Serine/threonine-protein kinase LMTK3

A serine/threonine-protein kinase LMTK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q04]

EC 2.7.11.1;
Lemur tyrosine kinase 3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bisindolylmaleimide i	Homo sapiens (human)	IC50	0.0001	1	0
staurosporine	Homo sapiens (human)	IC50	0.0000	2	1
sf 2370	Homo sapiens (human)	IC50	0.0794	1	0
bms 754807	Homo sapiens (human)	IC50	3.1610	1	1
entrectinib	Homo sapiens (human)	IC50	4.6530	1	1

This protein enables 7 target(s):

Target	Category	Definition
molecular_function	molecular function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. [GOC:pdt]
protein serine/threonine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]
protein kinase activity	molecular function	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]

This protein is located in 3 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
axon	cellular component	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]

This protein is active in 1 target(s):

Target	Category	Definition
cellular_component	cellular component	A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). [GOC:pdt]

This protein is involved in 1 target(s):

Target	Category	Definition
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]