Proteins > Phosphatidylinositol 4-kinase type 2-alpha
Page last updated: 2024-08-07 13:43:13

Phosphatidylinositol 4-kinase type 2-alpha

A phosphatidylinositol 4-kinase type 2-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BTU6]

Synonyms

EC 2.7.1.67;
Phosphatidylinositol 4-kinase type II-alpha

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (50.00)2.80

Compounds (14)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
9-ethyladenineHomo sapiens (human)IC5032.400011
9-ethyladenineHomo sapiens (human)Ki25.500011
n(6),n(6)-dimethyladenineHomo sapiens (human)IC50218.000011
n(6),n(6)-dimethyladenineHomo sapiens (human)Ki150.200011
1-phenyl-4-pyrazolo[3,4-d]pyrimidinamineHomo sapiens (human)IC5016.100011
1-phenyl-4-pyrazolo[3,4-d]pyrimidinamineHomo sapiens (human)Ki11.000011
sq 22536Homo sapiens (human)IC5028.200011
sq 22536Homo sapiens (human)Ki21.200011
adenosine diphosphateHomo sapiens (human)IC50145.300011
adenosine diphosphateHomo sapiens (human)Ki100.100011
2-aminopurineHomo sapiens (human)IC50341.600011
2-aminopurineHomo sapiens (human)Ki235.400011
alpha-aminopyridineHomo sapiens (human)IC507.100011
9-benzyladenineHomo sapiens (human)IC5084.400011
9-benzyladenineHomo sapiens (human)Ki57.900011
adenosineHomo sapiens (human)IC5030.300011
adenosineHomo sapiens (human)Ki19.200011
benzylaminopurineHomo sapiens (human)IC50240.400011
benzylaminopurineHomo sapiens (human)Ki199.000011
9-methyladenineHomo sapiens (human)IC50161.000011
9-methyladenineHomo sapiens (human)Ki110.900011
4-aminopyrazolo(3,4-d)pyrimidineHomo sapiens (human)IC50144.900011
4-aminopyrazolo(3,4-d)pyrimidineHomo sapiens (human)Ki99.900011
4-aminoquinazolineHomo sapiens (human)IC5091.700011
4-aminoquinazolineHomo sapiens (human)Ki63.400011
wortmanninHomo sapiens (human)IC5030.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
9-ethyladenineHomo sapiens (human)Km257.000011
sq 22536Homo sapiens (human)Km261.800011
adenosineHomo sapiens (human)Km178.900011
benzylaminopurineHomo sapiens (human)Km239.000011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
magnesium ion bindingmolecular functionBinding to a magnesium (Mg) ion. [GOC:ai]
1-phosphatidylinositol 4-kinase activitymolecular functionCatalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+. [EC:2.7.1.67, RHEA:19877]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
AP-3 adaptor complex bindingmolecular functionBinding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). [PMID:21097499]

Located In

This protein is located in 16 target(s):

TargetCategoryDefinition
Golgi membranecellular componentThe lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
mitochondrioncellular componentA semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
lysosomal membranecellular componentThe lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
endosomecellular componentA vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
dendritecellular componentA neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
cytoplasmic vesiclecellular componentA vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]
early endosome membranecellular componentThe lipid bilayer surrounding an early endosome. [GOC:pz]
growing cell tipcellular componentThe region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs. [GOC:mah]
presynaptic membranecellular componentA specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
neuron projectioncellular componentA prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
neuronal cell bodycellular componentThe portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
perikaryoncellular componentThe portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
membrane raftcellular componentAny of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
trans-Golgi networkcellular componentThe network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
endosomecellular componentA vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
BLOC-1 complexcellular componentA protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. [PMID:15102850]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
phosphatidylinositol biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]
phosphatidylinositol phosphate biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. [ISBN:0198506732]
endosome organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. [GOC:dph, GOC:jl, GOC:mah]
Golgi organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. [GOC:dph, GOC:jl, GOC:mah]