Compounds > win 54954
Page last updated: 2024-12-08

win 54954

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Description

Win 54954: broad-spectrum antipicornavirus drug; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID441048
CHEMBL ID6594
CHEBI ID10029
SCHEMBL ID8755546
MeSH IDM0173069

Synonyms (31)

Synonym
C06493
5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methylisoxazole
win54954
107355-45-3
win 54954
5-[5-[2,6-dichloro-4-(4,5-dihydrooxazol-2-yl)phenoxy]pentyl]-3-methyl-isoxazole
isoxazole, 5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methyl-
DB08723
win-54954
chebi:10029 ,
CHEMBL6594
AC1L9AGT ,
5-[5-[2,6-dichloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl]-3-methyl-1,2-oxazole
JJDHAOLOHQTGMG-UHFFFAOYSA-N
5-{5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-methylisoxazole
iy9rjd7jgi ,
unii-iy9rjd7jgi
5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methylisoxazole
5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methyl isoxazole
SCHEMBL8755546
surecn8755546
isoxazole, 5-[5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl]-3-methyl-
5-{5-[2,6-dichloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole
Q27097908
5-(5-(2,6-dichloro-4-(4,5-dihydrooxazol-2-yl)phenoxy)pentyl)-3-methylisoxazole
MS-26285
DTXSID90910301
5-{5-[2,6-dichloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methyl-1,2-oxazole
HY-106296
EX-A5700
CS-0025537

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" At the PD50 doses for these two viruses, levels of WIN 54954 in serum were maintained above the in vitro MICs for a significant portion of the dosing interval."( In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug.
Diana, GD; Dutko, FJ; McKinlay, MA; Otto, MJ; Rogge, MC; Woods, MG, 1989)		0.8
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (145)

