Dihydrofolate reductase

[no definition available]

EC 1.5.1.3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
trimethoprim	Lacticaseibacillus casei	IC50	0.3492	4	4
trimethoprim	Lacticaseibacillus casei	Ki	0.1318	1	1
trimetrexate	Lacticaseibacillus casei	IC50	0.1435	2	2
cycloguanil	Lacticaseibacillus casei	Ki	17.3780	1	1
4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine	Lacticaseibacillus casei	Ki	19.9526	1	1
diaveridine	Lacticaseibacillus casei	Ki	0.1202	1	1
piritrexim	Lacticaseibacillus casei	IC50	0.0015	1	1
tetroxoprim	Lacticaseibacillus casei	Ki	0.5495	1	1
metioprim	Lacticaseibacillus casei	Ki	0.0562	1	1
aditoprim	Lacticaseibacillus casei	Ki	0.3548	1	1
brodimoprim	Lacticaseibacillus casei	Ki	0.0319	2	2
epiroprim	Lacticaseibacillus casei	Ki	0.0468	1	1
sori 8895	Lacticaseibacillus casei	IC50	0.0390	1	1
2,4-diamino-5-benzylpyrimidine	Lacticaseibacillus casei	Ki	6.3096	2	2
2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine	Lacticaseibacillus casei	Ki	79.4328	1	1
10-deazaaminopterin	Lacticaseibacillus casei	IC50	0.0204	6	7
methotrexate	Lacticaseibacillus casei	IC50	0.0138	29	30
methotrexate	Lacticaseibacillus casei	Ki	0.0000	1	1
n-(4-(n-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid	Lacticaseibacillus casei	IC50	0.5600	2	2
aminopterin	Lacticaseibacillus casei	IC50	0.0050	1	1
edatrexate	Lacticaseibacillus casei	IC50	0.0178	5	6
n-(4(n-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid	Lacticaseibacillus casei	IC50	3.2740	3	3
pemetrexed	Lacticaseibacillus casei	IC50	173.0750	4	4

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gamma-tert-butyl methotrexate	Lacticaseibacillus casei	ID50	0.0185	2	2
methotrexate	Lacticaseibacillus casei	ID50	0.0130	5	5
aminopterin	Lacticaseibacillus casei	ID50	0.0270	1	1
dihydrofolate	Lacticaseibacillus casei	Km	0.3600	1	1