Compounds > n,n-dimethylarginine
Page last updated: 2024-09-25

n,n-dimethylarginine

Description

N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N(omega),N(omega)-dimethyl-L-arginine : A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID123831
CHEMBL ID457530
CHEBI ID17929
SCHEMBL ID196828
SCHEMBL ID12094101
MeSH IDM0070136

Synonyms (70)

Synonym
n(5)-((dimethylamino)iminomethyl)-l-ornithine
(2s)-2-amino-5-(n',n'-dimethylcarbamimidamido)pentanoic acid
asymmetric dimethylarginine
n(omega),n(omega)-dimethyl-l-arginine
n(5)-[(dimethylamino)(imino)methyl]-l-ornithine
n(g),n(g)-dimethylarginine
n(g1),n(g1)-dimethylarginine
guanidino-n,n-dimethylarginine
n(5)-(n,n-dimethylcarbamimidoyl)-l-ornithine
n(g)-dimethylarginine
(2s)-2-amino-5-{[(dimethylamino)(imino)methyl]amino}pentanoic acid
CHEBI:17929 ,
NCGC00015343-01
lopac-d-4268
HSCI1_000241
LOPAC0_000388
30315-93-6
adma
nomega,nomega-dimethyl-l-arginine
n,n-dimethylarginine
C03626
ng,ng-dimethyl-l-arginine
DB01686
l-ng,ng-dimethylarginine
dimethyl-l-arginine
ng,ng-dimethylarginine hydrochloride
l-ornithine, n5-((dimethylamino)iminomethyl)-
NCGC00162138-01
asymmetric dimethylarginine (adma)
n5-[(dimethylamino)(imino)methyl]-l-ornithine
NCGC00162138-02
(2s)-2-amino-5-[[amino(dimethylamino)methylidene]amino]pentanoic acid
2-amino-5-(amino-dimethylamino-methylidene)amino-pentanoic acid
CHEMBL457530
CCG-204482
adma, 3
bdbm92901
63cv1gek3y ,
unii-63cv1gek3y
(2s)-2-amino-5-[(amino-dimethylamino-methylidene)amino]pentanoic acid
(2s)-2-amino-5-(1,1-dimethylcarbamimidamido)pentanoic acid
gtpl5229
SCHEMBL196828
SCHEMBL12094101
(s)-2-amino-5-(3,3-dimethylguanidino)pentanoic acid
65005-57-4
l-ornithine, n5-[(dimethylamino)iminomethyl]-
n5-[(dimethylamino)iminomethyl]-l-ornithine
omega-n,omega-n-dimethyl-l-arginine
assymetric dimethyl-l-arginine
assymetric dimethylarginine
AKOS026674196
AKOS030240986
2-amino-5-(amino-dimethylamino-methylidene)amino-pentanoate
nomega,nomega'-dimethyl-l-arginine
ng-dimethylarginine
F16326
n-n-dimethylarginine
HY-113216
CS-0059330
n~5~-(n,n-dimethylcarbamimidoyl)-l-ornithine
ng,ng-dimethylarginine
mfcd00038406
Q752685
DTXSID401017725
SDCCGSBI-0050375.P002
asymmetrical-dimethylarginine
A897915
(s)-2-amino-5-(3,3-dimethylguanidino)pentanoicacid
(2s)-2-amino-5-{[amino(dimethylamino)methylidene]amino}pentanoic acid

Roles (1)

RoleDescription
EC 1.14.13.39 (nitric oxide synthase) inhibitorAn EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of nitric oxide synthase (EC 1.14.13.39).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
non-proteinogenic L-alpha-amino acidAny L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
guanidinesAny organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas.
L-arginine derivativeA proteinogenic amino acid derivative resulting from reaction of L-arginine at the amino group, the carboxy group, or the guanidyl group, or from the replacement of any hydrogen of L-arginine by a heteroatom.
dimethylarginineAn arginine derivative that is arginine substituted by two methyl groups. A "closed" class.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

n,n-dimethylarginine is involved in 1 pathway(s), involving a total of 0 unique proteins and 6 unique compounds

PathwayProteinsCompounds
Nitric oxide metabolism in cystic fibrosis06

Protein Targets (12)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
thioredoxin reductaseRattus norvegicus (Norway rat)Potency1.12200.100020.879379.4328AID588453
NFKB1 protein, partialHomo sapiens (human)Potency28.18380.02827.055915.8489AID895; AID928
thyroid stimulating hormone receptorHomo sapiens (human)Potency3.98110.001318.074339.8107AID926; AID938
arylsulfatase AHomo sapiens (human)Potency0.21331.069113.955137.9330AID720538
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.25890.035520.977089.1251AID504332
cytochrome P450 2C19 precursorHomo sapiens (human)Potency10.00000.00255.840031.6228AID899
flap endonuclease 1Homo sapiens (human)Potency4.22840.133725.412989.1251AID588795
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)Ki0.70000.05001.49292.0000AID1799854
Nitric oxide synthase, brainHomo sapiens (human)Ki0.70000.01501.18117.3000AID1799854
Nitric oxide synthase, brain Rattus norvegicus (Norway rat)Ki0.70000.05001.53334.5500AID1799854
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (44)

Processvia Protein(s)Taxonomy
citrulline metabolic processN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
regulation of systemic arterial blood pressureN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
arginine catabolic processN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
nitric oxide mediated signal transductionN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
negative regulation of cell population proliferationN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
negative regulation of vascular permeabilityN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
positive regulation of nitric oxide biosynthetic processN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
positive regulation of angiogenesisN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
nitric oxide metabolic processN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
negative regulation of cellular response to hypoxiaN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
arginine metabolic processN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
response to hypoxiaNitric oxide synthase, brainHomo sapiens (human)
regulation of sodium ion transportNitric oxide synthase, brainHomo sapiens (human)
arginine catabolic processNitric oxide synthase, brainHomo sapiens (human)
nitric oxide biosynthetic processNitric oxide synthase, brainHomo sapiens (human)
striated muscle contractionNitric oxide synthase, brainHomo sapiens (human)
myoblast fusionNitric oxide synthase, brainHomo sapiens (human)
response to heatNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transport into cytosolNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingNitric oxide synthase, brainHomo sapiens (human)
peptidyl-cysteine S-nitrosylationNitric oxide synthase, brainHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationNitric oxide synthase, brainHomo sapiens (human)
multicellular organismal response to stressNitric oxide synthase, brainHomo sapiens (human)
xenobiotic catabolic processNitric oxide synthase, brainHomo sapiens (human)
vasodilationNitric oxide synthase, brainHomo sapiens (human)
negative regulation of potassium ion transportNitric oxide synthase, brainHomo sapiens (human)
cell redox homeostasisNitric oxide synthase, brainHomo sapiens (human)
positive regulation of DNA-templated transcriptionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IINitric oxide synthase, brainHomo sapiens (human)
negative regulation of hydrolase activityNitric oxide synthase, brainHomo sapiens (human)
negative regulation of serotonin uptakeNitric oxide synthase, brainHomo sapiens (human)
negative regulation of calcium ion transportNitric oxide synthase, brainHomo sapiens (human)
regulation of cardiac muscle contractionNitric oxide synthase, brainHomo sapiens (human)
regulation of ryanodine-sensitive calcium-release channel activityNitric oxide synthase, brainHomo sapiens (human)
cellular response to growth factor stimulusNitric oxide synthase, brainHomo sapiens (human)
positive regulation of the force of heart contractionNitric oxide synthase, brainHomo sapiens (human)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayNitric oxide synthase, brainHomo sapiens (human)
positive regulation of sodium ion transmembrane transportNitric oxide synthase, brainHomo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelNitric oxide synthase, brainHomo sapiens (human)
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potentialNitric oxide synthase, brainHomo sapiens (human)
positive regulation of guanylate cyclase activityNitric oxide synthase, brainHomo sapiens (human)
nitric oxide mediated signal transductionNitric oxide synthase, brainHomo sapiens (human)
response to hormoneNitric oxide synthase, brainHomo sapiens (human)
negative regulation of blood pressureNitric oxide synthase, brainHomo sapiens (human)
response to lipopolysaccharideNitric oxide synthase, brainHomo sapiens (human)
nitric oxide biosynthetic processN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Bos taurus (cattle)
protein nitrosylationN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Bos taurus (cattle)
citrulline metabolic processN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Bos taurus (cattle)
positive regulation of nitric oxide biosynthetic processN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (20)

Processvia Protein(s)Taxonomy
catalytic activityN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
dimethylargininase activityN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
metal ion bindingN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
amino acid bindingN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
nitric-oxide synthase activityNitric oxide synthase, brainHomo sapiens (human)
calcium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
protein bindingNitric oxide synthase, brainHomo sapiens (human)
calmodulin bindingNitric oxide synthase, brainHomo sapiens (human)
FMN bindingNitric oxide synthase, brainHomo sapiens (human)
sodium channel regulator activityNitric oxide synthase, brainHomo sapiens (human)
heme bindingNitric oxide synthase, brainHomo sapiens (human)
tetrahydrobiopterin bindingNitric oxide synthase, brainHomo sapiens (human)
arginine bindingNitric oxide synthase, brainHomo sapiens (human)
transmembrane transporter bindingNitric oxide synthase, brainHomo sapiens (human)
cadmium ion bindingNitric oxide synthase, brainHomo sapiens (human)
calcium-dependent protein bindingNitric oxide synthase, brainHomo sapiens (human)
flavin adenine dinucleotide bindingNitric oxide synthase, brainHomo sapiens (human)
NADP bindingNitric oxide synthase, brainHomo sapiens (human)
scaffold protein bindingNitric oxide synthase, brainHomo sapiens (human)
zinc ion bindingN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Bos taurus (cattle)
dimethylargininase activityN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (18)

Processvia Protein(s)Taxonomy
cytosolN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
extracellular exosomeN(G),N(G)-dimethylarginine dimethylaminohydrolase 1Homo sapiens (human)
photoreceptor inner segmentNitric oxide synthase, brainHomo sapiens (human)
nucleoplasmNitric oxide synthase, brainHomo sapiens (human)
cytoplasmNitric oxide synthase, brainHomo sapiens (human)
mitochondrionNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
cytoskeletonNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
sarcoplasmic reticulumNitric oxide synthase, brainHomo sapiens (human)
sarcolemmaNitric oxide synthase, brainHomo sapiens (human)
dendritic spineNitric oxide synthase, brainHomo sapiens (human)
membrane raftNitric oxide synthase, brainHomo sapiens (human)
synapseNitric oxide synthase, brainHomo sapiens (human)
perinuclear region of cytoplasmNitric oxide synthase, brainHomo sapiens (human)
cell peripheryNitric oxide synthase, brainHomo sapiens (human)
protein-containing complexNitric oxide synthase, brainHomo sapiens (human)
plasma membraneNitric oxide synthase, brainHomo sapiens (human)
postsynaptic densityNitric oxide synthase, brainHomo sapiens (human)
cytosolNitric oxide synthase, brainHomo sapiens (human)
nucleusNitric oxide synthase, brainHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (31)

