxide synthase, brainHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, brainHomo sapiens (human)
arginine catabolic processNitric oxide synthase, brainHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, brainHomo sapiens (human)
striated muscle contractionNitric oxide synthase, brainHomo sapiens (human)
myoblast fusionNitric oxide synthase, brainHomo sapiens (human)
response to heatNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transport into cytosolNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingNitric oxide synthase, brainHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, brainHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationNitric oxide synthase, brainHomo sapiens (human)
multicellular organismal response to stressNitric oxide synthase, brainHomo sapiens (human)
xenobiotic catabolic processNitric oxide synthase, brainHomo sapiens (human)
vasodilationNitric oxide synthase, brainHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, brainHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, brainHomo sapiens (human)
positive regulation of DNA-templated transcriptionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IINitric oxide synthase, brainHomo sapiens (human)
negative regulation of hydrolase activityNitric oxide synthase, brainHomo sapiens (human)
negative regulation of serotonin uptakeNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contractionNitric oxide synthase, brainHomo sapiens (human)
regulation of ryanodine-sensitive calcium-release channel activityNitric oxide synthase, brainHomo sapiens (human)
cellular response to growth factor stimulusNitric oxide synthase, brainHomo sapiens (human)
positive regulation of the force of heart contractionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayNitric oxide synthase, brainHomo sapiens (human)
positive regulation of sodium ion transmembrane transportNitric oxide synthase, brainHomo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelNitric oxide synthase, brainHomo sapiens (human)
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potentialNitric oxide synthase, brainHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, brainHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, brainHomo sapiens (human)
response to hormoneNitric oxide synthase, brainHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, brainHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, brainHomo sapiens (human)
response to hypoxiaNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of leukocyte mediated cytotoxicityNitric oxide synthase, inducibleHomo sapiens (human)
innate immune response in mucosaNitric oxide synthase, inducibleHomo sapiens (human)
arginine catabolic processNitric oxide synthase, inducibleHomo sapiens (human)
superoxide metabolic processNitric oxide synthase, inducibleHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, inducibleHomo sapiens (human)
circadian rhythmNitric oxide synthase, inducibleHomo sapiens (human)
response to bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of gene expressionNitric oxide synthase, inducibleHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, inducibleHomo sapiens (human)
prostaglandin secretionNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of interleukin-6 productionNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of interleukin-8 productionNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cell population proliferationNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of protein catabolic processNitric oxide synthase, inducibleHomo sapiens (human)
defense response to bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cellular respirationNitric oxide synthase, inducibleHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, inducibleHomo sapiens (human)
regulation of insulin secretionNitric oxide synthase, inducibleHomo sapiens (human)
defense response to Gram-negative bacteriumNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of killing of cells of another organismNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to lipopolysaccharideNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to type II interferonNitric oxide synthase, inducibleHomo sapiens (human)
cellular response to xenobiotic stimulusNitric oxide synthase, inducibleHomo sapiens (human)
regulation of cytokine production involved in inflammatory responseNitric oxide synthase, inducibleHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, inducibleHomo sapiens (human)
response to hormoneNitric oxide synthase, inducibleHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, inducibleHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, inducibleHomo sapiens (human)
inflammatory responseNitric oxide synthase, inducibleHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, inducibleHomo sapiens (human)
inositol phosphate metabolic processInositol hexakisphosphate kinase 1Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (35)

Processvia Protein(s)Taxonomy
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
signaling receptor bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
peptide antigen bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein-folding chaperone bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
actin monomer bindingNitric oxide synthase, endothelialHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, endothelialHomo sapiens (human)
protein bindingNitric oxide synthase, endothelialHomo sapiens (human)
calmodulin bindingNitric oxide synthase, endothelialHomo sapiens (human)
FMN bindingNitric oxide synthase, endothelialHomo sapiens (human)
heme bindingNitric oxide synthase, endothelialHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, endothelialHomo sapiens (human)
arginine bindingNitric oxide synthase, endothelialHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, endothelialHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, endothelialHomo sapiens (human)
NADP bindingNitric oxide synthase, endothelialHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, endothelialHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, brainHomo sapiens (human)
