spironolactone has been researched along with Necrosis in 19 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
Excerpt | Relevance | Reference |
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" Administration of angiotensin II and Nomega-nitro-L-arginine methyl ester (L-NAME; nitric oxide synthesis inhibitor) to male rats drinking 1% saline caused hypertension, severe biventricular myocardial necrosis, proteinuria, and fibrinoid necrosis of renal and cardiac vessels." | 7.70 | Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. ( Adler, GK; Kifor, I; Ochoa-Maya, MR; Rennke, HG; Rocha, R; Stier, CT; Williams, GH, 2000) |
"The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone." | 7.65 | Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970) |
" Administration of angiotensin II and Nomega-nitro-L-arginine methyl ester (L-NAME; nitric oxide synthesis inhibitor) to male rats drinking 1% saline caused hypertension, severe biventricular myocardial necrosis, proteinuria, and fibrinoid necrosis of renal and cardiac vessels." | 3.70 | Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. ( Adler, GK; Kifor, I; Ochoa-Maya, MR; Rennke, HG; Rocha, R; Stier, CT; Williams, GH, 2000) |
"The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone." | 3.65 | Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (89.47) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (10.53) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Rocha, R | 2 |
Martin-Berger, CL | 1 |
Yang, P | 1 |
Scherrer, R | 1 |
Delyani, J | 1 |
McMahon, E | 1 |
RAAB, W | 1 |
SELYE, H | 3 |
Stier, CT | 1 |
Kifor, I | 1 |
Ochoa-Maya, MR | 1 |
Rennke, HG | 1 |
Williams, GH | 1 |
Adler, GK | 1 |
Mihas, AA | 1 |
Foster, MM | 1 |
Barnes, S | 1 |
Mihas, TA | 1 |
Hirschowitz, BI | 1 |
Spenney, JG | 1 |
Somogyi, A | 5 |
Kovacs, K | 6 |
Solymoss, B | 1 |
Kuntzman, R | 1 |
Conney, AH | 1 |
Bordás, E | 1 |
Bretter, E | 1 |
Lazar, G | 1 |
Szabo, S | 1 |
Bjondahl, K | 1 |
Möttönen, M | 1 |
Nieminen, L | 1 |
Gardell, C | 1 |
Blascheck, JA | 1 |
Savoie, LL | 1 |
Savoie, L | 1 |
Krajny, M | 1 |
Kleiman, B | 1 |
Moudgil, LR | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomised Open Label, Blinded End Point Trial to Compare the Effects of Spironolactone With Chlortalidone on LV Mass in Stage 3 Chronic Kidney Disease (SPIRO-CKD)[NCT02502981] | Phase 4 | 154 participants (Actual) | Interventional | 2014-06-30 | Active, not recruiting | ||
Is Spironolactone Safe and Effective in the Treatment of Cardiovascular Disease in Mild Chronic Renal Failure?[NCT00291720] | Phase 2 | 120 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055] | Phase 4 | 75 participants (Anticipated) | Interventional | 2023-08-25 | Recruiting | ||
Usefulness of Spironolactone for the Prevention of Acute Kidney Injury in Critically Ill Patients With Invasive Mechanical Ventilation[NCT03206658] | Phase 3 | 90 participants (Anticipated) | Interventional | 2017-08-01 | Not yet recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for spironolactone and Necrosis
Article | Year |
---|---|
NEUROGENIC MULTIFOCAL DESTRUCTION OF MYOCARDIAL TISSUE (PATHOGENIC MECHANISM AND ITS PREVENTION).
Topics: Adrenal Cortex Hormones; Catecholamines; Epinephrine; Heart Diseases; Hypoxia; Myocardial Infarction | 1963 |
18 other studies available for spironolactone and Necrosis
Article | Year |
---|---|
Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Body Weight; Coronary Disease; Coronary Vessels | 2002 |
Protection by a steroid-spirolactone against certain types of cardiac necroses.
Topics: Aldosterone; Heart; Humans; Mineralocorticoid Receptor Antagonists; Myocardium; Necrosis; Spironolac | 1960 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi | 2000 |
Modification of D-galactosamine-induced liver injury in the rat by spironolactone.
Topics: Animals; Aspartate Aminotransferases; Bile Acids and Salts; Galactosamine; Injections, Intraperitone | 1979 |
Suppression of 7,12-dimethylbenz( )anthracene-produced adrenal necrosis by steroids capable of inducing aryl hydrocarbon hydroxylase.
Topics: Adrenal Gland Diseases; Androstanes; Animals; Benz(a)Anthracenes; Benzopyrenes; Betamethasone; Dexam | 1971 |
Effect of stress on the adrenocorticolytic and carcinogenic action of 7,12-dimethylbenz(a)anthracene.
Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Necrosis; Neoplasms, Experimental; Physical Exertion; R | 1971 |
Prevention of various forms of metabolic myocardial necrosis by catatoxic steroids.
Topics: Animals; Cardiomyopathies; Desoxycorticosterone; Digitoxin; Disease Models, Animal; Ethylestrenol; F | 1970 |
[Effect of spironolactone in experimental myocardial necrosis].
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Female; Heart Diseases; Hyperplasia; Male; Myocardi | 1972 |
Effect of hypophysectomy and catatoxic steroids on thioacetamide-induced adrenal lesions in rats.
Topics: Acetamides; Adrenal Gland Diseases; Adrenal Glands; Anabolic Agents; Animals; Dexamethasone; Ethyles | 1973 |
The effect of spironolactone on acute toxicity and liver damage in mice induced by cerium chloride.
Topics: Animals; Cerium; Female; Liver; Mice; Necrosis; Spironolactone | 1973 |
[Spironolactone protection against experimental cardiopathy due to digitoxin, disodium phosphate and oil].
Topics: Animals; Cardiomyopathies; Digitoxin; Enzyme Induction; Heart; Microscopy, Electron; Myocardium; Nec | 1970 |
[Effect of antikaliuretics on the development of cardiac lesions in potassium or magnesium deficiencies in the rat].
Topics: Amiloride; Animals; Chlorides; Diet; Diuretics; Female; Heart; Heart Diseases; Magnesium; Magnesium | 1971 |
Digitoxin induced cardiac necrosis and its inhibition.
Topics: Animals; Cardiomyopathies; Digitoxin; Drug Synergism; Enzyme Induction; Female; Heart; Injections, S | 1969 |
Mercury poisoning: prevention by spironolactone.
Topics: Acute Kidney Injury; Animals; Chelating Agents; Dimercaprol; Female; Kidney Tubules; Mercury Poisoni | 1970 |
Inhibition by spironolactone of 7-hydroxymethyl-12-methylbenz(a)anthracene-induced adrenal necrosis in rats.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Female; Necrosis; Rats; Spirono | 1970 |
Effect of various steroids on the adrenal necrosis induced by 7,12-dimethylbenz(a)anthracene in rats.
Topics: Adrenal Gland Diseases; Adrenal Glands; Anabolic Agents; Animals; Benz(a)Anthracenes; Desoxycorticos | 1970 |
Possible protective action of antialdosterone compounds in myocardial necrosis in rats.
Topics: Animals; Cardiomyopathies; Isoproterenol; Mineralocorticoid Receptor Antagonists; Necrosis; Rats; Sp | 1969 |
Prevention by spironolactone of 7,12-dimethylbenz(a)anthracene-induced adrenal necrosis.
Topics: Adrenal Gland Diseases; Animals; Benz(a)Anthracenes; Female; Hemorrhage; Necrosis; Rats; Spironolact | 1969 |