Assay IDTitleYearJournalArticle
AID386441Activity at human recombinant wild type DDAH12007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386449Ratio of Kcat to Km for rat wild type DDAH12007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386451Ratio of Kcat to Km for Pseudomonas aeruginosa wild type DDAH12007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386447Ratio of Kcat to Km for human recombinant wild type DDAH12007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386450Ratio of Kcat to Km for bovine wild type DDAH12007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386445Activity at bovine wild type DDAH12007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386444Activity at rat wild type DDAH12007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386443Activity at human DDAH1 H173A mutant2007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386442Activity at human DDAH1 C275A mutant2007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386446Activity at Pseudomonas aeruginosa wild type DDAH12007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID386448Ratio of Kcat to Km for human DDAH1 C275A mutant2007The Journal of biological chemistry, Nov-30, Volume: 282, Issue:48
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID504836Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation2002The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
AID1347057CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347050Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347045Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347405qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347410qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library2019Cellular signalling, 08, Volume: 60A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347059CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID588378qHTS for Inhibitors of ATXN expression: Validation
AID1347151Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588349qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347058CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347049Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1799854Inhibition Assay from Article 10.1021/bi9007098: \\Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.\\2009Biochemistry, Sep-15, Volume: 48, Issue:36
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (2,130)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (0.38)18.7374
1990's59 (2.77)18.2507
2000's718 (33.71)29.6817
2010's1192 (55.96)24.3611
2020's153 (7.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials228 (10.29%)5.53%
Reviews249 (11.24%)6.00%
Case Studies4 (0.18%)4.05%
Observational27 (1.22%)0.25%
Other1,708 (77.08%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Study on Some Biomarkers in Bronchial Asthma in Children[NCT04175093]105 participants (Anticipated)Observational2019-11-29Not yet recruiting
Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With Acute Myeloid Leukemia[NCT05703126]100 participants (Anticipated)Interventional2022-12-01Recruiting
Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis[NCT03377465]100 participants (Actual)Interventional2016-11-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
lysine[no description available]medium120aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
lysine[no description available]medium121aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
arginine[no description available]medium2,1920arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
arginine[no description available]medium2,192220arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
homocysteine[no description available]medium1300amino acid zwitterion;
homocysteine;
serine family amino acid		fundamental metabolite;
mouse metabolite
homocysteine[no description available]medium13016amino acid zwitterion;
homocysteine;
serine family amino acid		fundamental metabolite;
mouse metabolite
s-nitrosoglutathione[no description available]medium20glutathione derivative;
nitrosothio compound		bronchodilator agent;
nitric oxide donor;
platelet aggregation inhibitor;
signalling molecule
s-methylthiocitrulline[no description available]high20imidothiocarbamic ester;
L-arginine derivative;
L-ornithine derivative;
non-proteinogenic L-alpha-amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
neuroprotective agent
omega-n-methylarginine[no description available]medium740amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
omega-n-methylarginine[no description available]medium741amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
s-nitrosohomocysteine[no description available]medium10
citrulline[no description available]medium560amino acid zwitterion;
citrulline		Daphnia magna metabolite;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
protective agent;
Saccharomyces cerevisiae metabolite
citrulline[no description available]medium566amino acid zwitterion;
citrulline		Daphnia magna metabolite;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
protective agent;
Saccharomyces cerevisiae metabolite
n(g)-iminoethylornithine[no description available]medium20L-alpha-amino acid
n(g),n(g')-dimethyl-l-arginine[no description available]medium2,203220alpha-amino acid
symmetric dimethylarginine[no description available]high2400amino acid zwitterion;
dimethylarginine;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor
symmetric dimethylarginine[no description available]high24019amino acid zwitterion;
dimethylarginine;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor
dimethylarginine[no description available]medium474
cholecalciferol[no description available]medium31D3 vitamins;
hydroxy seco-steroid;
seco-cholestane;
secondary alcohol;
steroid hormone		geroprotector;
human metabolite
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
s-adenosylmethionine[no description available]medium80organic cation;
sulfonium compound		coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
metformin[no description available]medium150guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
metformin[no description available]medium158guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
thyroxine[no description available]medium402-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
ornithine[no description available]medium150non-proteinogenic L-alpha-amino acid;
ornithine		algal metabolite;
hepatoprotective agent;
mouse metabolite
glucose, (beta-d)-isomer[no description available]medium11D-glucopyranoseepitope;
mouse metabolite
dapagliflozin[no description available]medium11aromatic ether;
C-glycosyl compound;
monochlorobenzenes		hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
empagliflozin[no description available]medium11aromatic ether;
C-glycosyl compound;
monochlorobenzenes;
tetrahydrofuryl ether		hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
homoarginine[no description available]medium370homoarginine;
L-lysine derivative;
non-proteinogenic L-alpha-amino acid		biomarker;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
human metabolite;
rat metabolite;
xenobiotic metabolite
homoarginine[no description available]medium376homoarginine;
L-lysine derivative;
non-proteinogenic L-alpha-amino acid		biomarker;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
human metabolite;
rat metabolite;
xenobiotic metabolite
malondialdehyde[no description available]medium468dialdehydebiomarker
nitrites[no description available]medium8417monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
nitrates[no description available]medium8217monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
valproic acid[no description available]medium50branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent
levetiracetam[no description available]medium10pyrrolidin-2-onesanticonvulsant;
environmental contaminant;
xenobiotic
ng-nitroarginine methyl ester[no description available]high390alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
ng-nitroarginine methyl ester[no description available]high392alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
dehydroepiandrosterone[no description available]medium1017-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid		androgen;
human metabolite;
mouse metabolite
nitroglycerin[no description available]medium71nitroglycerolexplosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic
resveratrol[no description available]medium71resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
trimethyloxamine[no description available]medium50tertiary amine oxideEscherichia coli metabolite;
metabolite;
osmolyte
glucagon-like peptide 1[no description available]medium31
D-fructopyranose[no description available]medium30cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
exenatide[no description available]medium20
sitagliptin phosphate[no description available]medium10
tryptophan[no description available]medium21erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
endothelin-1[no description available]medium386
aldosterone[no description available]medium4011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
angiotensin ii[no description available]medium190amino acid zwitterion;
angiotensin II		human metabolite
losartan[no description available]medium121biphenylyltetrazole;
imidazoles		angiotensin receptor antagonist;
anti-arrhythmia drug;
antihypertensive agent;
endothelin receptor antagonist
melatonin[no description available]medium80acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
methotrexate[no description available]medium30dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
cadmium[no description available]medium10cadmium molecular entity;
zinc group element atom
urea[no description available]medium121isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
uric acid[no description available]medium155uric acidEscherichia coli metabolite;
human metabolite;
mouse metabolite
selenium[no description available]medium32chalcogen;
nonmetal atom		micronutrient
zinc oxide[no description available]medium20zinc molecular entity
iopromide[no description available]medium10dicarboxylic acid diamide;
organoiodine compound		environmental contaminant;
nephrotoxic agent;
radioopaque medium;
xenobiotic
iohexol[no description available]medium10benzenedicarboxamide;
organoiodine compound		environmental contaminant;
radioopaque medium;
xenobiotic
piperidines[no description available]medium10
amikacin[no description available]medium10
quercetin[no description available]medium517-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
cellulose[no description available]medium10glycoside
(3,4-dihydroxyphenylamino)-2-imidazoline[no description available]medium10
tetramethylpyrazine[no description available]medium10alkaloid;
pyrazines		antineoplastic agent;
apoptosis inhibitor;
bacterial metabolite;
neuroprotective agent;
platelet aggregation inhibitor;
vasodilator agent
pyrazines[no description available]medium10diazine;
pyrazines		Daphnia magna metabolite
ampelopsin[no description available]medium10dihydromyricetin;
secondary alpha-hydroxy ketone		antineoplastic agent;
antioxidant;
metabolite
3-hydroxyflavone[no description available]medium10flavonols;
monohydroxyflavone
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
dipyridamole[no description available]medium40piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol		adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent
retinol[no description available]medium20retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite
caffeic acid phenethyl ester[no description available]medium20alkyl caffeate esteranti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiviral agent;
immunomodulator;
metabolite;
neuroprotective agent
phenylethyl alcohol[no description available]medium20benzenes;
primary alcohol		Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite
febuxostat[no description available]medium221,3-thiazolemonocarboxylic acid;
aromatic ether;
nitrile		EC 1.17.3.2 (xanthine oxidase) inhibitor
allopurinol[no description available]medium52nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
benzbromarone[no description available]medium111-benzofurans;
aromatic ketone		uricosuric drug
sodium nitrite[no description available]medium11inorganic sodium salt;
nitrite salt		antidote to cyanide poisoning;
antihypertensive agent;
antimicrobial food preservative;
food antioxidant;
poison
isoquercitrin[no description available]medium11
adenosine diphosphate[no description available]medium21adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
adenosine[no description available]medium42adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
tamoxifen[no description available]medium20stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
natriuretic peptide, brain[no description available]medium293polypeptide
proline[no description available]medium20amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
adenine[no description available]medium106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
3-methyladenine[no description available]medium10
acetonitrile[no description available]medium10aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
acetylcysteine[no description available]medium80acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
3-nitrotyrosine[no description available]medium1532-nitrophenols;
C-nitro compound;
nitrotyrosine;
non-proteinogenic alpha-amino acid
tyrosine[no description available]medium163amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
pantoprazole[no description available]medium20aromatic ether;
benzimidazoles;
organofluorine compound;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
environmental contaminant;
xenobiotic
indomethacin[no description available]medium40aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
perindopril[no description available]medium30alpha-amino acid ester;
dicarboxylic acid monoester;
ethyl ester;
organic heterobicyclic compound		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
mocetinostat[no description available]medium171aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
glycine[no description available]medium90alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
methionine[no description available]medium181aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
25-hydroxyvitamin d 2[no description available]medium11hydroxycalciol;
seco-ergostane;
vitamin D		bone density conservation agent;
human xenobiotic metabolite;
nutraceutical
pyrazolanthrone[no description available]medium10anthrapyrazole;
aromatic ketone;
cyclic ketone		antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector
neurokinin a[no description available]medium10
cysteine[no description available]medium40cysteiniumfundamental metabolite
losartan potassium[no description available]medium152
bilirubin[no description available]medium20biladienes;
dicarboxylic acid		antioxidant;
human metabolite;
mouse metabolite
phytosterols[no description available]medium11
campesterol[no description available]medium113beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C28-steroid;
phytosterols		mouse metabolite
glycocyamine[no description available]medium20guanidinoacetic acids;
zwitterion		bacterial metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
rat metabolite
atrial natriuretic factor[no description available]medium20polypeptide
1-hydroxypyrene[no description available]medium10pyrenes
stilbenes[no description available]medium41stilbene
arginine methyl ester[no description available]medium20alpha-amino acid ester
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid[no description available]medium32(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
valsartan[no description available]medium106biphenylyltetrazole;
monocarboxylic acid amide;
monocarboxylic acid		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic
paricalcitol[no description available]medium11hydroxy seco-steroid;
seco-cholestane		antiparathyroid drug
vitamin d 2[no description available]medium21hydroxy seco-steroid;
seco-ergostane;
vitamin D		bone density conservation agent;
nutraceutical;
plant metabolite;
rodenticide
lysophosphatidylcholines[no description available]medium601-O-acyl-sn-glycero-3-phosphocholine
phosphatidylcholines[no description available]medium201,2-diacyl-sn-glycero-3-phosphocholine
hippuric acid[no description available]medium10N-acylglycinehuman blood serum metabolite;
uremic toxin
phosphorus[no description available]medium10monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
indican[no description available]medium41beta-D-glucoside;
exopolysaccharide;
indolyl carbohydrate
hydrogen sulfide[no description available]medium100gas molecular entity;
hydracid;
mononuclear parent hydride;
sulfur hydride		Escherichia coli metabolite;
genotoxin;
metabolite;
signalling molecule;
toxin;
vasodilator agent
diclofenac[no description available]medium10amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
celecoxib[no description available]medium20organofluorine compound;
pyrazoles;
sulfonamide;
toluenes		cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
prednisolone[no description available]medium1011beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
glycolipids[no description available]medium10
sildenafil citrate[no description available]medium70citrate saltEC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
vasodilator agent
ammonium hydroxide[no description available]medium20azane;
gas molecular entity;
mononuclear parent hydride		EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant
8-epi-prostaglandin f2alpha[no description available]medium144F2-isoprostanebiomarker;
bronchoconstrictor agent;
vasoconstrictor agent
dinoprost[no description available]medium144monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite
betaine[no description available]medium10amino-acid betaine;
glycine derivative		fundamental metabolite
interleukin-8[no description available]medium80
apelin-13 peptide[no description available]medium40oligopeptideantihypertensive agent;
autophagy inhibitor;
biomarker;
human metabolite;
neuroprotective agent
lead[no description available]medium10carbon group element atom;
elemental lead;
metal atom		neurotoxin
chenodeoxycholic acid[no description available]medium10bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid		human metabolite;
mouse metabolite
obeticholic acid[no description available]medium103alpha-hydroxy steroid;
7alpha-hydroxy steroid;
dihydroxy-5beta-cholanic acid		farnesoid X receptor agonist;
hepatoprotective agent
agmatine[no description available]medium10guanidines;
primary amino compound		Escherichia coli metabolite;
mouse metabolite
kynurenine[no description available]medium20aromatic ketone;
non-proteinogenic alpha-amino acid;
substituted aniline		human metabolite
neopterin[no description available]medium30
phencyclidine[no description available]medium10benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
atenolol[no description available]medium41ethanolamines;
monocarboxylic acid amide;
propanolamine		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic
7-nitroindazole[no description available]medium40
indazoles[no description available]medium40indazole
thioacetamide[no description available]medium30thiocarboxamidehepatotoxic agent
glutamine[no description available]medium20amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
cyclic gmp[no description available]medium4363',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
probucol[no description available]medium51dithioketal;
polyphenol		anti-inflammatory drug;
anticholesteremic drug;
antilipemic drug;
antioxidant;
cardiovascular drug
arsenic[no description available]medium30metalloid atom;
pnictogen		micronutrient
leptin[no description available]medium91
deoxyguanosine[no description available]medium82purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
8-hydroxy-2'-deoxyguanosine[no description available]medium82guanosinesbiomarker
dimethylamine[no description available]medium40methylamines;
secondary aliphatic amine		metabolite
loganic acid[no description available]medium10alpha,beta-unsaturated monocarboxylic acid;
cyclopentapyran;
glucoside		plant metabolite
iridoids[no description available]medium10
imidazolone[no description available]medium11organonitrogen heterocyclic compound
pyruvaldehyde[no description available]medium312-oxo aldehyde;
propanals		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
lactic acid[no description available]medium302-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
catechin[no description available]medium61catechinantioxidant;
plant metabolite
procyanidin b2[no description available]medium10biflavonoid;
hydroxyflavan;
polyphenol;
proanthocyanidin		antioxidant;
metabolite
procyanidin[no description available]medium10proanthocyanidin
niacinamide[no description available]medium20pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
dronedarone[no description available]medium101-benzofurans;
aromatic ether;
aromatic ketone;
sulfonamide;
tertiary amino compound		anti-arrhythmia drug;
environmental contaminant;
xenobiotic
silver[no description available]medium10copper group element atom;
elemental silver		Escherichia coli metabolite
osteoprotegerin[no description available]medium70long-chain fatty acid
angiotensin i[no description available]medium20angiotensin;
peptide zwitterion		human metabolite;
neurotransmitter agent
angiotensin ii, des-phe(8)-[no description available]medium20amino acid zwitterion;
angiotensin		vasodilator agent
n-epsilon-acetyllysine[no description available]medium10acetyl-L-lysine;
amino acid zwitterion;
N(6)-acyl-L-lysine		human metabolite
carnitine[no description available]medium40amino-acid betainehuman metabolite;
mouse metabolite
salvianolic acid a[no description available]medium10stilbenoid
aspirin[no description available]medium71benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
cardiovascular agents[no description available]medium123
ezetimibe[no description available]medium52azetidines;
beta-lactam;
organofluorine compound		anticholesteremic drug;
antilipemic drug;
antimetabolite
morin-5'-sulfonic acid[no description available]medium10
methamphetamine[no description available]medium10amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
hydralazine[no description available]medium20azaarene;
hydrazines;
ortho-fused heteroarene;
phthalazines		antihypertensive agent;
vasodilator agent
cortistatin 14[no description available]medium10
pentoxifylline[no description available]medium10oxopurine
nitroarginine[no description available]medium30guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
oxadiazoles[no description available]medium10
4-hydroxy-2-nonenal[no description available]medium404-hydroxynon-2-enal;
4-hydroxynonenal
s-adenosylethionine[no description available]medium11
trimethyllysine[no description available]medium21alpha-amino-acid cationhuman metabolite;
mouse metabolite
vitamin b 12[no description available]medium147
folic acid[no description available]medium2410folic acids;
N-acyl-amino acid		human metabolite;
mouse metabolite;
nutrient
ethionine[no description available]medium11S-ethylhomocysteineantimetabolite;
carcinogenic agent
vitamin b 6[no description available]medium73
pioglitazone[no description available]medium43aromatic ether;
pyridines;
thiazolidinediones		antidepressant;
cardioprotective agent;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hypoglycemic agent;
insulin-sensitizing drug;
PPARgamma agonist;
xenobiotic
glimepiride[no description available]medium11sulfonamide
lansoprazole[no description available]medium32benzimidazoles;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
s 1743[no description available]medium10magnesium saltanti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
cyproterone acetate[no description available]medium5220-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
chlorinated steroid;
steroid ester		androgen antagonist;
geroprotector;
progestin
ethinyl estradiol[no description available]medium5217-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
cyproterone acetate, ethinyl estradiol drug combination[no description available]medium10
sphingosine[no description available]medium20sphing-4-eninehuman metabolite;
mouse metabolite
n-acetylsphingosine[no description available]medium10N-acylsphingosine
mycophenolic acid[no description available]medium202-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
tacrolimus[no description available]medium40macrolide lactambacterial metabolite;
immunosuppressive agent
prednisone[no description available]medium1011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
immunosuppressive agent;
prodrug
sodium nitrate[no description available]medium10inorganic nitrate salt;
inorganic sodium salt		fertilizer;
NMR chemical shift reference compound
peroxynitrous acid[no description available]medium90nitrogen oxoacid
pyrroles[no description available]medium85pyrrole;
secondary amine
atorvastatin[no description available]medium115aromatic amide;
dihydroxy monocarboxylic acid;
monofluorobenzenes;
pyrroles;
statin (synthetic)		environmental contaminant;
xenobiotic
fluorobenzenes[no description available]medium41monofluorobenzenesNMR chemical shift reference compound
phosphoserine[no description available]medium10non-proteinogenic alpha-amino acid;
O-phosphoamino acid;
serine derivative		human metabolite
curcumin[no description available]medium10aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
transforming growth factor beta[no description available]medium70
ribavirin[no description available]medium201-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
vildagliptin[no description available]medium11amino acid amide
adamantane[no description available]medium11adamantanes;
polycyclic alkane
fibrinogen[no description available]medium62iditolfungal metabolite
gw 4064[no description available]medium30stilbenoid
capsaicin[no description available]medium10capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
isoxazoles[no description available]medium30isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
eicosapentaenoic acid[no description available]medium30icosapentaenoic acid;
omega-3 fatty acid		anticholesteremic drug;
antidepressant;
antineoplastic agent;
Daphnia galeata metabolite;
fungal metabolite;
micronutrient;
mouse metabolite;
nutraceutical
fluorodeoxyglucose f18[no description available]medium112-deoxy-2-((18)F)fluoro-D-glucose;
2-deoxy-2-fluoro-aldehydo-D-glucose
guanidine[no description available]medium10carboxamidine;
guanidines;
one-carbon compound
s-adenosylhomocysteine[no description available]medium40adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide		cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite
aliskiren[no description available]medium31monocarboxylic acid amide;
monomethoxybenzene		antihypertensive agent
fumarates[no description available]medium31butenedioate;
C4-dicarboxylate		human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
caffeine[no description available]medium10purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
alanine[no description available]medium10alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
11-dehydro-thromboxane b2[no description available]medium31thromboxanehuman metabolite
thromboxane b2[no description available]medium41thromboxanes Bhuman metabolite;
mouse metabolite
propargylglycine[no description available]medium10
avapro[no description available]medium20azaspiro compound;
biphenylyltetrazole		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic
formestane[no description available]medium1017-oxo steroid;
3-oxo-Delta(4) steroid;
enol;
hydroxy steroid		antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
androstenedione[no description available]medium1017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
alpha-linolenic acid[no description available]medium21linolenic acid;
omega-3 fatty acid		micronutrient;
mouse metabolite;
nutraceutical
desoxycorticosterone acetate[no description available]medium10corticosteroid hormone
topiramate[no description available]medium10cyclic ketal;
ketohexose derivative;
sulfamate ester		anticonvulsant;
sodium channel blocker
galactosamine[no description available]medium10D-galactosamine;
primary amino compound		toxin
oxymatrine[no description available]medium20
isoproterenol[no description available]medium20catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
6-sulfatoxymelatonin[no description available]medium10acetamides
oxyntomodulin[no description available]medium10
acetovanillone[no description available]medium50acetophenones;
aromatic ketone;
methyl ketone		antirheumatic drug;
EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite
gliclazide[no description available]medium10
prostaglandin i3[no description available]medium10prostanoid
alprostadil[no description available]medium21prostaglandins Eanticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent
cyclosporine[no description available]medium40
gamma-aminobutyric acid[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
firefly luciferin[no description available]medium101,3-thiazolemonocarboxylic acid;
benzothiazoles;
imidothioate		luciferin
sirolimus[no description available]medium30antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
3-carboxy-4-methyl-5-propyl-2-furanpropionic acid[no description available]medium10dicarboxylic acid;
furoic acid		human metabolite;
uremic toxin
fenofibrate[no description available]medium32aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
vardenafil dihydrochloride[no description available]medium11
papaverine[no description available]medium20benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
n(6)-carboxymethyllysine[no description available]medium20L-lysine derivative;
non-proteinogenic L-alpha-amino acid		antigen
coenzyme q10[no description available]medium21ubiquinonesantioxidant;
ferroptosis inhibitor;
human metabolite
ubiquinone[no description available]medium21
glutathione disulfide[no description available]medium10glutathione derivative;
organic disulfide		Escherichia coli metabolite;
mouse metabolite
ascorbic acid[no description available]medium82ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
d-alpha tocopherol[no description available]medium144alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
sphingosine 1-phosphate[no description available]medium10sphingoid 1-phosphatemouse metabolite;
signalling molecule;
sphingosine-1-phosphate receptor agonist;
T-cell proliferation inhibitor;
vasodilator agent
technetium tc 99m sestamibi[no description available]medium10
icariin[no description available]medium10flavonols;
glycosyloxyflavone		antioxidant;
bone density conservation agent;
EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
phytoestrogen
bradykinin[no description available]medium11oligopeptidehuman blood serum metabolite;
vasodilator agent
ramipril[no description available]medium53azabicycloalkane;
cyclopentapyrrole;
dicarboxylic acid monoester;
dipeptide;
ethyl ester		bradykinin receptor B2 agonist;
cardioprotective agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
matrix metalloproteinase inhibitor;
prodrug
oleanolic acid[no description available]medium10hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
creatine[no description available]medium30glycine derivative;
guanidines;
zwitterion		geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical
telmisartan[no description available]medium62benzimidazoles;
biphenyls;
carboxybiphenyl		angiotensin receptor antagonist;
antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
environmental contaminant;
xenobiotic
captopril[no description available]medium51alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
bardoxolone methyl[no description available]medium10cyclohexenones
hydrochlorothiazide[no description available]medium21benzothiadiazine;
organochlorine compound;
sulfonamide		antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
linagliptin[no description available]medium11aminopiperidine;
quinazolines		EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
hypoglycemic agent
triiodothyronine[no description available]medium302-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
phenylalanine[no description available]medium31amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
pindolol[no description available]medium10indoles;
secondary amine		antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
serotonergic antagonist;
vasodilator agent
phenylephrine[no description available]medium70phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
cyanopindolol[no description available]medium10indoles
butoxamine[no description available]medium10
esmolol[no description available]medium30aromatic ether;
ethanolamines;
methyl ester;
secondary alcohol;
secondary amino compound
n-methylnicotinamide[no description available]medium10pyridinecarboxamidemetabolite
calpain[no description available]medium10
epigallocatechin gallate[no description available]medium30flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
diallyl trisulfide[no description available]medium10organic trisulfideanti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
antioxidant;
antiprotozoal drug;
apoptosis inducer;
estrogen receptor antagonist;
insecticide;
platelet aggregation inhibitor;
vasodilator agent
naproxen[no description available]medium10methoxynaphthalene;
monocarboxylic acid		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
atb-346[no description available]medium10
simvastatin[no description available]medium136delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
statin (semi-synthetic)		EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
ferroptosis inducer;
geroprotector;
prodrug
omeprazole[no description available]medium10aromatic ether;
benzimidazoles;
pyridines;
sulfoxide
suramin[no description available]medium10naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
glutamic acid[no description available]medium50glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
s-nitroso-n-acetylpenicillamine[no description available]medium60nitroso compound;
nitrosothio compound		nitric oxide donor;
vasodilator agent
choline[no description available]medium20cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
adrenomedullin[no description available]medium20
sucrose[no description available]medium20glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
allantoin[no description available]medium20imidazolidine-2,4-dione;
ureas		Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite;
vulnerary
hypochlorous acid[no description available]medium20chlorine oxoacid;
reactive oxygen species		EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite
taurine[no description available]medium30amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
methacholine chloride[no description available]medium10quaternary ammonium salt
ibuprofen[no description available]medium10monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
ibuprofen arginine[no description available]medium10
3-aminoisobutyric acid[no description available]medium10amino acid zwitterion;
beta-amino acid		metabolite
uracil[no description available]medium11pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
trelagliptin[no description available]medium11benzenes;
nitrile
tanshinone[no description available]medium10abietane diterpenoidanticoronaviral agent
iloprost[no description available]medium31carbobicyclic compound;
monocarboxylic acid;
secondary alcohol		platelet aggregation inhibitor;
vasodilator agent
heme[no description available]medium10
nadp[no description available]medium20
sapropterin[no description available]medium1105,6,7,8-tetrahydrobiopterincoenzyme;
cofactor;
diagnostic agent;
human metabolite
carvedilol[no description available]medium21carbazoles;
secondary alcohol;
secondary amino compound		alpha-adrenergic antagonist;
antihypertensive agent;
beta-adrenergic antagonist;
cardiovascular drug;
vasodilator agent
epoetin alfa[no description available]medium20
trifluoroacetic acid[no description available]medium10fluoroalkanoic acidhuman xenobiotic metabolite;
NMR chemical shift reference compound;
reagent
acrylonitrile[no description available]medium10aliphatic nitrile;
volatile organic compound		antifungal agent;
carcinogenic agent;
fungal metabolite;
mutagen;
polar aprotic solvent
13-hydroxy-9,11-octadecadienoic acid[no description available]medium20octadecadienoic acid
noc 18[no description available]medium10
colchicine[no description available]medium10alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
pravastatin[no description available]medium543-hydroxy carboxylic acid;
carbobicyclic compound;
carboxylic ester;
hydroxy monocarboxylic acid;
secondary alcohol;
statin (semi-synthetic)		anticholesteremic drug;
environmental contaminant;
metabolite;
xenobiotic
nitrous oxide[no description available]medium21gas molecular entity;
nitrogen oxide		analgesic;
bacterial metabolite;
food packaging gas;
food propellant;
general anaesthetic;
greenhouse gas;
inhalation anaesthetic;
NMDA receptor antagonist;
raising agent;
refrigerant;
vasodilator agent
natriuretic peptide, c-type[no description available]medium10
fk 409[no description available]medium10
kt 5823[no description available]medium10gamma-lactam;
hemiaminal;
indolocarbazole;
methyl ester;
organic heterooctacyclic compound		EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor
8-bromocyclic gmp[no description available]medium603',5'-cyclic purine nucleotide;
organobromine compound		muscle relaxant;
protein kinase G agonist
quinapril[no description available]medium20dicarboxylic acid monoester;
ethyl ester;
isoquinolines;
tertiary carboxamide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
prodrug
edetic acid[no description available]medium10ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
thapsigargin[no description available]medium10butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole[no description available]medium10ether;
imidazoles;
monomethoxybenzene		TRP channel blocker
n-formylmethionine leucyl-phenylalanine[no description available]medium10tripeptide
lidocaine[no description available]medium10benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
thromboplastin[no description available]medium30
psyllium[no description available]medium10very long-chain fatty acid
8-iso-prostaglandin a2[no description available]medium10prostanoid
propane[no description available]medium71alkane;
gas molecular entity		food propellant
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid[no description available]medium11chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
n(omega)-hydroxyarginine[no description available]medium30amino acid zwitterion;
N(5)-[(E)-amino(hydroxyimino)methyl]ornithine;
N(5)-[(hydroxyamino)(imino)methyl]ornithine;
N(5)-[(Z)-amino(hydroxyimino)methyl]ornithine;
N(5)-[amino(hydroxyimino)methyl]-L-ornithine;
N(5)-[amino(hydroxyimino)methyl]ornithine;
N(omega)-hydroxy-L-arginine
ranolazine[no description available]medium11aromatic amide;
monocarboxylic acid amide;
monomethoxybenzene;
N-alkylpiperazine;
secondary alcohol
anandamide[no description available]medium10endocannabinoid;
N-acylethanolamine 20:4		human blood serum metabolite;
neurotransmitter;
vasodilator agent
am 404[no description available]medium10anilide
serine[no description available]medium10L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
buthionine sulfoximine[no description available]medium10diastereoisomeric mixture;
homocysteines;
non-proteinogenic alpha-amino acid;
sulfoximide		EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor;
ferroptosis inducer
rosiglitazone[no description available]medium32aminopyridine;
thiazolidinediones		EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug
pitavastatin[no description available]medium22cyclopropanes;
dihydroxy monocarboxylic acid;
monofluorobenzenes;
quinolines;
statin (synthetic)		antioxidant
carbamazepine[no description available]medium30dibenzoazepine;
ureas		analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic
5-methyltetrahydrofolate[no description available]medium11
thioctic acid[no description available]medium32dithiolanes;
heterocyclic fatty acid;
thia fatty acid		fundamental metabolite;
geroprotector
genistein[no description available]medium117-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
phytoestrogens[no description available]medium11
ethylene glycol[no description available]medium10ethanediol;
glycol		metabolite;
mouse metabolite;
solvent;
toxin
verapamil[no description available]medium10aromatic ether;
nitrile;
polyether;
tertiary amino compound
beta carotene[no description available]medium11carotenoid beta-end derivative;
cyclic carotene		antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A
1-methyl-4-phenylpyridinium[no description available]medium20pyridinium ionapoptosis inducer;
herbicide;
human xenobiotic metabolite;
neurotoxin
hydroxyl radical[no description available]medium10oxygen hydride;
oxygen radical;
reactive oxygen species
3,4',5-trimethoxystilbene[no description available]medium10
zidovudine[no description available]medium10azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
indinavir sulfate[no description available]medium10dicarboxylic acid diamide;
N-(2-hydroxyethyl)piperazine;
piperazinecarboxamide		HIV protease inhibitor
naloxone[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
morphine[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
candesartan[no description available]medium10benzimidazolecarboxylic acid;
biphenylyltetrazole		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic
monocrotaline[no description available]medium30pyrrolizidine alkaloid
3-hydroxybutyric acid[no description available]medium10(omega-1)-hydroxy fatty acid;
3-hydroxy monocarboxylic acid;
hydroxybutyric acid		human metabolite
ovalbumin[no description available]medium10
hydroxyindoleacetic acid[no description available]medium10indole-3-acetic acidsdrug metabolite;
human metabolite;
mouse metabolite
amoxicillin[no description available]medium11penicillin allergen;
penicillin		antibacterial drug
clarithromycin[no description available]medium11macrolide antibioticantibacterial drug;
environmental contaminant;
protein synthesis inhibitor;
xenobiotic
metoprolol[no description available]medium10aromatic ether;
propanolamine;
secondary alcohol;
secondary amino compound		antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
geroprotector;
xenobiotic
3,4,5,6-tetrahydroxyxanthone[no description available]medium10
phenanthrenes[no description available]medium10
1-keto-1,2,3,4-tetrahydrophenanthrene[no description available]medium10
arachidonic acid[no description available]medium10icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
amyloid beta-peptides[no description available]medium10
tolafentrine[no description available]medium20
neferine[no description available]medium10
malealdehyde[no description available]medium10but-2-enedial
epoxomicin[no description available]medium10morpholines;
tripeptide		proteasome inhibitor
chloroquine[no description available]medium10aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
leupeptins[no description available]medium10
benzyloxycarbonylleucyl-leucyl-leucine aldehyde[no description available]medium10amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
aconitic acid[no description available]medium10tricarboxylic acid
guanidinosuccinic acid[no description available]medium10L-alpha-amino acid anion
nicotine[no description available]medium413-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
indoleacetic acid[no description available]medium10indole-3-acetic acids;
monocarboxylic acid		auxin;
human metabolite;
mouse metabolite;
plant hormone;
plant metabolite
4-cresol sulfate[no description available]medium10aryl sulfategut flora metabolite;
human metabolite;
uremic toxin
aminooxyacetic acid[no description available]medium10amino acid;
hydroxylamines;
monocarboxylic acid		anticonvulsant;
EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
nootropic agent
cytochrome c-t[no description available]medium10
cyclin d1[no description available]medium10
silybin[no description available]medium10
l-arginine alpha-ketoglutarate[no description available]medium11
cytochalasin d[no description available]medium10
jasplakinolide[no description available]medium10cyclodepsipeptide;
phenols		actin polymerisation inducer;
animal metabolite;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
marine metabolite;
neuroprotective agent
tram 34[no description available]medium10organochlorine compound
ns 309[no description available]medium10
fluorescein-5-isothiocyanate[no description available]medium10fluorescein isothiocyanate
sb 203580[no description available]medium30imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent
t0156[no description available]medium10naphthyridine derivative
carbonates[no description available]medium10carbon oxoanion
puromycin aminonucleoside[no description available]medium203'-deoxyribonucleoside;
adenosines
ebselen[no description available]medium10benzoselenazoleanti-inflammatory drug;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 3.5.4.1 (cytosine deaminase) inhibitor;
EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor;
enzyme mimic;
ferroptosis inhibitor;
genotoxin;
hepatoprotective agent;
neuroprotective agent;
radical scavenger
liraglutide[no description available]medium11lipopeptide;
polypeptide		glucagon-like peptide-1 receptor agonist;
neuroprotective agent
prostaglandin f-main urinary metabolite[no description available]medium11
nisoldipine[no description available]medium11C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
methyl ester
olmesartan[no description available]medium11biphenylyltetrazoleangiotensin receptor antagonist;
antihypertensive agent
iberiotoxin[no description available]medium10
acetylcarnitine[no description available]medium10O-acylcarnitinehuman metabolite
pyrogallol[no description available]medium10benzenetriol;
phenolic donor		plant metabolite
valine[no description available]medium95L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
sulfasalazine[no description available]medium10
glycerol[no description available]medium10alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
tocopherols[no description available]medium11
gamma-tocopherol[no description available]medium11tocopherol;
vitamin E		algal metabolite;
food antioxidant;
plant metabolite
bisoprolol[no description available]medium11secondary alcohol;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent
landiolol[no description available]medium11morpholines
n-acetylaspartic acid[no description available]medium10N-acetyl-L-amino acid;
N-acyl-L-aspartic acid		antioxidant;
human metabolite;
mouse metabolite;
nutraceutical;
rat metabolite
aspartic acid[no description available]medium20aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
inositol[no description available]medium10cyclitol;
hexol
carbon monoxide[no description available]medium10carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
pimagedine[no description available]high30guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
pimagedine[no description available]high31guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
oxcarbazepine[no description available]medium10cyclic ketone;
dibenzoazepine		anticonvulsant;
drug allergen
digoxin[no description available]medium11cardenolide glycoside;
steroid saponin		anti-arrhythmia drug;
cardiotonic drug;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
epitope
isosorbide dinitrate[no description available]medium21glucitol derivative;
nitrate ester		nitric oxide donor;
vasodilator agent
isosorbide-5-mononitrate[no description available]medium11glucitol derivative;
nitrate ester		nitric oxide donor;
vasodilator agent
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cysteinylglycine[no description available]medium10dipeptide zwitterion;
dipeptide		Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea[no description available]medium10aminopyrimidine;
dichlorobenzene;
N-alkylpiperazine;
N-arylpiperazine;
phenylureas		antineoplastic agent;
fibroblast growth factor receptor antagonist
eprosartan[no description available]medium21dicarboxylic acid;
imidazoles;
thiophenes		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic
enalapril[no description available]medium54dicarboxylic acid monoester;
dipeptide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
geroprotector;
prodrug
thiophenes[no description available]medium21mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
raloxifene hydrochloride[no description available]medium11hydrochloridebone density conservation agent;
estrogen antagonist;
estrogen receptor modulator
2,3-naphthalenedicarboxaldehyde[no description available]medium10
pyridoxine[no description available]medium32hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
vitamin B6		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
homocystine[no description available]medium21amino acid zwitterion;
homocystines		human metabolite
trimegestone[no description available]medium1120-oxo steroid
promegestone[no description available]medium1120-oxo steroid;
3-oxo-Delta(4) steroid		antineoplastic agent;
progesterone receptor agonist;
progestin
dydrogesterone[no description available]medium1120-oxo steroid;
3-oxo-Delta(4) steroid		progestin
lipid a[no description available]medium10dodecanoate ester;
lipid A;
tetradecanoate ester		Escherichia coli metabolite
miconazole[no description available]medium10dichlorobenzene;
ether;
imidazoles
ethidium[no description available]medium20phenanthridinesfluorochrome;
intercalator
sepiapterin[no description available]medium20sepiapterin
7,8-dihydrobiopterin[no description available]medium207,8-dihydrobiopterin
pyridoxal phosphate[no description available]medium10methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate		coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
carbachol[no description available]medium20ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
zofenopril[no description available]medium11aryl sulfide;
L-proline derivative;
N-acyl-L-amino acid;
thioester		anticonvulsant;
apoptosis inhibitor;
cardioprotective agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
prodrug;
vasodilator agent
temocapril hydrochloride[no description available]medium20dipeptide
olmesartan medoxomil[no description available]medium10biphenyls
penicillamine[no description available]medium50non-proteinogenic alpha-amino acid;
penicillamine		antirheumatic drug;
chelator;
copper chelator;
drug allergen
benidipine[no description available]medium10
s-nitro-n-acetylpenicillamine[no description available]medium30
dihydropyridines[no description available]medium10
4-chloro-7-nitrobenzofurazan[no description available]medium10benzoxadiazole;
C-nitro compound;
organochlorine compound		EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.6.1.3 (adenosinetriphosphatase) inhibitor;
fluorescent probe;
fluorochrome
7-fluoro-4-nitrobenzo-2-oxa-1,3-diazole[no description available]medium10
hypoxanthine[no description available]medium11nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite
xanthine[no description available]medium11xanthineSaccharomyces cerevisiae metabolite
pyrrolidine dithiocarbamate[no description available]medium20dithiocarbamic acids;
pyrrolidines		anticonvulsant;
antineoplastic agent;
geroprotector;
neuroprotective agent;
NF-kappaB inhibitor;
radical scavenger
o-phthalaldehyde[no description available]medium20benzaldehydes;
dialdehyde		epitope
caseins[no description available]medium10
diphenyliodonium[no description available]medium10
niacin[no description available]medium10pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
alpha-cyano-4-hydroxycinnamate[no description available]medium10
sepharose[no description available]medium10
2-diethylaminoethanol[no description available]medium10ethanolamines;
primary alcohol;
tertiary amino compound
cotinine[no description available]medium30N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid		antidepressant;
biomarker;
human xenobiotic metabolite;
plant metabolite
4-butyrolactone[no description available]medium11butan-4-olidemetabolite;
neurotoxin
lignans[no description available]medium11
2,3-bis(3'-hydroxybenzyl)butyrolactone[no description available]medium11lignan
casein kinase ii[no description available]medium10
acetazolamide[no description available]medium10monocarboxylic acid amide;
sulfonamide;
thiadiazoles		anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
amlodipine[no description available]medium31dihydropyridine;
ethyl ester;
methyl ester;
monochlorobenzenes;
primary amino compound		antihypertensive agent;
calcium channel blocker;
vasodilator agent
dihydroethidium[no description available]medium10
calca protein, human[no description available]medium10
c-peptide[no description available]medium10
cortisone[no description available]medium1011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
puerarin[no description available]medium10C-glycosyl compound;
isoflavonoid
nateglinide[no description available]medium11phenylalanine derivative
calcimycin[no description available]medium40benzoxazole
desogestrel[no description available]medium1117beta-hydroxy steroid;
terminal acetylenic compound		contraceptive drug;
progestin;
synthetic oral contraceptive
salicylic acid[no description available]medium10monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
concanavalin a[no description available]medium10
alloxan[no description available]medium20pyrimidonehyperglycemic agent;
metabolite
trandolapril[no description available]medium11dicarboxylic acid monoester;
dipeptide;
ethyl ester;
organic heterobicyclic compound;
secondary amino compound;
tertiary carboxamide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
prodrug
ninhydrin[no description available]medium10aromatic ketone;
beta-diketone;
indanones;
ketone hydrate		colour indicator;
human metabolite
glyburide[no description available]medium11monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
glycogen[no description available]medium10
gw9662[no description available]medium10benzamides
beta-escin[no description available]medium10
3-methylhistidine[no description available]medium10L-histidine derivative;
non-proteinogenic L-alpha-amino acid;
zwitterion		human metabolite;
Saccharomyces cerevisiae metabolite
fibrin[no description available]medium10peptide
methylguanidine[no description available]high10guanidinesEC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite;
uremic toxin
methylguanidine[no description available]high11guanidinesEC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite;
uremic toxin
5-doxylstearate[no description available]medium10aminoxyls
estriol[no description available]medium1016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
myelin basic protein[no description available]medium10
n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide[no description available]medium10aromatic ether;
C-nitro compound;
sulfonamide		antineoplastic agent;
cyclooxygenase 2 inhibitor
thiazoles[no description available]medium101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
tretinoin[no description available]medium10retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
n-(3-(aminomethyl)benzyl)acetamidine[no description available]low00aralkylamine;
carboxamidine;
primary amino compound		angiogenesis inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
geroprotector
formamidine[no description available]low00carboxamidine;
formamidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
zaluzanin C[no description available]low00gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite
nitroflurbiprofen[no description available]low00biphenyls;
carboxylic ester;
nitrate ester;
organofluorine compound		cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
geroprotector;
non-steroidal anti-inflammatory drug;
vasodilator agent
yakuchinone-a[no description available]low00ketone;
monomethoxybenzene;
phenols		antineoplastic agent;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite
ng-nitroarginine methyl ester[no description available]low00hydrochlorideEC 1.14.13.39 (nitric oxide synthase) inhibitor
p-hydroxycinnamaldehyde[no description available]low00cinnamaldehydesapoptosis inducer;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