calcium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
protein bindingNitric oxide synthase, brainHomo sapiens (human)
calmodulin bindingNitric oxide synthase, brainHomo sapiens (human)
FMN bindingNitric oxide synthase, brainHomo sapiens (human)
sodium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
heme bindingNitric oxide synthase, brainHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, brainHomo sapiens (human)
arginine bindingNitric oxide synthase, brainHomo sapiens (human)
transmembrane transporter bindingNitric oxide synthase, brainHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, brainHomo sapiens (human)
calcium-dependent protein bindingNitric oxide synthase, brainHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, brainHomo sapiens (human)
NADP bindingNitric oxide synthase, brainHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, brainHomo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, inducibleHomo sapiens (human)
protein bindingNitric oxide synthase, inducibleHomo sapiens (human)
calmodulin bindingNitric oxide synthase, inducibleHomo sapiens (human)
FMN bindingNitric oxide synthase, inducibleHomo sapiens (human)
heme bindingNitric oxide synthase, inducibleHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, inducibleHomo sapiens (human)
arginine bindingNitric oxide synthase, inducibleHomo sapiens (human)
protein homodimerization activityNitric oxide synthase, inducibleHomo sapiens (human)
metal ion bindingNitric oxide synthase, inducibleHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, inducibleHomo sapiens (human)
NADP bindingNitric oxide synthase, inducibleHomo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol heptakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
ATP bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 1-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 3-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (39)

Processvia Protein(s)Taxonomy
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
Golgi membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
endoplasmic reticulumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi apparatusHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
cell surfaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
ER to Golgi transport vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
secretory granule membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
phagocytic vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
early endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
recycling endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular exosomeHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lumenal side of endoplasmic reticulum membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
MHC class I protein complexHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular spaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
external side of plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi membraneNitric oxide synthase, endothelialHomo sapiens (human)
nucleusNitric oxide synthase, endothelialHomo sapiens (human)
cytoplasmNitric oxide synthase, endothelialHomo sapiens (human)
Golgi apparatusNitric oxide synthase, endothelialHomo sapiens (human)
cytosolNitric oxide synthase, endothelialHomo sapiens (human)
cytoskeletonNitric oxide synthase, endothelialHomo sapiens (human)
plasma membraneNitric oxide synthase, endothelialHomo sapiens (human)
caveolaNitric oxide synthase, endothelialHomo sapiens (human)
endocytic vesicle membraneNitric oxide synthase, endothelialHomo sapiens (human)
nucleusNitric oxide synthase, endothelialHomo sapiens (human)
plasma membraneNitric oxide synthase, endothelialHomo sapiens (human)
cytosolNitric oxide synthase, endothelialHomo sapiens (human)
photoreceptor inner segmentNitric oxide synthase, brainHomo sapiens (human)
nucleoplasmNitric oxide synthase, brainHomo sapiens (human)
cytoplasmNitric oxide synthase, brainHomo sapiens (human)
mitochondrionNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
cytoskeletonNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
sarcoplasmic reticulumNitric oxide synthase, brainHomo sapiens (human)
sarcolemmaNitric oxide synthase, brainHomo sapiens (human)
dendritic spineNitric oxide synthase, brainHomo sapiens (human)
membrane raftNitric oxide synthase, brainHomo sapiens (human)
synapseNitric oxide synthase, brainHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, brainHomo sapiens (human)
cell peripheryNitric oxide synthase, brainHomo sapiens (human)
protein-containing complexNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
postsynaptic densityNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, inducibleHomo sapiens (human)
nucleoplasmNitric oxide synthase, inducibleHomo sapiens (human)
cytoplasmNitric oxide synthase, inducibleHomo sapiens (human)
peroxisomeNitric oxide synthase, inducibleHomo sapiens (human)
peroxisomal matrixNitric oxide synthase, inducibleHomo sapiens (human)
cytosolNitric oxide synthase, inducibleHomo sapiens (human)
cortical cytoskeletonNitric oxide synthase, inducibleHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, inducibleHomo sapiens (human)
plasma membraneNitric oxide synthase, inducibleHomo sapiens (human)
nucleusNitric oxide synthase, inducibleHomo sapiens (human)
cytosolNitric oxide synthase, inducibleHomo sapiens (human)
fibrillar centerInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
cytosolInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusInositol hexakisphosphate kinase 1Homo sapiens (human)
cytoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID225704Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOS2003Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
AID92147Selectivity ratio as IC50(i-NOS)/IC50 (n-NOS)2003Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
AID67991Selectivity as ratio of IC50(e-NOS)/IC50(n-NOS)2003Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
AID397947Inhibition of wild type rat nNOS at 420 nM by hemoglobin capture assay2009Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.
