Page last updated: 2024-08-07 16:17:02
Adenosine receptor A1
An adenosine receptor A1 that is encoded in the genome of rat. [OMA:P25099, PRO:DNx]
Synonyms
Research
Bioassay Publications (141)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 20 (14.18) | 18.7374 |
| 1990's | 51 (36.17) | 18.2507 |
| 2000's | 39 (27.66) | 29.6817 |
| 2010's | 28 (19.86) | 24.3611 |
| 2020's | 3 (2.13) | 2.80 |
Compounds (228)
Drugs with Potency Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| hexachlorophene | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 0 |
| streptonigrin | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 0 |
| 9,10-phenanthrenequinone | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 0 |
| epigallocatechin gallate | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 0 |
| toxoflavin | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 0 |
| gossypol acetic acid | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 0 |
| 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | Rattus norvegicus (Norway rat) | Potency | 1.4125 | 1 | 0 |
| 2-(1,3-benzoxazol-2-ylamino)-5-spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]one | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 0 |
| 1,6-dimethyl-3-(2-pyridinyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dione | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 0 |
| 1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | Rattus norvegicus (Norway rat) | Potency | 1.7783 | 1 | 0 |
| ml106 | Rattus norvegicus (Norway rat) | Potency | 0.0708 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.0631 | 1 | 0 |
| N-(2-furanylmethyl)-6-(3-methoxyphenyl)-N-methyl-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.3548 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1122 | 1 | 0 |
| 6-(2-chlorophenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 0 |
| 6-(3-furanyl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.2512 | 1 | 0 |
| 6-(3-pyridinyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 0 |
| 6-(3-furanyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.2239 | 1 | 0 |
| 6-(3-methoxyphenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 0 |
| 6-(2-chlorophenyl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 0 |
| 6-(3-methoxyphenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 0 |
| 6-(3-furanyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 0 |
| N-[(3-methylphenyl)methyl]-6-(3-pyridinyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 2.8184 | 1 | 0 |
| 3-bromo-N-[5-(4-morpholinylsulfonyl)-1,3,4-thiadiazol-2-yl]benzamide | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 0 |
| xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 0 |
| N-(2-furanylmethyl)-N-methyl-6-(1-methyl-5-indolyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 0 |
| 6-(2-chlorophenyl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 0 |
| 6-(3-methoxyphenyl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 0 |
| 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(3-methylphenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 0 |
| 6-(2-chlorophenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 0 |
| 6-(3-chlorophenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 0 |
| 6-(3-pyridinyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 0 |
| 6-(3-methylphenyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 0 |
| 6-(1-methyl-5-indolyl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 0 |
| 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(thiophen-2-ylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1413 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 1.7783 | 1 | 0 |
| 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.3981 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-[(3-fluorophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1413 | 1 | 0 |
| 6-(3-chlorophenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 4.4668 | 1 | 0 |