plant metabolite
propylthiouracil[no description available]low00pyrimidinethioneantidote to paracetamol poisoning;
antimetabolite;
antioxidant;
antithyroid drug;
carcinogenic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
hormone antagonist
myricitrin[no description available]low00alpha-L-rhamnoside;
glycosyloxyflavone;
monosaccharide derivative;
pentahydroxyflavone		anti-allergic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one[no description available]low00dihydroxyflavone;
monomethoxyflavone		antineoplastic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor
bis(7)-tacrine[no description available]low00secondary amino compoundapoptosis inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
neuroprotective agent
dihydroxanthohumol[no description available]low00aromatic ether;
dihydrochalcones;
polyphenol		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite
ainsliadimer a[no description available]low00sesquiterpene lactone;
spiro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite
levodopa[no description available]low00amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug
pyrrolidonecarboxylic acid[no description available]low005-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
diazooxonorleucine[no description available]low00amino acid zwitterion;
diazo compound;
ketone;
non-proteinogenic L-alpha-amino acid		analgesic;
antibacterial agent;
antimetabolite;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
bacterial metabolite;
EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor;
EC 3.5.1.2 (glutaminase) inhibitor;
EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor;
EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor;
EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor;
EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor;
EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor;
EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor;
glutamine antagonist
diiodotyrosine[no description available]low00diiodotyrosine;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		human metabolite;
mouse metabolite
3-methoxytyrosine[no description available]low00aromatic L-alpha-amino acid zwitterion;
L-tyrosine derivative;
monomethoxybenzene;
non-proteinogenic L-alpha-amino acid		human metabolite
kainic acid[no description available]low00dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
norleucine[no description available]low002-aminohexanoic acid;
L-alpha-amino acid zwitterion;
non-proteinogenic L-alpha-amino acid
phosphotyrosine[no description available]low00L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid;
O(4)-phosphotyrosine		Escherichia coli metabolite;
immunogen
methyldopa[no description available]low00L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		alpha-adrenergic agonist;
antihypertensive agent;
hapten;
peripheral nervous system drug;
sympatholytic agent
homocitrulline[no description available]low00amino acid zwitterion;
L-lysine derivative;
non-proteinogenic L-alpha-amino acid;
ureas		human metabolite;
mouse metabolite
cystine[no description available]low00cystine zwitterion;
cystine;
L-cysteine derivative;
non-proteinogenic L-alpha-amino acid		EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitor;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
djenkolic acid[no description available]low00dithioacetal;
L-cysteine derivative;
non-proteinogenic L-alpha-amino acid		plant metabolite;
toxin
furanomycin[no description available]low00dihydrofuran;
non-proteinogenic L-alpha-amino acid		antibacterial agent;
antimicrobial agent;
bacterial metabolite
biocytin[no description available]low00azabicycloalkane;
L-alpha-amino acid zwitterion;
L-lysine derivative;
monocarboxylic acid amide;
non-proteinogenic L-alpha-amino acid;
thiabicycloalkane;
ureas		mouse metabolite
o-methylserine[no description available]low00L-serine derivative;
non-proteinogenic L-alpha-amino acid		metabolite
methionine sulfoximine[no description available]low00L-alpha-amino acid zwitterion;
L-methionine derivative;
methionine sulfoximine;
non-proteinogenic L-alpha-amino acid		EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor;
geroprotector
1-methylhistidine[no description available]low00L-histidine derivative;
non-proteinogenic L-alpha-amino acid;
zwitterion		human metabolite
phospho-l-arginine[no description available]low00L-arginine derivative;
non-proteinogenic L-alpha-amino acid;
phosphagen;
phosphoamino acid		animal metabolite
albizziin[no description available]low00non-proteinogenic L-alpha-amino acid
s-2-aminoethyl cysteine[no description available]low00L-cysteine thioether;
non-proteinogenic L-alpha-amino acid		EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitor;
metabolite;
protein synthesis inhibitor
beta-n-methylamino-l-alanine[no description available]low00diamino acid;
L-alanine derivative;
non-proteinogenic L-alpha-amino acid;
secondary amino compound		bacterial metabolite;
neurotoxin
4-ketoproline[no description available]low004-oxoproline;
amino acid zwitterion;
L-proline derivative;
non-proteinogenic L-alpha-amino acid
indospicine[no description available]low00carboxamidine;
non-proteinogenic L-alpha-amino acid		hepatotoxic agent;
plant metabolite
coprine[no description available]low00cyclopropanes;
dicarboxylic acid monoamide;
L-glutamine derivative;
non-proteinogenic L-alpha-amino acid		EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
metabolite;
mycotoxin
3-chloro-L-tyrosine[no description available]low00chloroamino acid;
L-alpha-amino acid zwitterion;
L-tyrosine derivative;
monochlorobenzenes;
non-proteinogenic L-alpha-amino acid		biomarker;
human metabolite
tabtoxinine beta-lactam[no description available]low00beta-lactam antibiotic;
monobactam;
non-proteinogenic L-alpha-amino acid;
tertiary alpha-hydroxy ketone		apoptosis inducer;
bacterial metabolite;
EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
pentosidine[no description available]low00imidazopyridine;
non-proteinogenic L-alpha-amino acid		biomarker;
cross-linking reagent
mannopine[no description available]low00amino acid opine;
dicarboxylic acid monoamide;
hexitol derivative;
L-glutamine derivative;
non-proteinogenic L-alpha-amino acid;
secondary amino compound		plant metabolite
dansyllysine[no description available]low00L-lysine derivative;
non-proteinogenic L-alpha-amino acid;
sulfonamide		epitope
deoxyhypusine[no description available]low00L-lysine derivative;
non-proteinogenic L-alpha-amino acid		human metabolite
2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine[no description available]low00L-lysine derivative;
N-substituted pyrraline;
non-proteinogenic L-alpha-amino acid
5-fluorowillardiine[no description available]low00L-alanine derivative;
non-proteinogenic L-alpha-amino acid;
organofluorine compound		AMPA receptor agonist
4-fluorothreonine[no description available]low00amino acid zwitterion;
fluoroamino acid;
L-threonine derivative;
non-proteinogenic L-alpha-amino acid
ovothiol a[no description available]low00aryl thiol;
L-alpha-amino acid zwitterion;
L-histidine derivative;
non-proteinogenic L-alpha-amino acid		antioxidant;
marine metabolite;
radical scavenger
selenomethylselenocysteine[no description available]low00amino acid zwitterion;
L-selenocysteine derivative;
non-proteinogenic L-alpha-amino acid;
Se-methylselenocysteine		antineoplastic agent
beta-aspartyl phosphate[no description available]low00aminoacyl phosphate;
L-aspartic acid derivative;
non-proteinogenic L-alpha-amino acid		Escherichia coli metabolite
vinylglycine[no description available]low00glycine derivative;
L-alpha-amino acid zwitterion;
non-proteinogenic L-alpha-amino acid		EC 4.4.1.14 (1-aminocyclopropane-1-carboxylate synthase) inhibitor
methyl-3-tyrosine[no description available]low00amino acid zwitterion;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid
i-677[no description available]low00L-serine derivative;
non-proteinogenic L-alpha-amino acid		antimetabolite;
antimicrobial agent;
antineoplastic agent;
metabolite
allysine[no description available]low00allysine;
amino acid zwitterion;
aminoadipate semialdehyde;
non-proteinogenic L-alpha-amino acid		human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
kynurenine[no description available]low00amino acid zwitterion;
kynurenine;
non-proteinogenic L-alpha-amino acid		human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
n(5)-hydroxy-l-arginine[no description available]low00hydroxy-L-arginine;
non-proteinogenic L-alpha-amino acid
felinine[no description available]low00L-cysteine thioether;
non-proteinogenic L-alpha-amino acid;
S-alkyl-L-cysteine zwitterion		mammalian metabolite;
pheromone
serine o-sulfate[no description available]low00L-serine derivative;
non-proteinogenic L-alpha-amino acid;
O-sulfoamino acid
epsilon-n-methyllysine[no description available]low00L-lysine derivative;
non-proteinogenic L-alpha-amino acid
trifluoromethionine[no description available]low00L-methionine derivative;
non-proteinogenic L-alpha-amino acid;
organofluorine compound
cysteinesulfenic acid[no description available]low00L-cysteine derivative;
non-proteinogenic L-alpha-amino acid
delta-n-methylarginine[no description available]low00guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
2-amino-4-phosphonobutyric acid[no description available]low00non-proteinogenic L-alpha-amino acid;
phosphonic acids		metabotropic glutamate receptor agonist
epsilon n-dimethyllysine[no description available]low00L-lysine derivative;
non-proteinogenic L-alpha-amino acid
hydroxythreonine[no description available]low00amino acid zwitterion;
hydroxy-amino acid;
L-threonine derivative;
non-proteinogenic L-alpha-amino acid		Escherichia coli metabolite;
Saccharomyces cerevisiae metabolite
carbocysteine[no description available]low00L-cysteine thioether;
non-proteinogenic L-alpha-amino acid		mucolytic
acivicin[no description available]low00isoxazoles;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		antileishmanial agent;
antimetabolite;
antimicrobial agent;
antineoplastic agent;
EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor;
glutamine antagonist;
metabolite
canavanine[no description available]low00amino acid zwitterion;
non-proteinogenic L-alpha-amino acid		phytogenic insecticide;
plant metabolite
5-hydroxytryptophan[no description available]low005-hydroxytryptophan;
amino acid zwitterion;
hydroxy-L-tryptophan;
non-proteinogenic L-alpha-amino acid		human metabolite;
mouse metabolite;
plant metabolite
agaritine[no description available]low00amino acid zwitterion;
benzyl alcohols;
carbohydrazide;
L-glutamic acid derivative;
non-proteinogenic L-alpha-amino acid
monoiodotyrosine[no description available]low00amino acid zwitterion;
L-tyrosine derivative;
monoiodotyrosine;
non-proteinogenic L-alpha-amino acid		EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor;
human metabolite;
mouse metabolite
n'-formylkynurenine[no description available]low00amino acid zwitterion;
N-formylkynurenine;
non-proteinogenic amino acid derivative;
non-proteinogenic L-alpha-amino acid		human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
3,5-dichlorotyrosine[no description available]low00chloroamino acid;
dichlorobenzene;
dihalogenated L-tyrosine;
non-proteinogenic L-alpha-amino acid
willardiine[no description available]low00amino acid zwitterion;
L-alanine derivative;
non-proteinogenic L-alpha-amino acid
mimosine[no description available]low004-pyridones;
amino acid zwitterion;
non-proteinogenic L-alpha-amino acid		EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite
metyrosine[no description available]low00L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		antihypertensive agent;
EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor
canaline[no description available]low00amino acid zwitterion;
non-proteinogenic L-alpha-amino acid		antimetabolite;
antineoplastic agent;
phytogenic insecticide;
plant metabolite
2,5-dihydrophenylalanine[no description available]low00non-proteinogenic L-alpha-amino acid
c(alpha)-formylglycine[no description available]low003-oxoalanine;
amino acid zwitterion;
L-alanine derivative;
non-proteinogenic L-alpha-amino acid		Escherichia coli metabolite
3,5-dihydroxyphenylglycine[no description available]low00amino acid zwitterion;
non-proteinogenic L-alpha-amino acid;
resorcinols
methionine sulfone[no description available]low00L-alpha-amino acid zwitterion;
L-methionine derivative;
methionine sulfone;
non-proteinogenic L-alpha-amino acid		animal metabolite
cefoxitin[no description available]low00L-serine derivative;
non-proteinogenic L-alpha-amino acid		tumour antigen
(S)-ATPA[no description available]low00isoxazoles;
non-proteinogenic L-alpha-amino acid		metabolite
azaserine[no description available]low00carboxylic ester;
diazo compound;
L-serine derivative;
non-proteinogenic L-alpha-amino acid		antifungal agent;
antimetabolite;
antimicrobial agent;
antineoplastic agent;
glutamine antagonist;
immunosuppressive agent;
metabolite
melphalan[no description available]low00L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
4-fluorophenyl-L-alanine[no description available]low004-fluorophenylalanine;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid
o-methyl threonine[no description available]low00ether;
L-threonine derivative;
non-proteinogenic L-alpha-amino acid		antibacterial agent;
bleaching agent
n(6)-(1-iminoethyl)lysine[no description available]low00L-lysine derivative;
non-proteinogenic L-alpha-amino acid
glycerophosphoserine[no description available]low00glycerol 1-phosphodiester;
L-serine derivative;
non-proteinogenic L-alpha-amino acid
7-chlorotryptophan[no description available]low007-chlorotryptophan;
amino acid zwitterion;
L-tryptophan derivative;
non-proteinogenic L-alpha-amino acid
phosphothreonine[no description available]low00L-threonine derivative;
non-proteinogenic L-alpha-amino acid;
O-phosphoamino acid		Escherichia coli metabolite
leukotriene e4[no description available]low00amino dicarboxylic acid;
L-cysteine thioether;
leukotriene;
non-proteinogenic L-alpha-amino acid;
secondary alcohol
domoic acid[no description available]low00L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid;
tricarboxylic acid		algal metabolite;
hapten;
marine metabolite;
neuromuscular agent;
neurotoxin
4-chlorothreonine[no description available]low00chloroamino acid;
L-threonine derivative;
non-proteinogenic L-alpha-amino acid
cilastatin[no description available]low00carboxamide;
L-cysteine derivative;
non-proteinogenic L-alpha-amino acid;
organic sulfide		EC 3.4.13.19 (membrane dipeptidase) inhibitor;
environmental contaminant;
protease inhibitor;
xenobiotic
3-tyrosine[no description available]low00hydroxyphenylalanine;
L-alpha-amino acid zwitterion;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
phenols		plant metabolite
(S)-2-amino-6-boronohexanoic acid[no description available]low00non-proteinogenic L-alpha-amino acid;
organoboron compound
6-bromotryptophan[no description available]low00aromatic L-alpha-amino acid zwitterion;
bromoamino acid;
bromoindole;
L-alpha-amino acid zwitterion;
L-tryptophan derivative;
non-proteinogenic L-alpha-amino acid
6-chlorotryptophan[no description available]low00L-alpha-amino acid zwitterion;
L-tryptophan derivative;
non-proteinogenic L-alpha-amino acid;
organochlorine compound
anticapsin[no description available]low00alicyclic ketone;
epoxide;
L-alanine derivative;
L-alpha-amino acid zwitterion;
non-proteinogenic L-alpha-amino acid		antimetabolite;
antimicrobial agent;
bacterial metabolite;
EC 2.6.1.16 (glutamine--fructose-6-phosphate transaminase (isomerizing)) inhibitor
n(6)-(1-carboxyethyl)lysine[no description available]low00L-lysine derivative;
non-proteinogenic L-alpha-amino acid
lysine tyrosylquinone[no description available]low001,2-benzoquinones;
L-lysine derivative;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid
gamma-guanidinobutyric acid[no description available]low00guanidines;
monocarboxylic acid;
zwitterion		fungal metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
5-(n,n-hexamethylene)amiloride[no description available]low00aromatic amine;
azepanes;
guanidines;
monocarboxylic acid amide;
organochlorine compound;
pyrazines		antineoplastic agent;
apoptosis inducer;
odorant receptor antagonist;
sodium channel blocker
ethylisopropylamiloride[no description available]low00aromatic amine;
guanidines;
monocarboxylic acid amide;
organochlorine compound;
pyrazines;
tertiary amino compound		anti-arrhythmia drug;
neuroprotective agent;
sodium channel blocker
apraclonidine[no description available]low00dichlorobenzene;
guanidines;
imidazolines		alpha-adrenergic agonist;
antiglaucoma drug;
beta-adrenergic agonist;
diagnostic agent;
ophthalmology drug
arcaine[no description available]low00guanidines
bethanidine[no description available]low00guanidinesadrenergic antagonist;
antihypertensive agent
camostat[no description available]low00benzoate ester;
carboxylic ester;
diester;
guanidines;
tertiary carboxamide		anti-inflammatory agent;
anticoronaviral agent;
antifibrinolytic drug;
antihypertensive agent;
antineoplastic agent;
antiviral agent;
serine protease inhibitor
cimetidine[no description available]low00aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
epinastine[no description available]low00benzazepine;
guanidines		anti-allergic agent;
H1-receptor antagonist;
histamine antagonist;
ophthalmology drug
famotidine[no description available]low001,3-thiazoles;
guanidines;
sulfonamide		anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
guanethidine[no description available]low00azocanes;
guanidines		adrenergic antagonist;
antihypertensive agent;
sympatholytic agent
guazatine[no description available]low00aliphatic nitrogen antifungal agent;
guanidines;
secondary amino compound		antifungal agrochemical
nafamostat[no description available]low00benzoic acids;
guanidines
(n-(p-cyanophenyl)-n'-(diphenylmethyl)guanidine)acetic acid[no description available]low00glycine derivative;
guanidines		epitope;
sweetening agent
phenyl biguanide[no description available]low00guanidinescentral nervous system drug
biguanides[no description available]low00guanidines
diphenylguanidine[no description available]low00guanidinesallergen
dicyandiamido[no description available]low00guanidines;
nitrile		curing agent;
explosive;
fertilizer;
flame retardant;
nitrification inhibitor
galegine[no description available]low00guanidines
amiloride[no description available]low00aromatic amine;
guanidines;
organochlorine compound;
pyrazines		diuretic;
sodium channel blocker
guanazodine[no description available]low00guanidines
guanadrel[no description available]low00guanidines;
spiroketal		adrenergic antagonist;
antihypertensive agent
zanamivir[no description available]low00guanidinesantiviral agent;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
propamidine[no description available]low00aromatic ether;
guanidines;
polyether		antimicrobial agent;
antiseptic drug
hexamidine[no description available]low00aromatic ether;
guanidines;
polyether		antimicrobial agent;
antiseptic drug
synthalin a[no description available]low00guanidineshepatotoxic agent;
hypoglycemic agent;
nephrotoxin
guanidinopropionic acid[no description available]low00guanidines;
zwitterion		hypoglycemic agent
guanidinoethane sulfonate[no description available]low00guanidines;
organosulfonic acid;
zwitterion
hydroxyguanidine[no description available]low00guanidines;
one-carbon compound		antineoplastic agent;
antiviral agent
nopaline[no description available]low00amino acid opine;
D-glutamic acid derivative;
guanidines;
L-arginine derivative;
secondary amino compound;
tricarboxylic acid
benzamil[no description available]low00guanidines;
pyrazines
octopine[no description available]low00amino acid opine;
amino dicarboxylic acid;
D-alpha-amino acid zwitterion;
D-arginine derivative;
guanidines;
secondary amino compound		animal metabolite;
xenobiotic metabolite
3',4'-dichlorobenzamil[no description available]low00guanidines;
pyrazines
acetylphenylalanyl-prolyl-boroarginine[no description available]low00acetamides;
C-terminal boronic acid peptide;
guanidines		anticoagulant;
EC 3.4.21.5 (thrombin) inhibitor
e 64[no description available]low00dicarboxylic acid monoamide;
epoxy monocarboxylic acid;
guanidines;
L-leucine derivative;
zwitterion		antimalarial;
antiparasitic agent;
protease inhibitor
argininehydroxamic acid[no description available]low00guanidines;
hydroxamic acid;
L-arginine derivative
bcx 1812[no description available]low003-hydroxy monocarboxylic acid;
acetamides;
cyclopentanols;
guanidines		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
4-guanidinobenzoate[no description available]low00benzoic acids;
guanidines
aminopotentidine[no description available]low00aromatic ether;
benzamides;
guanidines;
nitrile;
piperidines;
substituted aniline		H2-receptor antagonist
argininamide[no description available]low00amino acid amide;
guanidines;
L-arginine derivative
n(1)-guanyl-1,7-diaminoheptane[no description available]low00guanidines;
primary amino compound		antineoplastic agent;
EC 2.5.1.46 (deoxyhypusine synthase) inhibitor
tosylarginine methyl ester[no description available]low00guanidines;
L-arginine ester;
methyl ester;
sulfonamide
N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide[no description available]low00D-leucine derivative;
dichlorobenzene;
furoic acid;
glycine derivative;
guanidines;
pyrazolylpiperidine
l803087[no description available]low00benzenes;
fluoroindole;
guanidines;
L-arginine derivative;
methyl ester;
phenylindole;
secondary carboxamide		somatostatin receptor agonist
mitoguazone[no description available]low00guanidines;
hydrazone		antineoplastic agent;
apoptosis inducer;
EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor
gabexate methanesulfonate[no description available]low00benzoate ester;
guanidines;
methanesulfonate salt
betrixaban[no description available]low00benzamides;
guanidines;
monochloropyridine;
monomethoxybenzene;
secondary carboxamide		anticoagulant;
EC 3.4.21.6 (coagulation factor Xa) inhibitor
massadine[no description available]low00alkaloid;
guanidines;
organobromine compound;
pyrrolecarboxamide		animal metabolite;
EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor;
marine metabolite
batzelladine a[no description available]low00alkaloid;
carboxylic ester;
guanidines;
organic heterotricyclic compound;
pyrrolopyrimidine;
triazaacenaphthylene		anti-HIV-1 agent;
metabolite
vanchrobactin[no description available]low00catechols;
dipeptide;
guanidines;
monocarboxylic acid;
primary alcohol;
triol		bacterial metabolite;
marine metabolite;
siderophore
decarbamylsaxitoxin[no description available]low00alkaloid;
guanidines;
ketone hydrate;
paralytic shellfish toxin;
primary alcohol;
pyrrolopurine		bacterial metabolite;
marine metabolite;
neurotoxin;
toxin;
xenobiotic
dibromophakellin[no description available]low00alkaloid;
guanidines;
organobromine compound		alpha-adrenergic agonist;
animal metabolite;
marine metabolite
guanidinohydantoin[no description available]low00guanidines;
imidazolidine-2,4-dione
hordatine a[no description available]low00aromatic ether;
benzofurans;
dicarboxylic acid diamide;
guanidines;
phenols		adrenergic antagonist;
metabolite
crambescidin 800[no description available]low00alkaloid;
carboxylic ester;
guanidines;
monocarboxylic acid amide;
organic heteropentacyclic compound;
primary amino compound;
secondary alcohol;
spiro compound		anti-HIV-1 agent;
anti-HSV-1 agent;
antimalarial;
marine metabolite
saxitoxin[no description available]low00alkaloid;
carbamate ester;
guanidines;
ketone hydrate;
paralytic shellfish toxin;
pyrrolopurine		cyanotoxin;
marine metabolite;
neurotoxin;
sodium channel blocker;
toxin
callipeltin a[no description available]low00cyclodepsipeptide;
guanidines;
lactone;
oligopeptide;
phenols		anti-HIV-1 agent;
antifungal agent;
metabolite
phleomycin d1[no description available]low00bi-1,3-thiazole;
chelate-forming peptide;
disaccharide derivative;
glycopeptide;
guanidines		antibacterial agent;
antifungal agent;
antimicrobial agent;
antineoplastic agent;
bacterial metabolite
phenylamil[no description available]low00guanidines;
pyrazines
tegaserod[no description available]low00carboxamidine;
guanidines;
hydrazines;
indoles		gastrointestinal drug;
serotonergic agonist
arginine beta-naphthylamide[no description available]low00amino acid amide;
L-arginine derivative;
N-(2-naphthyl)carboxamide		chromogenic compound
argpyrimidine[no description available]low00hydroxypyrimidine;
L-arginine derivative;
non-proteinogenic alpha-amino acid		epitope
EG00229[no description available]low00benzothiadiazole;
dicarboxylic acid monoamide;
L-arginine derivative;
secondary carboxamide;
sulfonamide;
thiophenes		angiogenesis inhibitor;
antineoplastic agent;
neuropilin receptor antagonist
adp-ribosylarginine[no description available]low00L-arginine derivativeEC 3.4.21.26 (prolyl oligopeptidase) inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
2019 Novel Coronavirus Disease0low40
2019 Novel Coronavirus Infection0low40
2019-nCoV Disease0low40
2019-nCoV Infection0low40
47,XX,+210low20
47,XY,+210low20
48,XXYY Syndrome0low20
49,XXXXY Syndrome0low20
Abdominal Migraine0low40
Abdominal Obesity0low20
Abnormal Deep Tendon Reflex0low10
Abnormal Reflex0low10
Abnormal Reflexes0low10
Abnormalities, Cardiovascular0medium11
Abnormality, Heart0low80
Absence Seizure0medium11
Absence Seizures0medium11
Ache0low20
Acne0low10
Acne Vulgaris0low10
Active Hyperemia0medium137
Acute Brain Injuries0medium21
Acute Confusional Migraine0low40
Acute Confusional Senile Dementia0medium71
Acute Coronary Syndrome0low30
Acute Disease0medium204
Acute Edematous Pancreatitis0low20
Acute Hepatic Failure0low30
Acute Hypercapnic Respiratory Failure0low10
Acute Hypoxemic Respiratory Failure0low10
Acute Ischemic Stroke0low10
Acute Kidney Failure0medium162
Acute Kidney Injury0medium162
Acute Kidney Insufficiency0medium162
Acute Liver Failure0low30
Acute Liver Injury, Drug-Induced0low10
Acute Lung Injury0low40
Acute Lymphoid Leukemia0low30
Acute Myelogenous Leukemia0low20
Acute Myeloid Leukemia0low20
Acute Myeloid Leukemia with Maturation0low20
Acute Myeloid Leukemia without Maturation0low20
Acute Onset Aura Migraine0low10
Acute Pancreatitis0low20
Acute Post-Traumatic Stress Disorder0low10
Acute Relapsing Multiple Sclerosis0low20
Acute Renal Failure0medium162
Acute Renal Injury0medium162
Acute Renal Insufficiency0medium162
Acute-Phase Reaction0low20
Acute-Phase State0low20
Adamantiades-Behcet Disease0low30
Addiction, Opioid0low20
Adenocarcinoma0medium11
Adenocarcinoma, Basal Cell0medium11
Adenocarcinoma, Granular Cell0medium11
Adenocarcinoma, Oxyphilic0medium11
Adenocarcinoma, Tubular0medium11
Adenohypophyseal Hyposecretion0low10
Adenoma, Malignant0medium11
Adjuvant Arthritis0low20
Adolescent Obesity0low40
Adolescent Overweight0low40
ADPKD0medium31
Adrenal Cancer0low10
Adrenal Gland Cancer0low10
Adrenal Gland Neoplasms0low10
Adrenal Neoplasm0low10
Adult Polycystic Kidney Disease0medium31
Adult Polycystic Kidney Disease Type 10medium31
Adult Polycystic Kidney Disease Type 20medium31
Adult Spinal Muscular Atrophy0low10
Adult-Onset Spinal Muscular Atrophy0low10
Affective Psychosis, Bipolar0low10
Age-Related Memory Disorders0low10
Age-Related Osteoporosis0low10
Aging0medium322
AIDS Seroconversion0low10
AIDS Seropositivity0low10
Airflow Obstruction, Chronic0low100
Airway Obstruction0low10
Airway Remodeling0low10
Airway Remodelling0low10
Airway Wall Remodelling0low10
Akinetic-Rigid Variant of Huntington Disease0low10
Albuminuria0medium212
Alcohol Abuse0low20
Alcohol Addiction0low20
Alcohol Dependence0low20
Alcohol Drinking0low10
Alcohol Use Disorder0low20
Alcoholic Cirrhosis0low30
Alcoholic Hepatitis0low10
Alcoholic Intoxication, Chronic0low20
Alcoholism0low20
ALL, Childhood0low30
Allergic Encephalomyelitis0low10
Allergic Encephalomyelitis, Experimental0low10
Alloxan Diabetes0low250
ALS - Amyotrophic Lateral Sclerosis0low10
Altitude Hypoxia0low20
Altitude Sickness0low20
Alzheimer Dementia0medium71
Alzheimer Disease0medium71
Alzheimer Disease, Early Onset0medium71
Alzheimer Disease, Late Onset0medium71
Alzheimer Sclerosis0medium71
Alzheimer Syndrome0medium71
Alzheimer Type Senile Dementia0medium71
Alzheimer-Type Dementia (ATD)0medium71
Alzheimer's Disease0medium71
Alzheimer's Disease, Focal Onset0medium71
Alzheimer's Diseases0medium71
Amentia0low20
Amino Acid Metabolism Disorders, Inborn0medium21
Amino Acid Metabolism, Inborn Error0medium21
Amino Acid Metabolism, Inborn Errors0medium21
Amino Acid Metabolism, Inherited Disorders0medium21
Amino Acidopathies, Congenital0medium21
Amino Acidopathies, Inborn0medium21
Amnionitis0low10
Amyloid Deposits0low10
Amyloid Plaques0low10
Amyloidosis0low10
Amyotrophic Lateral Sclerosis0low10
Amyotrophic Lateral Sclerosis With Dementia0low10
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 10low10
Amyotrophic Lateral Sclerosis, Guam Form0low10
Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam0low10
Amyotrophy, Neurogenic Scapuloperoneal, New England Type0low10
Anemia0low50
Anemia, Cooley's0low30
Anemia, Erythroblastic0low30
Anemia, Fanconi0low10
Anemia, Mediterranean0low30
Anemia, Sickle Cell0medium101
Anesthesia0low10
Aneurysm, Anterior Cerebral Artery0low20
Aneurysm, Anterior Communicating Artery0low20
Aneurysm, Aortic0low10
Aneurysm, Basilar Artery0low20
Aneurysm, Cerebral0low20
Aneurysm, Intracranial0low20
Aneurysm, Middle Cerebral Artery0low20
Aneurysm, Posterior Cerebral Artery0low20
Aneurysm, Posterior Communicating Artery0low20
Aneurysm, Ruptured0low10
Angiitis0medium62
Angiitis, Central Nervous System0low10
Angina at Rest0low30
Angina Pectoris0medium133
Angina Pectoris with Normal Coronary Arteriogram0medium41
Angina Pectoris, Stable0low30
Angina Pectoris, Unstable0low30
Angina, Microvascular0medium41
Angina, Preinfarction0low30
Angina, Stable0low30
Angina, Unstable0low30
Angiogenesis, Pathologic0medium91
Angiogenesis, Pathological0medium91
Angiospasm, Intracranial0low110
Angor Pectoris0medium133
Ankylosing Spondylarthritis0medium91
Ankylosing Spondylitis0medium91
Ankylosing Spondyloarthritis0medium91
ANLL0low20
Anoxemia0medium141
Anoxia0medium141
ANS (Autonomic Nervous System) Diseases0low20
ANS Diseases0low20
Anterior Cerebral Artery Aneurysm0low20
Anterior Cerebral Circulation Infarction0low10
Anterior Choroidal Artery Infarction0low50
Anterior Circulation Brain Infarction0low10
Anterior Circulation Infarction, Brain0low10
Anterior Circulation Transient Ischemic Attack0low30
Anterior Communicating Artery Aneurysm0low20
Anterior Pituitary Hyposecretion Syndrome0low10
Anthrax0low10
Anti-HIV Positivity0low10
Anti-Phospholipid Antibody Syndrome0low20
Anti-Phospholipid Syndrome0low20
Antiphospholipid Antibody Syndrome0low20
Antiphospholipid Syndrome0low20
Anxiety0low10
Aortic Aneurysm0low10
Aortic Coarctation0low30
Aortic Diseases0low20
Aortic Stenosis0low60
Aortic Valve Disease 10low20
Aortic Valve Stenosis0low60
Aortic Valve, Bicuspid0low20
Apical Ballooning Syndrome0low10
Apnea, Obstructive Sleep0medium81
Apnea, Sleep0low20
Apolipoprotein B-100, Familial Defective0medium41
Apolipoprotein B-100, Familial Ligand-Defective0medium41
Apoplexy0medium364
Appendicitis0low10
Aprosodia0medium11
Aprosodic Speech0medium11
Argininosuccinate Synthase Deficiency Disease0low10
Argininosuccinate Synthetase Deficiency0low10
Argininosuccinic Acid Synthase Deficiency Disease0low10
Argininosuccinic Acid Synthetase Deficiency0low10
Argininosuccinic Acid Synthetase Deficiency Disease0low10
Argininosuccinic Acid Synthetase Deficiency Disease, Partial0low10
Argininosuccinic Acid Synthetase Deficiency, Complete0low10
Arnold-Chiari Deformity0low10
Arnold-Chiari Malformation0low10
Arnold-Chiari Malformation, Type 10low10
Arnold-Chiari Malformation, Type 20low10
Arnold-Chiari Malformation, Type 30low10
Arnold-Chiari Malformation, Type 40low10
Arnold-Chiari Malformation, Type I0low10
Arnold-Chiari Malformation, Type II0low10
Arnold-Chiari Malformation, Type III0low10
Arnold-Chiari Malformation, Type IV0low10
Arnold-Chiari Syndrome0low10
Arrhythmia0low10
Arrhythmias, Cardiac0low10
Arrythmia0low10
Arterial Diseases, Carotid0medium253
Arterial Diseases, Cerebral0low10
Arterial Diseases, Common Carotid0medium253
Arterial Diseases, External Carotid0medium253
Arterial Diseases, Internal Carotid0medium253
Arterial Hyperemia0medium137
Arterial Obstructive Diseases0medium93
Arterial Occlusive Diseases0medium93
Arteriosclerosis0medium283
Arteriosclerosis, Coronary0medium778
Arthritis, Adjuvant0low20
Arthritis, Adjuvant-Induced0low20
Arthritis, Collagen-Induced0low20
Arthritis, Degenerative0medium21
Arthritis, Experimental0low20
Arthritis, Psoriatic0low40
Arthritis, Rheumatoid0medium275
Arthroses0medium21
Arthrosis0medium21
Ascites0low10
Aseptic Necrosis of Bone0low10
ASS Deficiency0low10
Asthma0medium161
Asthma, Bronchial0medium161
Asthmatic Airway Remodeling0low10
Asthmatic Airway Remodelling0low10
Asthmatic Airway Wall Remodeling0low10
Asthmatic Airway Wall Remodelling0low10
Asymmetric Diabetic Proximal Motor Neuropathy0low30
Asymptomatic Conditions0low50
Asymptomatic Diseases0low50
Asymptomatic States0low50
Asystole0low10
Atheroembolism0low10
Atherogenesis0medium1019
Atheroma0medium81
Atheromatous Plaque0medium81
Atheromatous Plaques0medium81
Atherosclerosis0medium1019
Atherosclerosis, Coronary0medium778
Atherosclerotic Disease, Carotid0medium253
Atherosclerotic Plaque0medium81
Atherosclerotic Plaques0medium81
Atonic Absence Seizure0medium11
Atonic Absence Seizures0medium11
Atonic Seizure0medium11
Atonic Seizures0medium11
Atrial Fibrillation0medium162
Atrioventricular Nodal Re-Entrant Tachycardia0low10
Atrioventricular Reentrant Tachycardia0low10
Atypical Lipomatous Tumor0low10
Auditory Processing Disorder, Central0medium11
Aura0low50
Auricular Fibrillation0medium162
Autoimmune Diabetes0medium185
Autoimmune Disease0low10
Autoimmune Diseases0low10
Autoimmune Encephalomyelitis, Experimental0low10
Autoimmune Experimental Encephalomyelitis0low10
Autoimmune Thyroiditis0low10
Autonomic Central Nervous System Diseases0low20
Autonomic Diseases0low20
Autonomic Nervous System Diseases0low20
Autonomic Nervous System Disorders0low20
Autonomic Peripheral Nervous System Diseases0low20
Autosomal Dominant Polycystic Kidney0medium31
Avascular Necrosis of Bone0low10
Awakening Epilepsy0low50
B-Cell Chronic Lymphocytic Leukemia0low10
B-Cell Leukemia, Chronic0low10
B-Cell Malignancy, Low-Grade0low10
B-Lymphocytic Leukemia, Chronic0low10
Bacillus anthracis Infection0low10
Bacteremia0low20
Bacterial Disease0low10
Bacterial Infection0low10
Bacterial Infections0low10
Bacterial Skin Diseases0low10
Basedow Disease0low10
Basedow's Disease0low10
Basilar Artery Aneurysm0low20
Basilar Artery Migraine0low10
Basilar Migraine0low10
Basilar-Type Migraine0low10
Bechterew Disease0medium91
Bechterew's Disease0medium91
Becker Muscular Dystrophy0medium11
Becker's Muscular Dystrophy0medium11
Behcet Disease0low30
Behcet Syndrome0low30
Behcet Triple Symptom Complex0low30
Behcet's Disease0low30
Behcet's Syndrome0low30
Behu00E7et Disease0low30
Benign Neoplasms0low30
Benign Paroxysmal Peritonitis0low20
Berger Disease0low10
Berger's Disease0low10
Berry Aneurysm0low20
beta Thalassemia0low30
beta-Thalassemia0low30
BH4 Deficiency0low20
Bicuspid Aortic Valve0low20
Bicuspid Aortic Valve Disease0low20
Bilateral Headache0medium11
Bile Duct Obstruction0low20
Bile Duct Obstruction, Extrahepatic0low10
Bile Duct Obstruction, Intrahepatic0low10
Biliary Cirrhosis0low10
Biliary Cirrhosis, Primary0low10
Biliary Cirrhosis, Primary, 10low10
Biliary Cirrhosis, Secondary0low10
Biliary Stasis0low20
Biliary Stasis, Extrahepatic0low10
Biliary Stasis, Intrahepatic0low10
Bipolar Disorder0low10
Bipolar Mood Disorder0low10
Birth Weight0low40
Bladder Cancer0low10
Bladder Neoplasms0low10
Bladder Tumors0low10
Bleeding0low20
Blood Clot0low100
Blood Poisoning0medium91
Blood Pressure, High0medium18024
Blood Pressure, Low0low70
Bloodstream Infection0medium91
Body Weight0medium215
Bone Loss, Age-Related0low10
Bone Loss, Osteoclastic0low10
Bone Loss, Perimenopausal0low10
Bone Loss, Postmenopausal0low10
Bone Necrosis0low10
Bone Resorption0low10
Bowel Diseases, Inflammatory0low10
Brachial Paresis0medium11
Brain Aneurysm0low20
Brain Damage, Chronic0low10
Brain Diseases0low10
Brain Disorders0low10
Brain Hemorrhage0low10
Brain Hemorrhage, Cerebral0low30
Brain Infarct0low10
Brain Infarction0low10
Brain Infarction, Anterior Circulation0low10
Brain Infarction, Posterior Circulation0low10
Brain Infarction, Venous0low10
Brain Injuries0medium21
Brain Injuries, Acute0medium21
Brain Injuries, Focal0medium21
Brain Ischemia0medium122
Brain Lacerations0medium21
Brain Stem Ischemia, Transient0low30
Brain Stem Transient Ischemic Attack0low30
Brain TIA0low30
Brain Vascular Disorders0low110
Brainstem Ischemia, Transient0low30
Brainstem Transient Ischemic Attack0low30
Branch Vein Occlusion0low20
Breast Cancer0low40
Breast Carcinoma0low40
Breast Neoplasms0low40
Breast Tumors0low40
Bright Disease0low30
Broken Heart Syndrome0low10
Bronchial Asthma0medium161
Bronchial Hyperreactivity0low30
Bronchopulmonary Dysplasia0low30
Brucella Infection0low10
Brucellosis0low10
Brucellosis, Pulmonary0low10
Buerger Disease0low20
Buerger's Disease0low20
Bulbocavernosus Reflex, Decreased0low10
Bulbocavernousus Reflex Absent0low10
Bulbospinal Neuronopathy0low10
Cachexia0low10
CADASIL0low10
CADASILM0low10
Cadaver0low10
Calcification, Pathologic0low110
Calcinosis0low110
Calcinosis, Tumoral0low110
Cancer0low30
Cancer of Bladder0low10
Cancer of Breast0low40
Cancer of Cervix0low10
Cancer of Colon0low30
Cancer of Liver0low10
Cancer of Lung0low20
Cancer of Prostate0low20
Cancer of Stomach0medium11
Cancer of the Adrenal Gland0low10
Cancer of the Bladder0low10
Cancer of the Breast0low40
Cancer of the Cervix0low10
Cancer of the Colon0low30
Cancer of the Liver0low10
Cancer of the Lung0low20
Cancer of the Prostate0low20
Cancer of the Stomach0medium11
Cancer of the Uterine Cervix0low10
Cancer, Hepatocellular0low10
Canine Diseases0low10
Carbon Monoxide Poisoning0low20
Carcinoma, Cribriform0medium11
Carcinoma, Epidermoid0low10
Carcinoma, Granular Cell0medium11
Carcinoma, Hepatocellular0low10
Carcinoma, Non-Small Cell Lung0low10
Carcinoma, Non-Small-Cell Lung0low10
Carcinoma, Planocellular0low10
Carcinoma, Squamous0low10
Carcinoma, Squamous Cell0low10
Carcinoma, Tubular0medium11
Cardiac Arrest0low10
Cardiac Arrest, Sudden0low10
Cardiac Arrhythmia0low10
Cardiac Arrhythmias0low10
Cardiac Death0low10
Cardiac Diseases0low80
Cardiac Disorders0low80
Cardiac Dysrhythmia0low10
Cardiac Failure0medium419
Cardiac Hypertrophy0low30
Cardiac Output, Low0low10
Cardiac Remodeling, Ventricular0low60
Cardiac Rupture, Traumatic0low10
Cardiac Sudden Death0low10
Cardiac Syndrome X0medium41
Cardiac Toxicity0low10
Cardio-Renal Syndrome0low40
Cardiomegaly0low30
Cardiometabolic Syndrome0medium327
Cardiomyopathies0low20
Cardiomyopathies, Primary0low20
Cardiomyopathies, Secondary0low20
Cardiomyopathy, Congestive0low20
Cardiomyopathy, Dilated0low20
Cardiomyopathy, Dilated, 1a0low20
Cardiomyopathy, Dilated, 3B0medium11
Cardiomyopathy, Dilated, Autosomal Recessive0low20
Cardiomyopathy, Dilated, CMD1A0low20
Cardiomyopathy, Dilated, LMNA0low20
Cardiomyopathy, Dilated, With Conduction Defect 10low20
Cardiomyopathy, Dilated, with Conduction Deffect10low20
Cardiomyopathy, Dilated, X-Linked0medium11
Cardiomyopathy, Familial Idiopathic0low20
Cardiomyopathy, Idiopathic Dilated0low20
Cardiopulmonary Arrest0low10
Cardiorenal Syndrome0low40
Cardiotoxicity0low10
Cardiovascular Abnormalities0medium11
Cardiovascular Diseases0medium28015
Cardiovascular Pregnancy Complications0low20
Cardiovascular Stroke0medium342
Carditis0low10
Carotid Arteriopathies, Traumatic0low40
Carotid Artery Diseases0medium253
Carotid Artery Disorders0medium253
Carotid Artery Injuries0low40
Carotid Artery Narrowing0low90
Carotid Artery Plaque0low90
Carotid Artery Stenosis0low90
Carotid Artery Thrombosis0low10
Carotid Artery Ulcerating Plaque0low90
Carotid Atherosclerosis0medium253
Carotid Atherosclerotic Disease0medium253
Carotid Circulation Transient Ischemic Attack0low30
Carotid False Aneurysm0low40
Carotid Pseudoaneurysm0low40
Carotid Stenosis0low90
Carotid Thrombosis0low10
Carotid Ulcer0low90
Cataract0low30
Cataract, Membranous0low30
CBS Deficiency0low20
Cell Transformation, Viral0low20
Central Auditory Processing Disorder0medium11
Central Autonomic Nervous System Diseases0low20
Central Hypothyroidism0low50
Central Nervous System Angiitis0low10
Central Nervous System Disorders, Intracranial0low10
Central Nervous System Intracranial Disorders0low10
Central Nervous System Vasculitis0low10
Central Obesity0low20
Central Retinal Vein Occlusion0low20
Cephalalgia0medium11
Cephalgia0medium11
Cephalodynia0medium11
Cerebral Aneurysm0low20
Cerebral Angiitis0low10
Cerebral Angiospasm0low110
Cerebral Arterial Diseases0low10
Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy0low10
Cerebral Arteriosclerosis0low20
Cerebral Artery Diseases0low10
Cerebral Artery Spasm0low110
Cerebral Atherosclerosis0low20
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy0low10
Cerebral Hemorrhage0low30
Cerebral Infarct0low50
Cerebral Infarction0low50
Cerebral Infarction, Left Hemisphere0low50
Cerebral Infarction, Middle Cerebral Artery0low20
Cerebral Infarction, Right Hemisphere0low50
Cerebral Ischemia0medium122
Cerebral Ischemia, Transient0low30
Cerebral Microangiopathies0low10
Cerebral Parenchymal Hemorrhage0low30
Cerebral Small Vessel Disease0low10
Cerebral Small Vessel Diseases0low10
Cerebral Stroke0medium364
Cerebral Vasculitis0low10
Cerebral Vasospasm0low110
Cerebral, Left Hemisphere, Infarction0low50
Cerebral, Right Hemisphere, Infarction0low50
Cerebrovascular Accident0medium364
Cerebrovascular Accident, Acute0medium364
Cerebrovascular Apoplexy0medium364
Cerebrovascular Diseases0low110
Cerebrovascular Disorders0low110
Cerebrovascular Insufficiency0low110
Cerebrovascular Occlusion0low110
Cerebrovascular Spasm0low110
Cerebrovascular Stroke0medium364
Cervical Cancer0low10
Cervical Migraine Syndrome0low40
Cervical Neoplasms0low10
Cervix Cancer0low10
Cervix Neoplasms0low10
Charcot Disease0low10
Chemical and Drug Induced Liver Injury0low10
Chemically-Induced Liver Toxicity0low10
Chest Pain0low10
Chiari Malformation Type 20low10
Chiari Malformation Type I0low10
Chiari Malformation Type II0low10
Child Development Deviations0medium11
Child Development Disorders0medium11
Child Development Disorders, Specific0medium11
Child Obesity0low40
Childhood Muscular Dystrophy, Pseudohypertrophic0medium11
Childhood Obesity0low40
Childhood Onset Obesity0low40
Childhood Overweight0low40
Childhood Pseudohypertrophic Muscular Dystrophy0medium11
Choking0low10
Cholangitis, Chronic Nonsuppurative Destructive0low10
Cholelithiasis0low10
Cholestasis0low20
Cholestasis, Extrahepatic0low10
Cholestasis, Intrahepatic0low10
Cholesterol Embolism0low10
Choline Deficiency0low10
Chondrodystrophic Myotonia0low10
Chorea, Chronic Progressive Hereditary (Huntington)0low10
Chorioamnionitis0low10
Chronic Airflow Obstruction0low100
Chronic Alcoholic Hepatitis0low10
Chronic Disease0medium527
Chronic Encephalopathy0low10
Chronic Hepatitis B0low10
Chronic Hepatitis B Virus Infection0low10
Chronic Hepatitis C0low30
Chronic Illness0medium527
Chronic Insomnia0low20
Chronic Kidney Diseases0medium664
Chronic Kidney Failure0medium12421
Chronic Kidney Insufficiency0medium664
Chronic Liver Failure0low30
Chronic Lymphocytic Leukemia0low10
Chronic Obstructive Airway Disease0low100
Chronic Obstructive Lung Disease0low100
Chronic Obstructive Pulmonary Disease0low100
Chronic Obstructive Pulmonary Diseases0low100
Chronic Post-Traumatic Stress Disorder0low10
Chronic Primary Open Angle Glaucoma0low10
Chronic Progressive Hereditary Chorea (Huntington)0low10
Chronic Renal Diseases0medium664
Chronic Renal Insufficiency0medium664
Chronic Stable Angina0low30
Chronically Ill0medium527
Circulatory Collapse0low10
Circulatory Failure0low10
Cirrhoses, Experimental Liver0low10
Cirrhosis0low210
Cirrhosis, Experimental Liver0low10
Cirrhosis, Liver0low100
Citrullinemia0low10
Citrullinemia 10low10
Citrullinemia Type 10low10
Citrullinemia, Classic0low10
Citrullinemia, Classical0low10
Citrullinemia, Late-Onset0low10
Citrullinemia, Neonatal0low10
Citrullinemia, Type I0low10
Citrullinuria0low10
Classic Migraine0low10
Classical Migraine0low10
Cleft Lip0low10
Cleft Palate0low10
Cleft Palate, Isolated0low10
Clonic Seizure0medium11
Clonic Seizures0medium11
Cluttering0medium11
CNS Disorders, Intracranial0low10
CNS Vasculitis0low10
Co-infection0low10
COAD0low100
Coarctation of Aorta0low30
Coarctation of Aorta Dominant0low30
Coarctation of the Aorta0low30
Cochlear Hearing Loss0low10
Cognition Disorders0low50
Cognitive Decline0low40
Cognitive Dysfunction0low40
Cognitive Impairments0low40
Coinfection0low10
Cold Fingers, Hereditary0low50
Colitis Gravis0medium31
Colitis, Granulomatous0low20
Colitis, Mucous0low10
Colitis, Ulcerative0medium31
Collagen Arthritis0low20
Colon Cancer0low30
Colon Neoplasms0low30
Colon, Irritable0low10
Colonic Cancer0low30
Colonic Neoplasms0low30
Common Carotid Artery Diseases0medium253
Common Carotid Artery Stenosis0low90
Common Carotid Artery Thrombosis0low10
Communicable Diseases0low10
Community Acquired Infection0low10
Community-Acquired Infection0low10
Community-Acquired Infections0low10
Compensatory Hyperinsulinemia0low30
Complete Argininosuccinic Acid Synthetase Deficiency Disease0low10
Complex Partial Seizure0medium11
Complex Partial Seizures0medium11
Complicated Migraine0low10
Complication, Postoperative0medium142
Complications of Diabetes Mellitus0low180
Complications, Cardiovascular Pregnancy0low20
Complications, Pregnancy0low10
Congenital Amino Acidopathies0medium21
Congenital Heart Defect0low80
Congenital Heart Defects0low80
Congenital Heart Disease0low80
Congenital Thrombotic Thrombocytopenic Purpura0low10
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Congestive Cardiomyopathy0low20
Congestive Heart Failure0medium419
Congo Virus Infection0low10
Congo-Crimean Hemorrhagic Fever0low10
Constriction, Pathologic0low10
Constriction, Pathological0low10
Contact Dermatitis0low10
Convulsion0medium11
Convulsion, Non-Epileptic0medium11
Convulsions0medium11
Convulsive Seizure0medium11
Convulsive Seizures0medium11
COPD0low100
Cor Pulmonale0low10
Coronary Arteriosclerosis0medium778
Coronary Artery Disease0medium778
Coronary Artery Stenosis0medium91
Coronary Artery Vasospasm0low30
Coronary Atherosclerosis0medium778
Coronary Disease0medium337
Coronary Heart Disease0medium337
Coronary Restenosis0low40
Coronary Stenoses0medium91
Coronary Stenosis0medium91
Coronary Vasospasm0low30
Coronavirus Disease 20190low40
Coronavirus Disease-190low40
Corpse0low10
COVID-190low40
COVID-19 Pandemic0low40
COVID-19 Pandemics0low40
COVID-19 Virus Disease0low40
COVID-19 Virus Infection0low40
COVID190low40
Coxarthrosis0low10
Cranial Pain0medium11
Crescendo Transient Ischemic Attacks0low30
Crimean-Congo Haemorrhagic Fever0low10
Crimean-Congo Hemorrhagic Fever0low10
Critical Illness0medium143
Critically Ill0medium143
Crohn Disease0low20
Crohn's Disease0low20
Crohn's Enteritis0low20
Crural Paresis0medium11
Cruveilhier-Baumgarten Syndrome0low80
Cryptogenic Embolism Stroke0low10
Cryptogenic Fibrosing Alveolitis0low20
Cryptogenic Ischemic Stroke0low10
Cryptogenic Stroke0low10
Cushing Syndrome0low10
Cushing's Syndrome0low10
CVA (Cerebrovascular Accident)0medium364
Cyanosis0low10
Cyprus Fever0low10
Cystathionine Beta Synthase Deficiency0low20
Cystathionine beta-Synthase Deficiency Disease0low20
Cystic Fibrosis0low20
Cystic Fibrosis of Pancreas0low20
Cytomegalic Inclusion Disease0low20
Cytomegalovirus Infections0low20
Day Blindness0medium11
Deafness Neurosensory0low10
Deafness, Transitory0low10
Death0low10
Death, Sudden, Cardiac0low10
Deep Vein Thrombosis0low10
Deep Venous Thrombosis0low10
Deep-Vein Thrombosis0low10
Deep-Venous Thrombosis0low10
Defects, Congenital Heart0low80
Deficiency Disease, Argininosuccinate Synthase0low10
Deficiency Disease, Argininosuccinic Acid Synthase0low10
Deficiency Disease, Cystathionine beta-Synthase0low20
Deficiency Disease, Dihydropteridine Reductase0low20
Deficiency Disease, Phenylalanine Hydroxylase0low20
Deficiency Disease, Phenylalanine Hydroxylase, Severe0low20
Deficiency, Argininosuccinic Acid Synthetase, Complete0low10
Deficiency, Argininosuccinic Acid Synthetase, Partial0low10
Deficiency, Choline0low10
Deficiency, Folic Acid0low10
Deficiency, Glucosephosphatase0low10
Deficiency, Mental0medium11
Deficiency, Oxygen0medium141
Deficiency, Pyridoxine0low10
Deficiency, Vitamin B0low20
Deficiency, Vitamin B 120low10
Deficiency, Vitamin B 60low10
Deficiency, Vitamin B120low10
Deficiency, Vitamin B60low10
Deficiency, Vitamin D0medium31
Delayed Effects, Prenatal Exposure0low60
Delayed Onset Post-Traumatic Stress Disorder0low10
Dementia0low20
Dementia Praecox0low70
Dementia With Amyotrophic Lateral Sclerosis0low10
Dementia, Alzheimer Type0medium71
Dementia, Hereditary Multi-Infarct Type0low10
Dementia, Presenile0medium71
Dementia, Primary Senile Degenerative0medium71
Dementia, Senile0medium71
Dengue Hemorrhagic Fever0low10
Dengue Shock Syndrome0low10
Dependence, Opioid0low20
Depression0low40
Depression, Bipolar0low10
Depression, Endogenous0low10
Depression, Involutional0low40
Depression, Neurotic0low10
Depression, Unipolar0low10
Depressive Disorder0low10
Depressive Disorder, Major0low40
Depressive Syndrome0low10
Dermatitis Venenata0low10
Dermatitis, Atopic0low10
Dermatitis, Contact0low10
Determination of Death0low10
Development Disorders, Child0medium11
Developmental Delay Disorders0medium11
Developmental Disabilities0medium11
Developmental Disorder, Speech or Language0medium11
Developmental Language Disorders0medium11
Devic Disease0medium11
Devic Neuromyelitis Optica0medium11
Devic Syndrome0medium11
Devic's Disease0medium11
Devic's Neuromyelitis Optica0medium11
Devic's Syndrome0medium11
DHPR Deficiency0low20
Diabetes Complications0low180
Diabetes Mellitus0medium282
Diabetes Mellitus, Adult-Onset0medium9320
Diabetes Mellitus, Brittle0medium185
Diabetes Mellitus, Experimental0low250
Diabetes Mellitus, Gestational0low120
Diabetes Mellitus, Insulin-Dependent0medium185
Diabetes Mellitus, Insulin-Dependent, 10medium185
Diabetes Mellitus, Juvenile-Onset0medium185
Diabetes Mellitus, Ketosis-Prone0medium185
Diabetes Mellitus, Ketosis-Resistant0medium9320
Diabetes Mellitus, Maturity-Onset0medium9320
Diabetes Mellitus, Non Insulin Dependent0medium9320
Diabetes Mellitus, Non-Insulin-Dependent0medium9320
Diabetes Mellitus, Noninsulin Dependent0medium9320
Diabetes Mellitus, Noninsulin-Dependent0medium9320
Diabetes Mellitus, Slow-Onset0medium9320
Diabetes Mellitus, Stable0medium9320
Diabetes Mellitus, Sudden-Onset0medium185
Diabetes Mellitus, Type 10medium185
Diabetes Mellitus, Type 20medium9320
Diabetes Mellitus, Type I0medium185
Diabetes Mellitus, Type II0medium9320
Diabetes-Related Complications0low180
Diabetes, Autoimmune0medium185
Diabetes, Gestational0low120
Diabetes, Pregnancy-Induced0low120
Diabetic Amyotrophy0low30
Diabetic Angiopathies0medium221
Diabetic Asymmetric Polyneuropathy0low30
Diabetic Autonomic Neuropathy0low30
Diabetic Cardiomyopathies0low50
Diabetic Complications0low180
Diabetic Feet0low20
Diabetic Foot0low20
Diabetic Glomerulosclerosis0medium232
Diabetic Kidney Disease0medium232
Diabetic Mononeuropathy0low30
Diabetic Mononeuropathy Simplex0low30
Diabetic Nephropathies0medium232
Diabetic Nephropathy0medium232
Diabetic Neuralgia0low30
Diabetic Neuropathies0low30
Diabetic Neuropathy, Painful0low30
Diabetic Polyneuropathy0low30
Diabetic Retinopathy0low70
Diabetic Vascular Complications0medium221
Diabetic Vascular Diseases0medium221
Diastolic Heart Failure0medium11
Diathesis0low50
Diffuse Cutaneous Systemic Sclerosis0low10
Diffuse Mixed Small and Large Cell Lymphoma0low10
Diffuse Mixed-Cell Lymphoma0low10
Diffuse Myofascial Pain Syndrome0low10
Diffuse Scleroderma0low10
Diffuse Small Cleaved-Cell Lymphoma0low10
Diffuse Systemic Sclerosis0low10
Diffuse Undifferentiated Lymphoma0low10
Diffuse Well-Differentiated Lymphocytic Lymphoma0low10
Dihydropteridine Reductase Deficiency0low20
Dihydropteridine Reductase Deficiency Disease0low20
Dilatation, Pathologic0medium82
Dilatation, Pathological0medium82
Dilatations, Pathologic0medium82
Dilatations, Pathological0medium82
Dilated Cardiomyopathy0low20
DIMS (Disorders of Initiating and Maintaining Sleep)0low20
Disabilities, Developmental0medium11
Disability, Intellectual0medium11
Disease0low10
Disease Exacerbation0medium531
Disease Models, Animal0low900
Disease Progression0medium531
Disease Susceptibility0low50
Disease, Pulmonary0low30
Disease, Pulmonary Heart0low10
Diseases of Endocrine System0low10
Diseases, Metabolic0low40
Diseases, Peripheral Vascular0medium84
Diseases, Pulmonary0low30
Diseases, Pulmonary Heart0low10
Disorders of Initiating and Maintaining Sleep0low20
Disorders of the Autonomic Nervous System0low20
Disrupted In B-Cell Malignancy0low10
Distal Spinal Muscular Atrophy0low10
Dog Diseases0low10
Down Syndrome0low20
Down Syndrome, Partial Trisomy 210low20
Down's Syndrome0low20
Drug Withdrawal Symptoms0low10
Drug-Induced Acute Liver Injury0low10
Drug-Induced Liver Disease0low10
Drug-Induced Liver Injury0low10
Duchenne and Becker Muscular Dystrophy0medium11
Duchenne Muscular Dystrophy0medium11
Duchenne-Becker Muscular Dystrophy0medium11
Duchenne-Type Progressive Muscular Dystrophy0medium11
Dwarfism0low10
Dyschondroplasia0low10
Dyschondroplasias0low10
Dysglossia0medium11
Dyskinesia Syndromes0medium11
Dyslalia0medium11
Dyslipidemia0medium121
Dyslipidemias0medium121
Dyslipoproteinemias0medium121
Dysmenorrhea0low20
Dysmetabolic Syndrome X0medium327
Dysmyelopoietic Syndromes0low10
E coli Infections0medium11
E. coli Infection0medium11
Early Awakening0low20
Early Onset Alzheimer Disease0medium71
EBV Infections0low10
Ectasia0medium82
Ectopic Ossification0low10
Eczema, Atopic0low10
Eczema, Contact0low10
Eczema, Infantile0low10
Edema-Proteinuria-Hypertension Gestosis0low450
Edema, Pulmonary0low10
Edemas, Pulmonary0low10
Eisenmenger Complex0low10
Eisenmenger Syndrome0low10
Eisenmenger's Complex0low10
Eisenmenger's Syndrome0low10
Electrolytes0low20
Elevated Cholesterol0medium367
Embolic Infarction, Middle Cerebral Artery0low20
Embolism, Cholesterol0low10
Embolism, Pulmonary0low40
Embolisms, Pulmonary0low40
Embolus, Middle Cerebral Artery0low20
Emesis0medium11
Encephalomyelitis, Allergic0low10
Encephalomyelitis, Autoimmune, Experimental0low10
Encephalomyelitis, Experimental Autoimmune0low10
Encephalon Diseases0low10
Encephalopathy0low10
Encephalopathy, Chronic0low10
Encephalopathy, Hepatic0low20
Encephalopathy, Hepatocerebral0low20
Encephalopathy, Ischemic0medium122
Encephalopathy, Portal-Systemic0low20
Encephalopathy, Portosystemic0low20
End Of Life0low10
End Stage Liver Disease0low30
End-Of-Life0low10
End-Stage Kidney Disease0medium12421
End-Stage Renal Disease0medium12421
Endocrine Diseases0low10
Endocrine System Diseases0low10
Endogenous Hyperinsulinism0low30
Endometrioma0low30
Endometriosis0low30
Endosteal Hyperostosis, Autosomal Recessive0low10
Endotoxemia0medium71
Endotoxin Shock0medium122
Enlarged Heart0low30
Enteritis, Granulomatous0low20
Enteritis, Regional0low20
EPH Complex0low450
EPH Gestosis0low450
EPH Toxemias0low450
Epilepsy0low50
Epilepsy, Cryptogenic0low50
Epileptic Seizure0medium11
Epileptic Seizures0medium11
Epstein-Barr Virus Infection0low10
Epstein-Barr Virus Infections0low10
Equine Diseases0low10
Erectile Dysfunction0medium112
Erythroblastic Anemia0low30
Erythroblastosis Fetalis0low10
Erythroblastosis, Fetal0low10
Escherichia coli Infections0medium11
Esophageal and Gastric Varices0low10
Esophageal Reflux0low20
Esophageal Varices0low10
Esophageal Varix0low10
ESRD0medium12421
Essential Hypertension0low20
Etat Marbre0medium11
Ethanol Abuse0low20
Exfoliation Glaucoma0low40
Exfoliation Syndrome0low40
Exfoliative Syndrome0low40
Exogenous Hyperinsulinism0low30
Exophthalmic Goiter0low10
Experimental Allergic Encephalomyelitis0low10
Experimental Autoimmune Encephalomyelitis0low10
Experimental Diabetes Mellitus0low250
Experimental Hepatoma0low30
Experimental Hepatomas0low30
Experimental Liver Cirrhoses0low10
Experimental Liver Cirrhosis0low10
Experimental Liver Neoplasms0low30
Experimental Lung Inflammation0low30
Experimental Mammary Neoplasms0low10
Experimental Radiation Injuries0low10
External Carotid Artery Diseases0medium253
External Carotid Artery Stenosis0low90
External Carotid Artery Thrombosis0low10
Extrahepatic Cholestasis0low10
Extravascular Hemolysis0low70
Eye Infections0low10
False Aneurysm, Carotid0low40
Familial Alzheimer Disease (FAD)0medium71
Familial Atrial Fibrillation0medium162
Familial Combined Hyperlipoproteinemia0medium41
Familial Dementia0low20
Familial Hemiplegic Migraine0low10
Familial Hyperpotassemia and Hypertension0low10
Familial Hypertensive Hyperkalemia0low10
Familial Idiopathic Pulmonary Fibrosis0low20
Familial Mediterranean Fever0low20
Familial Mediterranean Fever, Autosomal Recessive0low20
Familial Paroxysmal Polyserositis0low20
Familial Primary Pulmonary Hypertension0low30
Familial Thrombotic Thrombocytopenia Purpura0low10
Familial Thrombotic Thrombocytopenic Purpura0low10
Fanconi Anemia0low10
Fanconi Hypoplastic Anemia0low10
Fanconi Pancytopenia0low10
Fanconi Panmyelopathy0low10
Fanconi's Anemia0low10
Fatty Liver0low80
Fatty Liver, Nonalcoholic0low60
Fatty Streak, Arterial0medium81
Febrile Neutropenia0low10
Fetal Growth Restriction0low130
Fetal Growth Retardation0low130
Fever, Zika0low10
Fibroatheroma0medium81
Fibroatheromatous Plaques0medium81
Fibrocystic Disease of Pancreas0low20
Fibrocystic Pulmonary Dysplasia0low20
Fibromyalgia0low10
Fibromyalgia-Fibromyositis Syndrome0low10
Fibromyalgia, Primary0low10
Fibromyalgia, Secondary0low10
Fibromyositis-Fibromyalgia Syndrome0low10
Fibrosing Alveolitis, Cryptogenic0low20
Fibrosis0low210
Fibrosis, Liver0low100
Fibrositis0low10
Focal Brain Injuries0medium21
Focal Onset Alzheimer's Disease0medium71
Focal Segmental Glomerulosclerosis0low50
Folic Acid Deficiency0low10
Folling Disease0low20
Folling's Disease0low20
Foot Ulcer, Diabetic0low20
Fulminant Hepatic Failure0low30
Fulminant Hepatic Failure with Cerebral Edema0low20
Fulminating Hepatic Failure0low30
Fulminating Liver Failure0low30
Funisitis0low10
Gallstone Disease0low10
Gasser Syndrome0low20
Gasser's Syndrome0low20
Gastric Acid Reflux0low20
Gastric Acid Reflux Disease0low20
Gastric Cancer0medium11
Gastric Cancer, Familial Diffuse0medium11
Gastric Diseases0low20
Gastric Neoplasms0medium11
Gastric Ulcer0low20
Gastric Varices0low10
Gastric Varix0low10
Gastro-Esophageal Reflux0low20
Gastro-Esophageal Reflux Disease0low20
Gastro-oesophageal Reflux0low20
Gastroduodenal Ulcer0low10
Gastroesophageal Reflux0low20
Gastroesophageal Reflux Disease0low20
Gehrig's Disease0low10
Gender Dysphoria0low10
Gender Identity Disorder0low10
Generalized Absence Seizure0medium11
Generalized Absence Seizures0medium11
Generalized Headache0medium11
Generalized Tonic-Clonic Seizures0medium11
Genetic Predisposition0low100
Genetic Predisposition to Disease0low100
Genetic Susceptibility0low100
GERD0low20
Gestational Diabetes0low120
Gestosis, EPH0low450
Giant Intracranial Aneurysm0low20
Gibraltar Fever0low10
Gierke Disease0low10
Gierke's Disease0low10
Gingivitis0low10
Glaucoma0low40
Glaucoma Capsulare0low40
Glaucoma Simplex0low10
Glaucoma, Compensated0low10
Glaucoma, Compensative0low10
Glaucoma, Open Angle0low10
Glaucoma, Open-Angle0low10
Glaucoma, Pigmentary0low10
Glaucoma, Primary Open Angle0low10
Glaucoma, Secondary Open Angle0low10
Glaucoma, Simple0low10
Glial Cell Tumors0low20
Glioma0low20
Glomerulonephritis0low30
Glomerulonephritis, Focal Sclerosing0low50
Glomerulonephritis, IGA0low10
Glomerulosclerosis, Diabetic0medium232
Glomerulosclerosis, Focal0low50
Glomerulosclerosis, Focal Segmental0low50
Glucose Intolerance0medium52
Glucose-6-Phosphatase Deficiency0low10
Glucosephosphatase Deficiency0low10
Glycogen Storage Disease 1 (GSD I)0low10
Glycogen Storage Disease Type I0low10
Glycogenosis 10low10
Goiter, Exophthalmic0low10
Goiter, Nodular0low10
Goldblatt Syndrome0low50
Gordon Hyperkalemia-Hypertension Syndrome0low10
Graft Occlusion, Vascular0low30
Graft Restenosis, Vascular0low30
Graft vs Host Disease0medium11
Graft-Versus-Host Disease0medium11
Graft-vs-Host Disease0medium11
Granulomatous Angiitis0low10
Granulomatous Arteritis0low10
Graves Disease0low10
Graves' Disease0low10
Growth Disorders0medium42
Growth Retardation, Intrauterine0low130
Guam Disease0low10
Guam Form of Amyotrophic Lateral Sclerosis0low10
Haemolysis0low70
Hangman Fracture0low10
Hangman's Fracture0low10
Harelip0low10
HbS Disease0medium101
Head Pain0medium11
Headache0medium11
Headache, Migraine0low40
Hearing Impairment0low10
Hearing Loss0low10
Hearing Loss, Cochlear0low10
Hearing Loss, Sensorineural0low10
Hearing Loss, Transitory0low10
Heart Abnormalities0low80
Heart Arrest0low10
Heart Attack0medium342
Heart Decompensation0medium419
Heart Defect, Congenital0low80
Heart Defects, Congenital0low80
Heart Disease, Ischemic0medium111
Heart Disease, Pulmonary0low10
Heart Diseases0low80
Heart Diseases, Pulmonary0low10
Heart Disorders0low80
Heart Enlargement0low30
Heart Failure0medium419
Heart Failure, Congestive0medium419
Heart Failure, Diastolic0medium11
Heart Failure, Left-Sided0medium419
Heart Failure, Right-Sided0medium419
Heart Failure, Systolic0low10
Heart Hypertrophy0low30
Heart Injuries0low10
Heart Rupture, Traumatic0low10
Heart Valve Diseases0low40
Heart Valvular Disease0low40
Heart, Malformation Of0low80
Helicobacter Infections0medium41
Hematologic Malignancies0low10
Hematologic Malignancy0low10
Hematologic Neoplasms0low10
Hematological Malignancies0low10
Hematological Neoplasms0low10
Hematopoetic Myelodysplasia0low10
Hematopoietic Malignancies0low10
Hematopoietic Neoplasms0low10
Hemeralopia0medium11
Hemicrania0medium11
Hemicrania Migraine0low40
Hemiparesis0medium11
Hemiplegic Migraine, Familial0low10
Hemiplegic-Ophthalmoplegic Migraine0low10
Hemoglobin F Disease0low30
Hemoglobin S Disease0medium101
Hemolysis0low70
Hemolytic Disease of Newborn0low10
Hemolytic-Uremic Syndrome0low20
Hemorrhage0low20
Hemorrhage, Cerebral0low30
Hemorrhage, Cerebrum0low30
Hemorrhage, Intracranial0low10
Hemorrhage, Subarachnoid0low130
Hemorrhagic Dengue0low10
Hemorrhagic Fever, Crimean0low10
Hemorrhagic Fever, Dengue0low10
Hemorrhagic Shock0low40
Hemorrhagic Thrombocythemia0low10
Hemorrhoids0low10
Hepatic Cancer0low10
Hepatic Cirrhosis0low100
Hepatic Cirrhosis, Alcoholic0low30
Hepatic Cirrhosis, Experimental0low10
Hepatic Coma0low20
Hepatic Encephalopathy0low20
Hepatic Failure0low20
Hepatic Failure, Acute0low30
Hepatic Failure, Fulminant0low30
Hepatic Neoplasms0low10
Hepatic Stupor0low20
Hepatitis B Virus Infection, Chronic0low10
Hepatitis B, Chronic0low10
Hepatitis C0low10
Hepatitis C, Chronic0low30
Hepatitis, Alcoholic0low10
Hepatitis, Alcoholic, Chronic0low10
Hepatitis, Drug-Induced0low10
Hepatitis, Toxic0low10
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted0low10
Hepatocellular Cancer0low10
Hepatocellular Carcinoma0low10
Hepatocerebral Encephalopathy0low20
Hepatoma0low10
Hepatoma, Experimental0low30
Hepatoma, Morris0low30
Hepatoma, Novikoff0low30
Hepatomas, Experimental0low30
Hepatorenal Glycogen Storage Disease0low10
Hepatorenal Syndrome0low20
Hereditary Motor Neuronopathy0low10
Heritable Pulmonary Arterial Hypertension0low30
Herpesvirus 4 Infections, Human0low10
Heterotopic Ossification0low10
High Cholesterol Levels0medium367
HIV0low10
HIV Antibody Positivity0low10
HIV Coinfection0medium141
HIV Infections0medium141
HIV Seroconversion0low10
HIV Seropositivity0low10
Hives0low10
Hoffman's Reflex0low10
Homocystinuria0low20
Homologous Wasting Disease0medium11
Horse Diseases0low10
HPABH4C0low20
HTLV-III Infections0medium141
HTLV-III Seroconversion0low10
HTLV-III Seropositivity0low10
HTLV-III-LAV Infections0medium141
Hughes Syndrome0low20
Human Herpes Virus 4 Infections0low10
Human Herpesvirus 4 Infections0low10
Human Mammary Carcinoma0low40
Huntington Chorea0low10
Huntington Chronic Progressive Hereditary Chorea0low10
Huntington Disease0low10
Huntington Disease, Akinetic-Rigid Variant0low10
Huntington Disease, Juvenile0low10
Huntington Disease, Juvenile-Onset0low10
Huntington Disease, Late Onset0low10
Huntington's Chorea0low10
Huntington's Disease0low10
Hyalinosis, Segmental0low50
Hyalinosis, Segmental Glomerular0low50
Hydronephrosis0low10
Hyper-beta-Lipoproteinemia0medium41
Hyper-Low Density Lipoproteinemia0medium41
Hyper-Low-Density-Lipoproteinemia0medium41
Hyperandrogenism0medium21
Hyperbetalipoproteinemia0medium41
Hypercapnic Acute Respiratory Failure0low10
Hypercapnic Respiratory Failure0low10
Hypercholesteremia0medium367
Hypercholesterolemia0medium367
Hypercholesterolemia, Autosomal Dominant0medium41
Hypercholesterolemia, Autosomal Dominant, Type B0medium41
Hypercholesterolemia, Essential0medium41
Hypercholesterolemia, Familial0medium41
Hypercholesterolemic Xanthomatosis, Familial0medium41
Hypercoagulability0medium11
Hypercortisolism0low10
Hyperemia0medium137
Hyperglycemia0medium164
Hyperglycemia, Postprandial0medium164
Hypergonadotropic Hypogonadism0medium22
Hyperhomocysteinemia0medium456
Hyperinsulinemia0low30
Hyperinsulinism0low30
Hyperkalemia0low10
Hyperlipemia0medium142
Hyperlipidemia0medium142
Hyperlipidemias0medium142
Hyperlipoproteinemia Type 20medium41
Hyperlipoproteinemia Type II0medium41
Hyperlipoproteinemia Type IIa0medium41
Hyperlipoproteinemia Type IIb0medium41
Hyperlipoproteinemia, Type II0medium41
Hyperlipoproteinemia, Type IIa0medium41
Hyperostosis Corticalis Generalisata0low10
Hyperoxaluria0low10
Hyperoxia0medium11
Hyperphenylalaninaemia0low20
Hyperphenylalaninemia Caused by a Defect in Biopterin Metabolism0low20
Hyperphenylalaninemia, BH4-Deficient, C0low20
Hyperphenylalaninemia, Non-Phenylketonuric0low20
Hyperphenylalaninemia, Tetrahydrobiopterin-Deficient, Due To DHPR Deficiency0low20
Hyperphosphatasemia Tarda0low10
Hyperplasia0low90
Hyperpotassemia0low10
Hyperpotassemia and Hypertension, Familial0low10
Hyperreflexia0low10
Hypersensitivity, Contact0low10
Hypersomnia with Periodic Respiration0low20
Hypertension0medium18024
Hypertension-Edema-Proteinuria Gestosis0low450
Hypertension, Essential0low20
Hypertension, Goldblatt0low50
Hypertension, Portal0low80
Hypertension, Pulmonary0medium402
Hypertension, Renal0medium81
Hypertension, Renovascular0low50
Hypertensive Hyperkalemia, Familial0low10
Hyperthyroid0low30
Hyperthyroidism0low30
Hyperthyroidism, Autoimmune0low10
Hypertriglyceridemia0medium41
Hypertrophy0low20
Hypertrophy, Left Ventricular0medium141
Hyperuricemia0medium41
Hyperventilation0low10
Hypoacusis0low10
Hypogonadism0medium22
Hypogonadism, Isolated Hypogonadotropic0medium22
Hypogonadotropic Hypogonadism0medium22
Hypopituitarism0low10
Hyporeflexia0low10
Hyposecretion Syndrome, Anterior Pituitary0low10
Hyposecretion, Adenohypophyseal0low10
Hypospermatogenesis0low10
Hypotension0low70
Hypotension, Vascular0low70
Hypothyroidism0low50
Hypovolemic Shock0low10
Hypoxemia0medium141
Hypoxemic Acute Respiratory Failure0low10
Hypoxemic Respiratory Failure0low10
Hypoxia0medium141
IDDM0medium185
Idiocy0medium11
Idiopathic Fibrosing Alveolitis, Chronic Form0low20
Idiopathic Parkinson Disease0low10
Idiopathic Parkinson's Disease0low10
Idiopathic Proctocolitis0medium31
Idiopathic Pulmonary Arterial Hypertension0low30
Idiopathic Pulmonary Fibrosis0low20
Idiopathic Pulmonary Fibrosis, Familial0low20
Idiopathic Pulmonary Hypertension0low30
Idiopathic Ventricular Tachycardia0low10
IGA Glomerulonephritis0low10
IGA Nephropathy0low10
Iga Nephropathy 10low10
Ileitis, Regional0low20
Ileitis, Terminal0low20
Ileocolitis0low20
Illuminating Gas Poisoning0low20
Immunoglobulin A Nephropathy0low10
Impaired Glucose Tolerance0medium52
Impotence0medium112
Impotence, Arteriogenic0low50
Impotence, Vasculogenic0low50
Impotence, Venogenic0low50
Inadequate Sleep0low20
Inborn Errors, Amino Acid Metabolism0medium21
Inborn Urea Cycle Disorder0low10
Inclusion Disease0low20
Infant Obesity0low40
Infant Overweight0low40
Infant, Newborn, Diseases0low10
Infant, Premature, Diseases0low10
Infant, Small for Gestational Age0low30
Infantile Obesity0low40
Infantile Respiratory Distress Syndrome0low30
Infarction, Anterior Cerebral Circulation0low10
Infarction, Anterior Circulation, Brain0low10
Infarction, Brain, Anterior Circulation0low10
Infarction, Brain, Posterior Circulation0low10
Infarction, Cerebral0low50
Infarction, Cerebral, Left Hemisphere0low50
Infarction, Cerebral, Right Hemisphere0low50
Infarction, Left Hemisphere, Cerebral0low50
Infarction, Middle Cerebral Artery0low20
Infarction, Posterior Circulation, Brain0low10
Infarction, Right Hemisphere, Cerebral0low50
Infection, Bacterial0low10
Infection, Congo Virus0low10
Infections, Bacterial0low10
Infections, Community-Acquired0low10
Infections, Cytomegalovirus0low20
Infections, E coli0medium11
Infections, EBV0low10
Infections, Epstein-Barr Virus0low10
Infections, Escherichia coli0medium11
Infections, Helicobacter0medium41
Infections, Plasmodium0low10
Infections, Soft Tissue0medium11
Infectious Diseases0low10
Infertility0low10
Infertility, Male0low10
Inflammation0medium868
Inflammatory Bowel Disease 10low20
Inflammatory Bowel Disease, Ulcerative Colitis Type0medium31
Inflammatory Bowel Diseases0low10
Inflammatory Response Syndrome, Systemic0low20
Inherited Errors of Amino Acid Metabolism0medium21
Injuries0medium21
Injuries and Wounds0medium21
Injuries, Acute Brain0medium21
Injuries, Brain0medium21
Injuries, Carotid Artery0low40
Injuries, Experimental Radiation0low10
Injuries, Heart0low10
Injuries, Spinal Cord0medium11
Injuries, Wounds0medium21
Injury, Ischemia-Reperfusion0low150
Injury, Myocardial Reperfusion0low60
Injury, Reperfusion0low150
Innate Inflammatory Response0medium868
Insomnia0low20
Insomnia Disorder0low20
Insufficient Sleep0low20
Insufficient Sleep Syndrome0low20
Insulin Resistance0medium667
Insulin Resistance Syndrome X0medium327
Insulin Sensitivity0medium667
Insulin-Dependent Diabetes Mellitus 10medium185
Intellectual Development Disorder0medium11
Intellectual Disability0medium11
Intermittent Claudication0medium43
Internal Carotid Artery Diseases0medium253
Internal Carotid Artery Stenosis0low90
Internal Carotid Artery Thrombosis0low10
Interstitial Nephritis0low10
Interstitial Pneumonitis, Usual0low20
Intestinal Diseases0low10
Intracapillary Glomerulosclerosis0medium232
Intracerebral Hemorrhage0low30
Intracranial Aneurysm0low20
Intracranial Angiospasm0low110
Intracranial Arteriosclerosis0low20
Intracranial Atherosclerosis0low20
Intracranial Central Nervous System Disorders0low10
Intracranial CNS Disorders0low10
Intracranial Hemorrhages0low10
Intracranial Vascular Disorders0low110
Intracranial Vascular Spasm0low110
Intracranial Vasospasm0low110
Intrahepatic Cholestasis0low10
Intraocular Pressure0low40
Intrauterine Growth Restriction0low130
Intrauterine Growth Retardation0low130
Intravascular Hemolysis0low70
Invasiveness, Neoplasm0medium21
Iron Overload0low30
Irritable Bowel Syndrome0low10
Ischaemic Stroke0low10
Ischemia0medium121
Ischemia-Reperfusion Injury0low150
Ischemia, Cerebral0medium122
Ischemia, Myocardial0medium111
Ischemic Attack, Transient0low30
Ischemic Encephalopathy0medium122
Ischemic Heart Disease0medium111
Ischemic Stroke0low10
Isolated Clinic Hypertension0low10
Itching0low10
Jacksonian Seizure0medium11
Juvenile Huntington Disease0low10
Juvenile-Onset Diabetes0medium185
Juvenile-Onset Huntington Disease0low10
Kawasaki Disease0low10
Kawasaki Syndrome0low10
Kidney Diseases0medium613
Kidney Failure0medium222
Kidney Failure, Acute0medium162
Kidney Failure, Chronic0medium12421
Kidney Insufficiency0medium222
Kidney Insufficiency, Acute0medium162
Kidney Insufficiency, Chronic0medium664
Kidney Scarring0low30
Kidney, Polycystic, Autosomal Dominant0medium31
Kienbock Disease0low10
Kienbock's Disease0low10
Kienboeck Disease0low10
Kienboeck's Disease0low10
Kimmelstiel-Wilson Disease0medium232
Kimmelstiel-Wilson Syndrome0medium232
Klinefelter Syndrome0low20
Klinefelter Syndrome, Variants0low20
Klinefelter's Syndrome0low20
Koch's Disease0low10
Kochs Disease0low10
Language Delay0medium11
Language Development Disorders0medium11
Language Disorders, Developmental0medium11
Late Effects, Prenatal Exposure0low60
Late Onset Alzheimer Disease0medium71
Late-Onset Huntington Disease0low10
Late-Onset Spondyloepiphyseal Dysplasia0low10
LDL Receptor Disorder0medium41
Left Hemisphere, Cerebral Infarction0low50
Left Hemisphere, Infarction, Cerebral0low50
Left Main Coronary Artery Disease0medium778
Left Main Coronary Disease0medium778
Left Main Disease0medium778
Left Middle Cerebral Artery Infarction0low20
Left Ventricle Remodeling0low60
Left Ventricular Apical Ballooning Syndrome0low10
Left Ventricular Dysfunction0medium151
Left Ventricular Hypertrophy0medium141
Left Ventricular Remodeling0low60
Left-Sided Heart Failure0medium419
Leg Ulcer0low10
Leishmania Infection0low10
Leishmaniasis0low10
Lens Opacities0low30
Leukemia, Acute Lymphoblastic0low30
Leukemia, Acute Myelogenous0low20
Leukemia, Acute Myeloid0low20
Leukemia, B Cell, Chronic0low10
Leukemia, B-Cell, Chronic0low10
Leukemia, Chronic Lymphatic0low10
Leukemia, Chronic Lymphocytic0low10
Leukemia, Chronic Lymphocytic, B-Cell0low10
Leukemia, Lymphoblastic0low30
Leukemia, Lymphoblastic, Acute0low30
Leukemia, Lymphoblastic, Acute, L10low30
Leukemia, Lymphoblastic, Acute, L20low30
Leukemia, Lymphoblastic, Acute, Philadelphia-Positive0low30
Leukemia, Lymphoblastic, Chronic0low10
Leukemia, Lymphocytic, Acute0low30
Leukemia, Lymphocytic, Acute, L10low30
Leukemia, Lymphocytic, Acute, L20low30
Leukemia, Lymphocytic, Chronic0low10
Leukemia, Lymphocytic, Chronic, B Cell0low10
Leukemia, Lymphocytic, Chronic, B-Cell0low10
Leukemia, Lymphoid, Acute0low30
Leukemia, Myeloblastic, Acute0low20
Leukemia, Myelocytic, Acute0low20
Leukemia, Myelogenous, Acute0low20
Leukemia, Myeloid, Acute0low20
Leukemia, Myeloid, Acute, M10low20
Leukemia, Myeloid, Acute, M20low20
Leukemia, Nonlymphoblastic, Acute0low20
Leukemia, Nonlymphocytic, Acute0low20
Leukoaraiosis0low30
Leukocytosis0medium11
Lewy Body Parkinson Disease0low10
Lewy Body Parkinson's Disease0low10
Libman-Sacks Disease0low30
Limited Scleroderma0low10
Limited Systemic Scleroderma0low10
Lipemia0medium142
Lipidemia0medium142
Liposarcoma0low10
Liposarcoma, Dedifferentiated0low10
Liposarcoma, Pleomorphic0low10
Liposarcoma, Well Differentiated0low10
Liver Cancer0low10
Liver Cancer, Adult0low10
Liver Cell Carcinoma0low10
Liver Cell Carcinoma, Adult0low10
Liver Cirrhoses, Experimental0low10
Liver Cirrhosis0low100
Liver Cirrhosis, Alcoholic0low30
Liver Cirrhosis, Biliary0low10
Liver Cirrhosis, Experimental0low10
Liver Cirrhosis, Obstructive0low10
Liver Diseases0low90
Liver Dysfunction0low90
Liver Failure0low20
Liver Failure, Acute0low30
Liver Failure, Chronic0low30
Liver Failure, Fulminant0low30
Liver Fibrosis0low100
Liver Injury, Drug-Induced0low10
Liver Injury, Drug-Induced, Acute0low10
Liver Neoplasms0low10
Liver Neoplasms, Experimental0low30
Liver Steatosis0low80
Lobar Pneumonia0low30
Long Sleeper Syndrome0medium21
Lou Gehrig Disease0low10
Lou Gehrig's Disease0low10
Lou-Gehrigs Disease0low10
Low Blood Pressure0low70
Low Cardiac Output0low10
Low Cardiac Output Syndrome0low10
Low Sperm Count0low10
Lower Extremity Paresis0medium11
Lung Cancer0low20
Lung Diseases0low30
Lung Inflammation0low30
Lung Injury, Acute0low40
Lung Neoplasms0low20
Lupus Erythematosus Disseminatus0low30
Lupus Erythematosus, Systemic0low30
Lymph Node Syndrome, Mucocutaneous0low10
Lymphatic Sarcoma0low10
Lymphoblastic Leukemia0low30
Lymphoblastic Leukemia, Acute0low30
Lymphoblastic Leukemia, Acute, Adult0low30
Lymphoblastic Leukemia, Acute, Childhood0low30
Lymphoblastic Leukemia, Acute, L10low30
Lymphoblastic Leukemia, Acute, L20low30
Lymphoblastic Leukemia, Chronic0low10
Lymphoblastic Lymphoma0low30
Lymphocytic Leukemia, Acute0low30
Lymphocytic Leukemia, Chronic0low10
Lymphocytic Leukemia, Chronic, B Cell0low10
Lymphocytic Leukemia, Chronic, B-Cell0low10
Lymphocytic Leukemia, L10low30
Lymphocytic Leukemia, L20low30
Lymphocytic Lymphoma0low10
Lymphocytic Lymphoma, Diffuse, Well Differentiated0low10
Lymphocytic Lymphoma, Diffuse, Well-Differentiated0low10
Lymphocytic Lymphoma, Well Differentiated0low10
Lymphocytic Lymphoma, Well-Differentiated0low10
Lymphoma, Atypical Diffuse Small Lymphoid0low10
Lymphoma, Diffuse0low10
Lymphoma, Diffuse, Mixed Lymphocytic-Histiocytic0low10
Lymphoma, High-Grade0low10
Lymphoma, Intermediate-Grade0low10
Lymphoma, Low-Grade0low10
Lymphoma, Lymphoblastic0low30
Lymphoma, Lymphocytic0low10
Lymphoma, Lymphocytic, Diffuse, Well Differentiated0low10
Lymphoma, Lymphocytic, Diffuse, Well-Differentiated0low10
Lymphoma, Lymphocytic, Well Differentiated0low10
Lymphoma, Lymphocytic, Well-Differentiated0low10
Lymphoma, Lymphoplasmacytoid, CLL0low10
Lymphoma, Mixed0low10
Lymphoma, Mixed Cell, Diffuse0low10
Lymphoma, Mixed Lymphocytic-Histiocytic0low10
Lymphoma, Mixed Small and Large Cell, Diffuse0low10
Lymphoma, Mixed-Cell0low10
Lymphoma, Mixed-Cell, Diffuse0low10
Lymphoma, Non-Hodgkin0low10
Lymphoma, Non-Hodgkin, Familial0low10
Lymphoma, Non-Hodgkin's0low10
Lymphoma, Non-Hodgkins0low10
Lymphoma, Nonhodgkin's0low10
Lymphoma, Nonhodgkins0low10
Lymphoma, Pleomorphic0low10
Lymphoma, Small and Large Cleaved-Cell, Diffuse0low10
Lymphoma, Small Cleaved Cell, Diffuse0low10
Lymphoma, Small Cleaved-Cell, Diffuse0low10
Lymphoma, Small Lymphocytic0low10
Lymphoma, Small Lymphocytic, Plasmacytoid0low10
Lymphoma, Small Non-Cleaved-Cell0low10
Lymphoma, Small Noncleaved-Cell0low10
Lymphoma, Small-Cell0low10
Lymphoma, Undifferentiated0low10
Lymphoma, Undifferentiated, Diffuse0low10
Lymphoplasmacytoid Lymphoma, CLL0low10
Lymphosarcoma0low10
Macropsia0medium11
Major Depressive Disorder0low40
Malaria0low10
Malaria, Falciparum0low10
Male Impotence0medium112
Male Sexual Impotence0medium112
Malformation, Arnold-Chiari0low10
Malignancies, Hematologic0low10
Malignancy0low30
Malignancy, Hematologic0low10
Malignant Glioma0low20
Malignant Neoplasm of Breast0low40
Malignant Neoplasms0low30
Malignant Tumor of Breast0low40
Malignant Tumor of Urinary Bladder0low10
Malnourishment0low30
Malnutrition0low30
Malta Fever0low10
Mammary Cancer0low40
Mammary Carcinoma, Human0low40
Mammary Neoplasm, Human0low40
Mammary Neoplasms, Experimental0low10
Mammary Neoplasms, Human0low40
Manic Depression0low10
Manic Disorder0low10
Manic-Depressive Psychosis0low10
Marginal Ulcer0low10
Marie-Struempell Disease0medium91
Marsh Fever0low10
Masked Hypertension0low30
Maturity-Onset Diabetes0medium9320
Maturity-Onset Diabetes Mellitus0medium9320
MCA Infarct0low20
MCA Infarction0low20
Mediterranean Anemia0low30
Mediterranean Fever, Familial0low20
Melancholia0low10
Melancholia, Involutional0low40
MELAS0medium11
MELAS Syndrome0medium11
Melnick-Needles Osteodysplasty0low10
Melnick-Needles Syndrome0low10
Memory Deficits0low10
Memory Disorder, Semantic0low10
Memory Disorder, Spatial0low10
Memory Disorders0low10
Memory Disorders, Age-Related0low10
Memory Loss0low10
Menopause0medium11
Menstruation, Painful0low20
Mental Deficiency0medium11
Mental Deterioration0low40
Mental Retardation0medium11
Mental Retardation, Psychosocial0medium11
Metabolic Cardiovascular Syndrome0medium327
Metabolic Diseases0low40
Metabolic Syndrome0medium327
Metabolic Syndrome X0medium327
Metabolic X Syndrome0medium327
Metamorphopsia0medium11
Microangiopathic Hemolytic Anemia, Congenital0low10
Microangiopathy, Diabetic0medium221
Microcalcification0low110
Microcalcinosis0low110
Microcytemia, beta Type0low30
Micropsia0medium11
Microvascular Angina0medium41
Middle Cerebral Artery Aneurysm0low20
Middle Cerebral Artery Circulation Infarction0low20
Middle Cerebral Artery Embolic Infarction0low20
Middle Cerebral Artery Embolus0low20
Middle Cerebral Artery Infarction0low20
Middle Cerebral Artery Occlusion0low20
Middle Cerebral Artery Stroke0low20
Middle Cerebral Artery Syndrome0low20
Middle Cerebral Artery Thrombosis0low20
Middle Cerebral Artery Thrombotic Infarction0low20
Migraine0low40
Migraine Aura without Headache0low10
Migraine Disorders0low40
Migraine Headache0low40
Migraine Variant0low40
Migraine with Acute Onset Aura0low10
Migraine with Aura0low10
Migraine with Prolonged Aura0low10
Migraine with Typical Aura0low10
Migraine, Classic0low10
Migraine, Prolonged Aura0low10
Mild Cognitive Impairment0low40
Mild Neurocognitive Disorder0low40
Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes0medium11
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes0medium11
Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode0medium11
Mixed Central and Obstructive Sleep Apnea0low20
Mixed Glioma0low20
Mixed Infection0low10
Mixed Small and Large Cell Lymphoma, Diffuse0low10
Mixed-Cell Lymphoma0low10
Mixed-Cell Lymphoma, Diffuse0low10
MODS0medium111
MODY0medium9320
Mongolism0low20
Mononeuropathy, Diabetic0low30
Monoparesis0medium11
Moral Injury0low10
Morbid Obesity0medium51
Moschcowitz Disease0low10
Moschkowitz Disease0low10
Motor Neuron Disease, Amyotrophic Lateral Sclerosis0low10
Mountain Sickness0low20
Movement Disorder Syndromes0medium11
Movement Disorders0medium11
MS (Multiple Sclerosis)0medium41
Mucocutaneous Lymph Node Syndrome0low10
Mucoviscidosis0low20
Multiple Epiphyseal Dysplasia0low10
Multiple Organ Dysfunction Syndrome0medium111
Multiple Organ Failure0medium111
Multiple Sclerosis0medium41
Multiple Sclerosis, Acute Fulminating0medium41
Multiple Sclerosis, Acute Relapsing0low20
Multiple Sclerosis, Relapsing-Remitting0low20
Muscle Contraction0low50
Muscle Paresis0medium11
Muscle Relaxation0low50
Muscular Atrophy, Adult Spinal0low10
Muscular Atrophy, Spinal0low10
Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type0medium11
Muscular Dystrophy, Becker0medium11
Muscular Dystrophy, Becker Type0medium11
Muscular Dystrophy, Childhood, Pseudohypertrophic0medium11
Muscular Dystrophy, Duchenne0medium11
Muscular Dystrophy, Duchenne and Becker Types0medium11
Muscular Dystrophy, Duchenne Type0medium11
Muscular Dystrophy, Pseudohypertrophic0medium11
Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type0medium11
Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type0medium11
Muscular Dystrophy, Pseudohypertrophic, Childhood0medium11
Muscular Paresis0medium11
Mycobacterium tuberculosis Infection0low10
Mycotic Aneurysm, Intracranial0low20
Myeloblastic Leukemia, Acute0low20
Myelocytic Leukemia, Acute0low20
Myelodysplastic Syndromes0low10
Myelogenous Leukemia, Acute0low20
Myeloid Leukemia, Acute0low20
Myeloid Leukemia, Acute, M10low20
Myeloid Leukemia, Acute, M20low20
Myelopathic Muscular Atrophy0low10
Myelopathic Muscular Atrophy, Progressive0low10
Myelopathy, Traumatic0medium11
Myocardial Diseases0low20
Myocardial Diseases, Primary0low20
Myocardial Diseases, Secondary0low20
Myocardial Failure0medium419
Myocardial Infarct0medium342
Myocardial Infarction0medium342
Myocardial Ischemia0medium111
Myocardial Ischemic Reperfusion Injury0low60
Myocardial Preinfarction Syndrome0low30
Myocardial Remodeling, Ventricular0low60
Myocardial Reperfusion Injury0low60
Myocardiopathies0low20
Myocarditis0low10
Myoclonic Seizure0medium11
Myoclonic Seizures0medium11
Myofascial Pain Syndrome, Diffuse0low10
Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke0medium11
Myotonic Chondrodystrophy0low10
Myotonic Myopathy, Dwarfism, Chondrodystrophy, And Ocular And Facial Abnormalities0low10
NAFLD0low60
Nanism0low10
Nasal Polyps0low10
Near-Death Experience0low10
Necrosis0low10
Necrosis, Aseptic, of Bone0low10
Necrosis, Avascular, of Bone0low10
Neointima0low30
Neointima Formation0low30
Neonatal Diseases0low10
Neonatal Respiratory Distress Syndrome0low30
Neoplasia0low30
Neoplasm0low30
Neoplasm Invasion0medium21
Neoplasm Invasiveness0medium21
Neoplasms0low30
Neoplasms, Adrenal Gland0low10
Neoplasms, Benign0low30
Neoplasms, Bladder0low10
Neoplasms, Breast0low40
Neoplasms, Cervical0low10
Neoplasms, Cervix0low10
Neoplasms, Colonic0low30
Neoplasms, Experimental Liver0low30
Neoplasms, Experimental Mammary0low10
Neoplasms, Gastric0medium11
Neoplasms, Hematologic0low10
Neoplasms, Hematopoietic0low10
Neoplasms, Hepatic0low10
Neoplasms, Liver0low10
Neoplasms, Lung0low20
Neoplasms, Prostate0low20
Neoplasms, Prostatic0low20
Neoplasms, Pulmonary0low20
Neoplasms, Stomach0medium11
Neovascularization, Optic Disc0low10
Neovascularization, Pathologic0medium91
Neovascularization, Pathological0medium91
Neovascularization, Retinal0low10
Nephritis0low10
Nephritis, IGA Type0low10
Nephritis, Interstitial0low10
Nephritis, Tubulointerstitial0low10
Nephropathy, IGA0low10
Nephrosclerosis0low10
Nephrotic Syndrome0low20
Nervous System Diseases, Autonomic0low20
Nervous System Diseases, Parasympathetic0low20
Nervous System Diseases, Sympathetic0low20
Neuralgia, Diabetic0low30
Neuritic Plaques0low10
Neuroblastoma0low10
Neurodermatitis, Atopic0low10
Neurodermatitis, Disseminated0low10
Neuromyelitis Optica0medium11
Neuromyelitis Optica (NMO) Spectrum Disorder0medium11
Neuromyelitis Optica (NMO) Spectrum Disorders0medium11
Neuromyelitis Optica Spectrum Disorder0medium11
Neuromyelitis Optica Spectrum Disorders0medium11
Neuroses, Post-Traumatic0low10
Neuroses, Posttraumatic0low10
Neurosis, Depressive0low10
NIDDM0medium9320
NMO Spectrum Disorder0medium11
No-Reflow Phenomenon0low10
Nocturia0low10
Nodular Glomerulosclerosis0medium232
Nodular Goiter0low10
Non-alcoholic Fatty Liver Disease0low60
Non-Epileptic Seizure0medium11
Non-Epileptic Seizures0medium11
Non-Hodgkin Lymphoma0low10
Non-Hodgkin's Lymphoma0low10
Non-Phenylketonuric Hyperphenylalaninemia0low20
Non-Small Cell Lung Cancer0low10
Non-Small Cell Lung Carcinoma0low10
Non-Small-Cell Lung Carcinoma0low10
Nonalcoholic Fatty Liver Disease0low60
Nonalcoholic Steatohepatitis0low60
Nonepileptic Seizure0medium11
Nonepileptic Seizures0medium11
Noninsulin-Dependent Diabetes Mellitus0medium9320
Nonlymphoblastic Leukemia, Acute0low20
Nonlymphocytic Leukemia, Acute0low20
Nonorganic Insomnia0low20
Nonsmall Cell Lung Cancer0low10
Nonsustained Ventricular Tachycardia0low10
Nutritional Deficiency0low30
Nycturia0low10
Obesity0medium419
Obesity in Adolescence0low40
Obesity in Childhood0low40
Obesity, Abdominal0low20
Obesity, Morbid0medium51
Obesity, Severe0medium51
Obesity, Visceral0low20
Obstructive Sleep Apnea0medium81
Obstructive Sleep Apnea Syndrome0medium81
Occlusion, Middle Cerebral Artery0low20
Ocular Headache0medium11
Ocular Infections0low10
Oculopharyngeal Spinal Muscular Atrophy0low10
Old Silk Route Disease0low30
Oligoasthenoteratozoospermia0low10
Oligophrenia Phenylpyruvica0low20
Oligospermia0low10
Oligozoospermia0low10
Open-Angle Glaucoma0low10
Opiate Abuse0low20
Opiate Addiction0low20
Opiate Dependence0low20
Opioid Abuse0low20
Opioid Addiction0low20
Opioid Dependence0low20
Opioid Misuse0low20
Opioid Use Disorder0low20
Opioid-Related Disorders0low20
Optic Disc Neovascularization0low10
Optic Disk Neovascularization0low10
Organ Dysfunction Syndrome, Multiple0medium111
Organ Failure, Multiple0medium111
Orthostatic Headache0medium11
OSAHS0medium81
Ossification, Ectopic0low10
Ossification, Heterotopic0low10
Ossification, Pathologic0low10
Ossification, Pathological0low10
Osteoarthritis0medium21
Osteoarthritis Of Hip0low10
Osteoarthritis of Knee0low20
Osteoarthritis of the Hip0low10
Osteoarthritis of the Knee0low20
Osteoarthritis, Hip0low10
Osteoarthritis, Knee0low20
Osteoarthrosis0medium21
Osteoarthrosis Deformans0medium21
Osteochondrodysplasias0low10
Osteoclastic Bone Loss0low10
Osteodysplasty of Melnick and Needles0low10
Osteonecrosis0low10
Osteoporosis0low10
Osteoporosis, Age-Related0low10
Osteoporosis, Involutional0low10
Osteoporosis, Post-Menopausal0low10
Osteoporosis, Post-Traumatic0low10
Osteoporosis, Postmenopausal0low10
Osteoporosis, Senile0low10
Overinclusion0low50
Overweight0medium94
Oxalosis0low10
Oxaluria0low10
Oxygen Deficiency0medium141
PAH Deficiency0low20
Pain0low20
Pain, Burning0low20
Pain, Crushing0low20
Pain, Menstrual0low20
Pain, Migratory0low20
Pain, Radiating0low20
Pain, Splitting0low20
Palmo-Mental Reflex0low10
Palmoplantaris Pustulosis0low30
Paludism0low10
Pancreatic Cystic Fibrosis0low20
Pancreatic Parenchyma with Edema0low20
Pancreatic Parenchymal Edema0low20
Pancreatitis0low20
Pancreatitis, Acute0low20
Pancreatitis, Acute Edematous0low20
Pancytopenia0medium11
Paralysis Agitans0low10
Paraphrenia, Involutional0low40
Parasympathetic Nervous System Diseases0low20
Parenterally-Transmitted Non-A, Non-B Hepatitis0low10
Paresis0medium11
Parkinson Disease0low10
Parkinson Disease, Idiopathic0low10
Parkinson's Disease0low10
Parkinson's Disease, Idiopathic0low10
Parkinson's Disease, Lewy Body0low10
Parodontosis0medium21
Paroxysmal Atrial Fibrillation0medium162
Paroxysmal Supraventricular Tachycardia0low10
Partial Argininosuccinic Acid Synthetase Deficiency Disease0low10
Partial Seizure0medium11
Partial Seizures0medium11
Partial Trisomy 21 Down Syndrome0low20
Passive Hyperemia0medium137
Pathologic Angiogenesis0medium91
Pathologic Calcification0low110
Pathologic Constriction0low10
Pathologic Dilatation0medium82
Pathologic Dilatations0medium82
Pathologic Neovascularization0medium91
Pathologic Ossification0low10
Pediatric Obesity0low40
Pelvic Pain0low10
Peptic Ulcer0low10
Perforated Appendicitis0low10
Pericementitis0low10
Perimenopausal Bone Loss0low10
Perinatal Subarachnoid Hemorrhage0low130
Periodic Disease0low20
Periodic Disease, Wolff's0low20
Periodic Peritonitis0low20
Periodontal Diseases0medium21
Periodontitis0low10
Periorbital Headache0medium11
Peripancreatic Fat Necrosis0low20
Peripheral Angiopathies0medium84
Peripheral Arterial Disease0medium134
Peripheral Arterial Diseases0medium134
Peripheral Artery Disease0medium134
Peripheral Autonomic Nervous System Diseases0low20
Peripheral Vascular Diseases0medium84
Peritoneal Diseases0low10
Peritonitis0low10
Persistent Atrial Fibrillation0medium162
Petit Mal Convulsion0medium11
Phenylalanine Hydroxylase Deficiency0low20
Phenylalanine Hydroxylase Deficiency Disease0low20
Phenylalanine Hydroxylase Deficiency Disease, Severe0low20
Phenylketonuria0low20
Phenylketonuria I0low20
Phenylketonuria II0low20
Phenylketonuria Type 20low20
Phenylketonuria, Atypical0low20
Phenylketonuria, Classical0low20
Phenylketonurias0low20
Pheochromocytoma0low10
Pheochromocytoma, Extra-Adrenal0low10
Philippine Hemorrhagic Fever0low10
Phlebothrombosis0low10
Pituitary Insufficiency0low10
PKU, Atypical0low20
Placental Insufficiency0low10
Plaque, Amyloid0low10
Plaque, Atherosclerotic0medium81
Plaque, Ulcerating, Carotid Artery0low90
Plaques, Amyloid0low10
Plasmodium falciparum Malaria0low10
Plasmodium Infections0low10
Pleocytosis0medium11
Pneumonia0low30
Pneumonia, Lobar0low30
Pneumonitis0low30
Poisoning, Blood0medium91
Poisoning, Carbon Monoxide0low20
Poisoning, Illuminating Gas0low20
Polycystic Kidney Disease 20medium31
Polycystic Kidney Disease, Adult0medium31
Polycystic Kidney Disease, Adult Type 20medium31
Polycystic Kidney Disease, Adult, Type II0medium31
Polycystic Kidney Disease, Autosomal Dominant0medium31
Polycystic Kidney Disease, Type 20medium31
Polycystic Kidney, Autosomal Dominant0medium31
Polycystic Kidney, Type 1 Autosomal Dominant Disease0medium31
Polycystic Kidney, Type 2 Autosomal Dominant Disease0medium31
Polycystic Ovarian Syndrome0medium226
Polycystic Ovary Syndrome0medium226
Polycystic Ovary Syndrome 10medium226
Polymicrobial Infection0low10
Polyserositis, Familial Paroxysmal0low20
Polyserositis, Recurrent0low20
Portal-Systemic Encephalopathy0low20
Portosystemic Encephalopathy0low20
Post Traumatic Stress Disorder0low10
Post-Traumatic Myelopathy0medium11
Post-Traumatic Stress Disorders0low10
Posterior Cerebral Artery Aneurysm0low20
Posterior Choroidal Artery Infarction0low50
Posterior Circulation Brain Infarction0low10
Posterior Circulation Infarction, Brain0low10
Posterior Circulation Transient Ischemic Attack0low30
Posterior Communicating Artery Aneurysm0low20
Posterior Fossa Hemorrhage0low10
Postmenopausal Bone Loss0low10
Postmenopausal Osteoporosis0low10
Postoperative Complications0medium142
Postpartum Hypopituitarism0low10
Postpartum Panhypopituitarism0low10
Postpartum Pituitary Insufficiency0low10
Postprandial Hyperglycemia0medium164
Posttraumatic Stress Disorders0low10
Postzoster Arteritis0low10
Pph1 With Hht0low30
Pre-Eclampsia0low450
Pre-Hypertension0medium21
Pre-Symptomatic Diseases0low50
Precordial Catch0low10
Precordial Catch Syndrome0low10
Precursor Cell Lymphoblastic Leukemia-Lymphoma0low30
Prediabetes0low60
Prediabetic State0low60
Predisposition, Genetic0low100
Preeclampsia0low450
Preeclampsia Eclampsia 10low450
Pregnancy0low840
Pregnancy Complications0low10
Pregnancy Complications, Cardiovascular0low20
Pregnancy Toxemias0low450
Pregnancy, Cardiovascular Complications0low20
Prehypertension0medium21
Premature Birth0low60
Prenatal Exposure Delayed Effects0low60
Prescription Opioid Abuse0low20
Prescription Opioid Misuse0low20
Presenile Alzheimer Dementia0medium71
Presymptomatic Diseases0low50
Preterm Birth0low60
Priapism0low10
Primary Biliary Cholangitis0low10
Primary Biliary Cirrhosis0low10
Primary Central Nervous System Vasculitis0low10
Primary CNS Vasculitis0low10
Primary Graft Dysfunction0low10
Primary Hyperthyroidism0low30
Primary Hypothyroidism0low50
Primary Insomnia0low20
Primary Myocardial Diseases0low20
Primary Open Angle Glaucoma0low10
Primary Parkinsonism0low10
Primary Peritonitis0low10
Primary Pulmonary Hypertension0low30
Primary Senile Degenerative Dementia0medium71
Primary Thrombocythemia0low10
Progressive Chorea, Chronic Hereditary (Huntington)0low10
Progressive Chorea, Hereditary, Chronic (Huntington)0low10
Progressive Muscular Atrophy0low10
Progressive Muscular Dystrophy, Duchenne Type0medium11
Progressive Myelopathic Muscular Atrophy0low10
Progressive Proximal Myelopathic Muscular Atrophy0low10
Prostate Cancer0low20
Prostate Neoplasms0low20
Prostatic Cancer0low20
Prostatic Neoplasms0low20
Prosthesis Durability0low10
Prosthesis Failure0low10
Prosthesis Loosening0low10
Prosthesis Migration0low10
Prosthesis Survival0low10
Proteinuria0medium153
Proteinuria-Edema-Hypertension Gestosis0low450
Proximal Myelopathic Muscular Atrophy, Progressive0low10
Pruritis0low10
Pruritus0low10
Pseudo-Exfoliation Syndrome0low40
Pseudoaphakia0low30
Pseudoexfoliation Of The Lens0low40
Pseudoexfoliation Syndrome0low40
Pseudohypertrophic Childhood Muscular Dystrophy0medium11
Pseudohypertrophic Muscular Dystrophy, Childhood0medium11
Pseudohypoaldosteronism0low10
Pseudohypoaldosteronism Type 10low10
Pseudohypoaldosteronism Type 1, Autosomal Dominant0low10
Pseudohypoaldosteronism Type 1, Autosomal Recessive0low10
Pseudohypoaldosteronism Type 20low10
Pseudohypoaldosteronism Type I0low10
Pseudohypoaldosteronism Type II0low10
Pseudohypoaldosteronism, Type I0low10
Pseudohypoaldosteronism, Type I, Autosomal Dominant0low10
Pseudohypoaldosteronism, Type I, Autosomal Recessive0low10
Pseudohypoaldosteronism, Type II0low10
Psoriasis0low30
Psoriasis Arthropathica0low40
Psoriasis, Arthritic0low40
Psoriatic Arthritis0low40
Psoriatic Arthropathy0low40
Psychophysiological Insomnia0low20
Psychoses0low20
Psychoses, Manic-Depressive0low10
Psychosis0low20
Psychosis, Brief Reactive0low20
Psychosis, Involutional0low40
Psychosis, Manic-Depressive0low10
Psychotic Disorders0low20
PT-NANBH0low10
PTSD0low10
Pulmonary Arterial Remodeling0low70
Pulmonary Cancer0low20
Pulmonary Consumption0low10
Pulmonary Cystic Fibrosis0low20
Pulmonary Disease0low30
Pulmonary Disease, Chronic Obstructive0low100
Pulmonary Diseases0low30
Pulmonary Edema0low10
Pulmonary Edemas0low10
Pulmonary Embolism0low40
Pulmonary Embolisms0low40
Pulmonary Fibrosis, Idiopathic0low20
Pulmonary Heart Disease0low10
Pulmonary Heart Diseases0low10
Pulmonary Hypertension0medium402
Pulmonary Hypertension, Primary, 10low30
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia0low30
Pulmonary Hypertension, Primary, Dexfenfluramine-Associated0low30
Pulmonary Hypertension, Primary, Fenfluramine-Associated0low30
Pulmonary Inflammation0low30
Pulmonary Neoplasms0low20
Pulmonary Phthisis0low10
Pulmonary Thromboembolism0low40
Pulmonary Thromboembolisms0low40
Pulmonary Tuberculoses0low10
Pulmonary Tuberculosis0low10
Purpura, Thrombotic Thrombocytopenic0low10
Purpura, Thrombotic Thrombopenic0low10
Pustular Psoriasis of Palms and Soles0low30
Pustulosis of Palms and Soles0low30
Pustulosis Palmaris et Plantaris0low30
Pyaemia0medium91
Pyemia0medium91
Pyohemia0medium91
Pyorrhea Alveolaris0medium21
Pyridoxine Deficiency0low10
QDPR Deficiency0low20
Quinoid Dihydropteridine Reductase Deficiency0low20
Radiation Injuries, Experimental0low10
Raynaud Disease0low50
Raynaud Phenomenon0low50
Raynaud's Disease0low50
Reaction, Acute-Phase0low20
Reactive Hyperemia0medium137
Reaven Syndrome X0medium327
Rebound Insomnia0low20
Recrudescence0low80
Recurrence0low80
Recurrent Polyserositis0low20
Reflex, Abnormal0low10
Reflex, Absent0low10
Reflex, Acoustic, Abnormal0low10
Reflex, Anal, Absent0low10
Reflex, Anal, Decreased0low10
Reflex, Ankle, Abnormal0low10
Reflex, Ankle, Absent0low10
Reflex, Ankle, Decreased0low10
Reflex, Biceps, Abnormal0low10
Reflex, Biceps, Absent0low10
Reflex, Biceps, Decreased0low10
Reflex, Corneal, Absent0low10
Reflex, Corneal, Decreased0low10
Reflex, Decreased0low10
Reflex, Deep Tendon, Abnormal0low10
Reflex, Deep Tendon, Absent0low10
Reflex, Gag, Absent0low10
Reflex, Gag, Decreased0low10
Reflex, Knee, Abnormal0low10
Reflex, Knee, Decreased0low10
Reflex, Moro, Asymmetric0low10
Reflex, Pendular0low10
Reflex, Triceps, Abnormal0low10
Reflex, Triceps, Absent0low10
Reflex, Triceps, Decreased0low10
Reflexes, Abnormal0low10
Reflux, Gastroesophageal0low20
Regional Enteritis0low20
Relapse0low80
Relapsing-Remitting Multiple Sclerosis0low20
REM Sleep Deprivation0low20
Remittent Fever0low10
Remitting-Relapsing Multiple Sclerosis0low20
Renal Artery Obstruction0low10
Renal Artery Stenosis0low10
Renal Disease, End-Stage0medium12421
Renal Failure0medium222
Renal Failure, Acute0medium162
Renal Failure, Chronic0medium12421
Renal Failure, End-Stage0medium12421
Renal Insufficiency0medium222
Renal Insufficiency, Acute0medium162
Renal Insufficiency, Chronic0medium664
Reno-Cardiac Syndrome0low40
Renocardiac Syndrome0low40
Reperfusion Damage0low150
Reperfusion Injury0low150
Reperfusion Injury, Myocardial0low60
Reproductive Sterility0low10
Research-Related Injuries0medium21
Respiratory Depression0low10
Respiratory Distress Syndrome, Infant0low30
Respiratory Distress Syndrome, Newborn0low30
Respiratory Failure0low10
Respiratory Insufficiency0low10
Respiratory Tract Diseases0low10
Response, Acute-Phase0low20
Retardation, Mental0medium11
Retention Disorders, Cognitive0low10
Reticulosarcoma0low10
Reticulum Cell Sarcoma0low10
Reticulum-Cell Sarcoma0low10
Retinal Branch Vein Occlusion0low20
Retinal Diseases0low10
Retinal Neovascularization0low10
Retinal Vein Occlusion0low20
Retinal Vein Thrombosis0low20
Retinopathy of Prematurity0low10
Retro-Ocular Headache0medium11
Retrolental Fibroplasia0low10
Rheumatic Diseases0low30
Rheumatism0low30
Rheumatism, Muscular0low10
Rheumatoid Arthritis0medium275
Rheumatoid Spondylitis0medium91
Rhinolalia0medium11
Right Hemisphere, Cerebral Infarction0low50
Right Hemisphere, Infarction, Cerebral0low50
Right Middle Cerebral Artery Infarction0low20
Right Ventricular Dysfunction0low20
Right-Sided Heart Failure0medium419
Rock Fever0low10
Runt Disease0medium11
Ruptured Aneurysm0low10
Ruptured Appendicitis0low10
SAH (Subarachnoid Hemorrhage)0low130
Salivary Gland Virus Disease0low20
Sarcoma, Lymphatic0low10
Sarcoma, Reticulum-Cell0low10
Sarcopenia0low10
SARS Coronavirus 2 Infection0low40
SARS-CoV-2 Infection0low40
Scapuloperoneal Form of Spinal Muscular Atrophy0low10
Scapuloperoneal Spinal Muscular Atrophy0low10
Schizoaffective Disorder0low20
Schizophrenia0low70
Schizophrenic Disorders0low70
Schizophreniform Disorders0low20
Schulman-Upshaw Syndrome0low10
Schwartz Jampel Aberfeld syndrome0low10
Schwartz-Jampel Syndrome0low10
Schwartz-Jampel Syndrome, Type 10low10
Schwartz-Jampel-Aberfeld Syndrome0low10
Sclerocystic Ovarian Degeneration0medium226
Sclerocystic Ovaries0medium226
Sclerocystic Ovary Syndrome0medium226
Scleroderma, Diffuse0low10
Scleroderma, Limited0low10
Scleroderma, Progressive0low10
Scleroderma, Systemic0low110
Sclerosis0low30
Sclerosis, Disseminated0medium41
Sclerosis, Progressive Systemic0low10
Sclerosis, Systemic0low110
Sea Fan Neovascularization0low10
Secondary Biliary Cholangitis0low10
Secondary Biliary Cirrhosis0low10
Secondary CNS Vasculitis0low10
Secondary Hypothyroidism0low50
Secondary Infection0low10
Secondary Infections0low10
Secondary Insomnia0low20
Secondary Myocardial Diseases0low20
Secondary Open Angle Glaucoma0low10
Secondary Peritonitis0low10
SED Tarda0low10
Segmental Autonomic Dysfunction0low20
Segmental Glomerular Hyalinosis0low50
Seizure0medium11
Seizure Disorder0low50
Seizures0medium11
Seizures, Auditory0medium11
Seizures, Clonic0medium11
Seizures, Convulsive0medium11
Seizures, Epileptic0medium11
Seizures, Focal0medium11
Seizures, Generalized0medium11
Seizures, Gustatory0medium11
Seizures, Motor0medium11
Seizures, Olfactory0medium11
Seizures, Sensory0medium11
Seizures, Somatosensory0medium11
Seizures, Tonic0medium11
Seizures, Tonic-Clonic0medium11
Seizures, Vertiginous0medium11
Seizures, Vestibular0medium11
Seizures, Visual0medium11
Semantic Memory Disorder0low10
Semantic-Pragmatic Disorder0medium11
Senile Dementia, Acute Confusional0medium71
Senile Dementia, Alzheimer Type0medium71
Senile Osteoporosis0low10
Senile Paranoid Dementia0low20
Senile Plaques0low10
Sensitivity and Specificity0medium364
Sensitivity, Contact0low10
Sensorineural Hearing Loss0low10
Sepsis0medium91
Sepsis Syndrome0low20
Septic Shock0medium122
Septicemia0medium91
Severe Dengue0low10
Severe Sepsis0medium91
Sharp Headache0medium11
Sheehan Syndrome0low10
Sheehan's Syndrome0low10
Shock0low10
Shock, Cardiogenic0low20
Shock, Endotoxic0medium122
Shock, Hemorrhagic0low40
Shock, Septic0medium122
Shock, Toxic0medium122
Short Sleep Phenotype0medium21
Short Sleeper Syndrome0medium21
Sick Headache0low40
Sickle Cell Anemia0medium101
Sickle Cell Disease0medium101
Sickle Cell Disorders0medium101
Sickle Cell Trait0low10
Sickling Disorder Due to Hemoglobin S0medium101
Simmonds Disease0low10
Simmonds' Disease0low10
Singapore Hemorrhagic Fever0low10
Single Seizure0medium11
SJA Syndrome0low10
Skin Diseases, Bacterial0low10
Sleep Apnea Hypopnea Syndrome0medium81
Sleep Apnea Syndrome, Obstructive0medium81
Sleep Apnea Syndromes0low20
Sleep Apnea, Mixed0low20
Sleep Apnea, Mixed Central and Obstructive0low20
Sleep Apnea, Obstructive0medium81
Sleep Debt0low20
Sleep Deprivation0low20
Sleep Disorders0medium21
Sleep Fragmentation0low20
Sleep Hypopnea0low20
Sleep Initiation and Maintenance Disorders0low20
Sleep Initiation Dysfunction0low20
Sleep Insufficiency0low20
Sleep Wake Disorders0medium21
Sleep-Disordered Breathing0low20
Sleep-Related Neurogenic Tachypnea0medium21
Sleeplessness0low20
Slow-Flow Phenomenon0low10
Small Airway Remodeling0low10
Small Airway Remodelling0low10
Small Cleaved-Cell Lymphoma, Diffuse0low10
Small Non-Cleaved-Cell Lymphoma0low10
Small Noncleaved-Cell Lymphoma0low10
Small-Cell Lymphoma0low10
Snoring0low10
Soft Tissue Infections0medium11
Sost Sclerosing Bone Dysplasia0low10
Sost-Related Sclerosing Bone Dysplasia0low10
Spatial Memory Disorder0low10
Speech Delay0medium11
Speech Disorders0medium11
Speech or Language, Developmental Disorder0medium11
Spinal Amyotrophy0low10
Spinal Cord Contusion0medium11
Spinal Cord Injuries0medium11
Spinal Cord Laceration0medium11
Spinal Cord Transection0medium11
Spinal Cord Trauma0medium11
Spinal Fractures0low10
Spinal Muscular Atrophy0low10
Spinal Muscular Atrophy, Distal0low10
Spinal Muscular Atrophy, Oculopharyngeal0low10
Spinal Muscular Atrophy, Scapuloperoneal0low10
Spinal Muscular Atrophy, Scapuloperoneal Form0low10
Spondylarthritis Ankylopoietica0medium91
Spondylitis Ankylopoietica0medium91
Spondylitis, Ankylosing0medium91
Spondylo-Epimetaphyseal Dysplasia With Myotonia0low10
Spondyloarthritis Ankylopoietica0medium91
Spondyloepiphyseal Dysplasia0low10
Spondyloepiphyseal Dysplasia Tarda, X-Linked0low10
Spondyloepiphyseal Dysplasia, Late0low10
Squamous Cell Carcinoma0low10
ST Elevated Myocardial Infarction0low10
ST Elevation Myocardial Infarction0low10
ST Segment Elevation Myocardial Infarction0low10
Status Marmoratus0medium11
Status Migrainosus0low40
Steatohepatitis0low80
Steatosis of Liver0low80
Stein-Leventhal Syndrome0medium226
STEMI0low10
Stenocardia0medium133
Stenosis0low10
Stenosis, Common Carotid Artery0low90
Stenosis, External Carotid Artery0low90
Sterility0low10
Sterility, Male0low10
Sterility, Reproductive0low10
Stomach Cancer0medium11
Stomach Diseases0low20
Stomach Neoplasms0medium11
Stomach Ulcer0low20
Streptozocin Diabetes0low250
Streptozotocin Diabetes0low250
Stress Cardiomyopathy0low10
Stress Disorder, Post Traumatic0low10
Stress Disorders, Post-Traumatic0low10
Stress Disorders, Posttraumatic0low10
Stricture0low10
Stroke0medium364
Stroke, Acute0medium364
Stroke, Middle Cerebral Artery0low20
Stunted Growth0medium42
Stunting0medium42
Sub-Fertility0low10
Sub-Fertility, Male0low10
Subarachnoid Hemorrhage0low130
Subarachnoid Hemorrhage, Aneurysmal0low130
Subarachnoid Hemorrhage, Intracranial0low130
Subarachnoid Hemorrhage, Spontaneous0low130
Subcortical Infarction0low50
Subfertility0low10
Subfertility, Male0low10
Substance Withdrawal Syndrome0low10
Subwakefullness Syndrome0medium21
Sudden Cardiac Arrest0low10
Sudden Cardiac Death0low10
Sudden Onset Scleroderma0low10
Suffering, Physical0low20
Susceptibility, Disease0low50
Susceptibility, Genetic0low100
Symmetric Diabetic Proximal Motor Neuropathy0low30
Sympathetic Nervous System Diseases0low20
Symptom Cluster0medium51
Syndrome0medium51
Syndrome X, Angina0medium41
Syndrome X, Cardiac0medium41
Syndrome X, Insulin Resistance0medium327
Syndrome X, Metabolic0medium327
Syndrome, Obstructive Sleep Apnea0medium81
Syndrome, Sleep Apnea, Obstructive0medium81
Syndrome, Upper Airway Resistance, Sleep Apnea0medium81
Systemic Inflammatory Response Syndrome0low20
Systemic Lupus Erythematosus0low30
Systemic Scleroderma0low110
Systemic Sclerosis0low110
Systemic Vasculitis0low10
Systolic Heart Failure0low10
T-Lymphotropic Virus Type III Infections, Human0medium141
Tachyarrhythmia0low10
Tachycardia0low10
Tachycardia, Ventricular0low10
Tako-tsubo Cardiomyopathy0low10
Tako-tsubo Syndrome0low10
Takotsubo Cardiomyopathy0low10
Takotsubo Syndrome0low10
Tetrahydrobiopterin Deficiency0low20
Texidor's Twinge0low10
Thai Hemorrhagic Fever0low10
Thalassemia0low10
Thalassemia Intermedia0low30
Thalassemia Major0low30
Thalassemia Major (beta-Thalassemia Major)0low30
Thalassemia Minor0low30
Thalassemia Minor (beta-Thalassemia Minor)0low30
Thalassemia, beta Type0low30
Thalassemias0low10
Thesaurismosis0low40
Throbbing Headache0medium11
Thromboangiitis Obliterans0low20
Thromboangitis Obliterans0low20
Thrombocythemia, Essential0low10
Thrombocythemia, Hemorrhagic0low10
Thrombocythemia, Idiopathic0low10
Thrombocythemia, Primary0low10
Thrombocytopenia0low10
Thrombocytosis, Autosomal Dominant0low10
Thrombocytosis, Primary0low10
Thromboembolism0low10
Thromboembolism, Pulmonary0low40
Thromboembolisms, Pulmonary0low40
Thrombopenia0low10
Thrombophilia0medium11
Thrombosis0low100
Thrombosis, Carotid0low10
Thrombosis, Carotid Artery0low10
Thrombosis, Common Carotid Artery0low10
Thrombosis, Deep Vein0low10
Thrombosis, External Carotid Artery0low10
Thrombosis, Internal Carotid Artery0low10
Thrombosis, Middle Cerebral Artery0low20
Thrombosis, Retinal Vein0low20
Thrombosis, Venous0low10
Thrombotic Infarction, Middle Cerebral Artery0low20
Thrombotic Microangiopathy, Familial0low10
Thrombotic Thrombocytopenic Purpura0low10
Thrombotic Thrombocytopenic Purpura, Congenital0low10
Thrombotic Thrombocytopenic Purpura, Familial0low10
Thrombus0low100
Thyroid Diseases0low10
Thyroid-Stimulating Hormone Deficiency0low50
Thyroiditis, Autoimmune0low10
Thyroiditis, Lymphocytic0low10
Thyroiditis, Lymphomatous0low10
TIA (Transient Ischemic Attack)0low30
Tonic Clonic Seizure0medium11
Tonic Seizure0medium11
Tonic Seizures0medium11
Tonic-Clonic Seizure0medium11
Tonic-Clonic Seizures0medium11
Toxemia Of Pregnancy0low450
Toxemias, Pregnancy0low450
Toxic Hepatitis0low10
Toxic Shock0medium122
Toxic Shock Syndrome0medium122
Transformation, Viral Cell0low20
Transient Apical Ballooning Syndrome0low10
Transient Insomnia0low20
Transient Ischemic Attack0low30
Transient Ischemic Attack, Anterior Circulation0low30
Transient Ischemic Attack, Brain Stem0low30
Transient Ischemic Attack, Brainstem0low30
Transient Ischemic Attack, Carotid Circulation0low30
Transient Ischemic Attack, Posterior Circulation0low30
Transient Ischemic Attack, Vertebrobasilar Circulation0low30
Transient Ischemic Attacks, Crescendo0low30
Transient Tachypnea of Newborn0low10
Transient Tachypnea of the Newborn0low10
Transitory Hearing Loss0low10
Trauma0medium21
Trauma, Carotid Artery0low40
Tricuspid Incompetence0medium41
Tricuspid Regurgitation0medium41
Tricuspid Valve Incompetence0medium41
Tricuspid Valve Insufficiency0medium41
Tricuspid Valve Regurgitation0medium41
Triple Symptom Complex0low30
Triple-Symptom Complex0low30
Trisomy 210low20
Trisomy 21, Meiotic Nondisjunction0low20
Trisomy 21, Mitotic Nondisjunction0low20
Trisomy G0low20
TSH Deficiency0low50
Tuberculoses, Pulmonary0low10
Tuberculosis0low10
Tuberculosis, Pulmonary0low10
Tubulointerstitial Nephritis0low10
Tumors0low30
Tumors, Breast0low40
Type 1 Diabetes0medium185
Type 1 Diabetes Mellitus0medium185
Type 2 Diabetes0medium9320
Type 2 Diabetes Mellitus0medium9320
Type I Arnold-Chiari Malformation0low10
Type II Arnold-Chiari Malformation0low10
Type III Arnold-Chiari Malformation0low10
Type IV Arnold-Chiari Malformation0low10
Typical Aura without Headache0low10
Ulcerating Plaque, Carotid Artery0low90
Ulcerative Colitis0medium31
Undernutrition0low30
Undifferentiated Lymphoma0low10
Undulant Fever0low10
Unilateral Headache0medium11
Unipolar Depression0low10
Unstable Angina0low30
Upper Airway Resistance Sleep Apnea Syndrome0medium81
Upper Extremity Paresis0medium11
Upshaw Factor, Deficiency of0low10
Upshaw-Schulman Syndrome0low10
Urea Cycle Disorders0low10
Urea Cycle Disorders, Inborn0low10
Uremia0medium171
Ureteral Obstruction0low40
Urinary Bladder Cancer0low10
Urinary Bladder Neoplasms0low10
Urticaria0low10
Usual Interstitial Pneumonia0low20
Uterine Cervical Cancer0low10
Uterine Cervical Neoplasms0low10
Uveitis0low10
Valvular Heart Diseases0low40
Van Buchem Disease0low10
Varices0low10
Varicocele0medium21
Varicose Veins0low10
Varix0low10
Vascular Accident, Brain0medium364
Vascular Calcification0low10
Vascular Calcinosis0low10
Vascular Diseases0medium331
Vascular Diseases, Intracranial0low110
Vascular Diseases, Peripheral0medium84
Vascular Graft Occlusion0low30
Vascular Graft Restenosis0low30
Vascular Hypotension0low70
Vascular Injuries0low10
Vascular Remodeling0low70
Vascular System Injuries0low10
Vasculitis0medium62
Vasculitis, Central Nervous System0low10
Vasculitis, CNS, Secondary0low10
Vasospasm, Intracranial0low110
Venous Congestion0medium137
Venous Engorgement0medium137
Venous Infarction, Brain0low10
Venous Leakage, Penile0low50
Venous Thrombosis0low10
Ventilatory Depression0low10
Ventricle Remodeling0low60
Ventricular Dysfunction0low10
Ventricular Dysfunction, Left0medium151
Ventricular Dysfunction, Right0low20
Ventricular Hypertrophy, Left0medium141
Ventricular Remodeling0low60
Ventricular Tachyarrhythmias0low10
Ventricular Tachycardia0low10
Verbal Fluency Disorders0medium11
Vertebrobasilar Circulation Transient Ischemic Attack0low30
Vertex Headache0medium11
Viral Cell Transformation0low20
Visceral Obesity0low20
Visceral Steatosis0low80
Vision Disability0medium11
Vision Disorders0medium11
Visual Disorders0medium11
Visual Impairment0medium11
Vitamin B 12 Deficiency0low10
Vitamin B 6 Deficiency0low10
Vitamin B Deficiency0low20
Vitamin B12 Deficiency0low10
Vitamin B6 Deficiency0low10
Vitamin D Deficiency0medium31
Vitamin Deficiency, B60low10
Vomiting0medium11
von Gierke Disease0low10
von Gierke's Disease0low10
Wake-up Stroke0low10
Water Intoxication0low10
Weight Gain0low10
Weight Loss0medium63
Weight Reduction0medium63
Well Differentiated Liposarcoma0low10
Wet Lung0low10
Wet Macular Degeneration0low10
White Coat Hypertension0low10
White Coat Syndrome0low10
Withdrawal Symptoms0low10
Wolff Periodic Disease0low20
Wolff's Periodic Disease0low20
Wounds0medium21
Wounds and Injuries0medium21
Wounds and Injury0medium21
Wounds, Injury0medium21
X Syndrome, Angina0medium41
X-Linked SED0low10
X-Linked SEDT0low10
X-Linked Spondyloepiphyseal Dysplasia Tarda0low10
XXXY Males0low20
XXY Syndrome0low20
XXY Trisomy0low20
Xxyy Syndrome0low20
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Safety/Toxicity (12)

