Page last updated: 2024-12-10

oxalylglycine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

oxalylglycine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N-oxalylglycine : An amino dicarboxylic acid that is iminodiacetic acid with an oxo substituent. It is used as an inhibitor of alpha-ketoglutarate dependent (EC 1.14.11.*) enzymes. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3080614
CHEMBL ID90852
CHEBI ID44482
SCHEMBL ID435820
MeSH IDM0121617

Synonyms (52)

Synonym
n-carboxymethyl-oxalamic acid (oxaloglycine)(0.5h2o)
chebi:44482 ,
vvw38eb8ys ,
5262-39-5
glycine, n-(carboxycarbonyl)-
unii-vvw38eb8ys
oxaloglycine
chembl90852 ,
[(carboxymethyl)carbamoyl]formic acid
n-oxalyl glycine, 1a
bdbm26106
oxalylglycine
nog ,
n-oxalylglycine
OGA ,
2-(carboxymethylamino)-2-oxoacetic acid
AKOS006273715
148349-03-5
2-oxo-3-azaglutaric acid
n-(carboxycarbonyl)glycine
FT-0635591
148197-49-3
148349-66-0
h protein, drosophila
AB07678
2XML
4IDZ
3HQR
2OQ6
1H2K
SCHEMBL435820
oxaloglycine n-
oxamic acid, (carboxymethyl)-
2-((carboxymethyl)amino)-2-oxoacetic acid
4NRP
DTXSID20200601
D82028
AS-60026
2-(carboxyformamido)acetic acid
n-oxalylglycine, >=98% (hplc)
116998-09-5
pokkuri protein
mfcd00913253
oxamic acid, (carboxymethyl)- (7ci,8ci); n-oxaloglycine; n-oxalylglycine; oxalylglycine
undecyl dodecyl phthalate (technical)
n-(carboxycarbonyl)-glycine
n-oxalyl glycine
A870943
CS-0011055
HY-12315
SY076043
2-[(carboxymethyl)amino]-2-oxoacetic acid

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The purposes of this study were: 1) to analyze the temporal profile of HIF-1α, its downstream effectors VEGF, endothelin-1 (ET-1), iNOS, and glucose transporter 1 (GLUT1), and neuroinflammation in retinas of the murine model of rd10 ( retinal degeneration 10) mice with RP; 2) to study oxygen bioavailability in these retinas; and 3) to investigate how stabilizing HIF-1α proteins with dimethyloxaloglycine (DMOG), a prolyl hydroxylase inhibitor, affects retinal degeneration, neuroinflammation, and antioxidant response in rd10 mice."( HIF-1α stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa.
Hervás, D; Martínez-Fernández de la Cámara, C; Millán, JM; Olivares-González, L; Rodrigo, R, 2018
)
0.48
" This cascade process matches the wound-healing stages, ensuring suitable bioavailability and an effective duration of the active components while minimizing their side effects."( Sequential Anti-Infection and Proangiogenesis of DMOG@ZIF-8/Gelatin-PCL Electrospinning Dressing for Chronic Wound Healing.
Fang, L; Ke, Q; Su, J; Tang, Q; Yin, L; Zhang, X; Zhong, H, 2023
)
0.91

Dosage Studied

ExcerptRelevanceReference
"We show theoretically and experimentally a mechanism behind the emergence of wide or bimodal protein distributions in biochemical networks with nonlinear input-output characteristics (the dose-response curve) and variability in protein abundance."( Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.
Birtwistle, MR; Blanco Fernández, A; Cheong, A; Dobrzyński, M; Kholodenko, BN; Kolch, W; Nguyen, LK; von Kriegsheim, A, 2014
)
0.4
" DMOG given at lower dosage constantly after one week tends to have better effect than the group given at larger dosage in the early stage in this model, and promotes cell proliferation, as evidenced by Ki67 IHC."( PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat.
Arkudas, A; Beier, JP; Bleiziffer, O; Boos, AM; Brandl, A; Horch, RE; Kneser, U; Schmitz, M; Sun, J; Yuan, Q, 2014
)
0.4
" Dose-response studies supported the divergent effects of deferoxamine and dimethyloxalylglycine in RAW 264."( Effect of prolyl hydroxylase inhibitor-loaded collagen barrier membranes on osteoclastogenesis and osteoblastogenesis.
Agis, H; Al-Habbal, D; Edelmayer, M; Janjić, K; Pensch, M, 2017
)
0.68
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitorAn EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the function of any such enzyme using 2-oxoglutarate as one donor and incorporating one atom each of oxygen into both donors (EC 1.14.11.*).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
amino dicarboxylic acid
N-acylglycineAn N-acyl-amino acid in which amino acid specified is glycine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

PathwayProteinsCompounds
superpathway of taurine degradation637
taurine degradation IV116

Protein Targets (22)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Lysine-specific demethylase 4EHomo sapiens (human)IC50 (µMol)89.00000.20001.95696.3096AID1249054; AID1798635
Lysine-specific demethylase 6BHomo sapiens (human)IC50 (µMol)15.38860.01601.66726.9000AID1249069; AID1801992
Kynurenine 3-monooxygenaseHomo sapiens (human)IC50 (µMol)250.00000.03701.06884.2000AID499337
Lysine-specific demethylase 4AHomo sapiens (human)IC50 (µMol)208.75000.20002.83194.7600AID1594434; AID499337; AID639772; AID770458
Lysine-specific demethylase 5AHomo sapiens (human)IC50 (µMol)94.87000.13002.374710.0000AID1234007; AID1801992; AID770457
Lysine-specific demethylase 5CHomo sapiens (human)IC50 (µMol)16.15130.16002.68377.9433AID1249068; AID1801992
Prolyl 4-hydroxylase subunit alpha-1Rattus norvegicus (Norway rat)IC50 (µMol)2.89002.89004.03505.1800AID160198
Prolyl 4-hydroxylase subunit alpha-1Rattus norvegicus (Norway rat)Ki0.54000.54000.67000.8000AID160201
Peptidyl-prolyl cis-trans isomerase A Homo sapiens (human)IC50 (µMol)640.00000.00200.14381.5490AID770457
Methylcytosine dioxygenase TET2Homo sapiens (human)IC50 (µMol)15.50002.27002.27002.2700AID1763202; AID1853069
Lysine-specific demethylase 7AHomo sapiens (human)IC50 (µMol)250.00002.10002.10002.1000AID770453
Prolyl 4-hydroxylaseParamecium bursaria Chlorella virus 1IC50 (µMol)21.20005.00006.26678.5000AID1543452
Prolyl 4-hydroxylaseParamecium bursaria Chlorella virus 1Ki48.74001.07002.17503.2800AID1543452
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)IC50 (µMol)250.00000.02301.41534.2000AID499337
Prolyl hydroxylase EGLN2Homo sapiens (human)IC50 (µMol)1.68070.48001.40442.1000AID499338; AID517384; AID639778
Lysine-specific demethylase 5DHomo sapiens (human)IC50 (µMol)17.06330.16002.43006.9000AID1801992
Alpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)IC50 (µMol)44.00003.00006.10009.8000AID734755
Egl nine homolog 1Homo sapiens (human)IC50 (µMol)14.05000.00701.86148.0000AID1543453; AID440674; AID446353; AID499339; AID639776; AID721523
Egl nine homolog 1Homo sapiens (human)Ki8.00007.00007.66678.0000AID344914; AID604084
Lysine-specific demethylase 4CHomo sapiens (human)IC50 (µMol)141.04380.16002.11489.4000AID1234008; AID1801992; AID499336; AID639774; AID770459
Hypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)IC50 (µMol)46.00008.60008.60008.6000AID1916160
Lysine-specific demethylase 5BHomo sapiens (human)IC50 (µMol)17.80700.16002.36776.9000AID1801992; AID1856596
Histone lysine demethylase PHF8Homo sapiens (human)IC50 (µMol)445.00000.21001.36203.2000AID1234010; AID770460
Lysine-specific demethylase 2AHomo sapiens (human)IC50 (µMol)22.60810.16002.45966.9000AID1249066; AID1801992; AID770454
