Proteins > Metabotropic glutamate receptor 1
Page last updated: 2024-08-07 17:05:01
Metabotropic glutamate receptor 1
A metabotropic glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13255]
Synonyms
mGluR1
Research
Bioassay Publications (32)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (37.50) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 6 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (49)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| alpha-methyl-4-carboxyphenylglycine | Homo sapiens (human) | IC50 | 155.0000 | 2 | 2 |
| alpha-methyl-4-carboxyphenylglycine | Homo sapiens (human) | Ki | 295.0000 | 2 | 2 |
| ibotenic acid | Homo sapiens (human) | Ki | 43.0000 | 1 | 1 |
| 4-carboxy-3-hydroxyphenylglycine | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| 4-carboxy-3-hydroxyphenylglycine | Homo sapiens (human) | Ki | 30.0000 | 1 | 1 |
| 1-aminoindan-1,5-dicarboxylic acid | Homo sapiens (human) | IC50 | 110.5000 | 2 | 2 |
| 1-aminoindan-1,5-dicarboxylic acid | Homo sapiens (human) | Ki | 214.0000 | 1 | 1 |
| 4-carboxyphenylglycine | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | Ki | 3.6067 | 3 | 3 |
| quisqualic acid | Homo sapiens (human) | Ki | 1.1000 | 1 | 1 |
| L-2-aminoadipic acid | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| 1-amino-1,3-dicarboxycyclopentane | Homo sapiens (human) | Ki | 42.0000 | 1 | 1 |
| philanthotoxin 343 | Homo sapiens (human) | IC50 | 0.0230 | 1 | 1 |
| homocysteic acid | Homo sapiens (human) | Ki | 87.0000 | 1 | 1 |
| 2-amino-4-phosphonobutyric acid | Homo sapiens (human) | Ki | 1,000.0000 | 2 | 2 |
| eglumetad | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 3,5-dihydroxyphenylglycine | Homo sapiens (human) | Ki | 6.6000 | 1 | 1 |
| alpha-methyl-4-carboxyphenylglycine | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| 9-(dimethylamino)-3-(4-methoxyphenyl)-4-pyrido[1,2]thieno[3,4-d]pyrimidinone | Homo sapiens (human) | IC50 | 0.0095 | 3 | 3 |
| 4-bromohomoibotenic acid, (rs)-isomer | Homo sapiens (human) | Ki | 329.0000 | 1 | 1 |
| 6-methyl-2-(phenylethynyl)pyridine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 6-methyl-2-(phenylethynyl)pyridine | Homo sapiens (human) | Ki | 15.0180 | 2 | 2 |
| 4-methylglutamic acid, threo-(l)-isomer | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| sib 1757 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| sib 1757 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| l-2-(carboxypropyl)glycine | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| 2r,4r-4-aminopyrrolidine-2,4-dicarboxylate | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| upf 596 | Homo sapiens (human) | IC50 | 26.7500 | 4 | 4 |
| upf 596 | Homo sapiens (human) | Ki | 25.0000 | 1 | 1 |
| ly-367385 | Homo sapiens (human) | IC50 | 8.4000 | 2 | 2 |
| sib 1893 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| sib 1893 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 4-carboxy-3-hydroxyphenylglycine | Homo sapiens (human) | IC50 | 40.0000 | 2 | 2 |
| 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)piperidine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ly 341495 | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| ly 341495 | Homo sapiens (human) | Ki | 6.8000 | 1 | 1 |
| bay36-7620 | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| ly 389795 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| ly 379268 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| r 214127 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| jnj16259685 | Homo sapiens (human) | IC50 | 0.0359 | 2 | 3 |
| jnj16259685 | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| a 794282 | Homo sapiens (human) | IC50 | 0.0030 | 3 | 3 |
| a-841720 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| sp 203 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| fenobam | Homo sapiens (human) | Ki | 0.0067 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aspartic acid | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| d-glutamate | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | EC50 | 45.2375 | 4 | 4 |
| quisqualic acid | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| 1-amino-1,3-dicarboxycyclopentane, (trans)-isomer | Homo sapiens (human) | EC50 | 127.0000 | 1 | 1 |
| d-aspartic acid | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| L-2-aminoadipic acid | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| alpha-aminopimelic acid | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| 1-amino-1,3-dicarboxycyclopentane | Homo sapiens (human) | EC50 | 15.4333 | 3 | 3 |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| eglumetad | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| 3,5-dihydroxyphenylglycine | Homo sapiens (human) | EC50 | 6.6000 | 1 | 1 |
| upf 596 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
| 1-amino-1,3-dicarboxycyclopentane, cis-(1s,3s)-isomer | Homo sapiens (human) | EC50 | 300.0000 | 2 | 2 |
| ampa, (r)-isomer | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| ly 379268 | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
Drugs with Other Measurements
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptorJournal of medicinal chemistry, , May-24, Volume: 39, Issue:11, 1996
Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.Journal of medicinal chemistry, , Sep-15, Volume: 38, Issue:19, 1995
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.Journal of medicinal chemistry, , Sep-15, Volume: 38, Issue:19, 1995
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.Journal of medicinal chemistry, , Sep-15, Volume: 38, Issue:19, 1995
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.Bioorganic & medicinal chemistry, , Jan-01, Volume: 17, Issue:1, 2009
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.Journal of medicinal chemistry, , Sep-20, Volume: 50, Issue:19, 2007