| 6-(3-methylphenyl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-(3-pyridinylmethyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1259 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(2-chlorophenyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(3-pyridinyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 0 |
| N-(1,3-benzodioxol-5-ylmethyl)-6-(3-furanyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.7079 | 1 | 0 |
| 6-(2-chlorophenyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 0 |
| 6-(3-chlorophenyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 0 |
| 6-(3-methoxyphenyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.8913 | 1 | 0 |
| N-[(4-methyl-2-thiophenyl)methyl]-6-(3-pyridinyl)-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 4.4668 | 1 | 0 |
| 6-(1,3-benzodioxol-5-yl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.1585 | 1 | 0 |
| 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.4467 | 1 | 0 |
| 6-(3-furanyl)-N-[(4-methyl-2-thiophenyl)methyl]-4-quinazolinamine | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 0 |
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4-hydroxybenzoic acid | Rattus norvegicus (Norway rat) | Ki | 6.5200 | 3 | 3 |
| catechol | Rattus norvegicus (Norway rat) | Ki | 20.6667 | 3 | 3 |
| gallic acid | Rattus norvegicus (Norway rat) | Ki | 8.2600 | 3 | 3 |
| phenol | Rattus norvegicus (Norway rat) | Ki | 187.9000 | 3 | 3 |
| 1,3-diethyl-8-phenylxanthine | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 2 | 2 |
| 1,3-diethyl-8-phenylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0445 | 1 | 1 |
| 1,3-dipropyl-8-cyclopentylxanthine | Rattus norvegicus (Norway rat) | IC50 | 0.0051 | 2 | 3 |
| 1,3-dipropyl-8-cyclopentylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 24 | 32 |
| 1,3-dipropyl-8-(4-sulfophenyl)xanthine | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 1 | 2 |
| 1,3-dipropyl-8-(4-sulfophenyl)xanthine | Rattus norvegicus (Norway rat) | Ki | 0.2025 | 6 | 8 |
| enprofylline | Rattus norvegicus (Norway rat) | Ki | 97.3333 | 3 | 3 |
| 7-(2-chloroethyl)theophylline | Rattus norvegicus (Norway rat) | Ki | 11.6000 | 2 | 2 |
| etofylline | Rattus norvegicus (Norway rat) | Ki | 105.0000 | 1 | 1 |
| 8-(4-sulfophenyl)theophylline | Rattus norvegicus (Norway rat) | IC50 | 0.4480 | 1 | 1 |
| 8-(4-sulfophenyl)theophylline | Rattus norvegicus (Norway rat) | Ki | 2.1200 | 5 | 5 |
| 8-cyclopentyl-1,3-dimethylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0094 | 4 | 5 |
| 8-phenyltheophylline | Rattus norvegicus (Norway rat) | IC50 | 0.2756 | 3 | 3 |
| 8-phenyltheophylline | Rattus norvegicus (Norway rat) | Ki | 0.1922 | 12 | 13 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0336 | 3 | 3 |
| theophylline | Rattus norvegicus (Norway rat) | IC50 | 19.0000 | 2 | 2 |
| theophylline | Rattus norvegicus (Norway rat) | Ki | 9.2781 | 31 | 37 |
| aspirin | Rattus norvegicus (Norway rat) | IC50 | 5,000.0000 | 1 | 1 |
| caffeine | Rattus norvegicus (Norway rat) | IC50 | 113.5000 | 2 | 2 |
| caffeine | Rattus norvegicus (Norway rat) | Ki | 37.5909 | 30 | 33 |
| celecoxib | Rattus norvegicus (Norway rat) | IC50 | 13.5000 | 1 | 1 |
| cgs 15943 | Rattus norvegicus (Norway rat) | IC50 | 0.0060 | 1 | 1 |
| cgs 15943 | Rattus norvegicus (Norway rat) | Ki | 0.0163 | 6 | 7 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 0.3180 | 1 | 1 |
| ibuprofen | Rattus norvegicus (Norway rat) | IC50 | 1,030.0000 | 1 | 1 |
| indomethacin | Rattus norvegicus (Norway rat) | IC50 | 164.0000 | 1 | 1 |
| 1-methyl-3-isobutylxanthine | Rattus norvegicus (Norway rat) | IC50 | 7.0000 | 1 | 1 |
| 1-methyl-3-isobutylxanthine | Rattus norvegicus (Norway rat) | Ki | 5.7278 | 7 | 9 |
| n 0840 | Rattus norvegicus (Norway rat) | Ki | 0.2716 | 4 | 5 |
| n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | Rattus norvegicus (Norway rat) | IC50 | 53.0000 | 1 | 1 |
| rolipram | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| sb 206553 | Rattus norvegicus (Norway rat) | Ki | 50.1187 | 1 | 1 |
| theobromine | Rattus norvegicus (Norway rat) | Ki | 105.0000 | 1 | 1 |
| 8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0012 | 8 | 11 |
