Choline O-acetyltransferase

A choline O-acetyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28329]

CHOACTase;
ChAT;
Choline acetylase;
EC 2.3.1.6

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-anilino-8-naphthalenesulfonate	Homo sapiens (human)	Ki	200.0000	1	1
adenosine monophosphate	Homo sapiens (human)	IC50	1,800,000,000.0000	1	1
1-naphthalenesulfonic acid	Homo sapiens (human)	Ki	1,600.0000	1	1
congo red	Homo sapiens (human)	Ki	0.1000	1	1
coenzyme a	Homo sapiens (human)	Ki	75.0000	1	1
5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)	Homo sapiens (human)	Ki	3.0000	1	1
adenosine 3'-phosphate-5'-phosphate	Homo sapiens (human)	IC50	1,800,000,000.0000	1	1
Reactive blue 2	Homo sapiens (human)	Ki	0.8000	1	1
2-anilinonaphthalene-6-sulfonic acid	Homo sapiens (human)	Ki	800.0000	1	1

This protein enables 1 target(s):

Target	Category	Definition
choline O-acetyltransferase activity	molecular function	Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. [EC:2.3.1.6, RHEA:18821]

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

This protein is involved in 4 target(s):

Target	Category	Definition
phosphatidylcholine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [ISBN:0198506732]
neurotransmitter transport	biological process	The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai]
neuromuscular synaptic transmission	biological process	The process of synaptic transmission from a neuron to a muscle, across a synapse. [GOC:dos, GOC:jl, MeSH:D009435]
acetylcholine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. [GOC:jl, ISBN:0192800752]