fluoroacetamide profile

2-fluoroacetamide : Acetamide substituted at C-2 by a fluorine atom. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	12542
CHEMBL ID	160811
CHEBI ID	53124
MeSH ID	M0051101

Synonym
AKOS009031511
EN300-19853
wln: zv1f
fussol
nsc-31876
fluoroacetamide
compound 1081
nsc31876
megatox
afl 1081
fluorakil 100
640-19-7
fluoroacetic acid amide
monofluoroacetamide
acetamide, 2-fluoro-
fluoroakil 100
2-fluoroacetamide
yanock
fluorkill
baran
flutritex 1
fluoroacetamide [bsi:iso]
ai3-25667
einecs 211-363-1
amid kyseliny fluoroctove [czech]
hsdb 2880
caswell no. 461
navron
epa pesticide chemical code 075002
nsc 31876
rcra waste number p057
rcra waste no. p057
brn 1739054
NCGC00166013-01
fluoracetamide
CHEBI:53124 ,
2-fluoro-acetamide
CHEMBL160811
A834612
2-fluoranylethanamide
C18675
NCGC00257537-01
dtxcid0014255
dtxsid2034255 ,
tox21_301297
cas-640-19-7
F0029
b18r611m38 ,
amid kyseliny fluoroctove
unii-b18r611m38
FTM ,
fluoroacetamide [hsdb]
fluoroacetamide [iso]
fluoroacetamide [mi]
FVTWJXMFYOXOKK-UHFFFAOYSA-N
Q419124
bdbm50226191
fluoroacetamide 100 microg/ml in ethanol
Z104475768

Excerpt	Reference	Relevance
"Fluoroacetamide (FAM) is a small (77 Da) and highly toxic chemical, formerly used as a rodenticide and potentially as a poison by terrorists. "	( Hapten Design and Monoclonal Antibody to Fluoroacetamide, a Small and Highly Toxic Chemical. Li, Y; Shen, D; Shen, J; Wang, Z; Wen, K; Yang, L; Yu, X; Zhang, X, 2020)	2.27
"Fluoroacetamide (Mw = 77.06) is a lethal rodenticide to humans and animals which is still frequently abused in food storage somewhere in China. "	( In vitro selection of DNA aptamers binding pesticide fluoroacetamide. Cao, F; Chen, L; Hu, X; Lu, X; Sun, M; Zeng, L; Zhang, Y, 2016)	2.13

Excerpt	Reference	Relevance
"Fluoroacetamide may cause obvious heart damage, and also heart electrical alternation."	( [Acute fluoroacetamide poisoning with main damage to the heart]. Jiang, C; Lin, J; Ou, J; Xia, G, 2002)	2.21

Excerpt	Reference	Relevance
" The present study shows that 2-FA is a highly toxic chemical through the inhalation route based on the LC50 value."	( Acute inhalation toxicity study of 2-fluoroacetamide in rats. Kumar, P; Pant, SC; Singh, M; Singh, R; Sugendran, K; Vijayaraghavan, R, 2000)	0.58

