Bcl2-associated agonist of cell death

A Bcl2-associated agonist of cell death that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92934]

Synonyms

BAD;
Bcl-2-binding component 6;
Bcl-2-like protein 8;
Bcl2-L-8;
Bcl-xL/Bcl-2-associated death promoter;
Bcl2 antagonist of cell death

Research

Bioassay Publications (6)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (66.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (33.33)	2.80

Compounds (8)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gossypol	Homo sapiens (human)	Ki	0.4600	1	1
sanguinarine	Homo sapiens (human)	IC50	19.0000	1	1
epigallocatechin gallate	Homo sapiens (human)	Ki	0.4900	1	1
chelerythrine chloride	Homo sapiens (human)	IC50	100.0000	1	1
abt-737	Homo sapiens (human)	Ki	0.0008	2	2
navitoclax	Homo sapiens (human)	Ki	0.0008	2	2
abt-199	Homo sapiens (human)	Ki	16.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
5,6,7,8-tetrahydro-1-naphthol	Homo sapiens (human)	Kd	2,000.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
phospholipid binding	molecular function	Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
lipid binding	molecular function	Binding to a lipid. [GOC:ai]
cysteine-type endopeptidase activator activity involved in apoptotic process	molecular function	Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process. [GOC:mah, GOC:mtg_apoptosis]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
protein phosphatase binding	molecular function	Binding to a protein phosphatase. [GOC:jl]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial outer membrane	cellular component	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
BAD-BCL-2 complex	cellular component	A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]

Involved In

This protein is involved in 35 target(s):

Target	Category	Definition
glucose catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. [GOC:ai]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
activation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
extrinsic apoptotic signaling pathway via death domain receptors	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. [GOC:mah, GOC:mtg_apoptosis]
intrinsic apoptotic signaling pathway in response to DNA damage	biological process	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis]
positive regulation of autophagy	biological process	Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
positive regulation of mitochondrial membrane potential	biological process	Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:dph, GOC:tb]
cytokine-mediated signaling pathway	biological process	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629]
positive regulation of insulin secretion	biological process	Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]
positive regulation of glucokinase activity	biological process	Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. [GOC:mah]
positive regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]
glucose homeostasis	biological process	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
type B pancreatic cell proliferation	biological process	The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. [GOC:jl, GOC:yaf]
positive regulation of B cell differentiation	biological process	Any process that activates or increases the frequency, rate or extent of B cell differentiation. [GOC:go_curators]
positive regulation of T cell differentiation	biological process	Any process that activates or increases the frequency, rate or extent of T cell differentiation. [GOC:go_curators]
positive regulation of proteolysis	biological process	Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators]
ADP metabolic process	biological process	The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. [GOC:go_curators]
ATP metabolic process	biological process	The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]
regulation of mitochondrial membrane permeability	biological process	Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. [GOC:bf]
pore complex assembly	biological process	The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. [GOC:jl, GOC:mah]
positive regulation of epithelial cell proliferation	biological process	Any process that activates or increases the rate or extent of epithelial cell proliferation. [GOC:ai]
cellular response to mechanical stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:mah]
cellular response to nicotine	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:mah]
cellular response to lipid	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. [GOC:mah]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
positive regulation of release of cytochrome c from mitochondria	biological process	Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
extrinsic apoptotic signaling pathway	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]
extrinsic apoptotic signaling pathway in absence of ligand	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]
intrinsic apoptotic signaling pathway	biological process	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]
activation of cysteine-type endopeptidase activity	biological process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. [GOC:mtg_apoptosis, PMID:21726810]
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	biological process	Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
positive regulation of type B pancreatic cell development	biological process	Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. [GOC:obol, GOC:yaf]
release of cytochrome c from mitochondria	biological process	The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217]