Protein phosphatase 1B

A protein phosphatase 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75688]

Synonyms

EC 3.1.3.16;
Protein phosphatase 2C isoform beta;
PP2C-beta

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cantharidin	Homo sapiens (human)	IC50	1.7800	1	1
cyanoginosin-la	Homo sapiens (human)	IC50	0.0012	2	3
demethylcantharidin	Homo sapiens (human)	IC50	3.6450	2	2

Enables

This protein enables 5 target(s):

Target	Category	Definition
magnesium ion binding	molecular function	Binding to a magnesium (Mg) ion. [GOC:ai]
protein serine/threonine phosphatase activity	molecular function	Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. [GOC:bf]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
myosin phosphatase activity	molecular function	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16]
manganese ion binding	molecular function	Binding to a manganese ion (Mn). [GOC:ai]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleolus	cellular component	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
protein dephosphorylation	biological process	The process of removing one or more phosphoric residues from a protein. [GOC:hb]
N-terminal protein myristoylation	biological process	The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein. [GOC:mah]
negative regulation of interferon-beta production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]
peptidyl-threonine dephosphorylation	biological process	The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. [GOC:bf]
negative regulation of canonical NF-kappaB signal transduction	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
negative regulation of defense response to virus	biological process	Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. [GOC:ai]
negative regulation of non-canonical NF-kappaB signal transduction	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical NF-kappaB signaling cascade. [GOC:TermGenie]
positive regulation of canonical Wnt signaling pathway	biological process	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]