Proteins > Multidrug and toxin extrusion protein 2
Page last updated: 2024-08-08 00:01:41

Multidrug and toxin extrusion protein 2

A multidrug and toxin extrusion protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86VL8]

Synonyms

MATE-2;
hMATE-2;
Kidney-specific H(+)/organic cation antiporter;
Solute carrier family 47 member 2

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (37)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
tacrineHomo sapiens (human)IC50100.000011
bithionolHomo sapiens (human)IC506.600011
buspironeHomo sapiens (human)IC5046.000011
camostatHomo sapiens (human)IC5012.700011
cimetidineHomo sapiens (human)IC5039.000011
dipyridamoleHomo sapiens (human)IC5074.000011
disopyramideHomo sapiens (human)IC50100.000011
domperidoneHomo sapiens (human)IC5014.800011
epinastineHomo sapiens (human)IC5029.800011
gabexateHomo sapiens (human)IC5010.800011
granisetronHomo sapiens (human)IC50311.000011
imipramineHomo sapiens (human)IC50100.000011
mitoxantroneHomo sapiens (human)IC500.680022
nifekalantHomo sapiens (human)IC504.600022
ondansetronHomo sapiens (human)IC502.453333
orphenadrineHomo sapiens (human)IC50100.000011
pantoprazoleHomo sapiens (human)IC50271.600022
pentamidineHomo sapiens (human)IC506.550022
prazosinHomo sapiens (human)IC5038.400011
rimantadineHomo sapiens (human)IC50288.000011
risperidoneHomo sapiens (human)IC50291.000011
imatinibHomo sapiens (human)IC501.625022
ici 204,219Homo sapiens (human)IC507.600011
ethinyl estradiolHomo sapiens (human)IC5020.200011
tubocurarineHomo sapiens (human)IC5055.500011
dihydroergotamineHomo sapiens (human)IC5012.600011
pimozideHomo sapiens (human)IC50500.000011
vecuronium bromideHomo sapiens (human)IC5025.200011
topotecanHomo sapiens (human)IC508.600011
aripiprazoleHomo sapiens (human)IC50500.000011
irinotecanHomo sapiens (human)IC5043.250022
dabigatranHomo sapiens (human)IC5025.300011
ritonavirHomo sapiens (human)IC5014.050022
maravirocHomo sapiens (human)IC50297.000011
indinavir sulfateHomo sapiens (human)IC50253.900022
famotidineHomo sapiens (human)IC5036.200011
chlorhexidineHomo sapiens (human)IC500.500011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
organic cation transmembrane transporter activitymolecular functionEnables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
antiporter activitymolecular functionEnables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
transmembrane transporter activitymolecular functionEnables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
xenobiotic transmembrane transporter activitymolecular functionEnables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
polyspecific organic cation:proton antiporter activitymolecular functionEnables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics. [PMID:17047166, PMID:17509534]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
apical plasma membranecellular componentThe region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
organic cation transportbiological processThe directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. [GOC:ai]
transmembrane transportbiological processThe process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
proton transmembrane transportbiological processThe directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
xenobiotic detoxification by transmembrane export across the plasma membranebiological processA process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. [PMID:28355133]