Page last updated: 2024-08-07 16:42:26
Cannabinoid receptor 1
A cannabinoid receptor 1 that is encoded in the genome of mouse. [OMA:P47746, PRO:DNx]
Synonyms
CB-R;
CB1;
Brain-type cannabinoid receptor
Research
Bioassay Publications (23)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
Compounds (24)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nevirapine | Mus musculus (house mouse) | Ki | 7.2000 | 1 | 1 |
| dronabinol | Mus musculus (house mouse) | Ki | 0.0405 | 2 | 2 |
| o,o-diethyl o-3,5,6-trichloro-2-pyridyl phosphate | Mus musculus (house mouse) | IC50 | 0.0030 | 1 | 1 |
| efavirenz | Mus musculus (house mouse) | Ki | 0.0100 | 1 | 1 |
| (6ar-trans)-isomer of tetrahydrocannabivarin 9 | Mus musculus (house mouse) | Ki | 0.0750 | 1 | 1 |
| enkephalin, d-penicillamine (2,5)- | Mus musculus (house mouse) | Ki | 0.0017 | 1 | 1 |
| sr141716 | Mus musculus (house mouse) | IC50 | 0.0250 | 1 | 1 |
| sr141716 | Mus musculus (house mouse) | Ki | 0.0062 | 2 | 2 |
| resveratrol | Mus musculus (house mouse) | IC50 | 1,000.0000 | 1 | 2 |
| anandamide | Mus musculus (house mouse) | Ki | 1.8470 | 3 | 3 |
| 7,10,13,16-docosatetraenylethanolamide | Mus musculus (house mouse) | Ki | 0.0344 | 1 | 1 |
| (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone | Mus musculus (house mouse) | Ki | 0.0186 | 4 | 4 |
| jwh-073 | Mus musculus (house mouse) | Ki | 0.0129 | 1 | 1 |
| 1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea | Mus musculus (house mouse) | IC50 | 0.2850 | 2 | 2 |
| a-836339 | Mus musculus (house mouse) | Ki | 0.0006 | 1 | 1 |
| azd3514 | Mus musculus (house mouse) | IC50 | 1.7783 | 1 | 1 |
| tetracycline | Mus musculus (house mouse) | IC50 | 180.0000 | 1 | 1 |
| jd5037 | Mus musculus (house mouse) | IC50 | 1.0000 | 1 | 1 |
| 2-carboxyarabinitol 1-phosphate | Mus musculus (house mouse) | IC50 | 3.2000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cannabigerol | Mus musculus (house mouse) | K | 0.3800 | 1 | 1 |
| ly2033298 | Mus musculus (house mouse) | Kb | 0.2000 | 1 | 1 |
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 17, Issue:14, 2007
Potent anandamide analogs: the effect of changing the length and branching of the end pentyl chain.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CBJournal of medicinal chemistry, , 02-09, Volume: 60, Issue:3, 2017
Discovery of Potent Dual PPARα Agonists/CB1 Ligands.ACS medicinal chemistry letters, , Nov-10, Volume: 2, Issue:11, 2011
Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Potent anandamide analogs: the effect of changing the length and branching of the end pentyl chain.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor.Journal of medicinal chemistry, , Oct-01, Volume: 36, Issue:20, 1993
Discovery of Potent Dual PPARα Agonists/CB1 Ligands.ACS medicinal chemistry letters, , Nov-10, Volume: 2, Issue:11, 2011
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: discovery of CB2 receptor selective compounds.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 17, Issue:14, 2007
Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: identification of a lead and initial SAR studies.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 17, Issue:1, 2007
Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.Journal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006
Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.Journal of medicinal chemistry, , Oct-06, Volume: 48, Issue:20, 2005