Taste receptor type 2 member 16

A taste receptor type 2 member 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV7]

T2R16

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
isoproterenol	Homo sapiens (human)	EC50	0.0049	1
phenyl beta-d-glucopyranoside	Homo sapiens (human)	EC50	482.0920	5
salicin	Homo sapiens (human)	EC50	1,400.0000	2
arbutin	Homo sapiens (human)	EC50	5,800.0000	2
amygdalin	Homo sapiens (human)	EC50	20,000.0000	2

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
phenyl beta-d-glucopyranoside	Homo sapiens (human)	Activity	70.0000	2
4-nitrophenyl beta-d-glucoside	Homo sapiens (human)	Activity	1,000.0000	1
2-nitrophenyl-beta-d-glucopyranoside	Homo sapiens (human)	Activity	900.0000	2
4-nitrophenyl-beta-d-mannopyranoside	Homo sapiens (human)	Activity	1,000.0000	1
salicin	Homo sapiens (human)	Activity	70.0000	2
arbutin	Homo sapiens (human)	Activity	500.0000	2
amygdalin	Homo sapiens (human)	Activity	2,300.0000	2
esculin	Homo sapiens (human)	Activity	4,000.0000	2

This protein enables 3 target(s):

Target	Category	Definition
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
bitter taste receptor activity	molecular function	Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. [GOC:mah]

This protein is located in 5 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
trans-Golgi network	cellular component	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is active in 1 target(s):

Target	Category	Definition
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is involved in 2 target(s):

Target	Category	Definition
detection of chemical stimulus involved in sensory perception of bitter taste	biological process	The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]