Proteins > Peroxisome proliferator-activated receptor alpha
Page last updated: 2024-08-07 23:27:51
Peroxisome proliferator-activated receptor alpha
A peroxisome proliferator-activated receptor alpha that is encoded in the genome of rat. [OMA:P37230, PRO:DNx]
Synonyms
PPAR-alpha;
Nuclear receptor subfamily 1 group C member 1
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (9)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lg 100268 | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| lg 1506 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ciprofibrate | Rattus norvegicus (Norway rat) | EC50 | 10.0000 | 1 | 1 |
| fenofibrate | Rattus norvegicus (Norway rat) | EC50 | 29.5000 | 2 | 2 |
| pirinixic acid | Rattus norvegicus (Norway rat) | EC50 | 2.1000 | 1 | 1 |
| fenofibric acid | Rattus norvegicus (Norway rat) | EC50 | 131.3000 | 1 | 1 |
| gw 9578 | Rattus norvegicus (Norway rat) | EC50 | 0.1660 | 1 | 1 |
| aleglitazar | Rattus norvegicus (Norway rat) | EC50 | 2.2600 | 1 | 1 |
| bms 687453 | Rattus norvegicus (Norway rat) | EC50 | 5.3096 | 2 | 5 |
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 17, Issue:24, 2007
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.Journal of medicinal chemistry, , Aug-14, Volume: 46, Issue:17, 2003
Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARĪ± Selective Agonist.ACS medicinal chemistry letters, , Jun-09, Volume: 7, Issue:6, 2016
Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.The Journal of pharmacology and experimental therapeutics, , Volume: 327, Issue:3, 2008