| cordycepin | Rattus norvegicus (Norway rat) | Ki | 9.8133 | 3 | 3 |
| 2-chloroadenosine | Rattus norvegicus (Norway rat) | IC50 | 0.0370 | 1 | 1 |
| 2-chloroadenosine | Rattus norvegicus (Norway rat) | Ki | 0.1391 | 7 | 7 |
| catechin | Rattus norvegicus (Norway rat) | IC50 | 5,910.0000 | 1 | 1 |
| cyproterone acetate | Rattus norvegicus (Norway rat) | IC50 | 0.0450 | 2 | 3 |
| cyproterone acetate | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 2 | 2 |
| syringic acid | Rattus norvegicus (Norway rat) | Ki | 17.8500 | 3 | 3 |
| toyocamycin | Rattus norvegicus (Norway rat) | IC50 | 3,235,940.0000 | 1 | 1 |
| 2'-deoxyadenosine | Rattus norvegicus (Norway rat) | Ki | 23.3000 | 1 | 1 |
| nsc 65346 | Rattus norvegicus (Norway rat) | IC50 | 2,137,960.0000 | 1 | 1 |
| selegiline | Rattus norvegicus (Norway rat) | IC50 | 0.0067 | 1 | 1 |
| niguldipine | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| adenosine | Rattus norvegicus (Norway rat) | Ki | 0.1523 | 5 | 6 |
| xanthobine | Rattus norvegicus (Norway rat) | Ki | 49.0000 | 1 | 1 |
| rolofylline | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 5 | 5 |
| isoguanosine | Rattus norvegicus (Norway rat) | Ki | 0.0940 | 1 | 1 |
| 3'-amino-3'-deoxyadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0100 | 1 | 1 |
| aristeromycin | Rattus norvegicus (Norway rat) | Ki | 6.2600 | 1 | 1 |
| metrifudil | Rattus norvegicus (Norway rat) | Ki | 0.0980 | 1 | 1 |
| 9-methyladenine | Rattus norvegicus (Norway rat) | IC50 | 13.2333 | 2 | 3 |
| 9-methyladenine | Rattus norvegicus (Norway rat) | Ki | 13.6000 | 2 | 2 |
| 3-methylxanthine | Rattus norvegicus (Norway rat) | Ki | 35.0000 | 1 | 1 |
| 1-methylxanthine | Rattus norvegicus (Norway rat) | Ki | 17.7500 | 3 | 4 |
| n(6)-benzyladenosine | Rattus norvegicus (Norway rat) | IC50 | 0.1259 | 1 | 1 |
| n(6)-benzyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.8433 | 4 | 6 |
| 1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine | Rattus norvegicus (Norway rat) | Ki | 0.0025 | 3 | 4 |
| phenylisopropyladenosine | Rattus norvegicus (Norway rat) | IC50 | 0.0294 | 4 | 5 |
| phenylisopropyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.0248 | 18 | 21 |
| bromotubercidin | Rattus norvegicus (Norway rat) | IC50 | 8,317,640.0000 | 1 | 1 |
| 5-iodotubercidin | Rattus norvegicus (Norway rat) | IC50 | 38,904,500.0000 | 1 | 1 |
| 5-chlorotubercidin | Rattus norvegicus (Norway rat) | IC50 | 4,786,300.0000 | 1 | 1 |
| 5'-n-methylcarboxamideadenosine | Rattus norvegicus (Norway rat) | IC50 | 0.1050 | 1 | 1 |
| 5'-n-methylcarboxamideadenosine | Rattus norvegicus (Norway rat) | Ki | 1.8386 | 4 | 5 |
| 3,7-dimethyl-1-propargylxanthine | Rattus norvegicus (Norway rat) | Ki | 22.0000 | 4 | 4 |
| n(6)-phenyladenosine | Rattus norvegicus (Norway rat) | IC50 | 0.0049 | 2 | 2 |
| n(6)-phenyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.0051 | 8 | 10 |
| pd 81723 | Rattus norvegicus (Norway rat) | Ki | 2,208.8000 | 5 | 5 |
| bw a1433u | Rattus norvegicus (Norway rat) | Ki | 0.1850 | 4 | 6 |
| pd 128042 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.0139 | 2 | 3 |
| n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 5 | 6 |
| 2-chloro-n(6)cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 7 | 10 |
| cp 66713 | Rattus norvegicus (Norway rat) | IC50 | 0.2700 | 1 | 1 |
| cp 66713 | Rattus norvegicus (Norway rat) | Ki | 0.2700 | 2 | 3 |
| n-(4-(2-chlorophenyl)-6,7-dimethyl-3-quinolyl)-n'-(2,4-difluorophenyl)urea | Rattus norvegicus (Norway rat) | IC50 | 0.0058 | 1 | 1 |
| adenosine amine congener | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 3 | 3 |
| 8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0589 | 5 | 6 |
| ly 293558 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| 1-propylxanthine | Rattus norvegicus (Norway rat) | Ki | 8.1550 | 2 | 2 |
| 1,3-dipropyl-8-phenylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0107 | 8 | 9 |
| 8-(dicyclopropylmethyl)-1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| kfm 19 | Rattus norvegicus (Norway rat) | Ki | 0.0105 | 1 | 1 |
