A voltage-dependent calcium channel subunit alpha-2/delta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY47]
Voltage-gated calcium channel subunit alpha-2/delta-2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tacrine | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| nimodipine | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| reboxetine | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| pregabalin | Homo sapiens (human) | Ki | 0.0990 | 1 | 1 |
| ith 4012 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated calcium channel complex | cellular component | A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| neuromuscular junction development | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. [GOC:mtg_OBO2OWL_2013] |
| organ growth | biological process | The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. [GOC:bf, ISBN:0471245208, ISBN:0721662544] |
| regulation of multicellular organism growth | biological process | Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. [GOC:dph, GOC:ems, GOC:tb] |
| positive regulation of organ growth | biological process | Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. [GOC:bf, GOC:tb] |
| muscle cell development | biological process | The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. [CL:0000187, GOC:devbiol] |
| rhythmic synaptic transmission | biological process | Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit. [GOC:dph] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |