Page last updated: 2024-08-04 07:42:30

pkh 26

Description

PKH 26: no further information available 8/91 [MeSH]

Cross-References

ID SourceID
PubMed CID162642097
MeSH IDM0191029

Synonyms (5)

Synonym
MS-31801
pkh 26
HY-D1451
PD167419
CS-0378565

Research

Studies (253)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's56 (22.13)18.2507
2000's94 (37.15)29.6817
2010's85 (33.60)24.3611
2020's18 (7.11)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.39%)5.53%
Reviews3 (1.16%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other255 (98.46%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
adenine6-aminopurines;
purine nucleobase
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2013201311.0low000010
lactic acid2-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
2007200717.0low000100
palmitic acidlong-chain fatty acid;
straight-chain saturated fatty acid
algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite
2005200519.0low000100
antipyrinepyrazoloneantipyretic;
cyclooxygenase 3 inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
201520159.0low000010
busulfanmethanesulfonate esteralkylating agent;
antineoplastic agent;
carcinogenic agent;
insect sterilant;
teratogenic agent
202320231.0low000001
dapiindolesfluorochrome2009200915.0low000100
erythrosine1995202219.5medium007721
fluorouracilnucleobase analogue;
organofluorine compound
antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
202120213.0low000001
edaravonepyrazoloneantioxidant;
radical scavenger
201520159.0low000010
oxidopaminebenzenetriol;
catecholamine;
primary amino compound
drug metabolite;
human metabolite;
neurotoxin
2004200718.5low000200
ag 1879aromatic amine;
monochlorobenzenes;
pyrazolopyrimidine
beta-adrenergic antagonist;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector
2007200717.0low000100
propidiumphenanthridines;
quaternary ammonium ion
fluorochrome;
intercalator
2002200919.3low000300
prednisone11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
immunosuppressive agent;
prodrug
2008200816.0low000100
carbon tetrachloridechlorocarbon;
chloromethanes
hepatotoxic agent;
refrigerant
2010201014.0low000100
chlordancyclodiene organochlorine insecticideGABA-gated chloride channel antagonist;
persistent organic pollutant
2000200024.0low001000
adenosine diphosphateadenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate
fundamental metabolite;
human metabolite
2002200222.0low000100
bromodeoxyuridinepyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
2002201416.2low000510
cytarabinebeta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside
antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
2002200222.0low000100
xanthenesxanthene2013201311.0low000010
benzotriazolebenzotriazolesenvironmental contaminant;
xenobiotic
2002200222.0low000100
cyanuric chloridechloro-1,3,5-triazine;
organochlorine compound
cross-linking reagent2002200222.0low000100
framycetinaminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
1993199331.0low001000
azacitidineN-glycosyl-1,3,5-triazine;
nucleoside analogue
antineoplastic agent201520159.0low000010
cuprizoneorganonitrogen compound;
organooxygen compound
2013201311.0low000010
gentian violetorganic chloride saltanthelminthic drug;
antibacterial agent;
antifungal agent;
antiseptic drug;
histological dye
1994199430.0low001000
resazurinphenoxazine2013201311.0low000010
acetylcysteineacetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid
antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
202120213.0low000001
sodium hydroxidealkali metal hydroxide2005200519.0low000100
zinc oxidezinc molecular entity202320231.0low000001
vancomycinglycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
2007200717.0low000100
amiloridearomatic amine;
guanidines;
organochlorine compound;
pyrazines
diuretic;
sodium channel blocker
2000200024.0low001000
fluorescein-5-isothiocyanatefluorescein isothiocyanate1991201524.2low003010
chromiumchromium group element atom;
metal allergen
micronutrient2006200618.0low000100
tetradecanoylphorbol acetateacetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester
antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
1996199827.0low002000
paclitaxeltaxane diterpenoid;
tetracyclic diterpenoid
antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
2009201213.5low000110
