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Prostaglandin G/H synthase 2
A prostaglandin G/H synthase 2 that is encoded in the genome of cow. [OMA:O62698, PRO:DNx]
Synonyms
EC 1.14.99.1;
Cyclooxygenase-2;
COX-2;
PHS II;
Prostaglandin H2 synthase 2;
PGH synthase 2;
PGHS-2;
Prostaglandin-endoperoxide synthase 2
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (23)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| indomethacin | Bos taurus (cattle) | ID50 | 0.4300 | 1 | 1 |
| phenidone | Bos taurus (cattle) | ID50 | 6.9000 | 1 | 1 |
| zileuton | Bos taurus (cattle) | ID50 | 750.0000 | 1 | 1 |
1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.Journal of medicinal chemistry, , May-04, Volume: 43, Issue:9, 2000
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues.Journal of medicinal chemistry, , Volume: 27, Issue:11, 1984
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
Antiinflammatory agents. 2. Syntheses and antiinflammatory activity of substituted 2-aminophenylacetic acid derivatives.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982