| n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.0520 | 1 | 1 |
| n-(2,6-bis(isopropyl)phenyl)-n'-((1-(4-(dimethylaminomethyl)phenyl)cyclopentyl)methyl)urea | Rattus norvegicus (Norway rat) | IC50 | 0.0370 | 1 | 1 |
| safinamide | Rattus norvegicus (Norway rat) | IC50 | 0.0258 | 1 | 1 |
| ici d2138 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| 8-cyclopentyl-3-(3-((4-(fluorosulfonyl)benzoyl)oxy)propyl)-1-propylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.0115 | 1 | 2 |
| 2-(1-octynyl)adenosine | Rattus norvegicus (Norway rat) | IC50 | 2.9100 | 1 | 1 |
| 2-(1-octynyl)adenosine | Rattus norvegicus (Norway rat) | Ki | 0.2714 | 6 | 8 |
| 9-(2-hydroxy-3-nonyl)adenine | Rattus norvegicus (Norway rat) | Ki | 0.4550 | 1 | 1 |
| 1-isoamyl-3-isobutylxanthine | Rattus norvegicus (Norway rat) | Ki | 7.3000 | 2 | 2 |
| naproxen | Rattus norvegicus (Norway rat) | IC50 | 1,015.0000 | 1 | 1 |
| 1-deazaadenosine | Rattus norvegicus (Norway rat) | IC50 | 6.7000 | 1 | 1 |
| 1-deazaadenosine | Rattus norvegicus (Norway rat) | Ki | 0.1150 | 1 | 1 |
| Serotonin hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| 1,3-dipropyl-7-methylxanthine | Rattus norvegicus (Norway rat) | Ki | 7.3500 | 4 | 4 |
| bw a522 | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 2 | 2 |
| bw a522 | Rattus norvegicus (Norway rat) | Ki | 0.0370 | 1 | 2 |
| sdz wag-994 | Rattus norvegicus (Norway rat) | Ki | 0.0760 | 1 | 1 |
| 2-hexynyladenosine-5'-n-ethylcarboxamide | Rattus norvegicus (Norway rat) | IC50 | 4.3800 | 1 | 1 |
| 2-hexynyladenosine-5'-n-ethylcarboxamide | Rattus norvegicus (Norway rat) | Ki | 0.8965 | 6 | 8 |
| 1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | IC50 | 1.5000 | 1 | 1 |
| 1,3-dipropylxanthine | Rattus norvegicus (Norway rat) | Ki | 0.6925 | 9 | 12 |
| sch 58261 | Rattus norvegicus (Norway rat) | Ki | 0.1210 | 2 | 3 |
| erlotinib | Rattus norvegicus (Norway rat) | IC50 | 0.0063 | 1 | 1 |
| 5-chloropyrazinamide | Rattus norvegicus (Norway rat) | IC50 | 33.2000 | 1 | 1 |
| 8-cyclohexylcaffeine | Rattus norvegicus (Norway rat) | Ki | 10.0007 | 3 | 3 |
| mrs 1067 | Rattus norvegicus (Norway rat) | Ki | 55.0000 | 2 | 2 |
| mrs 1191 | Rattus norvegicus (Norway rat) | Ki | 30.0850 | 3 | 4 |
| mrs 1220 | Rattus norvegicus (Norway rat) | Ki | 0.1368 | 5 | 6 |
| 5'-methylthioadenosine | Rattus norvegicus (Norway rat) | IC50 | 5.4867 | 2 | 3 |
| 5'-methylthioadenosine | Rattus norvegicus (Norway rat) | Ki | 0.2000 | 3 | 3 |
| 5'-deoxyadenosine | Rattus norvegicus (Norway rat) | Ki | 6.9600 | 2 | 2 |
| ferulic acid | Rattus norvegicus (Norway rat) | Ki | 9.9033 | 3 | 3 |
| 2'-amino-2'-deoxyadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0100 | 1 | 1 |
| adenosine-5'-(n-ethylcarboxamide) | Rattus norvegicus (Norway rat) | IC50 | 21.8554 | 8 | 9 |
| adenosine-5'-(n-ethylcarboxamide) | Rattus norvegicus (Norway rat) | Ki | 0.1589 | 20 | 25 |
| 1-deaza-2-chloro-n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | IC50 | 0.3600 | 1 | 1 |
| 1-deaza-2-chloro-n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.0253 | 2 | 2 |
| 3'-c-methyladenosine | Rattus norvegicus (Norway rat) | Ki | 51.0000 | 1 | 1 |
| 2'-c-methyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.7400 | 1 | 1 |
| trans-4-coumaric acid | Rattus norvegicus (Norway rat) | Ki | 7.4833 | 3 | 3 |
| ly382884 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | IC50 | 3.1692 | 11 | 12 |
| n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.0422 | 28 | 41 |
| 1-methyltryptophan | Rattus norvegicus (Norway rat) | Ki | 6.6000 | 1 | 1 |
| caffeic acid | Rattus norvegicus (Norway rat) | Ki | 8.9500 | 3 | 3 |
| N-[4-(2-pyridinyl)-2-thiazolyl]cyclopentanecarboxamide | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 2 |
| fk 838 | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 1 | 2 |
| fk 838 | Rattus norvegicus (Norway rat) | Ki | 0.0066 | 2 | 2 |
| 2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide | Rattus norvegicus (Norway rat) | Ki | 0.8200 | 4 | 4 |
| adenosine-5'-(N-propyl)carboxamide | Rattus norvegicus (Norway rat) | Ki | 1.9200 | 3 | 4 |