Assay IDTitleYearJournalArticle
AID85066Minimum inhibitory concentration on HRV serotype 671995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85055Minimum inhibitory concentration on HRV serotype 551995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205047Minimum inhibitory concentration against human rhinovirus serotype 301992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID84737Minimum inhibitory concentration in vitro against HRV-14 in a plaque reduction assay1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID162234In vitro activity against polioviurs-1 (Mahoney)1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID68436In vitro activity against echovirus-61989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID162235In vitro activity against polioviurs-2 (Lansing)1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID68433In vitro activity against coxsackie A- 211989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID93741In vitro antiviral activity against human rhinovirus-41 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID205055In vitro inhibition of 80% of the serotypes1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID93743Minimum inhibitory concentration which inhibits 80% of serotypes was determined1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID85205Minimum inhibitory concentration on HRV serotype 961995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID68437In vitro activity against echovirus-9 (Barty)1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID93608In vitro antiviral activity against human rhinovirus 14 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID93621In vitro antiviral activity against human rhinovirus-30 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID84749Minimum inhibitory concentration on HRV serotype 161995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84917Minimum inhibitory concentration on HRV serotype 241995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85038Minimum inhibitory concentration on HRV serotype 351995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID15655Tested for pharmacokinetic parameter in fasted Beagle dogs (Clearance value of the compound) iv administration.1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Picornavirus inhibitors: trifluoromethyl substitution provides a global protective effect against hepatic metabolism.
AID84927Minimum inhibitory concentration on HRV serotype 331995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85061Minimum inhibitory concentration on HRV serotype 611995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205049Minimum inhibitory concentration against human rhinovirus serotype 501992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID205043Minimum inhibitory concentration against human rhinovirus serotype 21992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID199857In vitro anti-rhinovirus activity was measured as maximum testable levels - highest concentration of compound which causes no apparent effect on the cell monolayers1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID93613In vitro antiviral activity against human rhinovirus 6 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID85082Minimum inhibitory concentration on HRV serotype 851995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85042Minimum inhibitory concentration on HRV serotype 401995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID93615In vitro antiviral activity against human rhinovirus 86 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID54490In vitro activity against coxsackie A- 211989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID23988Partition coefficient (logP) (HPLC)1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID84897Minimum inhibitory concentration on HRV serotype 21995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84551Concentration inhibiting 50% of the serotypes tested to 50% of the viral concentration of untreated controls following 72 hr of exposure1995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85080Minimum inhibitory concentration on HRV serotype 831995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID93617In vitro antiviral activity against human rhinovirus-15 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID85039Minimum inhibitory concentration on HRV serotype 361995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84916Minimum inhibitory concentration on HRV serotype 231995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205044Minimum inhibitory concentration against human rhinovirus serotype 211992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID93612In vitro antiviral activity against human rhinovirus 50 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID54496In vitro activity against echovirus-121989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID93749In vitro antiviral activity against human rhinovirus 1A serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID85064Minimum inhibitory concentration on HRV serotype 641995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID199866Minimum inhibitory concentration against rhinovirus serotype 251989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID85046Minimum inhibitory concentration on HRV serotype 441995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85049Minimum inhibitory concentration on HRV serotype 491995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID54492In vitro activity against coxsackie A- 91989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID199870Minimum inhibitory concentration against rhinovirus serotype 6.1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID199869Minimum inhibitory concentration against rhinovirus serotype 501989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84923Minimum inhibitory concentration on HRV serotype 301995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205040Minimum inhibitory concentration against human rhinovirus serotype 151992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID85057Minimum inhibitory concentration on HRV serotype 571995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84585Tested for in vitro antiviral activity against Human rhinovirus (HRV)-141994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199862Minimum inhibitory concentration against rhinovirus serotype 1B.1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84750Minimum inhibitory concentration on HRV serotype 191995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID199867Minimum inhibitory concentration against rhinovirus serotype 301989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID199864Minimum inhibitory concentration against rhinovirus serotype 21.1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID85047Minimum inhibitory concentration on HRV serotype 461995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84581Minimum inhibitory concentration on HRV serotype 1001995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85081Minimum inhibitory concentration on HRV serotype 841995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85077Minimum inhibitory concentration on HRV serotype 801995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85202Minimum inhibitory concentration on HRV serotype 91995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85069Minimum inhibitory concentration on HRV serotype 681995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84918Minimum inhibitory concentration on HRV serotype 251995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205045Minimum inhibitory concentration against human rhinovirus serotype 221992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID85070Minimum inhibitory concentration on HRV serotype 71995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85054Minimum inhibitory concentration on HRV serotype 531995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID199868Minimum inhibitory concentration against rhinovirus serotype 411989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID93616In vitro antiviral activity against human rhinovirus 89 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID85048Minimum inhibitory concentration on HRV serotype 471995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84745Minimum inhibitory concentration on HRV serotype 151995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205039Minimum inhibitory concentration against human rhinovirus serotype 141992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID162236In vitro activity against polioviurs-2 (MEF)1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID205053Minimum inhibitory concentration against human rhinovirus serotype 891992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID54495In vitro activity against coxsackie B-41989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID68435In vitro activity against echovirus-41989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID54491In vitro activity against coxsackie A- 41989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID85053Minimum inhibitory concentration on HRV serotype 511995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85085Minimum inhibitory concentration on HRV serotype 881995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85040Minimum inhibitory concentration on HRV serotype 381995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85063Minimum inhibitory concentration on HRV serotype 631995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205042Minimum inhibitory concentration against human rhinovirus serotype 1B1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID84922Minimum inhibitory concentration on HRV serotype 291995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85045Minimum inhibitory concentration on HRV serotype 431995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID93619In vitro antiviral activity against human rhinovirus-22 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID85073Minimum inhibitory concentration on HRV serotype 751995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID54498In vitro activity of the compound against echovirus-121989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84889In vitro determined against HRV-1A in a plaque reduction assay1992Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25