Lysine-specific demethylase 3AHomo sapiens (human)IC50 (µMol)65.86960.15852.39307.9433AID1234009; AID1249065; AID1801992
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Egl nine homolog 1Homo sapiens (human)Kd2.90000.42001.95863.4000AID446352; AID446354; AID446355; AID446356; AID721520; AID721525
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (148)

Processvia Protein(s)Taxonomy
regulation of gene expressionLysine-specific demethylase 4EHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 4EHomo sapiens (human)
inflammatory response to antigenic stimulusLysine-specific demethylase 6BHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 6BHomo sapiens (human)
response to activityLysine-specific demethylase 6BHomo sapiens (human)
hippocampus developmentLysine-specific demethylase 6BHomo sapiens (human)
cell fate commitmentLysine-specific demethylase 6BHomo sapiens (human)
endothelial cell differentiationLysine-specific demethylase 6BHomo sapiens (human)
positive regulation of transcription by RNA polymerase IILysine-specific demethylase 6BHomo sapiens (human)
mesodermal cell differentiationLysine-specific demethylase 6BHomo sapiens (human)
cardiac muscle cell differentiationLysine-specific demethylase 6BHomo sapiens (human)
response to fungicideLysine-specific demethylase 6BHomo sapiens (human)
cellular response to hydrogen peroxideLysine-specific demethylase 6BHomo sapiens (human)
positive regulation of cold-induced thermogenesisLysine-specific demethylase 6BHomo sapiens (human)
heart developmentLysine-specific demethylase 6BHomo sapiens (human)
regulation of gene expressionLysine-specific demethylase 6BHomo sapiens (human)
tryptophan catabolic processKynurenine 3-monooxygenaseHomo sapiens (human)
response to salt stressKynurenine 3-monooxygenaseHomo sapiens (human)
NAD metabolic processKynurenine 3-monooxygenaseHomo sapiens (human)
quinolinate biosynthetic processKynurenine 3-monooxygenaseHomo sapiens (human)
kynurenic acid biosynthetic processKynurenine 3-monooxygenaseHomo sapiens (human)
'de novo' NAD biosynthetic process from tryptophanKynurenine 3-monooxygenaseHomo sapiens (human)
anthranilate metabolic processKynurenine 3-monooxygenaseHomo sapiens (human)
kynurenine metabolic processKynurenine 3-monooxygenaseHomo sapiens (human)
cellular response to lipopolysaccharideKynurenine 3-monooxygenaseHomo sapiens (human)
cellular response to interleukin-1Kynurenine 3-monooxygenaseHomo sapiens (human)
L-kynurenine metabolic processKynurenine 3-monooxygenaseHomo sapiens (human)
positive regulation of glutamate secretion, neurotransmissionKynurenine 3-monooxygenaseHomo sapiens (human)
negative regulation of autophagyLysine-specific demethylase 4AHomo sapiens (human)
positive regulation of gene expressionLysine-specific demethylase 4AHomo sapiens (human)
negative regulation of gene expressionLysine-specific demethylase 4AHomo sapiens (human)
cardiac muscle hypertrophy in response to stressLysine-specific demethylase 4AHomo sapiens (human)
apoptotic chromosome condensationLysine-specific demethylase 4AHomo sapiens (human)
response to nutrient levelsLysine-specific demethylase 4AHomo sapiens (human)
positive regulation of neuron differentiationLysine-specific demethylase 4AHomo sapiens (human)
negative regulation of DNA-templated transcriptionLysine-specific demethylase 4AHomo sapiens (human)
negative regulation of astrocyte differentiationLysine-specific demethylase 4AHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 4AHomo sapiens (human)
regulation of gene expressionLysine-specific demethylase 4AHomo sapiens (human)
negative regulation of transcription by RNA polymerase IILysine-specific demethylase 5AHomo sapiens (human)
circadian regulation of gene expressionLysine-specific demethylase 5AHomo sapiens (human)
positive regulation of DNA-templated transcriptionLysine-specific demethylase 5AHomo sapiens (human)
regulation of DNA-binding transcription factor activityLysine-specific demethylase 5AHomo sapiens (human)
facultative heterochromatin formationLysine-specific demethylase 5AHomo sapiens (human)
regulation of DNA-templated transcriptionLysine-specific demethylase 5AHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 5AHomo sapiens (human)
response to toxic substanceLysine-specific demethylase 5CHomo sapiens (human)
negative regulation of DNA-templated transcriptionLysine-specific demethylase 5CHomo sapiens (human)
rhythmic processLysine-specific demethylase 5CHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 5CHomo sapiens (human)
regulation of DNA-templated transcriptionLysine-specific demethylase 5CHomo sapiens (human)
protein peptidyl-prolyl isomerizationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
negative regulation of protein phosphorylationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
positive regulation of protein phosphorylationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
protein foldingPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
negative regulation of protein kinase activityPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
apoptotic processPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
viral release from host cellPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
platelet activationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
neuron differentiationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
neutrophil chemotaxisPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
leukocyte chemotaxisPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
activation of protein kinase B activityPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
negative regulation of stress-activated MAPK cascadePeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
lipid droplet organizationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
cellular response to oxidative stressPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
positive regulation of protein dephosphorylationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
endothelial cell activationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
positive regulation of MAPK cascadePeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
regulation of viral genome replicationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
positive regulation of viral genome replicationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
positive regulation of protein secretionPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activityPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
cell adhesion molecule productionPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
negative regulation of protein K48-linked ubiquitinationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
platelet aggregationPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
negative regulation of viral life cyclePeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
regulation of apoptotic signaling pathwayPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
leukocyte differentiationMethylcytosine dioxygenase TET2Homo sapiens (human)
5-methylcytosine catabolic processMethylcytosine dioxygenase TET2Homo sapiens (human)
protein O-linked glycosylationMethylcytosine dioxygenase TET2Homo sapiens (human)
response to organic cyclic compoundMethylcytosine dioxygenase TET2Homo sapiens (human)
myeloid cell differentiationMethylcytosine dioxygenase TET2Homo sapiens (human)
positive regulation of gene expression via chromosomal CpG island demethylationMethylcytosine dioxygenase TET2Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIMethylcytosine dioxygenase TET2Homo sapiens (human)
DNA demethylationMethylcytosine dioxygenase TET2Homo sapiens (human)
chromatin remodelingLysine-specific demethylase 7AHomo sapiens (human)
midbrain developmentLysine-specific demethylase 7AHomo sapiens (human)
positive regulation of DNA-templated transcriptionLysine-specific demethylase 7AHomo sapiens (human)
regulation of transcription by RNA polymerase IILysine-specific demethylase 7AHomo sapiens (human)
protein demethylationLysine-specific demethylase 7AHomo sapiens (human)
2-oxoglutarate metabolic processKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
glutamate metabolic processKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
biosynthetic processKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
L-lysine catabolic process to acetyl-CoA via saccharopineKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
kynurenine metabolic processKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
L-kynurenine metabolic processKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
alpha-amino acid metabolic processKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
regulation of cell growthProlyl hydroxylase EGLN2Homo sapiens (human)
response to hypoxiaProlyl hydroxylase EGLN2Homo sapiens (human)
peptidyl-proline hydroxylation to 4-hydroxy-L-prolineProlyl hydroxylase EGLN2Homo sapiens (human)
intracellular estrogen receptor signaling pathwayProlyl hydroxylase EGLN2Homo sapiens (human)
regulation of neuron apoptotic processProlyl hydroxylase EGLN2Homo sapiens (human)
cell redox homeostasisProlyl hydroxylase EGLN2Homo sapiens (human)
positive regulation of protein catabolic processProlyl hydroxylase EGLN2Homo sapiens (human)
cellular response to hypoxiaProlyl hydroxylase EGLN2Homo sapiens (human)
T cell antigen processing and presentationLysine-specific demethylase 5DHomo sapiens (human)
regulation of androgen receptor signaling pathwayLysine-specific demethylase 5DHomo sapiens (human)
regulation of DNA-templated transcriptionLysine-specific demethylase 5DHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 5DHomo sapiens (human)
temperature homeostasisAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
DNA alkylation repairAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
regulation of lipid storageAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
snRNA processingAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
regulation of multicellular organism growthAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
RNA repairAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
regulation of respiratory system processAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
adipose tissue developmentAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
mRNA destabilizationAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
regulation of white fat cell proliferationAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
regulation of brown fat cell differentiationAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
response to hypoxiaEgl nine homolog 1Homo sapiens (human)
intracellular iron ion homeostasisEgl nine homolog 1Homo sapiens (human)
intracellular oxygen homeostasisEgl nine homolog 1Homo sapiens (human)
negative regulation of DNA-binding transcription factor activityEgl nine homolog 1Homo sapiens (human)
regulation of angiogenesisEgl nine homolog 1Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIEgl nine homolog 1Homo sapiens (human)
negative regulation of cyclic-nucleotide phosphodiesterase activityEgl nine homolog 1Homo sapiens (human)
cardiac muscle tissue morphogenesisEgl nine homolog 1Homo sapiens (human)
heart trabecula formationEgl nine homolog 1Homo sapiens (human)
ventricular septum morphogenesisEgl nine homolog 1Homo sapiens (human)
labyrinthine layer developmentEgl nine homolog 1Homo sapiens (human)
response to nitric oxideEgl nine homolog 1Homo sapiens (human)
regulation of modification of postsynaptic structureEgl nine homolog 1Homo sapiens (human)
regulation protein catabolic process at postsynapseEgl nine homolog 1Homo sapiens (human)
peptidyl-proline hydroxylation to 4-hydroxy-L-prolineEgl nine homolog 1Homo sapiens (human)
cellular response to hypoxiaEgl nine homolog 1Homo sapiens (human)
blastocyst formationLysine-specific demethylase 4CHomo sapiens (human)
positive regulation of cell population proliferationLysine-specific demethylase 4CHomo sapiens (human)
stem cell population maintenanceLysine-specific demethylase 4CHomo sapiens (human)
androgen receptor signaling pathwayLysine-specific demethylase 4CHomo sapiens (human)
positive regulation of transcription by RNA polymerase IILysine-specific demethylase 4CHomo sapiens (human)
regulation of androgen receptor signaling pathwayLysine-specific demethylase 4CHomo sapiens (human)
regulation of stem cell differentiationLysine-specific demethylase 4CHomo sapiens (human)
regulation of gene expressionLysine-specific demethylase 4CHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 4CHomo sapiens (human)
positive regulation of myoblast differentiationHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
negative regulation of Notch signaling pathwayHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
negative regulation of DNA-templated transcriptionHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
positive regulation of vasculogenesisHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
single fertilizationLysine-specific demethylase 5BHomo sapiens (human)
post-embryonic developmentLysine-specific demethylase 5BHomo sapiens (human)
positive regulation of gene expressionLysine-specific demethylase 5BHomo sapiens (human)
positive regulation of mammary gland epithelial cell proliferationLysine-specific demethylase 5BHomo sapiens (human)
cellular response to fibroblast growth factor stimulusLysine-specific demethylase 5BHomo sapiens (human)
negative regulation of DNA-templated transcriptionLysine-specific demethylase 5BHomo sapiens (human)
rhythmic processLysine-specific demethylase 5BHomo sapiens (human)
branching involved in mammary gland duct morphogenesisLysine-specific demethylase 5BHomo sapiens (human)
mammary duct terminal end bud growthLysine-specific demethylase 5BHomo sapiens (human)
response to fungicideLysine-specific demethylase 5BHomo sapiens (human)
uterus morphogenesisLysine-specific demethylase 5BHomo sapiens (human)
lens fiber cell differentiationLysine-specific demethylase 5BHomo sapiens (human)