ArticleYear
Role of microcirculatory function and plasma biomarkers in determining the development of cardiovascular adverse events in patients with peripheral arterial disease: A 5-year follow-up.
Anatolian journal of cardiology, Volume: 20, Issue: 4		2018
Nebivolol suppresses asymmetric dimethylarginine and attenuates cyclosporine-induced nephrotoxicity and endothelial dysfunction in rats.
Pharmacological reports : PR, Volume: 68, Issue: 6		2016
Upregulation of CBS/H2S system contributes to asymmetric dimethylarginine-triggered protection against the neurotoxicity of glutamate to PC12 cells by inhibiting NOS/NO pathway.
Experimental cell research, 08-01, Volume: 346, Issue: 1		2016
Asymmetric dimethylarginine and heart-type fatty acid-binding protein 3 are risk markers of cardiotoxicity in carbon monoxide poisoning cases in Zagazig university hospitals.
Human & experimental toxicology, Volume: 36, Issue: 3		2017
Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.
Free radical biology & medicine, Volume: 79		2015
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs.
Circulation, Feb-17, Volume: 131, Issue: 7		2015
Plasma asymmetric dimethylarginine and adverse events in patients with atrial fibrillation referred for coronary angiogram.
PloS one, Volume: 8, Issue: 8		2013
Up-regulation of protein tyrosine nitration in methamphetamine-induced neurotoxicity through DDAH/ADMA/NOS pathway.
Neurochemistry international, Volume: 62, Issue: 8		2013
A novel mechanism of formaldehyde neurotoxicity: inhibition of hydrogen sulfide generation by promoting overproduction of nitric oxide.
PloS one, Volume: 8, Issue: 1		2013
Endogenous hydrogen sulfide is involved in asymmetric dimethylarginine-induced protection against neurotoxicity of 1-methyl-4-phenyl-pyridinium ion.
Neurochemical research, Volume: 36, Issue: 11		2011
Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics.
Toxicology and applied pharmacology, Aug-15, Volume: 247, Issue: 1		2010
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery.
Critical care medicine, Volume: 35, Issue: 8		2007
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (8)