AID68139Inhibitory concentration against recombinant human Endothelial nitric oxide synthase2003Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
AID92007Inhibitory concentration against human Inducible nitric oxide synthase2003Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
AID622720Neuroprotective activity in gerbil cerebral ischemia model2011Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (31.82)18.2507
2000's8 (36.36)29.6817
2010's4 (18.18)24.3611
2020's3 (13.64)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews1 (5.88%)6.00%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
7-nitroindazole[no description available]medium50
indazoles[no description available]medium60indazole
ng-nitroarginine methyl ester[no description available]medium40alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
3-bromo-7-nitroindazole[no description available]medium10
n-(3-(aminomethyl)benzyl)acetamidine[no description available]medium20aralkylamine;
carboxamidine;
primary amino compound		angiogenesis inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
geroprotector
edetic acid[no description available]medium10ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
phencyclidine[no description available]medium10benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
thiophenes[no description available]medium10mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
pyrazines[no description available]medium10diazine;
pyrazines		Daphnia magna metabolite
bn 80933[no description available]medium10
ly 293558[no description available]medium10
dizocilpine maleate[no description available]medium10maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
nitroarginine[no description available]medium10guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
endothelin-1[no description available]medium10
propranolol[no description available]medium10naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
tetrodotoxin[no description available]medium10azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
ng-nitroarginine methyl ester[no description available]medium10alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
omega-n-methylarginine[no description available]medium10amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
nitroarginine[no description available]medium20guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
alpha-aminopyridine[no description available]medium10
1-(2-trifluoromethylphenyl)imidazole[no description available]medium10imidazoles
7-nitroindazole[no description available]medium10
ng-nitroarginine methyl ester[no description available]medium10hydrochlorideEC 1.14.13.39 (nitric oxide synthase) inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Brain Injuries0low20
Acute Confusional Senile Dementia0low10
Akinetic-Rigid Variant of Huntington Disease0low10
ALS - Amyotrophic Lateral Sclerosis0low20
Alzheimer Dementia0low10
Alzheimer Disease0low10
Alzheimer Disease, Early Onset0low10
Alzheimer Disease, Late Onset0low10
Alzheimer Sclerosis0low10
Alzheimer Syndrome0low10
Alzheimer Type Senile Dementia0low10
Alzheimer-Type Dementia (ATD)0low10
Alzheimer's Disease0low10
Alzheimer's Disease, Focal Onset0low10
Alzheimer's Diseases0low10
Amyotrophic Lateral Sclerosis0low20
Amyotrophic Lateral Sclerosis With Dementia0low20
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 10low20
Amyotrophic Lateral Sclerosis, Guam Form0low20
Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam0low20
Anterior Choroidal Artery Infarction0low20
Anterior Circulation Transient Ischemic Attack0low10
Arterial Obstructive Diseases0low10
Arterial Occlusive Diseases0low10
Benign Neoplasms0low10
Brain Injuries0low20
Brain Injuries, Acute0low20
Brain Injuries, Focal0low20
Brain Ischemia0low50
Brain Lacerations0low20
Brain Stem Ischemia, Transient0low10
Brain Stem Transient Ischemic Attack0low10
Brain TIA0low10
Brainstem Ischemia, Transient0low10
Brainstem Transient Ischemic Attack0low10
Cancer0low10
Carotid Circulation Transient Ischemic Attack0low10
Cerebral Infarct0low20
Cerebral Infarction0low20
Cerebral Infarction, Left Hemisphere0low20
Cerebral Infarction, Right Hemisphere0low20
Cerebral Ischemia0low50
Cerebral Ischemia, Transient0low10
Cerebral, Left Hemisphere, Infarction0low20
Cerebral, Right Hemisphere, Infarction0low20
Charcot Disease0low20
Chorea, Chronic Progressive Hereditary (Huntington)0low10
Chronic Progressive Hereditary Chorea (Huntington)0low10
Crescendo Transient Ischemic Attacks0low10
Dementia With Amyotrophic Lateral Sclerosis0low20
Dementia, Alzheimer Type0low10
Dementia, Presenile0low10
Dementia, Primary Senile Degenerative0low10
Dementia, Senile0low10
