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proadifen and Necrosis

proadifen has been researched along with Necrosis in 21 studies

Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"The basis for susceptibility to halothane-induced liver necrosis in guinea-pigs was examined."3.69Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. ( Farrell, GC; Field, J; Frost, L; Mahoney, J; Tapner, M; Weltman, M, 1996)
" The overall results show the necessity of TASO bioactivation by mixed-function monooxygenases for the toxic action to be apparent; at the same time, the findings suggest FADM as the system mainly involved in TASO metabolism."1.27Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide. ( Chieli, E; Malvaldi, G, 1984)
"Hepatic necrosis was relatively mild, and was not observed in all animals treated with 1,1-DCE."1.27Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice. ( Forkert, PG; Racz, WJ; Stringer, V, 1986)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199020 (95.24)18.7374
1990's1 (4.76)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chieli, E1
Malvaldi, G1
Warren, DL1
Brown, DL1
Buckpitt, AR1
Farrell, GC1
Frost, L1
Tapner, M1
Field, J1
Weltman, M1
Mahoney, J1
Thompson, ML1
Shuster, L1
Shaw, K1
Forkert, PG1
Stringer, V1
Racz, WJ1
Hickie, RA1
Kalant, H1
Chopra, P1
Roy, S1
Ramalingaswami, V1
Nayak, NC1
Gillette, JR3
Reid, WD4
Krishna, G4
Zampaglione, N2
Jollow, DJ2
Mitchell, JR4
Stripp, B1
Hamrick, M1
Gillette, R1
Brodie, BB3
Blinder, LV1
Gasparian, SA1
Maliugin, EF1
Kliuchnikova, ZhI1
Archakov, AI1
Torrielli, MV1
Ugazio, G1
Gabriel, L1
Burdino, E1
Christie, B2
Moskowitz, J2
Seawright, AA1
Hrdlicka, J1
Bird, CC1
Crawford, AM1
Currie, AR1
Cignoli, EV1
Castro, JA1
Wheatley, DN1

Reviews

1 review available for proadifen and Necrosis

ArticleYear
Retrorsine.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 1976, Volume: 10

    Topics: Animals; Blood Proteins; Carcinogens; Drug Evaluation, Preclinical; Female; Lethal Dose 50; Liver; L

1976

Other Studies

20 other studies available for proadifen and Necrosis

ArticleYear
Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide.
    Toxicology, 1984, May-01, Volume: 31, Issue:1

    Topics: Acetamides; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liv

1984
Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene.
    Chemico-biological interactions, 1982, Jul-01, Volume: 40, Issue:3

    Topics: Animals; Bronchi; Cytochrome P-450 Enzyme System; Glutathione; Lung; Male; Maleates; Mice; Mice, Inb

1982
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow.
    Journal of gastroenterology and hepatology, 1996, Volume: 11, Issue:6

    Topics: Animals; Arteries; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fomepizole; Genetic Pred

1996
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
    Biochemical pharmacology, 1979, Aug-01, Volume: 28, Issue:15

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine

1979
Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice.
    Experimental and molecular pathology, 1986, Volume: 45, Issue:1

    Topics: Animals; Bronchi; Dichloroethylenes; Drug Interactions; Hydrocarbons, Chlorinated; Lung; Male; Methy

1986
Modification of hexobarbital metabolism by Morris hepatoma 5123tc.
    Canadian journal of physiology and pharmacology, 1967, Volume: 45, Issue:6

    Topics: Animals; Carcinoma, Hepatocellular; Female; Hexobarbital; In Vitro Techniques; Liver; Liver Neoplasm

1967
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
    Laboratory investigation; a journal of technical methods and pathology, 1972, Volume: 26, Issue:6

    Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

1972
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
    Biochemical pharmacology, 1974, Nov-01, Volume: 23, Issue:21

    Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; E

1974
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
    Experimental and molecular pathology, 1973, Volume: 18, Issue:1

    Topics: Animals; Benzene Derivatives; Bromine; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glu

1973
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver

1973
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons.
    Pharmacology, 1973, Volume: 10, Issue:4

    Topics: Animals; Benzene Derivatives; Bromine; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury;

1973
[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
    Biulleten' eksperimental'noi biologii i meditsiny, 1973, Volume: 75, Issue:5

    Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug I

1973
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
    Pharmacology, 1974, Volume: 11, Issue:3

    Topics: Animals; Benzene Derivatives; Biotransformation; Carbon Radioisotopes; Chemical and Drug Induced Liv

1974
Effect of drug pretreatment on CBrCl3-induced liver injury.
    Toxicology, 1974, Volume: 2, Issue:4

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromine; Chemical and Drug Induced Liver

1974
Bromobenzene-induced hepatic necrosis: species differences and protection by SKF 525-A.
    Research communications in chemical pathology and pharmacology, 1971, Volume: 2, Issue:6

    Topics: Age Factors; Animals; Animals, Newborn; Anura; Bufo marinus; Chemical and Drug Induced Liver Injury;

1971
The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.
    British journal of experimental pathology, 1972, Volume: 53, Issue:3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Lipid Metabolism; Liver; Male; Mice; Microsomes, Li

1972
Bromobenzene metabolism and hepatic necrosis.
    Pharmacology, 1971, Volume: 6, Issue:1

    Topics: Adipose Tissue; Animals; Benzene Derivatives; Bromine; Carbon Isotopes; Chemical and Drug Induced Li

1971
Foetal adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)-anthracene and its prevention.
    Nature, 1970, Oct-03, Volume: 228, Issue:5266

    Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Female; Fetal Diseases; Necrosi

1970
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
    Toxicology and applied pharmacology, 1971, Volume: 18, Issue:3

    Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi

1971
Prevention of the adrenocorticolytic actions of 7,12-dimethylbenz[a]anthracene and 7-hydroxymethyl-12-methylbenz[a]anthracene by beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A).
    British journal of experimental pathology, 1968, Volume: 49, Issue:1

    Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Drug Synergism; Ethionine; Female; Injections, Intraper

1968