cellular response to leukemia inhibitory factorLysine-specific demethylase 5BHomo sapiens (human)
regulation of estradiol secretionLysine-specific demethylase 5BHomo sapiens (human)
regulation of DNA-templated transcriptionLysine-specific demethylase 5BHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 5BHomo sapiens (human)
G1/S transition of mitotic cell cycleHistone lysine demethylase PHF8Homo sapiens (human)
chromatin remodelingHistone lysine demethylase PHF8Homo sapiens (human)
brain developmentHistone lysine demethylase PHF8Homo sapiens (human)
positive regulation of DNA-templated transcriptionHistone lysine demethylase PHF8Homo sapiens (human)
positive regulation of transcription by RNA polymerase IHistone lysine demethylase PHF8Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIHistone lysine demethylase PHF8Homo sapiens (human)
negative regulation of rDNA heterochromatin formationHistone lysine demethylase PHF8Homo sapiens (human)
regulation of transcription by RNA polymerase IIHistone lysine demethylase PHF8Homo sapiens (human)
protein demethylationHistone lysine demethylase PHF8Homo sapiens (human)
double-strand break repair via nonhomologous end joiningLysine-specific demethylase 2AHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 2AHomo sapiens (human)
negative regulation of transcription by competitive promoter bindingLysine-specific demethylase 2AHomo sapiens (human)
circadian regulation of gene expressionLysine-specific demethylase 2AHomo sapiens (human)
regulation of circadian rhythmLysine-specific demethylase 2AHomo sapiens (human)
protein demethylationLysine-specific demethylase 2AHomo sapiens (human)
regulation of transcription by RNA polymerase IILysine-specific demethylase 2AHomo sapiens (human)
chromatin remodelingLysine-specific demethylase 3AHomo sapiens (human)
spermatid nucleus elongationLysine-specific demethylase 3AHomo sapiens (human)
hormone-mediated signaling pathwayLysine-specific demethylase 3AHomo sapiens (human)
androgen receptor signaling pathwayLysine-specific demethylase 3AHomo sapiens (human)
positive regulation of DNA-templated transcriptionLysine-specific demethylase 3AHomo sapiens (human)
positive regulation of transcription by RNA polymerase IILysine-specific demethylase 3AHomo sapiens (human)
formaldehyde biosynthetic processLysine-specific demethylase 3AHomo sapiens (human)
positive regulation of cold-induced thermogenesisLysine-specific demethylase 3AHomo sapiens (human)
cellular response to leukemia inhibitory factorLysine-specific demethylase 3AHomo sapiens (human)
regulation of stem cell population maintenanceLysine-specific demethylase 3AHomo sapiens (human)
regulation of stem cell differentiationLysine-specific demethylase 3AHomo sapiens (human)
regulation of transcription by RNA polymerase IILysine-specific demethylase 3AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (73)

Processvia Protein(s)Taxonomy
metal ion bindingLysine-specific demethylase 4EHomo sapiens (human)
histone H3K9me2/H3K9me3 demethylase activityLysine-specific demethylase 4EHomo sapiens (human)
histone H3K9 demethylase activityLysine-specific demethylase 4EHomo sapiens (human)
protein bindingLysine-specific demethylase 6BHomo sapiens (human)
beta-catenin bindingLysine-specific demethylase 6BHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 6BHomo sapiens (human)
metal ion bindingLysine-specific demethylase 6BHomo sapiens (human)
histone H3K27me2/H3K27me3 demethylase activityLysine-specific demethylase 6BHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingLysine-specific demethylase 6BHomo sapiens (human)
chromatin DNA bindingLysine-specific demethylase 6BHomo sapiens (human)
kynurenine 3-monooxygenase activityKynurenine 3-monooxygenaseHomo sapiens (human)
NAD(P)H oxidase H2O2-forming activityKynurenine 3-monooxygenaseHomo sapiens (human)
flavin adenine dinucleotide bindingKynurenine 3-monooxygenaseHomo sapiens (human)
FAD bindingKynurenine 3-monooxygenaseHomo sapiens (human)
protein bindingLysine-specific demethylase 4AHomo sapiens (human)
zinc ion bindingLysine-specific demethylase 4AHomo sapiens (human)
ubiquitin protein ligase bindingLysine-specific demethylase 4AHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 4AHomo sapiens (human)
methylated histone bindingLysine-specific demethylase 4AHomo sapiens (human)
histone H3K36 demethylase activityLysine-specific demethylase 4AHomo sapiens (human)
histone H3K36me2/H3K36me3 demethylase activityLysine-specific demethylase 4AHomo sapiens (human)
histone H3K9me2/H3K9me3 demethylase activityLysine-specific demethylase 4AHomo sapiens (human)
histone H3K9 demethylase activityLysine-specific demethylase 4AHomo sapiens (human)
transcription cis-regulatory region bindingLysine-specific demethylase 5AHomo sapiens (human)
DNA bindingLysine-specific demethylase 5AHomo sapiens (human)
transcription coactivator activityLysine-specific demethylase 5AHomo sapiens (human)
enzyme inhibitor activityLysine-specific demethylase 5AHomo sapiens (human)
protein bindingLysine-specific demethylase 5AHomo sapiens (human)
zinc ion bindingLysine-specific demethylase 5AHomo sapiens (human)
chromatin DNA bindingLysine-specific demethylase 5AHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 5AHomo sapiens (human)
histone H3K4me/H3K4me2/H3K4me3 demethylase activityLysine-specific demethylase 5AHomo sapiens (human)
methylated histone bindingLysine-specific demethylase 5AHomo sapiens (human)
histone bindingLysine-specific demethylase 5AHomo sapiens (human)
DNA bindingLysine-specific demethylase 5CHomo sapiens (human)
protein bindingLysine-specific demethylase 5CHomo sapiens (human)
zinc ion bindingLysine-specific demethylase 5CHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 5CHomo sapiens (human)
histone H3K4 demethylase activityLysine-specific demethylase 5CHomo sapiens (human)
histone H3K4me/H3K4me2/H3K4me3 demethylase activityLysine-specific demethylase 5CHomo sapiens (human)
RNA bindingPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
peptidyl-prolyl cis-trans isomerase activityPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
integrin bindingPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
protein bindingPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
cyclosporin A bindingPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
virion bindingPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
unfolded protein bindingPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
heparan sulfate bindingPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
DNA bindingMethylcytosine dioxygenase TET2Homo sapiens (human)
protein bindingMethylcytosine dioxygenase TET2Homo sapiens (human)
ferrous iron bindingMethylcytosine dioxygenase TET2Homo sapiens (human)
zinc ion bindingMethylcytosine dioxygenase TET2Homo sapiens (human)
5-methylcytosine dioxygenase activityMethylcytosine dioxygenase TET2Homo sapiens (human)
iron ion bindingLysine-specific demethylase 7AHomo sapiens (human)
