Somatostatin receptor type 5

A somatostatin receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35346]

Synonyms

SS-5-R;
SS5-R;
SS5R

Research

Bioassay Publications (24)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (4.17)	18.2507
2000's	18 (75.00)	29.6817
2010's	5 (20.83)	24.3611
2020's	0 (0.00)	2.80

Compounds (13)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
astemizole	Homo sapiens (human)	Ki	4.0700	2	2
camptothecin	Homo sapiens (human)	IC50	0.0022	1	1
edotreotide	Homo sapiens (human)	IC50	0.3930	1	1
octreotide	Homo sapiens (human)	IC50	0.0220	1	1
l803087	Homo sapiens (human)	IC50	10.0000	3	3
seglitide	Homo sapiens (human)	IC50	0.0810	1	1
seglitide	Homo sapiens (human)	Ki	0.0126	1	1
lanreotide	Homo sapiens (human)	Ki	0.0040	1	1
l 363301	Homo sapiens (human)	Ki	0.0324	2	2
pasireotide	Homo sapiens (human)	Ki	0.0001	1	1
naluzotan	Homo sapiens (human)	Ki	2.0000	1	1
l 054522	Homo sapiens (human)	Ki	0.1630	1	1
somatostatin	Homo sapiens (human)	IC50	0.0030	6	7
somatostatin	Homo sapiens (human)	Ki	0.0115	9	11

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
obelin	Homo sapiens (human)	Kd	1.7783	1	1
l 363301	Homo sapiens (human)	Kd	0.0076	1	1
somatostatin	Homo sapiens (human)	EC50	0.0001	2	2

Enables

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
neuropeptide binding	molecular function	Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]
somatostatin receptor activity	molecular function	Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). [GOC:ai, GOC:bf, Wikipedia:Somatostatin]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]
negative regulation of cell population proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
positive regulation of cytokinesis	biological process	Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah]
somatostatin signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin]
cellular response to glucocorticoid stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:mah]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]
regulation of insulin secretion	biological process	Any process that modulates the frequency, rate or extent of the regulated release of insulin. [GOC:ai]

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