etoposidebeta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound
antineoplastic agent;
DNA synthesis inhibitor
2012201212.0low000010
colforsinacetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol
adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
2002200222.0low000100
acridine orangeaminoacridines;
aromatic amine;
tertiary amino compound
fluorochrome;
histological dye
2009200915.0low000100
plerixaforazacycloalkane;
azamacrocycle;
benzenes;
crown amine;
secondary amino compound;
tertiary amino compound
anti-HIV agent;
antineoplastic agent;
C-X-C chemokine receptor type 4 antagonist;
immunological adjuvant
2011201113.0low000010
fluorexonxanthene dyefluorochrome1999200024.5low002000
triazoles1,2,3-triazole2002200222.0low000100
diacetyldichlorofluorescein202220222.0low000001
mosapridearomatic ether;
benzamides;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
secondary carboxamide;
substituted aniline;
tertiary amino compound
201620168.0low000010
5-chloromethylfluorescein diacetateacetate esterfluorochrome2010201014.0low000100
5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)fluorescein1998200025.0low002000
biotinbiotins;
vitamin B7
coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
2002200222.0low000100
wortmanninacetate ester;
cyclic ketone;
delta-lactone;
organic heteropentacyclic compound
anticoronaviral agent;
antineoplastic agent;
autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector;
Penicillium metabolite;
radiosensitizing agent
2011201113.0low000010
fibrinpeptide2011201113.0low000010
bradykininoligopeptidehuman blood serum metabolite;
vasodilator agent
2006200618.0low000100
elastinoligopeptide202320231.0low000001
pectinsD-galactopyranuronic acid2011201113.0low000010
decitabine2'-deoxyribonucleoside201520159.0low000010
dactinomycinactinomycinmutagen2009200915.0low000100
bromochloroacetic acid2-bromocarboxylic acid;
monocarboxylic acid;
organochlorine compound
2001201416.5low000110
safranine torganic chloride saltfluorochrome;
histological dye
2008200816.0low000100
ovalbumin2012201510.5low000020
tetramethylrhodamine isothiocyanate1995199529.0low001000
rhodamine 123organic cation;
xanthene dye
fluorochrome2000200024.0low001000
myelin basic protein2012201212.0low000010
alprostadilprostaglandins Eanticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent
202320231.0low000001
sirolimusantibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol
antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
2008200816.0low000100
clobetasol11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(1),Delta(4)-steroid;
chlorinated steroid;
fluorinated steroid;
glucocorticoid;
tertiary alpha-hydroxy ketone
anti-inflammatory drug;
SMO receptor agonist
1994199430.0low001000
3,3'-dioctadecylindocarbocyanineCy5 dye;
indolium ion
fluorochrome1995199529.0low001000
carbocyaninescyanine dye;
organic iodide salt
fluorochrome1995200623.0low001400
involucrin2014201410.0low000010
concanamycin acarbamate ester;
concanamycin
antifungal agent;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
metabolite
2003200321.0low000100
pkh 2 dye2001200123.0medium000100
fluorescein thiosemicarbazide2000200024.0low001000
gadolinium dtpagadolinium coordination entityMRI contrast agent2010201511.5low000130
sq-23377cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid
calcium ionophore;
metabolite
1998199826.0low001000
7-aminoactinomycin d2009200915.0low000100
losartan potassium1999201911.8low001030
td-5108201620168.0low000010
technetium tc 99m exametazime2011201113.0low000010
acid phosphatase2006200618.0low000100
ceruletideoligopeptidediagnostic agent;
gastrointestinal drug
202120213.0low000001
hoe 333421991201423.0low003010
chitosan200920238.0low000101
to-pro-3cyanine dye;
organic iodide salt
fluorochrome2001200123.0low000200
ascorbic acidascorbic acid;
vitamin C
coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
202120213.0low000001
epidermal growth factor2002200222.0low000100
transforming growth factor beta2000200024.0low001000
cyclosporine2008200816.0low000100
cytochalasin d2014201410.0low000010
apyrase2006200618.0low000100
trypan blue1994199430.0low001000
concanavalin a1998199826.0low001000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Absence Status0201920195.0low000010
ACL Injuries02014201410.0low000010
Acute Brain Injuries02001201415.3low000120
Acute Confusional Senile Dementia02012201510.3low000030