zinc ion bindingLysine-specific demethylase 7AHomo sapiens (human)
2-oxoglutarate-dependent dioxygenase activityLysine-specific demethylase 7AHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 7AHomo sapiens (human)
histone H3K9 demethylase activityLysine-specific demethylase 7AHomo sapiens (human)
methylated histone bindingLysine-specific demethylase 7AHomo sapiens (human)
histone H4K20 demethylase activityLysine-specific demethylase 7AHomo sapiens (human)
histone H3K36 demethylase activityLysine-specific demethylase 7AHomo sapiens (human)
histone H3K27me2/H3K27me3 demethylase activityLysine-specific demethylase 7AHomo sapiens (human)
histone H3K9me/H3K9me2 demethylase activityLysine-specific demethylase 7AHomo sapiens (human)
transcription coregulator activityLysine-specific demethylase 7AHomo sapiens (human)
kynurenine-oxoglutarate transaminase activityKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
pyridoxal phosphate bindingKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
protein homodimerization activityKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
kynurenine-glyoxylate transaminase activityKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
2-aminoadipate transaminase activityKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
glycine:2-oxoglutarate aminotransferase activityKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
methionine-glyoxylate transaminase activityKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
protein bindingProlyl hydroxylase EGLN2Homo sapiens (human)
ferrous iron bindingProlyl hydroxylase EGLN2Homo sapiens (human)
2-oxoglutarate-dependent dioxygenase activityProlyl hydroxylase EGLN2Homo sapiens (human)
oxygen sensor activityProlyl hydroxylase EGLN2Homo sapiens (human)
L-ascorbic acid bindingProlyl hydroxylase EGLN2Homo sapiens (human)
peptidyl-proline 4-dioxygenase activityProlyl hydroxylase EGLN2Homo sapiens (human)
hypoxia-inducible factor-proline dioxygenase activityProlyl hydroxylase EGLN2Homo sapiens (human)
DNA bindingLysine-specific demethylase 5DHomo sapiens (human)
protein bindingLysine-specific demethylase 5DHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 5DHomo sapiens (human)
histone H3K4 demethylase activityLysine-specific demethylase 5DHomo sapiens (human)
metal ion bindingLysine-specific demethylase 5DHomo sapiens (human)
nuclear androgen receptor bindingLysine-specific demethylase 5DHomo sapiens (human)
histone H3K4me/H3K4me2/H3K4me3 demethylase activityLysine-specific demethylase 5DHomo sapiens (human)
ferrous iron bindingAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
transferase activityAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
oxidative RNA demethylase activityAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
broad specificity oxidative DNA demethylase activityAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
mRNA N6-methyladenosine dioxygenase activityAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
tRNA demethylase activityAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
protein bindingEgl nine homolog 1Homo sapiens (human)
ferrous iron bindingEgl nine homolog 1Homo sapiens (human)
2-oxoglutarate-dependent dioxygenase activityEgl nine homolog 1Homo sapiens (human)
enzyme bindingEgl nine homolog 1Homo sapiens (human)
L-ascorbic acid bindingEgl nine homolog 1Homo sapiens (human)
peptidyl-proline dioxygenase activityEgl nine homolog 1Homo sapiens (human)
hypoxia-inducible factor-proline dioxygenase activityEgl nine homolog 1Homo sapiens (human)
peptidyl-proline 4-dioxygenase activityEgl nine homolog 1Homo sapiens (human)
histone H3K9me2/H3K9me3 demethylase activityLysine-specific demethylase 4CHomo sapiens (human)
zinc ion bindingLysine-specific demethylase 4CHomo sapiens (human)
enzyme bindingLysine-specific demethylase 4CHomo sapiens (human)
nuclear receptor coactivator activityLysine-specific demethylase 4CHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 4CHomo sapiens (human)
histone H3K9 demethylase activityLysine-specific demethylase 4CHomo sapiens (human)
nuclear androgen receptor bindingLysine-specific demethylase 4CHomo sapiens (human)
histone H3K36 demethylase activityLysine-specific demethylase 4CHomo sapiens (human)
H3K9me3 modified histone bindingLysine-specific demethylase 4CHomo sapiens (human)
histone H3K9me2/H3K9me3 demethylase activityLysine-specific demethylase 4CHomo sapiens (human)
transcription corepressor activityHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
Notch bindingHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
protein bindingHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
ferrous iron bindingHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
zinc ion bindingHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
oxygen sensor activityHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
carboxylic acid bindingHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
peptidyl-histidine dioxygenase activityHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
[protein]-asparagine 3-dioxygenase activityHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
protein homodimerization activityHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
NF-kappaB bindingHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
peptidyl-aspartic acid 3-dioxygenase activityHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
ankyrin repeat bindingHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
nucleic acid bindingLysine-specific demethylase 5BHomo sapiens (human)
DNA bindingLysine-specific demethylase 5BHomo sapiens (human)
transcription corepressor activityLysine-specific demethylase 5BHomo sapiens (human)
protein bindingLysine-specific demethylase 5BHomo sapiens (human)
zinc ion bindingLysine-specific demethylase 5BHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 5BHomo sapiens (human)
histone H3K4 demethylase activityLysine-specific demethylase 5BHomo sapiens (human)
histone H3K4me/H3K4me2/H3K4me3 demethylase activityLysine-specific demethylase 5BHomo sapiens (human)
histone bindingLysine-specific demethylase 5BHomo sapiens (human)
sequence-specific double-stranded DNA bindingLysine-specific demethylase 5BHomo sapiens (human)
chromatin bindingHistone lysine demethylase PHF8Homo sapiens (human)
iron ion bindingHistone lysine demethylase PHF8Homo sapiens (human)
protein bindingHistone lysine demethylase PHF8Homo sapiens (human)
zinc ion bindingHistone lysine demethylase PHF8Homo sapiens (human)
2-oxoglutarate-dependent dioxygenase activityHistone lysine demethylase PHF8Homo sapiens (human)
histone demethylase activityHistone lysine demethylase PHF8Homo sapiens (human)
histone H3K9 demethylase activityHistone lysine demethylase PHF8Homo sapiens (human)
methylated histone bindingHistone lysine demethylase PHF8Homo sapiens (human)
histone H4K20 demethylase activityHistone lysine demethylase PHF8Homo sapiens (human)
histone H3K36 demethylase activityHistone lysine demethylase PHF8Homo sapiens (human)