| 2-((2-aminoethylamino)carbonylethylphenylethylamino)-5'-n-ethylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ki | 0.2400 | 1 | 1 |
| 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ki | 2.1438 | 11 | 13 |
| 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline | Rattus norvegicus (Norway rat) | Ki | 13.2000 | 1 | 1 |
| mrs 1523 | Rattus norvegicus (Norway rat) | Ki | 15.6000 | 1 | 1 |
| quercetin | Rattus norvegicus (Norway rat) | Ki | 8.9000 | 3 | 3 |
| linoleic acid | Rattus norvegicus (Norway rat) | IC50 | 65.0000 | 1 | 1 |
| quercitrin | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| hispidol | Rattus norvegicus (Norway rat) | Ki | 0.3520 | 1 | 1 |
| ellagic acid | Rattus norvegicus (Norway rat) | Ki | 10.5700 | 3 | 3 |
| mre 3008-f20 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| istradefylline | Rattus norvegicus (Norway rat) | Ki | 0.2300 | 1 | 1 |
| endomorphin 1 | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 1 |
| psb 1115 | Rattus norvegicus (Norway rat) | Ki | 1.7190 | 2 | 2 |
| n-(1-methyl-2-phenylethyl)adenosine, (s)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.1050 | 1 | 1 |
| n-(1-methyl-2-phenylethyl)adenosine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.1498 | 9 | 10 |
| 8-(3-chlorostyryl)caffeine | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 1 | 1 |
| 8-(3-chlorostyryl)caffeine | Rattus norvegicus (Norway rat) | Ki | 28.1333 | 2 | 3 |
| 7-chloro-4-hydroxy-2-phenyl-1,8-naphthyridine | Rattus norvegicus (Norway rat) | Ki | 0.6700 | 1 | 1 |
| squalestatin 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| bw a1433 | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 2 | 3 |
| fk 453 | Rattus norvegicus (Norway rat) | IC50 | 0.0171 | 3 | 4 |
| fk 453 | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| kf 17837 | Rattus norvegicus (Norway rat) | IC50 | 0.0620 | 1 | 1 |
| kf 17837 | Rattus norvegicus (Norway rat) | Ki | 0.4300 | 2 | 2 |
| bay-k-8644, (-)-isomer | Rattus norvegicus (Norway rat) | Ki | 6.6600 | 1 | 2 |
| mrs 1754 | Rattus norvegicus (Norway rat) | Ki | 0.0168 | 3 | 3 |
| bay-k-8644 | Rattus norvegicus (Norway rat) | Ki | 0.7850 | 1 | 2 |
| cv 1808 | Rattus norvegicus (Norway rat) | IC50 | 1.3800 | 1 | 1 |
| cv 1808 | Rattus norvegicus (Norway rat) | Ki | 0.5556 | 5 | 5 |
| dexniguldipine | Rattus norvegicus (Norway rat) | Ki | 41.3000 | 1 | 1 |
| binodenoson | Rattus norvegicus (Norway rat) | Ki | 0.2700 | 1 | 2 |
| 5'-amino-5'-deoxyadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0100 | 1 | 1 |
| n(6)-cyclohexyladenosine | Rattus norvegicus (Norway rat) | IC50 | 0.0024 | 4 | 5 |
| n(6)-cyclohexyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.0041 | 8 | 10 |
| pexacerfont | Rattus norvegicus (Norway rat) | Ki | 2.6600 | 1 | 1 |
| n-((1s,trans)-2-hydroxycyclopentyl)adenosine | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 1 | 1 |
| zaragozic acid b | Rattus norvegicus (Norway rat) | IC50 | 0.0002 | 1 | 1 |
| mrs 1097 | Rattus norvegicus (Norway rat) | Ki | 5.9300 | 2 | 3 |
| 3-iodo-4-aminobenzyl-5'-N-methylcarboxamidoadenosine | Rattus norvegicus (Norway rat) | Ki | 0.0034 | 1 | 1 |
| vuf 8504 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 3 |
| fauc 365 | Rattus norvegicus (Norway rat) | Ki | 0.3700 | 1 | 1 |
| n(6)-(2,2-diphenylethyl)adenosine | Rattus norvegicus (Norway rat) | Ki | 0.0142 | 4 | 5 |
| cgs 24012 | Rattus norvegicus (Norway rat) | Ki | 0.1140 | 4 | 4 |
| n-cyclopropyl adenosine-5'-carboxamide | Rattus norvegicus (Norway rat) | IC50 | 0.0105 | 1 | 1 |
| n-cyclopropyl adenosine-5'-carboxamide | Rattus norvegicus (Norway rat) | Ki | 0.1216 | 5 | 6 |
| psb 36 | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| lj 529 | Rattus norvegicus (Norway rat) | Ki | 0.1400 | 1 | 1 |
| zaragozic acid c | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 1 |
| psb603 | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| psb603 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.3530 | 1 | 1 |
| olanzapine | Rattus norvegicus (Norway rat) | Ki | 0.0850 | 1 | 1 |