ArticleYear
Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.
Pediatric research, Volume: 92, Issue: 6		2022
The detrimental effect of asymmetric dimethylarginine on cholesterol efflux of macrophage foam cells: Role of the NOX/ROS signaling.
Free radical biology & medicine, 11-01, Volume: 143		2019
Nebivolol suppresses asymmetric dimethylarginine and attenuates cyclosporine-induced nephrotoxicity and endothelial dysfunction in rats.
Pharmacological reports : PR, Volume: 68, Issue: 6		2016
Continuous exposure to L-arginine induces oxidative stress and physiological tolerance in cultured human endothelial cells.
Amino acids, Volume: 43, Issue: 3		2012
Reduction of plasma asymmetric dimethylarginine in obese patients with chronic kidney disease after three years of a low-protein diet supplemented with keto-amino acids: a randomized controlled trial.
Wiener klinische Wochenschrift, Volume: 120, Issue: 15-16		2008
Differential long-term effects of carvedilol on proinflammatory and antiinflammatory cytokines, asymmetric dimethylarginine, and left ventricular function in patients with heart failure.
Journal of cardiovascular pharmacology, Volume: 52, Issue: 1		2008
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals.
American journal of physiology. Renal physiology, Volume: 294, Issue: 2		2008
Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Volume: 20, Issue: 12		2005
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (8)

