Page last updated: 2024-11-07

spironolactone and Necrosis

spironolactone has been researched along with Necrosis in 19 studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" Administration of angiotensin II and Nomega-nitro-L-arginine methyl ester (L-NAME; nitric oxide synthesis inhibitor) to male rats drinking 1% saline caused hypertension, severe biventricular myocardial necrosis, proteinuria, and fibrinoid necrosis of renal and cardiac vessels."7.70Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. ( Adler, GK; Kifor, I; Ochoa-Maya, MR; Rennke, HG; Rocha, R; Stier, CT; Williams, GH, 2000)
"The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone."7.65Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970)
" Administration of angiotensin II and Nomega-nitro-L-arginine methyl ester (L-NAME; nitric oxide synthesis inhibitor) to male rats drinking 1% saline caused hypertension, severe biventricular myocardial necrosis, proteinuria, and fibrinoid necrosis of renal and cardiac vessels."3.70Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. ( Adler, GK; Kifor, I; Ochoa-Maya, MR; Rennke, HG; Rocha, R; Stier, CT; Williams, GH, 2000)
"The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone."3.65Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199017 (89.47)18.7374
1990's0 (0.00)18.2507
2000's2 (10.53)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rocha, R2
Martin-Berger, CL1
Yang, P1
Scherrer, R1
Delyani, J1
McMahon, E1
RAAB, W1
SELYE, H3
Stier, CT1
Kifor, I1
Ochoa-Maya, MR1
Rennke, HG1
Williams, GH1
Adler, GK1
Mihas, AA1
Foster, MM1
Barnes, S1
Mihas, TA1
Hirschowitz, BI1
Spenney, JG1
Somogyi, A5
Kovacs, K6
Solymoss, B1
Kuntzman, R1
Conney, AH1
Bordás, E1
Bretter, E1
Lazar, G1
Szabo, S1
Bjondahl, K1
Möttönen, M1
Nieminen, L1
Gardell, C1
Blascheck, JA1
Savoie, LL1
Savoie, L1
Krajny, M1
Kleiman, B1
Moudgil, LR1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised Open Label, Blinded End Point Trial to Compare the Effects of Spironolactone With Chlortalidone on LV Mass in Stage 3 Chronic Kidney Disease (SPIRO-CKD)[NCT02502981]Phase 4154 participants (Actual)Interventional2014-06-30Active, not recruiting
Is Spironolactone Safe and Effective in the Treatment of Cardiovascular Disease in Mild Chronic Renal Failure?[NCT00291720]Phase 2120 participants (Actual)Interventional2005-04-30Completed
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055]Phase 475 participants (Anticipated)Interventional2023-08-25Recruiting
Usefulness of Spironolactone for the Prevention of Acute Kidney Injury in Critically Ill Patients With Invasive Mechanical Ventilation[NCT03206658]Phase 390 participants (Anticipated)Interventional2017-08-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for spironolactone and Necrosis

ArticleYear
NEUROGENIC MULTIFOCAL DESTRUCTION OF MYOCARDIAL TISSUE (PATHOGENIC MECHANISM AND ITS PREVENTION).
    Revue canadienne de biologie, 1963, Volume: 22

    Topics: Adrenal Cortex Hormones; Catecholamines; Epinephrine; Heart Diseases; Hypoxia; Myocardial Infarction

1963

Other Studies

18 other studies available for spironolactone and Necrosis

ArticleYear
Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart.
    Endocrinology, 2002, Volume: 143, Issue:12

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Body Weight; Coronary Disease; Coronary Vessels

2002
Protection by a steroid-spirolactone against certain types of cardiac necroses.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1960, Volume: 104

    Topics: Aldosterone; Heart; Humans; Mineralocorticoid Receptor Antagonists; Myocardium; Necrosis; Spironolac

1960
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Modification of D-galactosamine-induced liver injury in the rat by spironolactone.
    Pharmacology, 1979, Volume: 18, Issue:5

    Topics: Animals; Aspartate Aminotransferases; Bile Acids and Salts; Galactosamine; Injections, Intraperitone