Conformationally restricted analogues of disoxaril: a comparison of the activity against human rhinovirus types 14 and 1A.
AID162233In vitro activity against coxsackie A- 41989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84926Minimum inhibitory concentration on HRV serotype 321995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID14911Tested for pharmacokinetic parameter in fasted Beagle dogs (Area Under Curve value) iv administration.1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Picornavirus inhibitors: trifluoromethyl substitution provides a global protective effect against hepatic metabolism.
AID199874Concentration required to inhibit 80 percent rhinovirus cell culture1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84548Antirhinoviral activity calculated for mean of fifteen serotypes (HRV-1A, -1B, -2, -6, -14, -15, -21, -22, -25, -30, -41, --50, -67, -86, -89)1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID85079Minimum inhibitory concentration on HRV serotype 821995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85206Minimum inhibitory concentration on HRV serotype T391995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84723Compound was tested in vitro for minimal inhibitory constant against HRV-141994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID54494In vitro activity against coxsackie B-21989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID68434In vitro activity against echovirus-31989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID205051Minimum inhibitory concentration against human rhinovirus serotype 671992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID85072Minimum inhibitory concentration on HRV serotype 731995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85071Minimum inhibitory concentration on HRV serotype 711995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85074Minimum inhibitory concentration on HRV serotype 761995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85041Minimum inhibitory concentration on HRV serotype 391995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85058Minimum inhibitory concentration on HRV serotype 581995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID54489In vitro activity against coxsackie A- 111989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID68432In vitr oactivity against echovirus-31989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID89493Compound was evaluated for inhibitory effect against human Rhinovirus-141992Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14.
AID84884Minimum inhibitory concentration on HRV serotype 1A1995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID93614In vitro antiviral activity against human rhinovirus 67 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID84910Minimum inhibitory concentration on HRV serotype 211995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205050Minimum inhibitory concentration against human rhinovirus serotype 61992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID93618In vitro antiviral activity against human rhinovirus-21 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID84553In vitro concentration required to inhibit 80 percent of human rhinovirus 15 serotypes was determined by TCID50 assay1994Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity.
AID84921Minimum inhibitory concentration on HRV serotype 281995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205046Minimum inhibitory concentration against human rhinovirus serotype 251992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID85062Minimum inhibitory concentration on HRV serotype 621995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85076Minimum inhibitory concentration on HRV serotype 791995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85078Minimum inhibitory concentration on HRV serotype 811995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID199860Minimum inhibitory concentration against rhinovirus serotype 151989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID85065Minimum inhibitory concentration on HRV serotype 661995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85050Minimum inhibitory concentration on HRV serotype 501995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID54497In vitro activity against echovirus-301989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID93748In vitro antiviral activity against human rhinovirus 1B serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID54493In vitro activity against coxsackie A-21989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84582Minimum inhibitory concentration on HRV serotype 111995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID23989Calculated partition coefficient (clogP)1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID199871Minimum inhibitory concentration against rhinovirus serotype 671989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID85086Minimum inhibitory concentration on HRV serotype 891995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85056Minimum inhibitory concentration on HRV serotype 561995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID23852Tested for pharmacokinetic parameter in fasted Beagle dogs (Half-life) iv administration.1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Picornavirus inhibitors: trifluoromethyl substitution provides a global protective effect against hepatic metabolism.
AID85204Minimum inhibitory concentration on HRV serotype 921995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID93611In vitro antiviral activity against human rhinovirus 2 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID199861Minimum inhibitory concentration against rhinovirus serotype 1A1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID93620In vitro antiviral activity against human rhinovirus-25 serotype1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Antipicornavirus activity of tetrazole analogues related to disoxaril.
AID84909Minimum inhibitory concentration on HRV serotype 201995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84913Minimum inhibitory concentration on HRV serotype 221995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID84928Minimum inhibitory concentration on HRV serotype 341995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205048Minimum inhibitory concentration against human rhinovirus serotype 411992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID199854Estimation by using phi 21 in combination with log P of compound 13 determined via RPHPLC-retention time procedure1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID85075Minimum inhibitory concentration on HRV serotype 781995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID85203Minimum inhibitory concentration on HRV serotype 901995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205041Minimum inhibitory concentration against human rhinovirus serotype 1A1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID84736In vitro determined against HRV-14 in a plaque reduction assay1992Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25
Conformationally restricted analogues of disoxaril: a comparison of the activity against human rhinovirus types 14 and 1A.
AID199856In vitro anti-rhinovirus activity was measured as mean MIC for five serotypes, HRV-1A, -2, -22, -41, and -501989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84893Minimum inhibitory concentration on HRV serotype 1B1995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors.
AID205052Minimum inhibitory concentration against human rhinovirus serotype 861992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Antirhinoviral activity of heterocyclic analogs of Win 54954.
AID199872Minimum inhibitory concentration against rhinovirus serotype 861989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (8.33)18.7374
1990's20 (83.33)18.2507
2000's2 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.02 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index5.31 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (8.33%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pleconaril
WIN 63843: structure given in first source		1.9810
win 52035
Win 52035: structure given in first source		2.6730aromatic ether
win 53338
WIN 53338: structure given in first source. 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole : An isoxazole compound having a methyl substituent at the 3-position and a 5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl substituent at the 5-position.		1.9810isoxazoles;
monochlorobenzenes		antiviral agent
win 52084
Win 52084: structure given in first source; RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 7/89		2.3820aromatic ether
fluoroform
fluoroform: structure		1.9810fluoromethanesrefrigerant
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		6.18182isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		1.97101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
disoxaril
disoxaril: antipicornavirus agent		2.3820aromatic ether
r 61837
R 61837: antirhinovirus cpd; structure given in first source		1.9810
win 56291
Win 56291: anti-rhinoviral drug; structure given in first source		2.3820
chiniofon
Hydroxyquinolines: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.		1.9810
roquinimex
roquinimex: structure in first source		1.9810aromatic amide
ConditionIndicatedRelationship StrengthStudiesTrials
Alloxan Diabetes
[description not available]		01.9810
Coxsackie Virus Infections
[description not available]		03.3770
Infections, Picornaviridae
[description not available]		03.7721
Carditis
[description not available]		03.0850
Myocarditis
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.		03.0850
Chicken Pox
[description not available]		01.9910
Chickenpox
A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)		01.9910
EHS Tumor
[description not available]		01.9910
Enterovirus Infections
Diseases caused by ENTEROVIRUS.		02.0110
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.0110
Echo Virus Infections
[description not available]		01.9710