Proteins > Amine oxidase [flavin-containing] B
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Amine oxidase [flavin-containing] B
An amine oxidase [flavin-containing] B that is encoded in the genome of rat. [OMA:P19643, PRO:DNx]
Synonyms
EC 1.4.3.4;
Monoamine oxidase type B;
MAO-B
Research
Bioassay Publications (55)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 4 (7.27) | 18.7374 |
| 1990's | 5 (9.09) | 18.2507 |
| 2000's | 18 (32.73) | 29.6817 |
| 2010's | 24 (43.64) | 24.3611 |
| 2020's | 4 (7.27) | 2.80 |
Compounds (69)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 1-(10h-phenothiazin-2-yl)ethanone | Rattus norvegicus (Norway rat) | EC50 | 50.0000 | 1 | 0 |
| u 69593 | Rattus norvegicus (Norway rat) | EC50 | 0.3300 | 1 | 1 |
| 1-(1-benzimidazolyl)-3-(1-cyclohex-3-enylmethoxy)-2-propanol | Rattus norvegicus (Norway rat) | EC50 | 50.0000 | 1 | 0 |
| 2-(2-phenylethylthio)-3-pyridinecarboxylic acid | Rattus norvegicus (Norway rat) | EC50 | 50.0000 | 1 | 0 |
| 4-(2-furanylmethyl)-3-(phenylmethyl)-1H-1,2,4-triazole-5-thione | Rattus norvegicus (Norway rat) | EC50 | 50.0000 | 1 | 0 |
| 4-oxido-3-(4-phenoxyphenyl)-4a,5,6,7,8,8a-hexahydroquinoxalin-1-ium 1-oxide | Rattus norvegicus (Norway rat) | EC50 | 50.0000 | 1 | 0 |
| (r)-n-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine | Rattus norvegicus (Norway rat) | EC50 | 2.2000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| selegiline | Rattus norvegicus (Norway rat) | Activity | 0.0011 | 1 | 2 |
| tryptoline | Rattus norvegicus (Norway rat) | Selectivity | 9.9100 | 1 | 1 |
| desmethylselegiline | Rattus norvegicus (Norway rat) | Activity | 0.0013 | 1 | 1 |
| md 230254 | Rattus norvegicus (Norway rat) | Kieq | 0.0007 | 1 | 1 |
Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 30, Issue:4, 2020
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.Chemical biology & drug design, , Volume: 88, Issue:6, 2016
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17, 2018
Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.Bioorganic & medicinal chemistry, , Feb-15, Volume: 18, Issue:4, 2010
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.Bioorganic & medicinal chemistry, , Sep-01, Volume: 15, Issue:17, 2007
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
[no title available]Journal of natural products, , 04-26, Volume: 82, Issue:4, 2019
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.Bioorganic & medicinal chemistry, , Sep-01, Volume: 15, Issue:17, 2007
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.ACS medicinal chemistry letters, , Oct-15, Volume: 3, Issue:1, 2011
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
New 6-Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models.Journal of medicinal chemistry, , 07-14, Volume: 59, Issue:13, 2016
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Synthesis and selective monoamine oxidase B-inhibiting properties of 1-methyl-1,2,3,6-tetrahydropyrid-4-yl carbamate derivatives: potential prodrugs of (R)- and (S)-nordeprenyl.Journal of medicinal chemistry, , Nov-22, Volume: 39, Issue:24, 1996
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors.Journal of medicinal chemistry, , Oct-02, Volume: 35, Issue:20, 1992
Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships.Journal of medicinal chemistry, , Volume: 28, Issue:2, 1985
Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Selective and potent monoamine oxidase type B inhibitors: 2-substituted 5-aryltetrazole derivatives.Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Discovery of 3, 6-disubstituted isobenzofuran-1(3H)-ones as novel inhibitors of monoamine oxidases.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 67, 2022
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.Journal of medicinal chemistry, , Oct-04, Volume: 50, Issue:20, 2007
Rasagiline derivatives combined with histamine HBioorganic & medicinal chemistry letters, , 10-01, Volume: 29, Issue:19, 2019
Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.Journal of medicinal chemistry, , Nov-21, Volume: 45, Issue:24, 2002
Synthetic approaches to unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles and their MAO-B inhibitory activity. A review.Bioorganic & medicinal chemistry, , 01-01, Volume: 29, 2021
Selective and potent monoamine oxidase type B inhibitors: 2-substituted 5-aryltetrazole derivatives.Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Rasagiline derivatives combined with histamine HBioorganic & medicinal chemistry letters, , 10-01, Volume: 29, Issue:19, 2019
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17, 2018
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.Journal of medicinal chemistry, , Feb-12, Volume: 58, Issue:3, 2015
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.The Journal of biological chemistry, , Apr-22, Volume: 280, Issue:16, 2005
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Acetylene Group, Friend or Foe in Medicinal Chemistry.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition.Journal of medicinal chemistry, , May-04, Volume: 43, Issue:9, 2000
Multi-target design strategies for the improved treatment of Alzheimer's disease.European journal of medicinal chemistry, , Aug-15, Volume: 176, 2019
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011