| psb 11 | Rattus norvegicus (Norway rat) | Ki | 0.4400 | 2 | 2 |
| cgs 15696 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor.Bioorganic & medicinal chemistry, , Oct-15, Volume: 23, Issue:20, 2015
Synthesis and adenosine receptor binding studies of some novel triazolothienopyrimidines.European journal of medicinal chemistry, , Volume: 43, Issue:3, 2008
Development of spin-labeled probes for adenosine receptors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.Journal of medicinal chemistry, , Apr-25, Volume: 45, Issue:9, 2002
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.Journal of natural products, , Volume: 65, Issue:10, 2002
Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist.Bioorganic & medicinal chemistry letters, , Jul-19, Volume: 9, Issue:14, 1999
Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)- pyridazinebutanoic acid (FK 838): a novel non-xanthine adenosine A1 receptor antagonist with potent diuretic activity.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application.Journal of medicinal chemistry, , Volume: 28, Issue:8, 1985
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-01, Volume: 45, Issue:16, 2002
Imidazodiazepinediones: a new class of adenosine receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:7, 1986
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application.Journal of medicinal chemistry, , Volume: 28, Issue:8, 1985
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Mesoionic xanthine analogues: antagonists of adenosine receptors.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Adenosine A2A receptor as a drug discovery target.Journal of medicinal chemistry, , May-08, Volume: 57, Issue:9, 2014
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-01, Volume: 45, Issue:16, 2002
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Imidazodiazepinediones: a new class of adenosine receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:5, 1988
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:7, 1986
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Mesoionic xanthine analogues: antagonists of adenosine receptors.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.Bioorganic & medicinal chemistry, , 04-01, Volume: 27, Issue:7, 2019
Fluorescent-Labeled Selective Adenosine AJournal of medicinal chemistry, , 05-24, Volume: 61, Issue:10, 2018
[no title available]European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Discovery of 1,3-diethyl-7-methyl-8-(phenoxymethyl)-xanthine derivatives as novel adenosine ABioorganic & medicinal chemistry letters, , 12-15, Volume: 26, Issue:24, 2016
[no title available]Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-01, Volume: 45, Issue:16, 2002
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Imidazodiazepinediones: a new class of adenosine receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:7, 1986
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Mesoionic xanthine analogues: antagonists of adenosine receptors.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Adenosine A2A receptor as a drug discovery target.Journal of medicinal chemistry, , May-08, Volume: 57, Issue:9, 2014
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.Journal of medicinal chemistry, , Mar-01, Volume: 44, Issue:5, 2001
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.Journal of medicinal chemistry, , Jul-16, Volume: 41, Issue:15, 1998
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Imidazodiazepinediones: a new class of adenosine receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:7, 1986
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.Journal of medicinal chemistry, , Apr-25, Volume: 45, Issue:9, 2002
Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995
5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.Journal of medicinal chemistry, , Mar-01, Volume: 44, Issue:5, 2001
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985
N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: a new class of non-xanthine adenosine A1 receptor antagonists.Journal of medicinal chemistry, , Nov-07, Volume: 40, Issue:23, 1997
Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Discovery and Structure-Activity Relationship Studies of Novel Adenosine AJournal of medicinal chemistry, , 11-10, Volume: 65, Issue:21, 2022
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues.Journal of medicinal chemistry, , Volume: 26, Issue:11, 1983
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Design and in Vivo Characterization of AJournal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:7, 1986
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985
Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.European journal of medicinal chemistry, , Aug-28, Volume: 101, 2015
Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.Journal of medicinal chemistry, , Sep-25, Volume: 57, Issue:18, 2014
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.Journal of medicinal chemistry, , Sep-13, Volume: 55, Issue:17, 2012
Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.Bioorganic & medicinal chemistry, , Jan-15, Volume: 20, Issue:2, 2012
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.Bioorganic & medicinal chemistry letters, , May-01, Volume: 18, Issue:9, 2008
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-13, Volume: 41, Issue:17, 1998
Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995
Design and in Vivo Characterization of AJournal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.Journal of medicinal chemistry, , Aug-30, Volume: 44, Issue:18, 2001
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
2-[N'-(3-arylallylidene)hydrazino]adenosines showing A2a adenosine agonist properties and vasodilation activity.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:7, 1986
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors.Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.Journal of medicinal chemistry, , May-13, Volume: 37, Issue:10, 1994
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.Journal of medicinal chemistry, , Sep-03, Volume: 36, Issue:18, 1993
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:7, 1986
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Mesoionic xanthine analogues: antagonists of adenosine receptors.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.Journal of medicinal chemistry, , Feb-10, Volume: 54, Issue:3, 2011
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.Journal of medicinal chemistry, , Mar-27, Volume: 46, Issue:7, 2003
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-01, Volume: 40, Issue:16, 1997
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.Journal of medicinal chemistry, , Jul-16, Volume: 41, Issue:15, 1998
Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-01, Volume: 40, Issue:16, 1997
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.Journal of medicinal chemistry, , Nov-04, Volume: 42, Issue:22, 1999
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.Journal of medicinal chemistry, , Jul-16, Volume: 41, Issue:15, 1998
Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-01, Volume: 40, Issue:16, 1997
Discovery and Structure-Activity Relationship Studies of Novel Adenosine AJournal of medicinal chemistry, , 11-10, Volume: 65, Issue:21, 2022
Design and in Vivo Characterization of AJournal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.Bioorganic & medicinal chemistry, , Jan-15, Volume: 21, Issue:2, 2013
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.Journal of medicinal chemistry, , May-10, Volume: 55, Issue:9, 2012
2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.Journal of medicinal chemistry, , Jan-18, Volume: 44, Issue:2, 2001
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
Nucleosides and nucleotides. 177. 9-(6,7-dideoxy-beta-D-allo-hept-5- ynofuranosyl)adenine: a selective and potent ligand for P3 purinoceptor-like protein.Journal of medicinal chemistry, , Jul-16, Volume: 41, Issue:15, 1998
2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors.Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
