Proteins > Aldo-keto reductase family 1 member B1
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Aldo-keto reductase family 1 member B1
[no definition available]
Synonyms
EC 1.1.1.21;
EC 1.1.1.300;
EC 1.1.1.372;
EC 1.1.1.54;
20-alpha-hydroxysteroid dehydrogenase;
20-alpha-HSD;
Aldehyde reductase;
Aldose reductase;
AR
Research
Bioassay Publications (21)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (23)
Drugs with Inhibition Measurements
Spiro hydantoin aldose reductase inhibitors.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.Journal of medicinal chemistry, , Volume: 27, Issue:3, 1984
Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors.Journal of medicinal chemistry, , Nov-19, Volume: 41, Issue:24, 1998
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Quinazolineacetic acids and related analogues as aldose reductase inhibitors.Journal of medicinal chemistry, , Volume: 34, Issue:4, 1991
(Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Computer-assisted design and synthesis of novel aldose reductase inhibitors.Journal of medicinal chemistry, , Volume: 32, Issue:4, 1989
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.Journal of medicinal chemistry, , Volume: 27, Issue:3, 1984
Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents.European journal of medicinal chemistry, , Jun-23, Volume: 81, 2014
In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Identification of new non-carboxylic acid containing inhibitors of aldose reductase.Bioorganic & medicinal chemistry, , Jun-01, Volume: 18, Issue:11, 2010
Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 17, Issue:14, 2007
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.Journal of medicinal chemistry, , Volume: 28, Issue:11, 1985
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.Journal of medicinal chemistry, , Volume: 27, Issue:3, 1984
Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 21, Issue:14, 2013
Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin.Bioorganic & medicinal chemistry, , May-01, Volume: 18, Issue:9, 2010
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 21, Issue:14, 2013
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.Journal of medicinal chemistry, , Jun-03, Volume: 42, Issue:11, 1999