Thioredoxin reductase 1, cytoplasmic

A thioredoxin reductase 1, cytoplasmic that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16881]

Synonyms

TR;
EC 1.8.1.9;
Gene associated with retinoic and interferon-induced mortality 12 protein;
GRIM-12;
Gene associated with retinoic and IFN-induced mortality 12 protein;
KM-102-derived reductase-like factor;
Thioredoxin reductase TR

Research

Bioassay Publications (13)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (38.46)	29.6817
2010's	6 (46.15)	24.3611
2020's	2 (15.38)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
methylene blue	Homo sapiens (human)	IC50	30.0000	1	1
3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene	Homo sapiens (human)	IC50	100.0000	1	1
naphthazarin	Homo sapiens (human)	IC50	20.0000	1	1
2,6-dichloroindophenol	Homo sapiens (human)	IC50	25.0000	1	1
4-aminophenylarsenoxide	Homo sapiens (human)	IC50	4.0000	1	1
tetramethylpyrazine	Homo sapiens (human)	IC50	200.0000	3	3
staurosporine	Homo sapiens (human)	IC50	0.0432	1	1
palmarumycin cp(1)	Homo sapiens (human)	IC50	6.1750	2	2
methylnaphthazarin	Homo sapiens (human)	IC50	2.4000	1	1
piplartine	Homo sapiens (human)	IC50	23.8400	2	2
xanthohumol	Homo sapiens (human)	IC50	40.0000	1	1
curcumin	Homo sapiens (human)	IC50	40.4667	3	3
ellagic acid	Homo sapiens (human)	IC50	176.8000	2	2
(1,2-bis(1,2-benzisoselenazolone-3(2h)-ketone))ethane	Homo sapiens (human)	IC50	5.0000	1	1
flavellagic acid	Homo sapiens (human)	IC50	46.7000	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
methylene blue	Homo sapiens (human)	Km	95.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
thioredoxin-disulfide reductase (NADPH) activity	molecular function	Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. [RHEA:20345]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
NADPH peroxidase activity	molecular function	Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+. [EC:1.11.1.2, RHEA:15173]
FAD binding	molecular function	Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
fibrillar center	cellular component	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
mesoderm formation	biological process	The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:go_curators]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
cell population proliferation	biological process	The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
cellular oxidant detoxification	biological process	Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. [GOC:dos, GOC:vw]
cell redox homeostasis	biological process	Any process that maintains the redox environment of a cell or compartment within a cell. [GOC:ai, GOC:dph, GOC:tb]