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
First enantiospecific synthesis of a 3,4-dihydroxy-L-glutamic acid [(3S,4S)-DHGA], a new mGluR1 agonist.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 10, Issue:2, 2000
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.Journal of medicinal chemistry, , Aug-02, Volume: 39, Issue:16, 1996
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.Journal of medicinal chemistry, , Aug-02, Volume: 39, Issue:16, 1996
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.Bioorganic & medicinal chemistry, , Jan-01, Volume: 17, Issue:1, 2009
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists fJournal of medicinal chemistry, , Mar-25, Volume: 42, Issue:6, 1999
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity.Journal of medicinal chemistry, , Dec-30, Volume: 42, Issue:26, 1999
A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 20, Issue:8, 2010
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity.Journal of medicinal chemistry, , Dec-30, Volume: 42, Issue:26, 1999
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synopsis of some recent tactical application of bioisosteres in drug design.Journal of medicinal chemistry, , Apr-28, Volume: 54, Issue:8, 2011
Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain.Journal of medicinal chemistry, , May-31, Volume: 50, Issue:11, 2007
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.Bioorganic & medicinal chemistry letters, , Jun-16, Volume: 8, Issue:12, 1998
(S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist.Journal of medicinal chemistry, , Jul-19, Volume: 39, Issue:15, 1996
GPCR crystal structures: Medicinal chemistry in the pocket.Bioorganic & medicinal chemistry, , Jul-15, Volume: 23, Issue:14, 2015
Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity.Journal of medicinal chemistry, , Dec-30, Volume: 42, Issue:26, 1999
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity.Journal of medicinal chemistry, , Dec-30, Volume: 42, Issue:26, 1999
Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain.Journal of medicinal chemistry, , May-31, Volume: 50, Issue:11, 2007
Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.Bioorganic & medicinal chemistry letters, , Oct-20, Volume: 8, Issue:20, 1998
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists fJournal of medicinal chemistry, , Mar-25, Volume: 42, Issue:6, 1999
Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain.Journal of medicinal chemistry, , May-31, Volume: 50, Issue:11, 2007
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain.Journal of medicinal chemistry, , May-31, Volume: 50, Issue:11, 2007
Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.Journal of medicinal chemistry, , Nov-17, Volume: 48, Issue:23, 2005
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| glutamate receptor activity | molecular function | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling] |
| G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | molecular function | A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse. [GOC:dos] |
| adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | molecular function | Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. [GOC:bf, GOC:dph] |
| neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | molecular function | Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. [GOC:dos] |
| G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential | molecular function | A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane. [GOC:dos] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| Schaffer collateral - CA1 synapse | cellular component | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689] |
| glutamatergic synapse | cellular component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| postsynaptic density membrane | cellular component | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Part Of
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor dimeric complex | cellular component | A protein complex that contains two G protein-coupled receptors. [GOC:al, GOC:bf, PMID:10713101] |
| G protein-coupled receptor homodimeric complex | cellular component | A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor. [GOC:al, GOC:bf, PMID:10713101, PMID:16670762] |
Involved In
This protein is involved in 14 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway | biological process | An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] |
| phospholipase C-activating G protein-coupled glutamate receptor signaling pathway | biological process | A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| locomotory behavior | biological process | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph] |
| sensory perception of pain | biological process | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators] |
| positive regulation of MAPK cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators] |
| regulation of sensory perception of pain | biological process | Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. [GOC:ai] |
| regulation of postsynaptic membrane potential | biological process | Any process that modulates the potential difference across a post-synaptic membrane. [GOC:dph, GOC:ef] |
| cellular response to electrical stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. [GOC:mah] |
| L-glutamate import across plasma membrane | biological process | The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos] |
| regulation of postsynaptic cytosolic calcium ion concentration | biological process | Any process that regulates the concentration of calcium in the postsynaptic cytosol. [GOC:dos] |
| G protein-coupled glutamate receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling, PMID:9131252] |
| regulation of synaptic transmission, glutamatergic | biological process | Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai] |