2-[N'-(3-arylallylidene)hydrazino]adenosines showing A2a adenosine agonist properties and vasodilation activity.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor.Bioorganic & medicinal chemistry, , Oct-15, Volume: 23, Issue:20, 2015
Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.Journal of natural products, , Volume: 65, Issue:10, 2002
5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.Journal of medicinal chemistry, , Aug-30, Volume: 44, Issue:18, 2001
Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'receptor knock-down' tool.Bioorganic & medicinal chemistry letters, , Mar-26, Volume: 11, Issue:6, 2001
2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes.Bioorganic & medicinal chemistry letters, , Sep-18, Volume: 10, Issue:18, 2000
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
5'-substituted adenosine analogs as new high-affinity partial agonists for the adenosine A1 receptor.Journal of medicinal chemistry, , Jan-01, Volume: 41, Issue:1, 1998
N6,C8-distributed adenosine derivatives as partial agonists for adenosine A1 receptors.Journal of medicinal chemistry, , Mar-29, Volume: 39, Issue:7, 1996
Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)- pyridazinebutanoic acid (FK 838): a novel non-xanthine adenosine A1 receptor antagonist with potent diuretic activity.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist.Bioorganic & medicinal chemistry letters, , Jul-19, Volume: 9, Issue:14, 1999
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.Bioorganic & medicinal chemistry letters, , May-01, Volume: 18, Issue:9, 2008
N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-13, Volume: 41, Issue:17, 1998
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.Journal of medicinal chemistry, , May-10, Volume: 55, Issue:9, 2012
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.Bioorganic & medicinal chemistry, , Jan-15, Volume: 21, Issue:2, 2013
2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
2-[N'-(3-arylallylidene)hydrazino]adenosines showing A2a adenosine agonist properties and vasodilation activity.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
AJournal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.Journal of medicinal chemistry, , Feb-12, Volume: 47, Issue:4, 2004
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor.Bioorganic & medicinal chemistry, , Oct-15, Volume: 23, Issue:20, 2015
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.Journal of medicinal chemistry, , Jan-18, Volume: 44, Issue:2, 2001
Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)- pyridazinebutanoic acid (FK 838): a novel non-xanthine adenosine A1 receptor antagonist with potent diuretic activity.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist.Bioorganic & medicinal chemistry letters, , Jul-19, Volume: 9, Issue:14, 1999
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.Journal of medicinal chemistry, , Jan-18, Volume: 44, Issue:2, 2001
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Adenosine A2A receptor as a drug discovery target.Journal of medicinal chemistry, , May-08, Volume: 57, Issue:9, 2014
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.Journal of medicinal chemistry, , Feb-11, Volume: 59, Issue:3, 2016
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues.Journal of medicinal chemistry, , Volume: 26, Issue:11, 1983
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-01, Volume: 40, Issue:16, 1997
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.Journal of medicinal chemistry, , Mar-01, Volume: 44, Issue:5, 2001
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Design and in Vivo Characterization of AJournal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.Journal of medicinal chemistry, , May-10, Volume: 55, Issue:9, 2012
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
Adenosine receptors: targets for future drugs.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Fluorescent-Labeled Selective Adenosine AJournal of medicinal chemistry, , 05-24, Volume: 61, Issue:10, 2018
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.Journal of medicinal chemistry, , Aug-01, Volume: 45, Issue:16, 2002