Disease Models, Animal0low40
Early Onset Alzheimer Disease0low10
Encephalopathy, Ischemic0low50
Familial Alzheimer Disease (FAD)0low10
Fasting Hypoglycemia0low10
Focal Brain Injuries0low20
Focal Onset Alzheimer's Disease0low10
Gehrig's Disease0low20
Guam Disease0low20
Guam Form of Amyotrophic Lateral Sclerosis0low20
Hemorrhagic Shock0low10
Huntington Chorea0low10
Huntington Chronic Progressive Hereditary Chorea0low10
Huntington Disease0low10
Huntington Disease, Akinetic-Rigid Variant0low10
Huntington Disease, Juvenile0low10
Huntington Disease, Juvenile-Onset0low10
Huntington Disease, Late Onset0low10
Huntington's Chorea0low10
Huntington's Disease0low10
Hypoglycemia0low10
Infarction, Cerebral0low20
Infarction, Cerebral, Left Hemisphere0low20
Infarction, Cerebral, Right Hemisphere0low20
Infarction, Left Hemisphere, Cerebral0low20
Infarction, Right Hemisphere, Cerebral0low20
Injuries, Acute Brain0low20
Injuries, Brain0low20
Injury, Ischemia-Reperfusion0low20
Injury, Reperfusion0low20
Ischemia-Reperfusion Injury0low20
Ischemia, Cerebral0low50
Ischemic Attack, Transient0low10
Ischemic Encephalopathy0low50
Juvenile Huntington Disease0low10
Juvenile-Onset Huntington Disease0low10
Late Onset Alzheimer Disease0low10
Late-Onset Huntington Disease0low10
Left Hemisphere, Cerebral Infarction0low20
Left Hemisphere, Infarction, Cerebral0low20
Lou Gehrig Disease0low20
Lou Gehrig's Disease0low20
Lou-Gehrigs Disease0low20
Malignancy0low10
Malignant Neoplasms0low10
MODS0low10
Motor Neuron Disease, Amyotrophic Lateral Sclerosis0low20
Multiple Organ Dysfunction Syndrome0low10
Multiple Organ Failure0low10
Muscle Contraction0low10
Necrosis0low10
Neoplasia0low10
Neoplasm0low10
Neoplasms0low10
Neoplasms, Benign0low10
Nerve Degeneration0low10
Nervous System Diseases0low10
Nervous System Disorders0low10
Neurologic Disorders0low10
Neurological Disorders0low10
Neuron Degeneration0low10
Organ Dysfunction Syndrome, Multiple0low10
Organ Failure, Multiple0low10
Postabsorptive Hypoglycemia0low10
Posterior Choroidal Artery Infarction0low20
Posterior Circulation Transient Ischemic Attack0low10
Postprandial Hypoglycemia0low10
Presenile Alzheimer Dementia0low10
Primary Senile Degenerative Dementia0low10
Progressive Chorea, Chronic Hereditary (Huntington)0low10
Progressive Chorea, Hereditary, Chronic (Huntington)0low10
Reactive Hypoglycemia0low10
Reperfusion Damage0low20
Reperfusion Injury0low20
Right Hemisphere, Cerebral Infarction0low20
Right Hemisphere, Infarction, Cerebral0low20
Senile Dementia, Acute Confusional0low10
Senile Dementia, Alzheimer Type0low10
Shock, Hemorrhagic0low10
Subcortical Infarction0low20
TIA (Transient Ischemic Attack)0low10
Transient Ischemic Attack0low10
Transient Ischemic Attack, Anterior Circulation0low10
Transient Ischemic Attack, Brain Stem0low10
Transient Ischemic Attack, Brainstem0low10
Transient Ischemic Attack, Carotid Circulation0low10
Transient Ischemic Attack, Posterior Circulation0low10
Transient Ischemic Attack, Vertebrobasilar Circulation0low10
Transient Ischemic Attacks, Crescendo0low10
Tumors0low10
Vertebrobasilar Circulation Transient Ischemic Attack0low10
Ache0low10
Allodynia0low10
Allodynia, Mechanical0low10
Allodynia, Tactile0low10
Allodynia, Thermal0low10
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Disease Models, Animal0low10
Fever, Zika0low10
Hyperalgesia0low10
Hyperalgesia, Mechanical0low10
Hyperalgesia, Primary0low10
Hyperalgesia, Secondary0low10
Hyperalgesia, Tactile0low10
Hyperalgesia, Thermal0low10
Hyperalgesic Sensations0low10
Hyperalgia0low10
Hyperalgia, Mechanical0low10
Hyperalgia, Primary0low10
Hyperalgia, Secondary0low10
Mechanical Allodynia0low10
Mechanical Hyperalgesia0low10
Nerve Pain0low10
Neuralgia0low10
Neuralgia, Atypical0low10
Neuralgia, Iliohypogastric Nerve0low10
Neuralgia, Ilioinguinal0low10
Neuralgia, Perineal0low10
Neuralgia, Stump0low10
Neuralgia, Supraorbital0low10
Neuralgia, Vidian0low10
Neurodynia0low10
Neuropathic Pain0low10
Pain0low10
Pain, Burning0low10
Pain, Crushing0low10
Pain, Migratory0low10
Pain, Radiating0low10
Pain, Splitting0low10
Paroxysmal Nerve Pain0low10
Suffering, Physical0low10
Tactile Allodynia0low10
Thermal Allodynia0low10
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Pharmacokinetics (2)

ArticleYear
Effect of AR-R 17477, a potent neuronal nitric oxide synthase inhibitor, on infarction volume resulting from permanent focal ischemia in rats.
Critical care medicine, Volume: 27, Issue: 11		1999
ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Volume: 16, Issue: 4		1996
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5		2019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]