Proteins > Inosine-5'-monophosphate dehydrogenase 1
Page last updated: 2024-08-07 16:09:38
Inosine-5'-monophosphate dehydrogenase 1
An inosine-5-monophosphate dehydrogenase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20839]
Synonyms
IMP dehydrogenase 1;
IMPD 1;
IMPDH 1;
EC 1.1.1.205;
IMPDH-I
Research
Bioassay Publications (18)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 11 (61.11) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nad | Homo sapiens (human) | Km | 100.0000 | 1 | 1 |
| inosinic acid | Homo sapiens (human) | Km | 12.0000 | 1 | 1 |
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.Journal of medicinal chemistry, , Dec-27, Volume: 50, Issue:26, 2007
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.Bioorganic & medicinal chemistry, , 11-01, Volume: 26, Issue:20, 2018
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.Bioorganic & medicinal chemistry, , Mar-01, Volume: 19, Issue:5, 2011
Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Mycophenolic acid analogs with a modified metabolic profile.Bioorganic & medicinal chemistry, , Oct-15, Volume: 16, Issue:20, 2008
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.Journal of medicinal chemistry, , Dec-27, Volume: 50, Issue:26, 2007
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 16, Issue:13, 2006
Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening.Bioorganic & medicinal chemistry letters, , May-19, Volume: 13, Issue:10, 2003
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.Journal of medicinal chemistry, , Jan-31, Volume: 45, Issue:3, 2002
Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.Journal of medicinal chemistry, , Feb-12, Volume: 41, Issue:4, 1998
Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
NAD-based inhibitors with anticancer potential.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 24, Issue:1, 2014
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.Bioorganic & medicinal chemistry, , Mar-01, Volume: 19, Issue:5, 2011
Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase.Journal of medicinal chemistry, , Aug-10, Volume: 49, Issue:16, 2006
Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.Journal of medicinal chemistry, , Jan-31, Volume: 45, Issue:3, 2002
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| nucleotide binding | molecular function | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. [GOC:mah, ISBN:0198547684] |
| nucleic acid binding | molecular function | Binding to a nucleic acid. [GOC:jl] |
| DNA binding | molecular function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| IMP dehydrogenase activity | molecular function | Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. [EC:1.1.1.205] |
Located In
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| secretory granule lumen | cellular component | The volume enclosed by the membrane of a secretory granule. [GOC:rph] |
| azurophil granule lumen | cellular component | The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095] |
| ficolin-1-rich granule lumen | cellular component | Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|
| GMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. [ISBN:0198506732] |
| GTP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. [ISBN:0198506732] |