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Dihydrofolate reductase
A protein that is a translation product of the DHFR gene in cow. [PRO:DNx, UniProtKB:P00376]
Synonyms
EC 1.5.1.3
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (9)
Drugs with Inhibition Measurements
1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Nonclassical antifolates, part 5. Benzodiazepine analogs as a new class of DHFR inhibitors: synthesis, antitumor testing and molecular modeling study.European journal of medicinal chemistry, , Mar-03, Volume: 74, 2014
Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study.European journal of medicinal chemistry, , Volume: 66, 2013
Nonclassical antifolates, part 3: synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones.European journal of medicinal chemistry, , Volume: 63, 2013
Antifolate and antiproliferative activity of 6,8,10-triazaspiro[4.5]deca-6,8-dienes and 1,3,5-triazaspiro[5.5]undeca-1,3-dienes.Bioorganic & medicinal chemistry, , Jan-15, Volume: 18, Issue:2, 2010
Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones.Bioorganic & medicinal chemistry, , Apr-15, Volume: 18, Issue:8, 2010
Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates.Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Antifolate and antibacterial activities of 5-substituted 2,4-diaminoquinazolines.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.Journal of medicinal chemistry, , Volume: 28, Issue:7, 1985
Methotrexate analogues. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters.Journal of medicinal chemistry, , Volume: 27, Issue:5, 1984