ArticleYear
The "Rise-Peak-Fall" Pattern of Time Dependency of the Cardiovascular Pleiotropic Effects of Treatment With Low-dose Atorvastatin, Losartan, and a Combination Thereof in Rats.
Journal of cardiovascular pharmacology, Volume: 68, Issue: 1		2016
Left atrial volume index and aortic stiffness index in adult hemodialysed patients--link between compliance and pressure mediated by endothelium dysfunction; a cross-sectional study.
BMC cardiovascular disorders, Nov-05, Volume: 12		2012
Reduced renal plasma clearance does not explain increased plasma asymmetric dimethylarginine in hypertensive subjects with mild to moderate renal insufficiency.
American journal of physiology. Renal physiology, Jul-01, Volume: 303, Issue: 1		2012
Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction.
Disease markers, Volume: 30, Issue: 5		2011
In patients with aortic stenosis increased flow-mediated dilation is independently associated with higher peak jet velocity and lower asymmetric dimethylarginine levels.
American heart journal, Volume: 161, Issue: 5		2011
Left atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis.
Clinical rheumatology, Volume: 29, Issue: 9		2010
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
British journal of clinical pharmacology, Volume: 65, Issue: 1		2008
ADMA metabolism and clearance.
Vascular medicine (London, England), Volume: 10 Suppl 1		2005
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (131)