Acute Disease01994200225.0low001200
Acute Edematous Pancreatitis0202120213.0low000001
Acute Hemolytic Transfusion Reaction02001200123.0low000100
Acute Hepatic Failure02010201014.0low000100
Acute Kidney Failure0201520159.0low000010
Acute Kidney Injury0201520159.0low000010
Acute Myelogenous Leukemia01994200027.0low002000
Adenocarcinoma02004200420.0low000100
Adenocarcinoma, Basal Cell02004200420.0low000100
Adhesions, Tissue0201820186.0low000010
African Lymphoma02000200322.5low001100
Age-Related Memory Disorders02008200816.0low000100
Aging02002200222.0low000100
AIDS, Simian02006200618.0low000100
Airway Hyper-Responsiveness0201520159.0low000010
Akinetic-Rigid Variant of Huntington Disease02008200816.0low000100
Alloxan Diabetes0201720177.0low000010
Alzheimer Disease02012201510.3low000030
Amyloid Angiopathy, Cerebral0201520159.0low000010
Aneuploid01993200923.0low001100
Angiogenesis, Pathologic0202220222.0low000001
Anoxia-Ischemia, Brain02014201410.0low000010
Anterior Cerebral Circulation Infarction02011201113.0low000010
Apoplexy02009200915.0low000100
Arthritis, Degenerative02014201410.0low000010
Arthropathies02003201415.5low000110
Astrocytoma, Grade IV02013201311.0low000010
Atrophy02004200420.0low000100
Autoimmune Diabetes01994199430.0low001000
Autoimmune Disease01998199826.0low001000
Autoimmune Diseases01998199826.0low001000
Autosomal Dominant Juvenile Parkinson Disease02004200718.5low000200
B-Cell Leukemia02000200024.0low001000
B-Cell Lymphoma02003200321.0low000100
B16 Melanoma01991199133.0low001000
Bare Lymphocyte Syndrome01995199529.0low001000
Benign Neoplasms, Brain02013201311.0low000010
Blood Clot01994199430.0low001000
Blunt Injuries0201820186.0low000010
Body Weight0202120213.0low000001
Brain Infarction02011201113.0low000010
Brain Injuries02001201415.3low000120
Brain Ischemia02007200717.0low000100
Brain Neoplasms02013201311.0low000010
Branch Vein Occlusion02001200123.0low000100
Breast Cancer0201320227.7low000021
Breast Neoplasms0201320227.7low000021
Burkitt Lymphoma02000200322.5low001100
Burns0201920195.0low000010
Cancer of Cervix0202220222.0low000001
Cancer of Liver01991201620.5low001010
Cancer of Lung01991199332.0low002000
Cancer of Nasopharynx02013201311.0low000010
Cancer of Ovary02009201213.5low000110
Cancer of Prostate02004200420.0low000100
Cancer of Stomach0201220217.5low000011
Canine Diseases02014201410.0low000010
Carcinoma02012201311.5low000020
Carcinoma, Anaplastic02012201311.5low000020
Carcinoma, Hepatocellular0201620168.0low000010
Cardiac Diseases02008200816.0low000100
Cardiac Rupture, Traumatic02008200816.0low000100
Cardiovascular Stroke02009202310.2low000211
Carotid Artery Narrowing02001200123.0low000100
Carotid Stenosis02001200123.0low000100
Cartilage Diseases02006200618.0low000100
Cell Transformation, Neoplastic02013201311.0low000010
Cerebral Amyloid Angiopathy0201520159.0low000010
Cerebral Infarction, Middle Cerebral Artery02009200915.0low000100
Cerebral Ischemia02007200717.0low000100
Chest Injuries0201820186.0low000010
Chondromalacia02006200618.0low000100
Chronic Kidney Diseases02013201311.0low000010
Chronic Lung Injury0201520159.0low000010
Cirrhosis, Liver02008201413.0low000110
CJD (Creutzfeldt-Jakob Disease)02001200123.0low000100
Clinically Isolated CNS Demyelinating Syndrome02013201311.0low000010
Co-infection02013201311.0low000010
Complication, Postoperative02006200618.0low000100
Constriction, Pathologic0202220222.0low000001
Constriction, Pathological0202220222.0low000001
Creutzfeldt-Jakob Syndrome02001200123.0low000100
Cystadenocarcinoma, Serous02009200915.0low000100
Deep Vein Thrombosis02001200123.0low000100
Degenerative Disc Disease0201520159.0low000010
Delayed Hypersensitivity01994199430.0low001000
Demyelinating Diseases02013201311.0low000010
Diabetes Mellitus0202220222.0low000001
Diabetes Mellitus, Type 101994199430.0low001000
Disc, Herniated02003200321.0low000100
Disease Models, Animal01998201914.3low0028100
EHS Tumor01991199133.0low001000
Experimental Hepatoma02000200024.0low001000
Experimental Neoplasms01993201122.0low001010
Extravascular Hemolysis02014201410.0low000010
Fat Necrosis02006200618.0low000100
Fatty Liver, Nonalcoholic0202120213.0low000001
Fibrosarcoma02000200024.0low001000
Glaucoma, Suspect01995199529.0low001000
Glioblastoma02013201311.0low000010
Graft Occlusion, Vascular01994199430.0low001000
