ofloxacin has been researched along with Necrosis in 9 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chondrocyte toxicity and necrosis were seen with electron microscopy after incubation of human adult cartilage biopsy specimens in ciprofloxacin or ofloxacin." | 3.69 | Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro. ( Erlacher, L; Graninger, W; Graninger, WB; Köller, M; Menschik, M; Neumüller, J; Steiner, CW; Ullrich, R, 1997) |
| "Facial paralysis was present in 19." | 1.34 | Necrotizing external otitis: a report of 46 cases. ( Bebear, C; Blanchet, H; Darrouzet, V; Dutronc, H; Franco-Vidal, V, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trad, S | 1 |
| Saadoun, D | 1 |
| Barete, S | 1 |
| Frances, C | 1 |
| Piette, JC | 1 |
| Wechsler, B | 1 |
| Shaw, PJ | 1 |
| Ditewig, AC | 1 |
| Waring, JF | 1 |
| Liguori, MJ | 1 |
| Blomme, EA | 1 |
| Ganey, PE | 1 |
| Roth, RA | 1 |
| Le Falher, G | 1 |
| Makinson, A | 1 |
| Eden, A | 1 |
| Lesnik, A | 1 |
| Le Moing, V | 1 |
| Reynes, J | 1 |
| Wellinghausen, N | 1 |
| Sing, A | 1 |
| Kern, WV | 1 |
| Perner, S | 1 |
| Marre, R | 1 |
| Rentschler, J | 1 |
| Franco-Vidal, V | 1 |
| Blanchet, H | 1 |
| Bebear, C | 1 |
| Dutronc, H | 1 |
| Darrouzet, V | 1 |
| Koch, K | 1 |
| Drewelow, B | 1 |
| Brinckmann, W | 1 |
| Menschik, M | 1 |
| Neumüller, J | 1 |
| Steiner, CW | 1 |
| Erlacher, L | 1 |
| Köller, M | 1 |
| Ullrich, R | 1 |
| Graninger, W | 1 |
| Graninger, WB | 1 |
| Mueller-Buehl, U | 1 |
| Diehm, C | 2 |
| Gutzler, F | 2 |
| Adam, D | 1 |
| Müller-Bühl, U | 1 |
1 trial available for ofloxacin and Necrosis
| Article | Year |
|---|---|
Tissue concentrations of ofloxacin in necrotic foot lesions of diabetic and non-diabetic patients with peripheral arterial occlusive disease.
Topics: Aged; Bacterial Infections; Diabetic Angiopathies; Diabetic Neuropathies; Female; Foot; Humans; Isch | 1991 |
8 other studies available for ofloxacin and Necrosis
| Article | Year |
|---|---|
[Necrotizing folliculitis in Behçet's disease].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Toxins; Behcet | 2009 |
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury.
Topics: Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Female; Fluoroquinolones; Gen | 2009 |
[Two cases of pulmonary gangrene in HIV-infected patients: favorable outcome without surgery].
Topics: Acetamides; Adult; Alcoholism; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Gangre | 2011 |
A fatal case of necrotizing sinusitis due to toxigenic Corynebacterium ulcerans.
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; C | 2002 |
Necrotizing external otitis: a report of 46 cases.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Diabetes Complications; Facial Paralysis; Fem | 2007 |
[Pancreas penetration by ofloxacin--a pilot study].
Topics: Adenocarcinoma, Mucinous; Adult; Aged; Bile; Cholestasis, Extrahepatic; Chronic Disease; Duodenal Ne | 1993 |
Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro.
Topics: Adult; Anti-Infective Agents; Cartilage; Chondrocytes; Ciprofloxacin; Culture Techniques; Humans; Ma | 1997 |
Tissue concentrations of ofloxacin in necrotic lesions in patients with peripheral vascular disease and in diabetics.
Topics: Aged; Anti-Infective Agents; Arterial Occlusive Diseases; Bacterial Infections; Diabetic Angiopathie | 1986 |