Proteins > 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
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1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
A 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07973]
Synonyms
24-OHase;
Vitamin D(3) 24-hydroxylase;
EC 1.14.15.16;
Cytochrome P450 24A1;
Cytochrome P450-CC24
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| calcitriol | Homo sapiens (human) | EC50 | 0.0030 | 1 | 1 |
Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Analysis of the binding sites of vitamin D 1α-hydroxylase (CYP27B1) and vitamin D 24-hydroxylase (CYP24A1) for the design of selective CYP24A1 inhibitors: Homology modelling, molecular dynamics simulations and identification of key binding requirements.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation.Journal of medicinal chemistry, , Sep-25, Volume: 57, Issue:18, 2014
Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3).Journal of medicinal chemistry, , Dec-30, Volume: 47, Issue:27, 2004
Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry.Journal of medicinal chemistry, , 12-10, Volume: 63, Issue:23, 2020
Screening of selective inhibitors of 1α,25-dihydroxyvitamin D3 24-hydroxylase using recombinant human enzyme expressed in Escherichia coli.Biochemistry, , Dec-14, Volume: 49, Issue:49, 2010
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| 25-hydroxycholecalciferol-24-hydroxylase activity | molecular function | Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol. [ISBN:0471331309] |
| heme binding | molecular function | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai] |
| 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity | molecular function | Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol). [PMID:8506296] |
| 25-hydroxycholecalciferol-23-hydroxylase activity | molecular function | Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]. [PMID:22100522, PMID:30205156, RHEA:46616] |
| 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity | molecular function | Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]. [PMID:22100522, PMID:30205156, RHEA:49192] |
| vitamin D 25-hydroxylase activity | molecular function | Catalysis of the hydroxylation of C-25 of any form of vitamin D. [GOC:BHF, GOC:mah] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| mitochondrial inner membrane | cellular component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| osteoblast differentiation | biological process | The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid] |
| vitamin metabolic process | biological process | The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. [GOC:ai] |
| response to vitamin D | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. [GOC:sl] |
| vitamin D metabolic process | biological process | The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309] |
| vitamin D catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309] |
| vitamin D receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands. [GOC:BHF, GOC:mah, PMID:12637589] |