Page last updated: 2024-08-07 15:26:46
Prostaglandin G/H synthase 2
A prostaglandin G/H synthase 2 that is encoded in the genome of cow. [OMA:O62698, PRO:DNx]
Synonyms
EC 1.14.99.1;
Cyclooxygenase-2;
COX-2;
PHS II;
Prostaglandin H2 synthase 2;
PGH synthase 2;
PGHS-2;
Prostaglandin-endoperoxide synthase 2
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (23)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| amfenac | Bos taurus (cattle) | IC50 | 0.2000 | 1 | 2 |
| aspirin | Bos taurus (cattle) | IC50 | 1,500.0000 | 1 | 2 |
| celecoxib | Bos taurus (cattle) | IC50 | 0.0570 | 1 | 1 |
| ibuprofen | Bos taurus (cattle) | IC50 | 1.1000 | 1 | 1 |
| indomethacin | Bos taurus (cattle) | IC50 | 0.7764 | 6 | 9 |
| ketoconazole | Bos taurus (cattle) | IC50 | 750.0000 | 1 | 2 |
| masoprocol | Bos taurus (cattle) | IC50 | 14.0000 | 1 | 1 |
| rofecoxib | Bos taurus (cattle) | IC50 | 0.4300 | 1 | 1 |
| zomepirac | Bos taurus (cattle) | IC50 | 15.0000 | 1 | 1 |
| 1-naphthol | Bos taurus (cattle) | IC50 | 2.0000 | 1 | 1 |
| proquazone | Bos taurus (cattle) | IC50 | 0.0700 | 1 | 2 |
| lonapalene | Bos taurus (cattle) | IC50 | 750.0000 | 1 | 2 |
| ilomastat | Bos taurus (cattle) | IC50 | 0.0006 | 1 | 1 |
| ml-3000 | Bos taurus (cattle) | IC50 | 0.2100 | 1 | 2 |
| 2-(phenylmethyl)-1-naphthol | Bos taurus (cattle) | IC50 | 501.1333 | 2 | 3 |
| dinoprost | Bos taurus (cattle) | IC50 | 0.0713 | 2 | 2 |
| cloprostenol | Bos taurus (cattle) | IC50 | 0.0010 | 1 | 1 |
| l 651896 | Bos taurus (cattle) | IC50 | 57.0000 | 1 | 1 |
| 16,16-dimethylprostaglandin f2alpha | Bos taurus (cattle) | IC50 | 0.0160 | 1 | 1 |
| ahr 5850 | Bos taurus (cattle) | IC50 | 0.2000 | 2 | 2 |
| piroxicam | Bos taurus (cattle) | IC50 | 65.0000 | 1 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| indomethacin | Bos taurus (cattle) | ID50 | 0.4300 | 1 | 1 |
| phenidone | Bos taurus (cattle) | ID50 | 6.9000 | 1 | 1 |
| zileuton | Bos taurus (cattle) | ID50 | 750.0000 | 1 | 1 |