1979
Suppression of 7,12-dimethylbenz( )anthracene-produced adrenal necrosis by steroids capable of inducing aryl hydrocarbon hydroxylase.
    Life sciences. Pt. 2: Biochemistry, general and molecular biology, 1971, Nov-22, Volume: 10, Issue:22

    Topics: Adrenal Gland Diseases; Androstanes; Animals; Benz(a)Anthracenes; Benzopyrenes; Betamethasone; Dexam

1971
Effect of stress on the adrenocorticolytic and carcinogenic action of 7,12-dimethylbenz(a)anthracene.
    Zeitschrift fur Krebsforschung, 1971, Volume: 75, Issue:4

    Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Necrosis; Neoplasms, Experimental; Physical Exertion; R

1971
Prevention of various forms of metabolic myocardial necrosis by catatoxic steroids.
    Journal of molecular and cellular cardiology, 1970, Volume: 1, Issue:1

    Topics: Animals; Cardiomyopathies; Desoxycorticosterone; Digitoxin; Disease Models, Animal; Ethylestrenol; F

1970
[Effect of spironolactone in experimental myocardial necrosis].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Sep-01, Volume: 27, Issue:17

    Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Female; Heart Diseases; Hyperplasia; Male; Myocardi

1972
Effect of hypophysectomy and catatoxic steroids on thioacetamide-induced adrenal lesions in rats.
    Endokrinologie, 1973, Volume: 61, Issue:1

    Topics: Acetamides; Adrenal Gland Diseases; Adrenal Glands; Anabolic Agents; Animals; Dexamethasone; Ethyles

1973
The effect of spironolactone on acute toxicity and liver damage in mice induced by cerium chloride.
    Experientia, 1973, Jun-15, Volume: 29, Issue:6

    Topics: Animals; Cerium; Female; Liver; Mice; Necrosis; Spironolactone

1973
[Spironolactone protection against experimental cardiopathy due to digitoxin, disodium phosphate and oil].
    Pathologie-biologie, 1970, Volume: 18, Issue:3

    Topics: Animals; Cardiomyopathies; Digitoxin; Enzyme Induction; Heart; Microscopy, Electron; Myocardium; Nec

1970
[Effect of antikaliuretics on the development of cardiac lesions in potassium or magnesium deficiencies in the rat].
    Revue canadienne de biologie, 1971, Volume: 30, Issue:4

    Topics: Amiloride; Animals; Chlorides; Diet; Diuretics; Female; Heart; Heart Diseases; Magnesium; Magnesium

1971
Digitoxin induced cardiac necrosis and its inhibition.
    Cardiologia, 1969, Volume: 54, Issue:5

    Topics: Animals; Cardiomyopathies; Digitoxin; Drug Synergism; Enzyme Induction; Female; Heart; Injections, S

1969
Mercury poisoning: prevention by spironolactone.
    Science (New York, N.Y.), 1970, Aug-21, Volume: 169, Issue:3947

    Topics: Acute Kidney Injury; Animals; Chelating Agents; Dimercaprol; Female; Kidney Tubules; Mercury Poisoni

1970
Inhibition by spironolactone of 7-hydroxymethyl-12-methylbenz(a)anthracene-induced adrenal necrosis in rats.
    Endokrinologie, 1970, Volume: 56, Issue:2

    Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Female; Necrosis; Rats; Spirono

1970
Effect of various steroids on the adrenal necrosis induced by 7,12-dimethylbenz(a)anthracene in rats.
    Revue canadienne de biologie, 1970, Volume: 29, Issue:2

    Topics: Adrenal Gland Diseases; Adrenal Glands; Anabolic Agents; Animals; Benz(a)Anthracenes; Desoxycorticos

1970
Possible protective action of antialdosterone compounds in myocardial necrosis in rats.
    British journal of pharmacology, 1969, Volume: 35, Issue:3

    Topics: Animals; Cardiomyopathies; Isoproterenol; Mineralocorticoid Receptor Antagonists; Necrosis; Rats; Sp

1969
Prevention by spironolactone of 7,12-dimethylbenz(a)anthracene-induced adrenal necrosis.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1969, Volume: 131, Issue:4

    Topics: Adrenal Gland Diseases; Animals; Benz(a)Anthracenes; Female; Hemorrhage; Necrosis; Rats; Spironolact

1969