ArticleYear
The effect of haptoglobin genotype on the association of asymmetric dimethylarginine and DDAH 1 polymorphism with diabetic macroangiopathy.
Cardiovascular diabetology, 12-02, Volume: 21, Issue: 1		2022
Increased Plasma L-Arginine Levels and L-Arginine/ADMA Ratios after Twelve Weeks of Omega-3 Fatty Acid Supplementation in Amateur Male Endurance Runners.
Nutrients, Nov-10, Volume: 14, Issue: 22		2022
Serum L-arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case-control study.
United European gastroenterology journal, Volume: 9, Issue: 7		2021
A Cross-Talk between the Erythrocyte L-Arginine/ADMA/Nitric Oxide Metabolic Pathway and the Endothelial Function in Subjects with Type 2 Diabetes Mellitus.
Nutrients, Jul-04, Volume: 13, Issue: 7		2021
Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases.
Molecules (Basel, Switzerland), Jul-30, Volume: 26, Issue: 15		2021
Whole-Body Cryotherapy Increases the Activity of Nitric Oxide Synthase in Older Men.
Biomolecules, 07-16, Volume: 11, Issue: 7		2021
Determination of serum methylarginine levels by tandem mass spectrometric method in patients with ankylosing spondylitis.
Amino acids, Volume: 53, Issue: 9		2021
Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
Hypertension research : official journal of the Japanese Society of Hypertension, Volume: 44, Issue: 3		2021
Resistance training improves sleep quality, redox balance and inflammatory profile in maintenance hemodialysis patients: a randomized controlled trial.
Scientific reports, 07-16, Volume: 10, Issue: 1		2020
Intraplatelet L-Arginine-Nitric Oxide Metabolic Pathway: From Discovery to Clinical Implications in Prevention and Treatment of Cardiovascular Disorders.
Oxidative medicine and cellular longevity, Volume: 2020		2020
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
American journal of physiology. Renal physiology, 02-01, Volume: 318, Issue: 2		2020
Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria.
The Journal of infectious diseases, 01-01, Volume: 221, Issue: 1		2020
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).
Oxidative medicine and cellular longevity, Volume: 2019		2019
Association between asymmetric dimethylarginine and in-stent restenosis tissue characteristics assessed by optical coherence tomography.
International journal of cardiology, 08-15, Volume: 289		2019
Testosterone Deficiency and Endothelial Dysfunction: Nitric Oxide, Asymmetric Dimethylarginine, and Endothelial Progenitor Cells.
Sexual medicine reviews, Volume: 7, Issue: 4		2019
Arginine bioavailability and endothelin-1 system in the regulation of vascular function of umbilical vein endothelial cells from intrauterine growth restricted newborns.
Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume: 28, Issue: 12		2018
AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.
Molecular biology reports, Volume: 45, Issue: 6		2018
Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
Diabetes, obesity & metabolism, Volume: 21, Issue: 2		2019
Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
Arthritis research & therapy, 06-08, Volume: 20, Issue: 1		2018
Malaria in pregnancy alters l-arginine bioavailability and placental vascular development.
Science translational medicine, 03-07, Volume: 10, Issue: 431		2018
Global arginine bioavailability ratio is decreased in patients with major depressive disorder.
Journal of affective disorders, 03-15, Volume: 229		2018
Testosterone Deficiency Causes Endothelial Dysfunction via Elevation of Asymmetric Dimethylarginine and Oxidative Stress in Castrated Rats.
The journal of sexual medicine, Volume: 14, Issue: 12		2017
Effects of betaine supplementation on nitric oxide metabolism, atherosclerotic parameters, and fatty liver in guinea pigs fed a high cholesterol plus methionine diet.
Nutrition (Burbank, Los Angeles County, Calif.), Volume: 45		2018
Nitric oxide bioavailability dysfunction involves in atherosclerosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Volume: 97		2018
Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Volume: 43, Issue: 5		2017
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Basic research in cardiology, 08-17, Volume: 112, Issue: 5		2017
Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization.
Atherosclerosis, Volume: 254		2016
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
Pulmonary medicine, Volume: 2016		2016
Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension, Volume: 39, Issue: 10		2016
Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment.
Psychiatry research, Apr-30, Volume: 238		2016
Effect of asymmetric dimethylarginine (ADMA) on heart failure development.
Nitric oxide : biology and chemistry, Apr-01, Volume: 54		2016
Does the ADMA/DDAH/NO pathway modulate early regression of left ventricular hypertrophy with esmolol?
Medical hypotheses, Volume: 87		2016
Methylarginines in Mice with Experimental Atherosclerosis.
Bulletin of experimental biology and medicine, Volume: 160, Issue: 1		2015
Nitric Oxide-Related Biological Pathways in Patients with Major Depression.
PloS one, Volume: 10, Issue: 11		2015
ADMA, subclinical changes and atrial fibrillation in the general population.
International journal of cardiology, Jan-15, Volume: 203		2016
Elevated Levels of Asymmetric Dimethylarginine (ADMA) in the Pericardial Fluid of Cardiac Patients Correlate with Cardiac Hypertrophy.
PloS one, Volume: 10, Issue: 8		2015
Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy.
Journal of clinical hypertension (Greenwich, Conn.), Volume: 17, Issue: 1		2015
Synergism between asymmetric dimethylarginine (ADMA) and a genetic marker of uric acid in CKD progression.
Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume: 25, Issue: 2		2015
The impact of different supervised exercise regimens on endothelial function in patients with intermittent claudication.
Vascular, Volume: 23, Issue: 6		2015
Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.
American journal of physiology. Renal physiology, Dec-15, Volume: 307, Issue: 12		2014
Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells.
Clinical and experimental pharmacology & physiology, Volume: 41, Issue: 7		2014
The effects of Ramadan fasting on endothelial function in patients with cardiovascular diseases.
European journal of clinical nutrition, Volume: 68, Issue: 7		2014
The relation of maternal serum eNOS, NOSTRIN and ADMA levels with aetiopathogenesis of preeclampsia and/or intrauterine fetal growth restriction.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, Volume: 28, Issue: 1		2015
Elevated asymmetric dimethylarginine is associated with oxidant stress aggravation in patients with early stage autosomal dominant polycystic kidney disease.
Kidney & blood pressure research, Volume: 38, Issue: 1		2013
Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate.
Translational research : the journal of laboratory and clinical medicine, Volume: 163, Issue: 1		2014
Asymmetric dimethylarginine (ADMA) and soluble vascular cell adhesion molecule 1(sVCAM-1) as circulating markers for endothelial dysfunction in patients with pheochromocytoma.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, Volume: 121, Issue: 9		2013
Low-fat milk ingestion prevents postprandial hyperglycemia-mediated impairments in vascular endothelial function in obese individuals with metabolic syndrome.
The Journal of nutrition, Volume: 143, Issue: 10		2013
Reactive metabolites and AGE-RAGE-mediated inflammation in patients following liver transplantation.
Mediators of inflammation, Volume: 2013		2013
Asymmetric dimethylarginine predicts decline of glucose tolerance in men with stable coronary artery disease: a 4.5-year follow-up study.
Cardiovascular diabetology, Volume: 12		2013
Beta blockers, nitric oxide, and cardiovascular disease.
Current opinion in pharmacology, Volume: 13, Issue: 2		2013
Vaspin increases nitric oxide bioavailability through the reduction of asymmetric dimethylarginine in vascular endothelial cells.
PloS one, Volume: 7, Issue: 12		2012
Asymmetric dimethylarginine plasma levels and endothelial function in newly diagnosed type 2 diabetic patients.
International journal of molecular sciences, Oct-24, Volume: 13, Issue: 11		2012
Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients.
Clinical and experimental medicine, Volume: 14, Issue: 1		2014
The protection by heme oxygenase-1 induction against thioacetamide-induced liver toxicity is associated with changes in arginine and asymmetric dimethylarginine.
Cell biochemistry and function, Volume: 31, Issue: 2		2013
Asymmetric dimethylarginine reduces nitric oxide donor-mediated dilation of arterioles by activating the vascular renin-angiotensin system and reactive oxygen species.
Journal of vascular research, Volume: 49, Issue: 4		2012
L-arginine and asymmetric dimethylarginine are early predictors for survival in septic patients with acute liver failure.
Mediators of inflammation, Volume: 2012		2012
Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency.
Atherosclerosis, Volume: 222, Issue: 2		2012
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume: 13, Issue: 4		2012
Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1.
Journal of the American College of Cardiology, Mar-27, Volume: 59, Issue: 13		2012
Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study.
Journal of cardiovascular pharmacology and therapeutics, Volume: 17, Issue: 3		2012
Birth by cesarean section is associated with elevated neonatal plasma levels of dimethylarginines.
Pediatrics international : official journal of the Japan Pediatric Society, Volume: 54, Issue: 4		2012
The combined ratios of L-arginine and asymmetric and symmetric dimethylarginine as biomarkers in spontaneously hypertensive rats.
Translational research : the journal of laboratory and clinical medicine, Volume: 159, Issue: 2		2012
Peripheral hemorheological and vascular correlates of coronary blood flow.
Clinical hemorheology and microcirculation, Volume: 49, Issue: 1-4		2011
Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats.
Liver international : official journal of the International Association for the Study of the Liver, Volume: 32, Issue: 1		2012
Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
Circulation, Dec-13, Volume: 124, Issue: 24		2011
Aliskiren prevents hypertension and reduces asymmetric dimethylarginine in young spontaneously hypertensive rats.
European journal of pharmacology, Nov-30, Volume: 670, Issue: 2-3		2011
Postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing asymmetric dimethylarginine:arginine.
The Journal of nutrition, Volume: 141, Issue: 11		2011
Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people.
Wiener klinische Wochenschrift, Volume: 123, Issue: 15-16		2011
Asymmetric dimethylarginine: a novel biomarker of gastric mucosal injury?
World journal of gastroenterology, May-07, Volume: 17, Issue: 17		2011
Cellular hypomethylation is associated with impaired nitric oxide production by cultured human endothelial cells.
Amino acids, Volume: 42, Issue: 5		2012
Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women.
Journal of clinical laboratory analysis, Volume: 25, Issue: 3		2011
Oxidative stress and endothelial dysfunction in hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension, Volume: 34, Issue: 6		2011
Elevated concentration of asymmetric dimethylarginine (ADMA) in individuals with metabolic syndrome.
Nitric oxide : biology and chemistry, May-31, Volume: 24, Issue: 4		2011
Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis.
PloS one, Feb-18, Volume: 6, Issue: 2		2011
The adipose tissue gene expression in mice with different nitric oxide availability.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, Volume: 61, Issue: 5		2010
Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes.
European heart journal, Volume: 32, Issue: 10		2011
Association between plasma asymmetrical dimethylarginine activity and severity of aortic valve stenosis.
Journal of cardiovascular medicine (Hagerstown, Md.), Volume: 12, Issue: 2		2011
Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism.
Circulation research, Jul-09, Volume: 107, Issue: 1		2010
Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability.
Arteriosclerosis, thrombosis, and vascular biology, Volume: 30, Issue: 4		2010
Association between plasma asymmetrical dimethylarginine activity and saphenous vein graft disease in patients with coronary bypass.
Coronary artery disease, Volume: 21, Issue: 1		2010
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase.
Journal of the American Chemical Society, Oct-28, Volume: 131, Issue: 42		2009
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition.
Arteriosclerosis, thrombosis, and vascular biology, Volume: 29, Issue: 9		2009
Asymmetric dimethylarginine and mortality in stages 3 to 4 chronic kidney disease.
Clinical journal of the American Society of Nephrology : CJASN, Volume: 4, Issue: 6		2009
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
British journal of haematology, Volume: 145, Issue: 4		2009
ADMA injures the glomerular filtration barrier: role of nitric oxide and superoxide.
American journal of physiology. Renal physiology, Volume: 296, Issue: 6		2009
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
European heart journal, Volume: 30, Issue: 9		2009
Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients.
World journal of gastroenterology, Dec-21, Volume: 14, Issue: 47		2008
Role of asymmetric dimethylarginine (ADMA) in diabetic vascular complications.
Current pharmaceutical design, Volume: 14, Issue: 25		2008
Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function.
Journal of cardiovascular pharmacology and therapeutics, Volume: 13, Issue: 4		2008
Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease.
Current opinion in nephrology and hypertension, Volume: 17, Issue: 6		2008
Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study.
Hypertension (Dallas, Tex. : 1979), Volume: 52, Issue: 6		2008
ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway.
Hypertension (Dallas, Tex. : 1979), Volume: 52, Issue: 5		2008
Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, Volume: 40, Issue: 9		2008
[The effect of plasma asymmetric dimethylarginine (ADMA) level and L-arginine/ADMA ratio on the development of coronary collaterals].
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, Volume: 36, Issue: 3		2008
Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus.
Transplantation, Mar-27, Volume: 85, Issue: 6		2008
Asymmetric dimethylarginine and impaired cardiovascular healing.
Journal of thrombosis and thrombolysis, Volume: 27, Issue: 2		2009
Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.
American journal of physiology. Cell physiology, Volume: 293, Issue: 5		2007
Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease.
Clinical and experimental nephrology, Volume: 11, Issue: 2		2007
Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism.
Molecular genetics and metabolism, Volume: 91, Issue: 4		2007
Asymmetric dimethylarginine levels in thyroid diseases.
Journal of endocrinological investigation, Volume: 30, Issue: 3		2007
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (9)

ArticleYear
The clinical effects of l-arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon.
Journal of the European Academy of Dermatology and Venereology : JEADV, Volume: 33, Issue: 3		2019
Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway.
Journal of natural medicines, Volume: 66, Issue: 4		2012
Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function.
Diabetic medicine : a journal of the British Diabetic Association, Volume: 29, Issue: 9		2012
Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics.
Toxicology and applied pharmacology, Aug-15, Volume: 247, Issue: 1		2010
Reduction of plasma asymmetric dimethylarginine in obese patients with chronic kidney disease after three years of a low-protein diet supplemented with keto-amino acids: a randomized controlled trial.
Wiener klinische Wochenschrift, Volume: 120, Issue: 15-16		2008
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
British journal of clinical pharmacology, Volume: 65, Issue: 1		2008
Asymmetric dimethylarginine (ADMA)--a modulator of nociception in opiate tolerance and addiction?
Nitric oxide : biology and chemistry, Volume: 17, Issue: 2		2007
Gene polymorphism and requirement for vasopressor infusion after cardiac surgery.
The Annals of thoracic surgery, Volume: 82, Issue: 3		2006
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (2)

ArticleYear
Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginine.
Journal of the American College of Cardiology, Jun-12, Volume: 49, Issue: 23		2007
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]