metyrapone has been researched along with Necrosis in 16 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls." | 7.66 | [Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. ( Krüger, R; Nastainczyk, W; Rendic, S; Ullrich, V, 1982) |
| "The basis for susceptibility to halothane-induced liver necrosis in guinea-pigs was examined." | 3.69 | Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. ( Farrell, GC; Field, J; Frost, L; Mahoney, J; Tapner, M; Weltman, M, 1996) |
| "Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls." | 3.66 | [Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. ( Krüger, R; Nastainczyk, W; Rendic, S; Ullrich, V, 1982) |
| "Metyrapone was effective in preventing death when given up to 2 h after acetaminophen administration." | 1.26 | Effectiveness of methyrapone in the treatment of acetaminophen toxicity in mice. ( Goldstein, M; Montes, M; Nelson, EB, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (93.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| CURRIE, AR | 2 |
| HELFENSTEIN, JE | 2 |
| YOUNG, S | 2 |
| WONG, TW | 1 |
| WARNER, NE | 1 |
| Nastainczyk, W | 1 |
| Rendic, S | 1 |
| Ullrich, V | 1 |
| Krüger, R | 1 |
| Nelson, EB | 1 |
| Montes, M | 1 |
| Goldstein, M | 1 |
| Farrell, GC | 1 |
| Frost, L | 1 |
| Tapner, M | 1 |
| Field, J | 1 |
| Weltman, M | 1 |
| Mahoney, J | 1 |
| Del Conte, E | 1 |
| Carter, JH | 1 |
| Carter, HW | 1 |
| Meade, J | 1 |
| Lund, BO | 1 |
| Bergman, A | 1 |
| Brandt, I | 1 |
| Jellinck, PH | 2 |
| Garrett, T | 1 |
| Colby, HD | 1 |
| Skelton, FR | 1 |
| Brownie, AC | 1 |
| Frenkel, G | 1 |
| Kraicer, PF | 1 |
| Garland, M | 1 |
| McRitchie, D | 1 |
| Wheatley, DN | 2 |
| Jull, JW | 1 |
| Hamilton, AG | 1 |
| Boyland, E | 1 |
| Sims, P | 1 |
16 other studies available for metyrapone and Necrosis
| Article | Year |
|---|---|
Massive adrenal necrosis in rats caused by 9,10-dimethyl-1,2-benzanthracene and its inhibition by metyrapone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenal Gland Diseases; Animals; Benz(a)Anthracenes; Ketones; Mety | 1962 |
EFFECT OF 2-METHYL-1,2-BIS-(3-PYRIDYL)-1-PROPANONE (METYRAPONE) ON THE PRODUCTION OF MAMMARY TUMOURS INDUCED IN RATS BY ORAL FEEDING WITH DIMETHYLBENZANTHRACENE.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenal Glands; Animals; Antineoplastic Agents; Benz(a)Anthracenes | 1963 |
INHIBITION OF DIMETHYLBENZANTHRACENE-INDUCED ADRENAL CORTICAL NECROSIS.
Topics: Adrenal Gland Diseases; Benz(a)Anthracenes; Carcinogens; Ketones; Metyrapone; Mineralocorticoid Rece | 1964 |
[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Halothane; L-Iditol | 1982 |
Effectiveness of methyrapone in the treatment of acetaminophen toxicity in mice.
Topics: Acetaminophen; Animals; Female; Glutathione; Lethal Dose 50; Liver; Metyrapone; Mice; Necrosis; Time | 1980 |
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow.
Topics: Animals; Arteries; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fomepizole; Genetic Pred | 1996 |
Ultrastructural aspects of degradation and necrosis of Leydig cells in lizards by effect of metyrapone.
Topics: Animals; Leydig Cells; Lizards; Male; Metyrapone; Microscopy, Electron; Necrosis | 1979 |
Adrenal regulation of mammary tumorigenesis in female Sprague-Dawley rats: incidence, latency, and yield of mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Age Factor | 1988 |
Metabolic activation and toxicity of a DDT-metabolite, 3-methylsulphonyl-DDE, in the adrenal zona fasciculata in mice.
Topics: Adrenal Cortex; Animals; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cyt | 1988 |
Metabolism of metopirone and 3-(1,2,3,4-tetrahydro-1-oxo-2 naphthyl)-pyridine in relation to DMBA induced adrenal necrosis.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Carbon Isotopes; Ethionine; Fem | 1969 |
Metopirone-induced hypertension in the rat.
Topics: Adrenal Glands; Animals; Blood Pressure; Body Weight; Desoxycorticosterone; Female; Hypernatremia; H | 1970 |
The inhibition of adrenocortical function in the lizard Agama stellio.
Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Animals; Blood Glucose; Depression, | 1971 |
Effect of metopirone and 3-(1,2,3,4-tetrahydro-1-oxo-2-naphthyl)-pyridine on the metabolism of corticosteroids and DMBA in relation to adrenal necrosis.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Carbon Isotopes; Chromatography | 1968 |
Action of drugs affecting the functioning of the adrenal cortex on adrenal necrosis induced by 7,12-dimethylbenz(alpha)anthracene and its 7-hydroxymethyl derivative in rats.
Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Cycloh | 1968 |
7,12-dimethylbenz(a)anthracene-induced adrenocortical necrosis and its inhibition by metopirone (SU4885).
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Metyrapone; Necrosis; Rats; Tim | 1968 |
Adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and its prevention.
Topics: Adrenal Gland Diseases; Animals; Benz(a)Anthracenes; Carbon Tetrachloride; Female; Hepatectomy; Mety | 1966 |