Granulocytic Leukemia02002200222.0low000100
Haemonchiasis02000200024.0low001000
Hansen Disease02005200519.0low000100
Hay Fever02003200321.0low000100
Heart Disease, Ischemic02007200717.0low000100
Heart Diseases02008200816.0low000100
Hemolysis02014201410.0low000010
Hepatocellular Carcinoma0201620168.0low000010
HIV02012201212.0low000010
HIV Coinfection01994200624.0low001100
HIV Infections01994200624.0low001100
Huntington Disease02008200816.0low000100
Hyperlipemia0202120213.0low000001
Hyperlipidemias0202120213.0low000001
Hyperoxia0201520159.0low000010
Hypoxia-Ischemia, Brain02014201410.0low000010
Infarction, Middle Cerebral Artery02009200915.0low000100
Infections, Orthomyxoviridae02013201311.0low000010
Infections, Pneumococcal02013201311.0low000010
Infections, Tick-Borne0201620168.0low000010
Inflammation0200720239.2low000121
Injuries0201720177.0low000010
Injuries, Radiation02001200123.0low000100
Injuries, Soft Tissue02006200618.0low000100
Injuries, Spinal Cord0201520178.0low000020
Injury, Ischemia-Reperfusion0201520159.0low000010
Innate Inflammatory Response0200720239.2low000121
Intervertebral Disc Degeneration0201520159.0low000010
Intervertebral Disc Displacement02003200321.0low000100
Intraocular Pressure01995199529.0low001000
Ischemia0201420227.3low000021
Joint Diseases02003201415.5low000110
Koch's Disease02012201212.0low000010
Left Ventricular Dysfunction02009200915.0low000100
Leprosy02005200519.0low000100
Leucocythaemia01993201122.0low001010
Leukemia01993201122.0low001010
Leukemia, Lymphocytic, T Cell02000200024.0low001000
Leukemia, Myeloid02002200222.0low000100
Leukemia, Myeloid, Acute01994200027.0low002000
Leukemia, Pre-B-Cell01994199430.0low001000
Leukemia, T-Cell02000200024.0low001000
Liver Cirrhosis02008201413.0low000110
Liver Failure, Acute02010201014.0low000100
Liver Neoplasms01991201620.5low001010
Lung Neoplasms01991199332.0low002000
Lymph Node Metastasis02000200024.0low001000
Lymphoma, B-Cell02003200321.0low000100
Memory Disorders02008200816.0low000100
Meniscitis02005200519.0low000100
Microbial Superinvasion02013201311.0low000010
Muscle Contraction0201720177.0low000010
Myocardial Infarction02009202310.2low000211
Myocardial Ischemia02007200717.0low000100
Nasopharyngeal Carcinoma02013201311.0low000010
Nasopharyngeal Neoplasms02013201311.0low000010
Necrosis02003201414.7low000120
Neuroretinitis01998199826.0low001000
Non-alcoholic Fatty Liver Disease0202120213.0low000001
Obesity02007200717.0low000100
Ocular Hypertension01995199529.0low001000
Orthomyxoviridae Infections02013201311.0low000010
Osteoarthritis02014201410.0low000010
Osteogenic Sarcoma02011201113.0low000010
Osteomyelitis02007200717.0low000100
Osteosarcoma02011201113.0low000010
Ovarian Neoplasms02009201213.5low000110
Pancreatitis0202120213.0low000001
Parkinsonian Disorders02004200718.5low000200
Pelvic Organ Prolapse0201720177.0low000010
Peripheral Nerve Injuries02011201710.0low000020
Peripheral Nerve Injury02011201710.0low000020
Peritoneal Carcinomatosis02000200024.0low001000
Peritoneal Neoplasms02000200024.0low001000
Pheochromocytoma02011201113.0low000010
Pheochromocytoma, Extra-Adrenal02011201113.0low000010
Pneumococcal Infections02013201311.0low000010
Postoperative Complications02006200618.0low000100
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma01994199430.0low001000
Pregnancy01998201418.0low001110
Prostatic Neoplasms02004200420.0low000100
Renal Insufficiency, Chronic02013201311.0low000010
Reperfusion Injury0201520159.0low000010
Retinal Vein Occlusion02001200123.0low000100
Retinitis01998199826.0low001000
Rhinitis, Allergic, Seasonal02003200321.0low000100
Rupture02014201410.0low000010
Sensitivity and Specificity01997200921.0low001400
Severe Combined Immunodeficiency01995199529.0low001000
Spinal Cord Injuries0201520178.0low000020
Status Epilepticus0201920195.0low000010
Stomach Neoplasms0201220217.5low000011
Stroke02009200915.0low000100
Thrombosis01994199430.0low001000
Toxoplasmosis, Animal01998199826.0low001000
Transfusion Reaction02001200123.0low000100
Tuberculosis02012201212.0low000010
Urogenital Prolapse0201720177.0low000010
Uterine Cervical Neoplasms0202220222.0low000001
Uveitis, Anterior01998199826.0low001000
Uveitis, Posterior01998199826.0low001000
Venous Thrombosis02001200123.0low000100
Ventricular Dysfunction, Left02009200915.0low000100
Weight Gain0201520159.0low000010
Wounds and Injuries0201720177.0low000010

