Inosine-5'-monophosphate dehydrogenase 1

An inosine-5-monophosphate dehydrogenase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20839]

Synonyms

IMP dehydrogenase 1;
IMPD 1;
IMPDH 1;
EC 1.1.1.205;
IMPDH-I

Research

Bioassay Publications (18)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (5.56)	18.7374
1990's	2 (11.11)	18.2507
2000's	11 (61.11)	29.6817
2010's	4 (22.22)	24.3611
2020's	0 (0.00)	2.80

Compounds (11)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
adenosine	Homo sapiens (human)	Ki	100.0000	1	1
thiazole-4-carboxamide adenine dinucleotide	Homo sapiens (human)	Ki	0.1067	3	3
7-chloro-4-aminoquinoline	Homo sapiens (human)	IC50	168.0000	1	1
4-hydroxycarbazole	Homo sapiens (human)	IC50	54.0000	1	1
vx 497	Homo sapiens (human)	IC50	0.0070	1	1
6-chloropurine 9-beta-d-ribofuranosyl 5'-monophosphate	Homo sapiens (human)	Ki	62.0000	1	1
3-cyanoindole	Homo sapiens (human)	IC50	32.0000	1	1
mycophenolic acid	Homo sapiens (human)	IC50	3.3977	6	6
mycophenolic acid	Homo sapiens (human)	Ki	0.0365	8	8
c2-mycophenolic adenine dinucleotide	Homo sapiens (human)	Ki	0.3257	7	7
inosinic acid	Homo sapiens (human)	Ki	0.2500	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
nad	Homo sapiens (human)	Km	100.0000	1	1
inosinic acid	Homo sapiens (human)	Km	12.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
nucleotide binding	molecular function	Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. [GOC:mah, ISBN:0198547684]
nucleic acid binding	molecular function	Binding to a nucleic acid. [GOC:jl]
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
IMP dehydrogenase activity	molecular function	Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. [EC:1.1.1.205]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
secretory granule lumen	cellular component	The volume enclosed by the membrane of a secretory granule. [GOC:rph]
azurophil granule lumen	cellular component	The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]
ficolin-1-rich granule lumen	cellular component	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 2 target(s):

Target	Category	Definition
GMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. [ISBN:0198506732]
GTP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. [ISBN:0198506732]

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