proadifen has been researched along with Necrosis in 21 studies
Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The basis for susceptibility to halothane-induced liver necrosis in guinea-pigs was examined." | 3.69 | Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. ( Farrell, GC; Field, J; Frost, L; Mahoney, J; Tapner, M; Weltman, M, 1996) |
| " The overall results show the necessity of TASO bioactivation by mixed-function monooxygenases for the toxic action to be apparent; at the same time, the findings suggest FADM as the system mainly involved in TASO metabolism." | 1.27 | Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide. ( Chieli, E; Malvaldi, G, 1984) |
| "Hepatic necrosis was relatively mild, and was not observed in all animals treated with 1,1-DCE." | 1.27 | Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice. ( Forkert, PG; Racz, WJ; Stringer, V, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (95.24) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chieli, E | 1 |
| Malvaldi, G | 1 |
| Warren, DL | 1 |
| Brown, DL | 1 |
| Buckpitt, AR | 1 |
| Farrell, GC | 1 |
| Frost, L | 1 |
| Tapner, M | 1 |
| Field, J | 1 |
| Weltman, M | 1 |
| Mahoney, J | 1 |
| Thompson, ML | 1 |
| Shuster, L | 1 |
| Shaw, K | 1 |
| Forkert, PG | 1 |
| Stringer, V | 1 |
| Racz, WJ | 1 |
| Hickie, RA | 1 |
| Kalant, H | 1 |
| Chopra, P | 1 |
| Roy, S | 1 |
| Ramalingaswami, V | 1 |
| Nayak, NC | 1 |
| Gillette, JR | 3 |
| Reid, WD | 4 |
| Krishna, G | 4 |
| Zampaglione, N | 2 |
| Jollow, DJ | 2 |
| Mitchell, JR | 4 |
| Stripp, B | 1 |
| Hamrick, M | 1 |
| Gillette, R | 1 |
| Brodie, BB | 3 |
| Blinder, LV | 1 |
| Gasparian, SA | 1 |
| Maliugin, EF | 1 |
| Kliuchnikova, ZhI | 1 |
| Archakov, AI | 1 |
| Torrielli, MV | 1 |
| Ugazio, G | 1 |
| Gabriel, L | 1 |
| Burdino, E | 1 |
| Christie, B | 2 |
| Moskowitz, J | 2 |
| Seawright, AA | 1 |
| Hrdlicka, J | 1 |
| Bird, CC | 1 |
| Crawford, AM | 1 |
| Currie, AR | 1 |
| Cignoli, EV | 1 |
| Castro, JA | 1 |
| Wheatley, DN | 1 |
1 review available for proadifen and Necrosis
| Article | Year |
|---|---|
Retrorsine.
Topics: Animals; Blood Proteins; Carcinogens; Drug Evaluation, Preclinical; Female; Lethal Dose 50; Liver; L | 1976 |
20 other studies available for proadifen and Necrosis
| Article | Year |
|---|---|
Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide.
Topics: Acetamides; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liv | 1984 |
Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene.
Topics: Animals; Bronchi; Cytochrome P-450 Enzyme System; Glutathione; Lung; Male; Maleates; Mice; Mice, Inb | 1982 |
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow.
Topics: Animals; Arteries; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fomepizole; Genetic Pred | 1996 |
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine | 1979 |
Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice.
Topics: Animals; Bronchi; Dichloroethylenes; Drug Interactions; Hydrocarbons, Chlorinated; Lung; Male; Methy | 1986 |
Modification of hexobarbital metabolism by Morris hepatoma 5123tc.
Topics: Animals; Carcinoma, Hepatocellular; Female; Hexobarbital; In Vitro Techniques; Liver; Liver Neoplasm | 1967 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 1972 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; E | 1974 |
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glu | 1973 |
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver | 1973 |
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; | 1973 |
[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1973 |
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
Topics: Animals; Benzene Derivatives; Biotransformation; Carbon Radioisotopes; Chemical and Drug Induced Liv | 1974 |
Effect of drug pretreatment on CBrCl3-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromine; Chemical and Drug Induced Liver | 1974 |
Bromobenzene-induced hepatic necrosis: species differences and protection by SKF 525-A.
Topics: Age Factors; Animals; Animals, Newborn; Anura; Bufo marinus; Chemical and Drug Induced Liver Injury; | 1971 |
The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.
Topics: Animals; Chemical and Drug Induced Liver Injury; Lipid Metabolism; Liver; Male; Mice; Microsomes, Li | 1972 |
Bromobenzene metabolism and hepatic necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Bromine; Carbon Isotopes; Chemical and Drug Induced Li | 1971 |
Foetal adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)-anthracene and its prevention.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Female; Fetal Diseases; Necrosi | 1970 |
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi | 1971 |
Prevention of the adrenocorticolytic actions of 7,12-dimethylbenz[a]anthracene and 7-hydroxymethyl-12-methylbenz[a]anthracene by beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A).
Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Drug Synergism; Ethionine; Female; Injections, Intraper | 1968 |