Page last updated: 2024-08-07 23:18:51
Sucrase-isomaltase, intestinal
A sucrase-isomaltase, intestinal that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14410]
Synonyms
Research
Bioassay Publications (19)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 14 (73.68) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
Compounds (30)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,4-thiazolidinedione | Homo sapiens (human) | IC50 | 0.5400 | 1 | 1 |
| methyl acetoacetate | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| diethyl malonate | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 1-deoxynojirimycin | Homo sapiens (human) | IC50 | 77.8333 | 3 | 3 |
| acarbose | Homo sapiens (human) | IC50 | 504.7560 | 10 | 10 |
| miglustat | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| (-)-catechin | Homo sapiens (human) | IC50 | 53.8000 | 1 | 1 |
| terphenyllin | Homo sapiens (human) | IC50 | 4.7900 | 1 | 1 |
| terphenyllin | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| 1,4-dideoxy-1,4-iminoarabinitol | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| valiolamine | Homo sapiens (human) | IC50 | 0.0490 | 1 | 1 |
| migalastat | Homo sapiens (human) | IC50 | 0.2600 | 1 | 1 |
| 3-hydroxyterphenyllin | Homo sapiens (human) | IC50 | 11.3000 | 1 | 1 |
| valienamine | Homo sapiens (human) | IC50 | 53.0000 | 1 | 1 |
| miglitol | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| validamine | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
| 2-(Benzotriazol-1-yl)-1-(4-bromophenyl)ethanone | Homo sapiens (human) | IC50 | 2.7900 | 1 | 1 |
| trisindoline | Homo sapiens (human) | IC50 | 5.9000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 43.5000 | 2 | 2 |
| mangostin | Homo sapiens (human) | IC50 | 5.7000 | 1 | 1 |
| mangostin | Homo sapiens (human) | Ki | 7.3000 | 1 | 1 |
| 7,8-dihydroxy-4-methylcoumarin | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| gamma-mangostin | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| gamma-mangostin | Homo sapiens (human) | Ki | 1.4000 | 1 | 1 |
| beta-Mangostin | Homo sapiens (human) | IC50 | 22.6000 | 1 | 1 |
| 9-Hydroxycalabaxanthone | Homo sapiens (human) | IC50 | 11.4000 | 1 | 1 |
| n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | Homo sapiens (human) | IC50 | 0.5500 | 2 | 2 |
| l-altro-1-deoxynojirimycin | Homo sapiens (human) | IC50 | 220.0000 | 1 | 1 |
| sch 725680 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| aspernolide a | Homo sapiens (human) | IC50 | 47.3300 | 1 | 1 |
| aspulvinone E | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| pinophilin b | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| oligo-1,6-glucosidase activity | molecular function | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. [EC:3.2.1.10] |
| sucrose alpha-glucosidase activity | molecular function | Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. [EC:3.2.1.48, MetaCyc:RXN-1461] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| carbohydrate binding | molecular function | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah] |
| alpha-1,4-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. [EC:3.2.1.20] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| brush border | cellular component | The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. [GOC:sl, ISBN:0815316194] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| sucrose catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside. [GOC:go_curators] |
| polysaccharide digestion | biological process | The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism. [GOC:go_curators] |