Page last updated: 2024-08-07 20:11:27
Group IIF secretory phospholipase A2
A group IIF secretory phospholipase A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZM2]
Synonyms
GIIF sPLA2;
sPLA2-IIF;
EC 3.1.1.4;
Phosphatidylcholine 2-acylhydrolase 2F
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| varespladib | Homo sapiens (human) | IC50 | 0.1250 | 3 | 3 |
| indoxam | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 3-octylthio-1,1,1-trifluoro-2-propanone | Homo sapiens (human) | XI50 | 0.0001 | 1 | 1 |
| varespladib | Homo sapiens (human) | XI50 | 0.0010 | 7 | 7 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| phospholipase A2 activity | molecular function | Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801] |
| calcium-dependent phospholipase A2 activity | molecular function | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [EC:3.1.1.4] |
| phospholipid binding | molecular function | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| lipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators] |
| arachidonic acid metabolic process | biological process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732] |
| phosphatidylglycerol acyl-chain remodeling | biological process | Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. [GOC:mw, PMID:15485873, PMID:18458083] |
| phosphatidylserine acyl-chain remodeling | biological process | Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18287005, PMID:18458083] |
| phosphatidylcholine acyl-chain remodeling | biological process | Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18195019, PMID:18458083] |
| phosphatidylethanolamine acyl-chain remodeling | biological process | Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18287005, PMID:18458083] |
| innate immune response | biological process | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] |
| arachidonic acid secretion | biological process | The controlled release of arachidonic acid from a cell or a tissue. [GOC:ai] |
| phospholipid metabolic process | biological process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| negative regulation of T cell proliferation | biological process | Any process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl] |