An aminopeptidase N that is encoded in the genome of human. [PRO:WCB, UniProtKB:P15144]
AP-N;
hAPN;
EC 3.4.11.2;
Alanyl aminopeptidase;
Aminopeptidase M;
AP-M;
Microsomal aminopeptidase;
Myeloid plasma membrane glycoprotein CD13;
gp150
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 25 (73.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| n-butylboronic acid | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| ubenimex | Homo sapiens (human) | IC50 | 42.1737 | 24 | 24 |
| ubenimex | Homo sapiens (human) | Ki | 2.3700 | 1 | 1 |
| 1-amino-2-phenylethylphosphonic acid | Homo sapiens (human) | Ki | 27.5000 | 1 | 1 |
| angiotensin ii, des-asp(1)-des-arg(2)-ile(5)- | Homo sapiens (human) | Ki | 0.6397 | 4 | 4 |
| kelatorphan | Homo sapiens (human) | Ki | 7.0000 | 1 | 1 |
| 4-amino-n-(2,6-dimethylphenyl)phthalimide | Homo sapiens (human) | IC50 | 56.3000 | 1 | 1 |
| glutamate thiol | Homo sapiens (human) | Ki | 17.0000 | 1 | 1 |
| amastatin | Homo sapiens (human) | Ki | 0.2000 | 1 | 1 |
| puromycin | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| actinonin | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| actinonin | Homo sapiens (human) | Ki | 230.0567 | 3 | 3 |
| leucine phosphonic acid | Homo sapiens (human) | Ki | 0.0026 | 1 | 1 |
| curcumin | Homo sapiens (human) | IC50 | 15.5000 | 1 | 1 |
| 2-(2,6-diisopropylphenyl)-5-amino-1h-isoindole-1,3-dione | Homo sapiens (human) | IC50 | 16.8000 | 1 | 1 |
| sitagliptin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| thiorphan | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 1-amino-3-phenylpropylphosphonic acid | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| 2-(2,6-diisopropylphenyl)-5-hydroxy-1h-isoindole-1,3-dione | Homo sapiens (human) | IC50 | 46.4000 | 1 | 1 |
| tosedostat | Homo sapiens (human) | IC50 | 0.6800 | 1 | 1 |
| tosedostat | Homo sapiens (human) | Ki | 1.1800 | 1 | 1 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| virus receptor activity | molecular function | Combining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] |
| aminopeptidase activity | molecular function | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] |
| metallopeptidase activity | molecular function | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| signaling receptor activity | molecular function | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling] |
| metalloaminopeptidase activity | molecular function | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| peptide binding | molecular function | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl] |
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| lysosomal membrane | cellular component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| endoplasmic reticulum-Golgi intermediate compartment | cellular component | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. [GOC:pr, PMID:16723730] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| secretory granule membrane | cellular component | The lipid bilayer surrounding a secretory granule. [GOC:mah] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| angiogenesis | biological process | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453] |
| cell differentiation | biological process | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] |
| symbiont entry into host cell | biological process | The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl] |
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| peptide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:jl] |