histone H3K27me2/H3K27me3 demethylase activityHistone lysine demethylase PHF8Homo sapiens (human)
histone H3K36me/H3K36me2 demethylase activityHistone lysine demethylase PHF8Homo sapiens (human)
histone H3K9me/H3K9me2 demethylase activityHistone lysine demethylase PHF8Homo sapiens (human)
transcription coregulator activityHistone lysine demethylase PHF8Homo sapiens (human)
protein bindingLysine-specific demethylase 2AHomo sapiens (human)
zinc ion bindingLysine-specific demethylase 2AHomo sapiens (human)
histone demethylase activityLysine-specific demethylase 2AHomo sapiens (human)
unmethylated CpG bindingLysine-specific demethylase 2AHomo sapiens (human)
histone H3K36 demethylase activityLysine-specific demethylase 2AHomo sapiens (human)
histone H3K36me/H3K36me2 demethylase activityLysine-specific demethylase 2AHomo sapiens (human)
transcription coregulator activityLysine-specific demethylase 2AHomo sapiens (human)
iron ion bindingLysine-specific demethylase 3AHomo sapiens (human)
protein bindingLysine-specific demethylase 3AHomo sapiens (human)
histone H3K9 demethylase activityLysine-specific demethylase 3AHomo sapiens (human)
nuclear androgen receptor bindingLysine-specific demethylase 3AHomo sapiens (human)
histone H3K9me/H3K9me2 demethylase activityLysine-specific demethylase 3AHomo sapiens (human)
transcription coregulator activityLysine-specific demethylase 3AHomo sapiens (human)
chromatin DNA bindingLysine-specific demethylase 3AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (30)

Processvia Protein(s)Taxonomy
nucleusLysine-specific demethylase 4EHomo sapiens (human)
nucleoplasmLysine-specific demethylase 4EHomo sapiens (human)
chromatinLysine-specific demethylase 4EHomo sapiens (human)
nucleusLysine-specific demethylase 4EHomo sapiens (human)
nucleusLysine-specific demethylase 6BHomo sapiens (human)
nucleoplasmLysine-specific demethylase 6BHomo sapiens (human)
MLL3/4 complexLysine-specific demethylase 6BHomo sapiens (human)
extracellular spaceKynurenine 3-monooxygenaseHomo sapiens (human)
mitochondrial outer membraneKynurenine 3-monooxygenaseHomo sapiens (human)
cytosolKynurenine 3-monooxygenaseHomo sapiens (human)
mitochondrial outer membraneKynurenine 3-monooxygenaseHomo sapiens (human)
fibrillar centerLysine-specific demethylase 4AHomo sapiens (human)
nucleusLysine-specific demethylase 4AHomo sapiens (human)
nucleoplasmLysine-specific demethylase 4AHomo sapiens (human)
cytosolLysine-specific demethylase 4AHomo sapiens (human)
pericentric heterochromatinLysine-specific demethylase 4AHomo sapiens (human)
nucleusLysine-specific demethylase 4AHomo sapiens (human)
chromatinLysine-specific demethylase 4AHomo sapiens (human)
nucleusLysine-specific demethylase 5AHomo sapiens (human)
nucleoplasmLysine-specific demethylase 5AHomo sapiens (human)
nucleolusLysine-specific demethylase 5AHomo sapiens (human)
nucleusLysine-specific demethylase 5AHomo sapiens (human)
chromatinLysine-specific demethylase 5AHomo sapiens (human)
nucleusLysine-specific demethylase 5CHomo sapiens (human)
nucleoplasmLysine-specific demethylase 5CHomo sapiens (human)
cytosolLysine-specific demethylase 5CHomo sapiens (human)
nucleusLysine-specific demethylase 5CHomo sapiens (human)
chromatinLysine-specific demethylase 5CHomo sapiens (human)
extracellular regionPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
extracellular spacePeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
nucleusPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
cytoplasmPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
cytosolPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
focal adhesionPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
membranePeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
vesiclePeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
secretory granule lumenPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
extracellular exosomePeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
ficolin-1-rich granule lumenPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
protein-containing complexPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
cytoplasmPeptidyl-prolyl cis-trans isomerase A Homo sapiens (human)
nucleoplasmMethylcytosine dioxygenase TET2Homo sapiens (human)
chromosomeMethylcytosine dioxygenase TET2Homo sapiens (human)
nucleusMethylcytosine dioxygenase TET2Homo sapiens (human)
nucleusLysine-specific demethylase 7AHomo sapiens (human)
nucleoplasmLysine-specific demethylase 7AHomo sapiens (human)
nucleolusLysine-specific demethylase 7AHomo sapiens (human)
mitochondrial matrixKynurenine/alpha-aminoadipate aminotransferase, mitochondrialHomo sapiens (human)
nucleusProlyl hydroxylase EGLN2Homo sapiens (human)
nucleoplasmProlyl hydroxylase EGLN2Homo sapiens (human)
nucleusProlyl hydroxylase EGLN2Homo sapiens (human)
cytoplasmProlyl hydroxylase EGLN2Homo sapiens (human)
fibrillar centerLysine-specific demethylase 5DHomo sapiens (human)
nucleoplasmLysine-specific demethylase 5DHomo sapiens (human)
chromatinLysine-specific demethylase 5DHomo sapiens (human)
nucleusLysine-specific demethylase 5DHomo sapiens (human)
nucleusAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
nucleoplasmAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
cytoplasmAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
cytosolAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
plasma membraneAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
nuclear speckAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
intracellular membrane-bounded organelleAlpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)
cytoplasmEgl nine homolog 1Homo sapiens (human)
cytosolEgl nine homolog 1Homo sapiens (human)
postsynaptic densityEgl nine homolog 1Homo sapiens (human)
intracellular membrane-bounded organelleEgl nine homolog 1Homo sapiens (human)
glutamatergic synapseEgl nine homolog 1Homo sapiens (human)
nucleusEgl nine homolog 1Homo sapiens (human)
cytoplasmEgl nine homolog 1Homo sapiens (human)
nucleoplasmLysine-specific demethylase 4CHomo sapiens (human)
chromatinLysine-specific demethylase 4CHomo sapiens (human)
pericentric heterochromatinLysine-specific demethylase 4CHomo sapiens (human)
nucleusLysine-specific demethylase 4CHomo sapiens (human)
nucleusHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
nucleoplasmHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
cytoplasmHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
cytosolHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
perinuclear region of cytoplasmHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
cytoplasmHypoxia-inducible factor 1-alpha inhibitorHomo sapiens (human)
nucleusLysine-specific demethylase 5BHomo sapiens (human)
nucleoplasmLysine-specific demethylase 5BHomo sapiens (human)
cytosolLysine-specific demethylase 5BHomo sapiens (human)
nucleusLysine-specific demethylase 5BHomo sapiens (human)
chromatinLysine-specific demethylase 5BHomo sapiens (human)
nucleusHistone lysine demethylase PHF8Homo sapiens (human)
nucleoplasmHistone lysine demethylase PHF8Homo sapiens (human)