Safety/Toxicity (8)

ArticleYear
A flow cytometry based assay that simultaneously measures cytotoxicity and monocyte mediated antibody dependent effector activity.
Journal of immunological methods, , Volume: 462
2018
Role of monocytes in mediating HIV-specific antibody-dependent cellular cytotoxicity.
Journal of immunological methods, , Oct-31, Volume: 384, Issue:1-2
2012
CD4(+) CD25(+) FoxP3(+) regulatory T cells suppress cytotoxicity of CD8(+) effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level.
Journal of neuroinflammation, , Feb-28, Volume: 9
2012
A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity.
Journal of immunological methods, , Jan-20, Volume: 308, Issue:1-2
2006
Antibody-dependent cell-mediated cytotoxicity: a flow cytometry-based assay using fluorophores.
Journal of immunological methods, , Dec-01, Volume: 258, Issue:1-2
2001
Development of a novel flow cytometric cell-mediated cytotoxicity assay using the fluorophores PKH-26 and TO-PRO-3 iodide.
Journal of immunological methods, , Jun-01, Volume: 252, Issue:1-2
2001
Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line.
Cytometry, , Aug-01, Volume: 36, Issue:4
1999
A novel non-radioactive cellular cytotoxicity test based on the differential assessment of living and killed target and effector cells.
Journal of immunological methods, , Mar-13, Volume: 180, Issue:1
1995

Interactions (2)

ArticleYear
[Treatment of liver cancer in vitro and in mice by monoclonal antibody targeting epithelial specific antigen-positive liver cancer stem cells in combination with cisplatin].
Zhonghua zhong liu za zhi [Chinese journal of oncology], , May-23, Volume: 38, Issue:5
2016
Improved preparation of acellular nerve scaffold and application of PKH26 fluorescent labeling combined with in vivo fluorescent imaging system in nerve tissue engineering.
Neuroscience letters, , Nov-27, Volume: 556
2013