Class	Description
2-fluoroacetamides
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	1.0962	0.0002	29.3054	16,493.5996	AID743075
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Alcohol dehydrogenase E chain	Equus caballus (horse)	Ki	38,904.5000	0.1412	2.8927	8.7000	AID33855
Alcohol dehydrogenase S chain	Equus caballus (horse)	Ki	38,904.5000	0.1412	2.8927	8.7000	AID33855
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID674462	Dissociation constant, pKa of the compound in DMSO at 25 degC	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines.
AID1886676	GSH reactivity in potassium phosphate buffer at pH 7.4 assessed as half life at 0.15 mM at 37 degreeC measured for 30 to 60 mins by HPLC-MS analysis
AID23467	Partition coefficient (logP)	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	A quantitative structure-activity relationship and molecular graphics analysis of hydrophobic effects in the interactions of inhibitors with alcohol dehydrogenase.
AID33855	Inhibitory activity against horse liver alcohol dehydrogenase (ADH)	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	A quantitative structure-activity relationship and molecular graphics analysis of hydrophobic effects in the interactions of inhibitors with alcohol dehydrogenase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	12 (29.27)	18.7374
1990's	3 (7.32)	18.2507
2000's	13 (31.71)	29.6817
2010's	11 (26.83)	24.3611
2020's	2 (4.88)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.27%)	6.00%
Case Studies	5 (11.36%)	4.05%
Observational	0 (0.00%)	0.25%
Other	38 (86.36%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetamide acetimidic acid : A carboximidic acid that is acetic acid in which the carbonyl oxygen is replaced by an imino group.	3.29	6	acetamides; carboximidic acid; monocarboxylic acid amide; N-acylammonia
glycine [no description available]	2.13	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
pyrazole 1H-pyrazole : The 1H-tautomer of pyrazole.	1.96	1	pyrazole
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.4	2	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
fomepizole Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.. fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.	1.96	1	pyrazoles	antidote; EC 1.1.1.1 (alcohol dehydrogenase) inhibitor; protective agent
iodoacetamide [no description available]	1.96	1
fluoroacetic acid fluoroacetic acid: N1 same as NM; RN given refers to parent cpd. fluoroacetic acid : A haloacetic acid that is acetic acid in which one of the methyl hydrogens is substituted by fluorine.	8.82	3	haloacetic acid; organofluorine compound	EC 4.2.1.3 (aconitate hydratase) inhibitor
dinitrofluorobenzene Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.. 1-fluoro-2,4-dinitrobenzene : The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.	6.96	1	C-nitro compound; organofluorine compound	agrochemical; allergen; chromatographic reagent; EC 2.7.3.2 (creatine kinase) inhibitor; protein-sequencing agent; spectrophotometric reagent
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2.17	1	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
acrylamide [no description available]	1.96	1	acrylamides; N-acylammonia; primary carboxamide	alkylating agent; carcinogenic agent; Maillard reaction product; mutagen; neurotoxin
chloroacetamide [no description available]	1.96	1
methacrylamide [no description available]	1.96	1	acrylamides; primary carboxamide
benzothiazole benzothiazole: structure. benzothiazole : An organic heterobicyclic compound that is a fusion product between benzene and thiazole. The parent of the class of benzothiazoles.	2.05	1	benzothiazoles	environmental contaminant; plant metabolite; xenobiotic
2-phenylacetamide 2-phenylacetamide: structure. 2-phenylacetamide : A monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2.	1.96	1	monocarboxylic acid amide	mouse metabolite
4-phenylenediamine 4-phenylenediamine: agent hair dye responsible for contact dermatitis; RN given refers to parent cpd. 1,4-phenylenediamine : A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.	2.11	1	phenylenediamine	allergen; dye; hapten; reagent
calcium gluconate [no description available]	2.15	1	calcium salt	nutraceutical
citrulline citrulline : The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position.	2.17	1	amino acid zwitterion; citrulline	Daphnia magna metabolite; EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; protective agent; Saccharomyces cerevisiae metabolite
lucanthone hydrochloride Schistosomicides: Agents that act systemically to kill adult schistosomes.	1.96	1
2,2-dichloroacetamide [no description available]	1.96	1
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.1	1	metal allergen; nickel group element atom; platinum group metal atom
fluorine Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.	2.05	1	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	1.96	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
trichloroacetamide [no description available]	1.96	1
tetramethylenedisulfotetramine tetramethylenedisulfotetramine: induces convulsions; inhibitor of GABA; structure	4.39	6
trifluoroacetamide [no description available]	2.4	2
isobutyramide [no description available]	1.96	1	carboximidic acid
methanesulfonamide [no description available]	2.07	1
n-benzylformamide [no description available]	1.96	1	formamides
gliftor gliftor: combination of 1-chloro-3-fluoropropanol & 1,3-difluoro-2-propanol	3.55	2
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	2.07	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore
krn 7000 KRN 7000: has an alpha-galactosylceramide structure; structure given in first source. alpha-galactosylceramide : A galactosylceramide in which the galactosyl residue has alpha anomeric conofiguration.. 1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine : A glycophytoceramide having an alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen.	2.07	1	glycophytoceramide; N-acyl-beta-D-galactosylphytosphingosine	allergen; antigen; antineoplastic agent; epitope; immunological adjuvant
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.15	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent

Condition	Relationship Strength	Studies
MODS [description not available]	2.15	1
Multiple Organ Failure A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.	2.15	1
Autoimmune Disease [description not available]	2.17	1
Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	2.17	1
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	3.11	5
C gattii Infection [description not available]	2.21	1
Cryptococcosis Fungal infection caused by genus CRYPTOCOCCUS.	2.21	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.46	2
Emesis [description not available]	2.04	1
Vomiting The forcible expulsion of the contents of the STOMACH through the MOUTH.	2.04	1
Acute Disease Disease having a short and relatively severe course.	2.43	2
Absence Seizure [description not available]	2.03	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	2.03	1
Arrhythmia [description not available]	2.36	2
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	2.36	2
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2	1

fluoroacetamide

Description

Cross-References

Synonyms (59)

Research Excerpts

Overview

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Toxicity

Drug Classes (1)

Protein Targets (3)

Potency Measurements

Inhibition Measurements

Bioassays (4)

Research

Studies (41)

Market Indicators

Research Demand Index: 35.95

Study Types