Page last updated: 2024-11-01

ofloxacin and Necrosis

ofloxacin has been researched along with Necrosis in 9 studies

Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Chondrocyte toxicity and necrosis were seen with electron microscopy after incubation of human adult cartilage biopsy specimens in ciprofloxacin or ofloxacin."3.69Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro. ( Erlacher, L; Graninger, W; Graninger, WB; Köller, M; Menschik, M; Neumüller, J; Steiner, CW; Ullrich, R, 1997)
"Facial paralysis was present in 19."1.34Necrotizing external otitis: a report of 46 cases. ( Bebear, C; Blanchet, H; Darrouzet, V; Dutronc, H; Franco-Vidal, V, 2007)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's3 (33.33)18.2507
2000's4 (44.44)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Trad, S1
Saadoun, D1
Barete, S1
Frances, C1
Piette, JC1
Wechsler, B1
Shaw, PJ1
Ditewig, AC1
Waring, JF1
Liguori, MJ1
Blomme, EA1
Ganey, PE1
Roth, RA1
Le Falher, G1
Makinson, A1
Eden, A1
Lesnik, A1
Le Moing, V1
Reynes, J1
Wellinghausen, N1
Sing, A1
Kern, WV1
Perner, S1
Marre, R1
Rentschler, J1
Franco-Vidal, V1
Blanchet, H1
Bebear, C1
Dutronc, H1
Darrouzet, V1
Koch, K1
Drewelow, B1
Brinckmann, W1
Menschik, M1
Neumüller, J1
Steiner, CW1
Erlacher, L1
Köller, M1
Ullrich, R1
Graninger, W1
Graninger, WB1
Mueller-Buehl, U1
Diehm, C2
Gutzler, F2
Adam, D1
Müller-Bühl, U1

Trials

1 trial available for ofloxacin and Necrosis

ArticleYear
Tissue concentrations of ofloxacin in necrotic foot lesions of diabetic and non-diabetic patients with peripheral arterial occlusive disease.
    VASA. Zeitschrift fur Gefasskrankheiten, 1991, Volume: 20, Issue:1

    Topics: Aged; Bacterial Infections; Diabetic Angiopathies; Diabetic Neuropathies; Female; Foot; Humans; Isch

1991

Other Studies

8 other studies available for ofloxacin and Necrosis

ArticleYear
[Necrotizing folliculitis in Behçet's disease].
    La Revue de medecine interne, 2009, Volume: 30, Issue:3

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Toxins; Behcet

2009
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 107, Issue:1

    Topics: Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Female; Fluoroquinolones; Gen

2009
[Two cases of pulmonary gangrene in HIV-infected patients: favorable outcome without surgery].
    Medecine et maladies infectieuses, 2011, Volume: 41, Issue:2

    Topics: Acetamides; Adult; Alcoholism; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Gangre

2011
A fatal case of necrotizing sinusitis due to toxigenic Corynebacterium ulcerans.
    International journal of medical microbiology : IJMM, 2002, Volume: 292, Issue:1

    Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; C

2002
Necrotizing external otitis: a report of 46 cases.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2007, Volume: 28, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Diabetes Complications; Facial Paralysis; Fem

2007
[Pancreas penetration by ofloxacin--a pilot study].
    Zeitschrift fur Gastroenterologie, 1993, Volume: 31, Issue:10

    Topics: Adenocarcinoma, Mucinous; Adult; Aged; Bile; Cholestasis, Extrahepatic; Chronic Disease; Duodenal Ne

1993
Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:11

    Topics: Adult; Anti-Infective Agents; Cartilage; Chondrocytes; Ciprofloxacin; Culture Techniques; Humans; Ma

1997
Tissue concentrations of ofloxacin in necrotic lesions in patients with peripheral vascular disease and in diabetics.
    Infection, 1986, Volume: 14 Suppl 4

    Topics: Aged; Anti-Infective Agents; Arterial Occlusive Diseases; Bacterial Infections; Diabetic Angiopathie

1986