Proteins > Retinoic acid receptor RXR-gamma
Page last updated: 2024-08-07 16:21:55
Retinoic acid receptor RXR-gamma
A retinoic acid receptor RXR-gamma that is encoded in the genome of mouse. [OMA:P28705, PRO:DNx]
Synonyms
Nuclear receptor subfamily 2 group B member 3;
Retinoid X receptor gamma
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lg 100268 | Mus musculus (house mouse) | Ki | 10.0000 | 1 | 1 |
| tretinoin | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| isotretinoin | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| lg 1506 | Mus musculus (house mouse) | Ki | 1.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lg 100268 | Mus musculus (house mouse) | EC50 | 0.0040 | 1 | 1 |
| lg 100268 | Mus musculus (house mouse) | Kd | 0.0030 | 1 | 1 |
| bexarotene | Mus musculus (house mouse) | EC50 | 0.0225 | 2 | 2 |
| bexarotene | Mus musculus (house mouse) | Kd | 0.0290 | 2 | 2 |
| tretinoin | Mus musculus (house mouse) | EC50 | 0.4835 | 2 | 2 |
| tretinoin | Mus musculus (house mouse) | Kd | 0.3500 | 1 | 1 |
| alitretinoin | Mus musculus (house mouse) | EC50 | 0.1240 | 1 | 1 |
| alitretinoin | Mus musculus (house mouse) | Kd | 0.0040 | 1 | 1 |
Design, synthesis and structure-activity relationship of novel RXR-selective modulators.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 14, Issue:6, 2004
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.Journal of medicinal chemistry, , Aug-04, Volume: 38, Issue:16, 1995
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.Journal of medicinal chemistry, , Aug-04, Volume: 38, Issue:16, 1995
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.Journal of medicinal chemistry, , Sep-02, Volume: 37, Issue:18, 1994
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.Bioorganic & medicinal chemistry letters, , Jan-20, Volume: 13, Issue:2, 2003
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.Bioorganic & medicinal chemistry letters, , Jan-20, Volume: 13, Issue:2, 2003
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996