nucleolusHistone lysine demethylase PHF8Homo sapiens (human)
nuclear membraneHistone lysine demethylase PHF8Homo sapiens (human)
nucleoplasmLysine-specific demethylase 2AHomo sapiens (human)
chromosomeLysine-specific demethylase 2AHomo sapiens (human)
male germ cell nucleusLysine-specific demethylase 3AHomo sapiens (human)
nucleusLysine-specific demethylase 3AHomo sapiens (human)
nucleoplasmLysine-specific demethylase 3AHomo sapiens (human)
cytoplasmLysine-specific demethylase 3AHomo sapiens (human)
membraneLysine-specific demethylase 3AHomo sapiens (human)
histone deacetylase complexLysine-specific demethylase 3AHomo sapiens (human)
chromatinLysine-specific demethylase 3AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (81)

Assay IDTitleYearJournalArticle
AID426464Inhibition of JMJD2D-mediated H3K9 demethylation activity at 3 mM2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
AID446353Inhibition of human PHD2 at 293K temperature by solvent relaxation technique2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
AID734755Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as inhibition of 3-methylthymidine conversion to thymidine after 1 hr by liquid chromatographic analysis2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
Structural basis for inhibition of the fat mass and obesity associated protein (FTO).
AID499337Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
AID770457Inhibition of KDM5A (unknown origin) using H3K4me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assay2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
AID1249065Inhibition of KDM3A (unknown origin)2014MedChemComm, Dec-01, Volume: 5, Issue:12
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
AID1543452Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-incubated for 5 mins before 2OG as substrate and Fe2 as co-factor addition in presence of L-ascorbate and me2019Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
Inhibition of a viral prolyl hydroxylase.
AID446352Binding affinity to human PHD2 by nondenaturing ESI-MS2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
AID721528Displacement of 2OG from FIH (unknown origin) expressed in Escherichia coli at 400 uM2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID426465Inhibition of JMJD2D-mediated H3K9 demethylation activity at 1 mM2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
AID639778Inhibition of PHD12011Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
Lysine demethylases inhibitors.
AID770459Inhibition of KDM4C (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assay2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
AID1234008Inhibition of JMJD2C (unknown origin) using H3K9mel peptide2015ACS medicinal chemistry letters, Jun-11, Volume: 6, Issue:6
Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.
AID721523Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID499336Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
AID1543453Inhibition of recombinant human PHD2 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-ascorbate by LC-MS analysis2019Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
Inhibition of a viral prolyl hydroxylase.
AID344918Inhibition of 2-oxoglutarate-dependent human JMJD2E preincubated for 30 mins by FDH coupled assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
AID1916160Inhibition of FIH (unknown origin) assessed as hydroxylation of HIF1alphaCAD by MALDI-TOF-MS analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
AID1230198Inhibition of N-terminal hexa-histidine tagged human PHD2 (181 to 426 amino acids) at 10 uM pre-incubated for 2 mins followed by alpha-ketoglutarate addition using HIF1alpha peptide (556 to 574 amino acids) and 50 uM FeSO4 by RP-HPLC method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates.
AID770458Inhibition of KDM4A (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assay2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
AID440674Inhibition of human PHD2 catalytic domain (181-426) by FRET assay2009Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
AID721524Binding affinity to human FIH catalytic domain Mn2 expressed in Escherichia coli by NMR spectroscopic analysis2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID1249068Inhibition of KDM5C (unknown origin)2014MedChemComm, Dec-01, Volume: 5, Issue:12
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
AID770450Growth inhibition of human HeLa cells after 48 hrs by MTT assay2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
AID1234007Inhibition of JARID1A (unknown origin) using biotinylated H3K9mel peptide after 60 mins by Alpha screen assay2015ACS medicinal chemistry letters, Jun-11, Volume: 6, Issue:6
Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.
AID446354Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
AID639774Inhibition of KDM4C2011Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
Lysine demethylases inhibitors.
AID499340Selectivity ratio of IC50 for recombinant His-tagged JMJD2A to IC50 for recombinant His-tagged JMJD2C2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
AID446356Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
AID1249069Inhibition of KDM6B (unknown origin)2014MedChemComm, Dec-01, Volume: 5, Issue:12
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
AID661346Inhibition of Escherichia coli AlkB deltaN11 mutant using 5'-TTCmTTTTTTTTTTTT-3'-fluorescein as substrate after 4.5 mins by capillary electrophoresis-based laser-induced fluorescence assay2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
AID604084Inhibition of human PHD22011Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
Inhibitors of histone demethylases.
AID1853069Inhibition of N-terminal His6-tagged TET2 (unknown origin) expressed in Escherichia coli assessed as reduction in 5-methylcytosine oxidation by measuring 5-carboxylcytosine level by FRET assay2022RSC medicinal chemistry, Dec-14, Volume: 13, Issue:12
A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2.
AID426472Inhibition of JMJD2A-mediated H3K9 demethylation activity at 1 mM2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
AID1234010Inhibition of JHDM1F (unknown origin) using H3K9mel peptide2015ACS medicinal chemistry letters, Jun-11, Volume: 6, Issue:6
Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.
AID344917Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess H3K9me3 peptide and 10 uM Fe2 by FDH coupled assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
AID1810106Inhibition of recombinant human MINA53 expressed in Escherichia coli BL21 (DE3) using RPL27A G31RGNAGGLHHHRINFDKYHP49 as substrate preincubated for 15 mins followed by substrate addition and measured after 30 to 60 mins by RapidFire Mass spectrometry assa2021Journal of medicinal chemistry, 12-09, Volume: 64, Issue:23
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
AID639772Inhibition of KDM4A2011Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
Lysine demethylases inhibitors.
