tacrine has been researched along with Necrosis in 5 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The features of apoptotic dose responses typically have been evaluated over a broad dose-response continuum to differentiate apoptotic and necrotic responses." | 2.41 | Apoptosis: biphasic dose responses. ( Calabrese, EJ, 2001) |
| "Glioblastoma is the most common and aggressive glioma, characterized by brain invasion capability." | 1.48 | Tacrine derivatives stimulate human glioma SF295 cell death and alter important proteins related to disease development: An old drug for new targets. ( Bonacorso, HG; Costa Nunes, F; Creczynski-Pasa, TB; de Melo, LJ; Feitosa, SC; Martins, MAP; Rode, M; Silva, AH; Silva, LB; Winter, E; Zanatta, N, 2018) |
| "Tacrine has been shown to accumulate within mitochondria, and it particularly targets mtDNA." | 1.32 | Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver. ( Berson, A; Demeilliers, C; Descatoire, V; Feldmann, G; Fromenty, B; Haouzi, D; Mansouri, A; Pessayre, D; Sutton, A; Vadrot, N, 2003) |
| "Patients receiving THA for treatment of Alzheimer's disease need regular monitoring of liver function." | 1.28 | Heterogeneity of adverse hepatic reactions to tetrahydroaminoacridine. ( Ames, DJ; Bhathal, PS; Davies, BM; Fraser, JR; Gibson, PR; Roberts, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa Nunes, F | 1 |
| Silva, LB | 1 |
| Winter, E | 1 |
| Silva, AH | 1 |
| de Melo, LJ | 1 |
| Rode, M | 1 |
| Martins, MAP | 1 |
| Zanatta, N | 1 |
| Feitosa, SC | 1 |
| Bonacorso, HG | 1 |
| Creczynski-Pasa, TB | 1 |
| Mansouri, A | 1 |
| Haouzi, D | 1 |
| Descatoire, V | 1 |
| Demeilliers, C | 1 |
| Sutton, A | 1 |
| Vadrot, N | 1 |
| Fromenty, B | 1 |
| Feldmann, G | 2 |
| Pessayre, D | 2 |
| Berson, A | 1 |
| Calabrese, EJ | 1 |
| Ames, DJ | 1 |
| Bhathal, PS | 1 |
| Davies, BM | 1 |
| Fraser, JR | 1 |
| Gibson, PR | 1 |
| Roberts, S | 1 |
| Hammel, P | 1 |
| Larrey, D | 1 |
| Bernuau, J | 1 |
| Kalafat, M | 1 |
| Fréneaux, E | 1 |
| Babany, G | 1 |
| Degott, C | 1 |
| Benhamou, JP | 1 |
1 review available for tacrine and Necrosis
| Article | Year |
|---|---|
Apoptosis: biphasic dose responses.
Topics: Animals; Antioxidants; Apoptosis; Cycloheximide; Dementia; Dimethylformamide; Dose-Response Relation | 2001 |
4 other studies available for tacrine and Necrosis
| Article | Year |
|---|---|
Tacrine derivatives stimulate human glioma SF295 cell death and alter important proteins related to disease development: An old drug for new targets.
Topics: Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; Dacarbazine; Drug Screening Assays, Antitumor; Ge | 2018 |
Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver.
Topics: Animals; Apoptosis; DNA; DNA Fragmentation; DNA Polymerase gamma; DNA Replication; DNA-Directed DNA | 2003 |
Heterogeneity of adverse hepatic reactions to tetrahydroaminoacridine.
Topics: Aged; Alzheimer Disease; Aminoacridines; Chemical and Drug Induced Liver Injury; Female; Humans; Liv | 1990 |
Acute hepatitis after tetrahydroaminoacridine administration for Alzheimer's disease.
Topics: Acute Disease; Aged; Alzheimer Disease; Aminoacridines; Chemical and Drug Induced Liver Injury; Fema | 1990 |