AID721520Displacement of [13C]-2OG from catalytic domain of PHD2 (181 to 426) (unknown origin) expressed in Escherichia coli2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID721529Displacement of 2OG from catalytic domain of PHD2 (181 to 426) (unknown origin) expressed in Escherichia coli at 400 uM2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID721525Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID344916Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess 2-oxoglutarate and 10 uM Fe2 by FDH coupled assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
AID426473Inhibition of JMJD2C-mediated H3K9 demethylation activity at 1 mM2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
AID1594434Inhibition of C-terminal FLAG-tagged human KDM4A expressed in Escherichia coli pre-incubated for 4 hrs before substrate addition and measured after 1 hr by AlphaScreen assay2019Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10
Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors.
AID517384Inhibition of PHD1 by HTRF assay2010Bioorganic & medicinal chemistry letters, Oct-15, Volume: 20, Issue:20
Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
AID1763202Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc level incubated for 2 hrs by ELISA2021Bioorganic & medicinal chemistry, 06-01, Volume: 39SAR insights into TET2 catalytic domain inhibition: Synthesis of 2-Hydroxy-4-Methylene-pentanedicarboxylates.
AID770460Inhibition of KDM7B (unknown origin) using H3K4me3K9me2 and 2-oxoglutarate as substrate after 1 hr by matrix-assisted laser desorption ionization time of flight mass spectrometry2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
AID1856596Inhibition of KDM5B (unknown origin)2022Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
Discovery of Novel Pyrazole-Based KDM5B Inhibitor
AID1405297Inhibition of collagen prolyl 4-hydroxylase (unknown origin) using 2-ketoglutarate as co-factor assessed as formation of [14C]succinate by ion-exchnage chromatographic method2018Journal of medicinal chemistry, 12-13, Volume: 61, Issue:23
Collagen Prolyl 4-Hydroxylase as a Therapeutic Target.
AID770453Inhibition of KDM7A (unknown origin) using K27me2 peptide as substrate by MALDI assay2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
AID344915Inhibition of human FIH2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
AID349747Inhibition of human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) by TR-FRET assay2009Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.
AID1234009Inhibition of JMJD1A (unknown origin) using H3K9mel peptide2015ACS medicinal chemistry letters, Jun-11, Volume: 6, Issue:6
Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.
AID349748Destabilizing effect on human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) assessed as half life by limited trypsinolysis/MALDI-MS analysis in presence of ferrous ion2009Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.
AID426467Inhibition of JMJD2A-mediated H3K9 demethylation activity at 3 mM2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
AID639776Inhibition of PHD22011Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
Lysine demethylases inhibitors.
AID661345Binding affinity to Escherichia coli AlkB deltaN11 mutant assessed as change in melting temperature at 200 uM by differential scanning fluorimetry2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
AID1714493Displacement of sodium 5-(3-(8-(3-carboxy-N-hydroxyacrylamido)octyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoate from Naegleria Tet-1 incubated for 20 mins followed by sodium 5-(3-(8-(3-carboxy-N-hydroxyacrylamido)octyl)thioureido)-2-(6-hydroxy2016ACS medicinal chemistry letters, Feb-11, Volume: 7, Issue:2
A Fluorescence Polarization Biophysical Assay for the Naegleria DNA Hydroxylase Tet1.
AID499339Inhibition of human recombinant PHD2 expressed in Sf9 cells by time-resolved fluorescence assay2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
AID721519Displacement of 2OG from FBXL11 (1 to 517) (unknown origin) expressed in Escherichia coli at 800 uM2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID426466Inhibition of JMJD2C-mediated H3K9 demethylation activity at 3 mM2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
AID160201Compound was evaluated for the inhibition of prolyl 4-hydroxylase1992Journal of medicinal chemistry, Jul-10, Volume: 35, Issue:14
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives.
AID1249066Inhibition of KDM2A (unknown origin)2014MedChemComm, Dec-01, Volume: 5, Issue:12
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
AID160198Compound was evaluated for the inhibition of prolyl 4-hydroxylase1992Journal of medicinal chemistry, Jul-10, Volume: 35, Issue:14
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives.
AID1249054Inhibition of KDM4E (unknown origin)2014MedChemComm, Dec-01, Volume: 5, Issue:12
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
AID446355Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
AID770454Inhibition of KDM2A (unknown origin)2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
AID661344Binding affinity to Escherichia coli AlkB expressed in Escherichia coli BL21(DE3) at 15 uM for 30 mins by nondenaturing ESI-MS analysis2012Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
AID1810105Inhibition of recombinant human NO66 expressed in Escherichia coli BL21 (DE3) using RPL8 N205PVEHPFGGGNHQHIGKPST224 as substrate preincubated for 15 mins followed by substrate addition and measured after 30 to 60 mins by RapidFire Mass spectrometry assay2021Journal of medicinal chemistry, 12-09, Volume: 64, Issue:23
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
AID770449Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay2013Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
AID1763191Inhibition of TET (unknown origin)2021Bioorganic & medicinal chemistry, 06-01, Volume: 39SAR insights into TET2 catalytic domain inhibition: Synthesis of 2-Hydroxy-4-Methylene-pentanedicarboxylates.
AID499338Inhibition of human recombinant PHD1 expressed in Sf9 cells by time-resolved fluorescence assay2010Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
AID721522Inhibition of human FIH catalytic domain Mn2 expressed in Escherichia coli by NMR spectroscopic analysis2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID344914Inhibition of human recombinant PHD22008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
AID604083Inhibition of asparaginyl hydroxylase factor-inhibiting-HIF2011Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
Inhibitors of histone demethylases.
AID1801992Demethylase AlphaScreen Assay from Article 10.1038/nchembio.2087: \\Structural analysis of human KDM5B guides histone demethylase inhibitor development.\\2016Nature chemical biology, 07, Volume: 12, Issue:7
Structural analysis of human KDM5B guides histone demethylase inhibitor development.
AID1798635FDH Coupled Inhibition Assay from Article 10.1021/jm800936s: \\Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases.\\2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2011Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
Inhibitors of histone demethylases.
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2011Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
Lysine demethylases inhibitors.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
Structural basis for inhibition of the fat mass and obesity associated protein (FTO).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (344)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (0.29)18.7374
1990's15 (4.36)18.2507
2000's67 (19.48)29.6817
2010's224 (65.12)24.3611
2020's37 (10.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.72 (24.57)
Research Supply Index5.86 (2.92)
Research Growth Index6.08 (4.65)
Search Engine Demand Index32.99 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews6 (1.72%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other343 (98.28%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]